The smarter, the stronger: Intelligence level correlates with brain resilience to systematic insults

Cortex ◽  
2015 ◽  
Vol 64 ◽  
pp. 293-309 ◽  
Author(s):  
Emiliano Santarnecchi ◽  
Simone Rossi ◽  
Alessandro Rossi
Keyword(s):  
Intelligence Level ◽  
Brain Resilience

scholarly journals Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer’s Disease

2021 ◽  
Vol 22 (1) ◽  
pp. 461
Author(s):  
Sónia C. Correia ◽  
Nuno J. Machado ◽  
Marco G. Alves ◽  
Pedro F. Oliveira ◽  
Paula I. Moreira
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Brain Cortex ◽  
Neurodegenerative Disorder ◽  
Special Focus ◽  
Mitochondrial Bioenergetics ◽  
Related Phenotype ◽  
Brain Resilience ◽  
The Brain

The lack of effective disease-modifying therapeutics to tackle Alzheimer’s disease (AD) is unsettling considering the actual prevalence of this devastating neurodegenerative disorder worldwide. Intermittent hypoxic conditioning (IHC) is a powerful non-pharmacological procedure known to enhance brain resilience. In this context, the aim of the present study was to investigate the potential long-term protective impact of IHC against AD-related phenotype, putting a special focus on cognition and mitochondrial bioenergetics and dynamics. For this purpose, six-month-old male triple transgenic AD mice (3×Tg-AD) were submitted to an IHC protocol for two weeks and the behavioral assessment was performed at 8.5 months of age, while the sacrifice of mice occurred at nine months of age and their brains were removed for the remaining analyses. Interestingly, IHC was able to prevent anxiety-like behavior and memory and learning deficits and significantly reduced brain cortical levels of amyloid-β (Aβ) in 3×Tg-AD mice. Concerning brain energy metabolism, IHC caused a significant increase in brain cortical levels of glucose and a robust improvement of the mitochondrial bioenergetic profile in 3×Tg-AD mice, as mirrored by the significant increase in mitochondrial membrane potential (ΔΨm) and respiratory control ratio (RCR). Notably, the improvement of mitochondrial bioenergetics seems to result from an adaptative coordination of the distinct but intertwined aspects of the mitochondrial quality control axis. Particularly, our results indicate that IHC favors mitochondrial fusion and promotes mitochondrial biogenesis and transport and mitophagy in the brain cortex of 3×Tg-AD mice. Lastly, IHC also induced a marked reduction in synaptosomal-associated protein 25 kDa (SNAP-25) levels and a significant increase in both glutamate and GABA levels in the brain cortex of 3×Tg-AD mice, suggesting a remodeling of the synaptic microenvironment. Overall, these results demonstrate the effectiveness of the IHC paradigm in forestalling the AD-related phenotype in the 3×Tg-AD mouse model, offering new insights to AD therapy and forcing a rethink concerning the potential value of non-pharmacological interventions in clinical practice.

scholarly journals Brain Resilience: The Effect of White Matter Disease on Brain Networks in Cognitively Normal Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 918-918
Author(s):  
Blake Neyland ◽  
Christina Hugenschmidt ◽  
Samuel Lockhart ◽  
Laura Baker ◽  
Suzanne Craft ◽  
...  
Keyword(s):  
Older Adults ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Brain Networks ◽  
Network Connectivity ◽  
Anterior Cingulate ◽  
Functional Brain ◽  
Mobility Function ◽  
Functional Brain Networks ◽  
Brain Resilience

Abstract Brain pathologies are increasingly understood to confer mobility risk, but the malleability of functional brain networks may be a mechanism for mobility reserve. In particular, white matter hyperintensities (WMH) are strongly associated with mobility and alter functional network connectivity. To assess the potential role of brain networks as a mechanism of mobility reserve, 116 participants with MRI from the Brain Networks and Mobility Function (B-NET) were categorized into 4 groups based on median splits of SPPB scores and WMH burden: Expected Healthy (EH: low WMH, SPPB>10, N=45), Expected Impaired (EI: high WMH, SPPB10, N=24), Unexpected Impaired (EI: low WMH, SPPB<10, N=10) and Unexpected Unhealthy (UH: low WMH, SPPB<10, N=37). Functional brain networks were calculated using graph theory methods and white matter hyperintensities were quantified with the Lesion Segmentation Toolbox (LST) in SPM12. Somatomotor cortex community structure (SMC-CS) was similar between UH and EH with both having higher consistency than EI and UI. However, UH displayed a unique increase in second-order connections between the motor cortex and the anterior cingulate. It is possible that this increase in connections is a signal of higher reserve or resilience in UH participants and may indicate a mechanism of compensation in regards to mobility function and advanced WMH burden. These data suggest functional brain networks may be a mechanism for mobility resilience in older adults at mobility risk due to WMH burden.

scholarly journals Emotional Intelligence Differences between the Normal, the Blind and the Deaf in Adolescence in a Jordanian Sample

2015 ◽  
Vol 7 (2) ◽  
pp. 392
Author(s):  
Feryal Shnekat
Keyword(s):  
Emotional Intelligence ◽  
Female Students ◽  
Intelligence Scale ◽  
Male And Female ◽  
Intelligence Level ◽  
The Impact

<p>This study aimed to identify the Emotional intelligence differences between the normal, the<br />blind and the deaf in a Jordanian sample, in addition to the impact of the gender and type of<br />disability on the level of the emotional intelligence. The sample of the study consisted of 150<br />male and female students who are normal, deaf and blind in the adolescence. The researcher<br />collected data using Bar-On Emotional intelligence scale which is developed by Alia<br />Al-Oweidi and it is consisted of 60items distributed into six domains. Results showed the<br />highest mean of emotional intelligence level was for the normal students, the deaf and the<br />blind respectively. The results also showed that there were statistical significant differences<br />attributed to the type of the disability variable but there were no statistical significant<br />differences attributed to the gender variable.</p>

Characterizing the Resilience Effect of Neurodegeneration for the Mechanistic Pathway of Alzheimer’s Disease

2021 ◽  
pp. 1-12
Author(s):  
Di Hu ◽  
Chuning Liu ◽  
Kai Xia ◽  
Amy Abramowitz ◽  
Guorong Wu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rapid Development ◽  
Demographic Data ◽  
Strong Association ◽  
Synergetic Effect ◽  
Amyloid Β ◽  
Angular Gyrus ◽  
Limited Attention ◽  
Brain Resilience

Background: With the rapid development of neurobiology and neuroimaging technologies, mounting evidence shows that Alzheimer’s disease (AD) is caused by the build-up of two abnormal proteins, amyloid-β plaques (A) and neurofibrillary tangles (T). Over time, these AD-related neuropathological burdens begin to spread throughout the brain, which results in the characteristic progression of symptoms in AD. Objective: Although tremendous efforts have been made to link biological indicators to the progression of AD, limited attention has been paid to investigate the multi-factorial role of socioeconomic status (SES) in the prevalence or incidence of AD. There is high demand to explore the synergetic effect of sex and SES factors in moderating the neurodegeneration process caused by the accumulation of A and T biomarkers. Methods: We carry out a meta-data analysis on the longitudinal neuroimaging data, clinical outcomes, genotypes, and demographic data in Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (http://adni.loni.usc.edu). Results: Our major findings include 1) education and occupation show resilience effects at the angular gyrus, superior parietal lobule, lateral occipital-temporal sulcus, and posterior transverse collateral sulcus where we found significant slowdown of neurodegeneration due to higher education level or more advanced occupation rank; 2) A and T biomarkers manifest different spatial patterns of brain resilience; 3) BDNF (brain-derived neurotrophic factor) single nucleotide polymorphism (SNP) rs10835211 shows strong association to the identified resilience effect; 4) the identified resilience effect is associated with the clinical manifestation in memory, learning, and organization performance. Conclusion: Several brain regions manifest resilience from SES to A and T biomarkers. BDNF SNPs have a potential association with the resilience effect from SES. In addition, cognitive measures of learning and memory demonstrate the resilience effect.

HUBUNGAN INTELEGENSI DENGAN PERILAKU NERS TINGKAT II STIKES SANTA ELISABETH MEDAN

2016 ◽  
Vol 1 (1) ◽  
pp. 21-30
Author(s):  
Imelda Derang
Keyword(s):  
Student Nurses ◽  
Sampling Technique ◽  
P Value ◽  
Test Results ◽  
Cross Sectional ◽  
Intelligence Level ◽  
Level Ii ◽  
Study Population ◽  
Cross Sectional Design ◽  
The Relationship

Intelligence is the ability to apply the knowledge and experiences that have been gained into the effort tasks are challenging and flexible book. Behaviour is an action that involves aspects of affective, cognitive, and psychomotor. Goal: This study aims to determine the relationship between the behavior of student nurses intelligence level II STIKes Santa Elisabeth Medan. Method: This study uses correlation with cross sectional design. The study population was all students / i Ners Level II STIKes Santa Elisabeth Medan as 65. The samples used were 65 respondents, the sampling technique in this research is using purposive sampling. The instrument of this study using questionnaire and observation sheets by using product moment test person. Result: Intelligence students as many as 30 people (46.2%) classified as having an average level of intelligence. A total of 32 people (49.2%) classified as well-behaved students. Person product moment test results obtained p value = 0.172 where a significant level of p> 0.05 so that this value proves that the absence of a relationship between the behavior of student nurses intelligence level II STIKes Santa Elisabeth Medan. Conclusion: Recommended for institutions, motivating students in balancing the behavior and intelligence. 

Effects of Certain Subject Variables on Stanford-Binet Item Performance of Five-Year-Old Children

1970 ◽  
Vol 26 (3) ◽  
pp. 975-984
Author(s):  
Mary Juhan Larsen ◽  
Jerry C. Allen
Keyword(s):  
Socioeconomic Status ◽  
Test Performance ◽  
Intelligence Test ◽  
Single Variable ◽  
Community Size ◽  
Intelligence Level ◽  
Performance Differences ◽  
Subject Variables ◽  
Test Standardization

Item performance on the Stanford-Binet by a sample ( n = 289) of Georgia children (CA = 5) and by equivalent-aged children used in the test standardization was compared in terms of 5 subject variables: race, sex, socioeconomic status, intelligence level, and community size. The Georgia Sample's performance exceeded ( p < .01) the norm group's performance on 62% of the items. The five subject variables were associated with these differences: among levels of the variables, variations occurred in the presence and direction of item performance differences; generally, more than one subject variable influenced item performance. These data affirm that certain variables confound intelligence test performance and that norms based on a single variable, like race, do not eliminate test biases.

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