Recombinant human interleukin-11 (IL-11) is a protective factor in severe sepsis with thrombocytopenia: A case-control study

Cytokine ◽  
2015 ◽  
Vol 76 (2) ◽  
pp. 138-143 ◽  
Author(s):  
Bing Wan ◽  
Hao Zhang ◽  
Haiyan Fu ◽  
Yikun Chen ◽  
Liping Yang ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Protective Factor ◽  
Case Control Study ◽  
Case Control ◽  
Interleukin 11 ◽  
Control Study

scholarly journals High Blood Pressure during Pregnancy is not a Protective Factor for Preterm Infants with Very Low Birth Weight. A Case-Control Study

2017 ◽  
Vol 39 (04) ◽  
pp. 155-161 ◽  
Author(s):  
Annibal Sabino ◽  
Eduardo de Souza ◽  
Ana Goulart ◽  
Adriana Lima ◽  
Nelson Sass
Keyword(s):  
Blood Pressure ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Protective Factor ◽  
Case Control Study ◽  
Very Low Birth Weight ◽  
Case Control ◽  
World Health ◽  
Control Group ◽  
Control Study

Objective To evaluate whether the presence of maternal blood pressure reduces the risks of morbidity, perinatal mortality and morbidity at 24 months of age in very low birth weight infants (VLBWIs) compared with a control group. Methods A retrospective, observational, case-control study. Total 49 VLBWIs were allocated to the study group, called the maternal arterial hypertension group (AHG), and matched with 44 in the control group (CG). The infants were assessed during hospitalization and at 12 and 24 months corrected age at a specialized clinic. For the assessment of growth, the World Health Organization (WHO) Anthro software (Geneva, 2006) was used, and for the psychomotor assessment, the Denver II test was used. Results In relation to the antenatal variables, the infants of the AHG had more centralized circulation assessed by Doppler, received more corticosteroids and magnesium sulfate, and were born by cesarean section more frequently. In terms of the postnatal and in-hospital outcomes, the AHG had a higher gestational age at birth (30.7 versus 29.6 weeks) and a lower frequency of 5-minute Apgar scores of less than 7 (26.5% versus 52.3%). The CG had a higher rate of pulmonary dysplasia (30.2% versus 8.3%). There were no differences in terms of hospital mortality, complications, somatic growth and functional problems at 24 months of corrected age. Conclusion The presence of maternal hypertension, especially preeclampsia, was not a protective factor against morbidity, mortality and evolution in VLBWIs aged up to 24 months. Therefore, the clinical practice should be focused on prolonging the pregnancy for as long as possible in these conditions as well.

77 High blood pressure during pregnancy is not a protective factor for preterm infants with very low weight. A case-control study

2016 ◽  
Vol 6 (3) ◽  
pp. 215
Author(s):  
Annibal Tagliaferri Sabino ◽  
Eduardo de Souza ◽  
Ana Lucia Goulart ◽  
Adriana Martins de Lima ◽  
Nelson Sass
Keyword(s):  
Blood Pressure ◽  
Preterm Infants ◽  
High Blood Pressure ◽  
Protective Factor ◽  
Case Control Study ◽  
Case Control ◽  
Low Weight ◽  
Control Study

Risk factors for sporadic infection withSalmonellaInfantis: a matched case-control study

2013 ◽  
Vol 142 (4) ◽  
pp. 820-825 ◽  
Author(s):  
R. BASSAL ◽  
A. REISFELD ◽  
I. NISSAN ◽  
V. AGMON ◽  
D. TARAN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Protective Factor ◽  
Case Control Study ◽  
Tap Water ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

SUMMARYThis matched case-control study investigated the risk factors for sporadicSalmonellaInfantis infection in 263 affected children and 263 age-, gender- and neighbourhood-matched controls. Information about exposure to potential risk factors was obtained via telephone interview and evaluated by conditional logistic regression analysis. Age groups ⩽1 year (n = 77) and >1 year (n = 186) were analysed separately. Of those aged ⩽1 year, breastfeeding was a significant protective factor against infection [matched odds ratio (mOR) 0·24, 95% confidence interval (CI) 0·10–0·59,P < 0·01]. In the older group, consumption of eggs (mOR 1·87, 95% CI 1·00–3·49,P = 0·05) was a significant risk factor and thawing chicken in water (mOR 2·55, 95% CI 0·94–6·91,P = 0·07) was borderline risk factor, while consumption of carrots (mOR 0·46, 95% CI 0·26–0·83,P < 0·01), drinking tap water (mOR 0·44, 95% CI 0·22–0·85,P = 0·02), religious lifestyle (mOR 0·40, 95% CI 0·21–0·74,P < 0·01) and having a high number of children in the household (mOR 0·72, 95% CI 0·58–0·88,P < 0·01) were significant protective factors. Consumers should avoid eating undercooked eggs and food handlers should be educated regarding proper handling and cooking of eggs. Breastfeeding should be strongly encouraged by public health authorities. The public must be educated on stringent hygiene practices, especially proper cooking of eggs to reduce infection rates.

scholarly journals Risk factors of obesity among Brazilian adolescents: a case–control study

2003 ◽  
Vol 6 (8) ◽  
pp. 743-749 ◽  
Author(s):  
Marilda B Neutzling ◽  
José August AC Taddei ◽  
Denise P Gigante
Keyword(s):  
Risk Factors ◽  
Protective Factor ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Reference Population ◽  
Case Control ◽  
Overweight And Obesity ◽  
Factors Associated ◽  
History Of Obesity ◽  
Control Study

AbstractObjective:To study risk factors associated with overweight and obesity among adolescents enrolled in private high schools in the city of Pelotas, southern Brazil.Method:This was a case–control study. The subjects were 264 overweight (body mass index (BMI) ≥85th percentile of the National Center for Health Statistics (NCHS) reference population) and 264 non-overweight (BMI > 5th and <85th NCHS percentiles) adolescents identified by means of an anthropometric survey which included 1608 students. The adolescents were weighed, measured and interviewed about food habits and physical activity at school. Parents provided their own weights and heights when contacted by telephone, and parental BMI was calculated.Results:Hierarchical multiple conditional logistic regression showed that overweight and obesity were positively associated with mother's (odds ratio (OR) 2.86, 95% confidence interval (Cl) 1.43–5.74) and father's (OR 2.43, 95% Cl 1.37–4.30) BMI ≥ 30 kg m−2, being overweight before 10 years of age (OR 2.26, 95% Cl 1.30–3.90) and the habit of dieting (OR 3.53, 95% Cl 1.76–7.22). Having more than three meals per day was found to be a protective factor against overweight and obesity (OR 0.54, 95% Cl 0.29–1.00).Conclusion:The present study showed that a family history of obesity, overweight during childhood and the habit of dieting for weight-loss purposes are factors associated with obesity during adolescence. The habit of having more than three daily meals turned out to be a protective factor against overweight. These results suggest the necessity for early intervention at the family and general community levels aimed at the prevention of obesity through actions directed towards the modification of established behaviours.

scholarly journals Association Between Serum Microcystins Levels and Chronic Pelvic Inflammatory Disease: a Case-control Study

2021 ◽  
Author(s):  
Na Zhu ◽  
Xiaolan Wang ◽  
Jia Tan ◽  
Shuaishuai Xu ◽  
Yanhong Peng ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Protective Factor ◽  
Case Control Study ◽  
Binary Logistic Regression ◽  
Scientific Basis ◽  
Case Control ◽  
Central China ◽  
The Relationship ◽  
Control Study

Abstract Microcystins(MCs) have been reported to be closely related to the occurrence and development of inflammation by animal and cell experiments, but there are no study on the relationship between serum microcystin-LR(MC-LR) and chronic pelvic inflammatory disease (CPID) risk in populations. We designed a clinical case-control study to investigate the relationship between serum MC-LR and CPID risk. From October 2020 to March 2021, 50 patients diagnosed with CPID and 50 controls (frequency matched by age) were recruited from the First Hospital University of South China, in Hengyang, Central China. The basic information on lifestyle and history of disease was acquired through questionnaires. Blood samples were analyzed for MC-LR by ELISA. Binary logistic regression analyses and chi-square test were used to evaluate the effects of MC-LR on CPID risk. With the increase of serum MC-LR level (Q2, Q3 and Q4), the AOR of CPID risk increased (0.139, 0.167 and 0.040, respectively). The serum MC-LR(0.06 ~ 0.66µg/L) was an independent protective factor for CPID in humans, and the protective effect of concentrations ≥ 0.25μg/L was more obvious. Within the certain concentration range, MC-LR was an independent protective factor for the risk of CPID in humans, which will provide a scientific basis for the study of the relationship between serum microcystins and inflammation.

scholarly journals DOP40 Comorbidities and epidemiological risk factor but not immunosuppressive therapies increase the risk of COVID-19 in Inflammatory Bowel Disease (IBD): An ENEIDA-based, case-control study

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S078-S079
Author(s):  
Y Zabana Abdo ◽  
I Marín-Jiménez ◽  
I Rodríguez-Lago ◽  
I Vera ◽  
M D Martín ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Characteristics ◽  
Protective Factor ◽  
Case Control Study ◽  
Case Control ◽  
Occupational Risk ◽  
Disease Evolution ◽  
Epidemiological Risk ◽  
Epidemiological Risk Factor ◽  
Control Study

Abstract Background The information regarding IBD patients with COVID-19 suggests that the factors related to bad outcome are older age and comorbidity whereas immunosuppressants do not have a significant impact worsening the disease evolution. To date, there is no information to assess if there are differences in epidemiological, demographical, and clinical characteristics between infected and non-infected IBD patients. Methods Case-control study in IBD patients with COVID-19 (cases) compared to IBD without COVID-19 (controls) in the period March-July/2020 within the ENEIDA registry (promoted by GETECCU and with more than 60.000 IBD patients included). Cases were matched 1:2 by age (±5y), type of disease (CD/UC), gender, and centre. All controls were selected from only one investigator blind to other clinical characteristics of the patients to avoid selection bias. Results 496 cases and 964 controls from 63 Spanish centres were included. No differences were found within the basal characteristics including CD location, CD behaviour, extraintestinal manifestations, family history of IBD or smoking habits. Cases had ≥ 1 comorbidities (cases:43%vs. controls:36%, p=0.01) and occupational risk (cases:27% vs. controls:10.6%, p&lt;0.0001) in a higher proportion. Strict lockdown but not sick leave nor telecommuting was the only measure demonstrating protection against COVID-19 (cases:49% vs. controls:70%, p&lt;0.0001). There were no differences in the use of systemic steroids (p=0.19), immunosuppressants (p=0.54) or biologics (p=0.25) between cases and controls. Cases were more often treated with aminosalicylates (45% vs.34%, p=0.022). Having ≥ 1 comorbidities (OR:1.4, 95%CI: 1–1.8), occupational risk (OR:2.05, 95%CI:1.5–2.9) and the use of aminosalicylates (OR:1.4, 95%CI: 1–1.8) were risk factors for COVID-19. On the other hand, the strict lockdown was a protective factor (OR:0.36, CI:0.27–0.48). Conclusion Comorbidities and epidemiological risk factors are the most relevant aspects for the risk of COVID-19 in IBD patients. This risk of COVID-19 seems to be increased by aminosalicylates but not by immunosuppressants or biologics. The attitude regarding treating IBD patients with aminosalicylates during the COVID-19 pandemic deserves a deeper analysis. Funded by the Carlos III Health Institute COV20/00227.

scholarly journals Fluid resuscitation and outcomes in heart failure patients with severe sepsis or septic shock: A retrospective case-control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256368
Author(s):  
Roshan Acharya ◽  
Aakash Patel ◽  
Evan Schultz ◽  
Michael Bourgeois ◽  
Natalie Kandinata ◽  
...  
Keyword(s):  
Heart Failure ◽  
Septic Shock ◽  
Mechanical Ventilation ◽  
Severe Sepsis ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Fluid Bolus ◽  
Baseline Characteristics ◽  
Control Study

Background The use of ≥30 mL/Kg fluid bolus in congestive heart failure (CHF) patients presenting with severe sepsis or septic shock remained controversial due to the paucity of data. Methods The retrospective case-control study included 671 adult patients who presented to the emergency department of a tertiary care hospital from January 01, 2017 to December 31, 2019 with severe sepsis or septic shock. Patients were categorized into the CHF group and the non-CHF group. The primary outcome was to evaluate the compliance with ≥30 mL/Kg fluid bolus within 6 hours of presentation. The comparison of baseline characteristics and secondary outcomes were done between the groups who received ≥30 mL/Kg fluid bolus. For the subgroup analysis of the CHF group, it was divided based on if they received ≥30 mL/Kg fluid bolus or not, and comparison was done for baseline characteristics and secondary outcomes. Univariate and multivariable analyses were performed to explore the differences between the groups for in-hospital mortality and mechanical ventilation. Results The use of ≥30 mL/Kg fluid bolus was low in both the CHF and non-CHF groups [39% vs. 66% (p<0.05)]. Mortality was higher in the CHF group [33% vs 18% (p<0.05)]. Multivariable analysis revealed that the use of ≥30 mL/Kg fluid bolus decreased the chances of mortality by 12% [OR 0.88, 95% CI 0.82–0.95 (p<0.05)]. The use of ≥30 mL/Kg fluid bolus did not increase the odds of mechanical ventilation [OR 0.99, 95% CI 0.93–1.05 (p = 0.78)]. In subgroup analysis, the use of ≥30 mL/Kg fluid bolus decreased the chances of mortality by 5% [OR 0.95, 95% CI 0.90–0.99, (p<0.05)] and did not increase the odds of mechanical ventilation. The presence of the low ejection fraction did not influence the chance of getting fluid bolus. Conclusion The use of ≥30 mL/Kg fluid bolus seems to confer protection against in-hospital mortality and is not associated with increased chances of mechanical ventilation in heart failure patients presenting with severe sepsis or septic shock.

scholarly journals Genetic Association of Angiotensin-Converting Enzyme (ACE) Gene I/D Polymorphism with Preterm Birth in Korean Women: Case-Control Study and Meta-Analysis

Medicina ◽  
2019 ◽  
Vol 55 (6) ◽  
pp. 264 ◽  
Author(s):  
Noo Ri Lee ◽  
In Wook Hwang ◽  
Hyung Jun Kim ◽  
Yun Dan Kang ◽  
Jin Wan Park ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Angiotensin Converting Enzyme ◽  
Protective Factor ◽  
Case Control Study ◽  
Genetic Model ◽  
Meta Analysis ◽  
Case Control ◽  
Converting Enzyme ◽  
Ace Gene ◽  
Control Study

Background and Objectives: The ACE gene encodes the angiotensin-converting enzyme (ACE), a component of the renin-angiotensin system. Increased ACE activity may cause abnormal regulation of placental circulation and angiogenesis, resulting in adverse pregnancy outcomes. Previous studies have reported that the insertion/deletion (I/D) polymorphism of the ACE gene is associated with the development of preterm birth (PTB). However, results of the association between ACE gene I/D and PTB are inconsistent in various populations. Therefore, we performed a case-control study and a meta-analysis to evaluate the association between ACE I/D polymorphism and PTB. Materials and Methods: We analyzed a total of 254 subjects (111 patients with PTB and 143 women at ≥38 weeks gestation) for the case-control study. For the meta-analysis, we searched Google Scholar, PubMed, and NCBI databases with the terms “ACE,” “angiotensin-converting enzyme,” “preterm birth,” “preterm delivery,” and their combinations. Results: Our results of the case-control study indicated that ACE I/D polymorphism is significantly associated with PTBs in the overdominant genetic model (odds ratio (OR) 0.57, 95% confidence interval (CI) 0.347–0.949, p = 0.029) and that the ID genotype of ACE I/D polymorphism has a protective effect for PTB (OR 0.57, 95% CI 0.333–0.986, p = 0.043). Similarly, the meta-analysis showed that the OR for the ACE gene ID genotype was 0.66 (95% CI 0.490–0.900, p < 0.01). Conclusion: The ACE gene ID genotype has a significant association with PTB and is a protective factor for PTB. A larger sample set and functional studies are required to further elucidate of our findings.

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