scholarly journals Ellagic acid plays an important role in enhancing productive performance and alleviating oxidative stress, apoptosis in laying quail exposed to lead toxicity

2021 ◽  
Vol 208 ◽  
pp. 111608
Author(s):  
Seda Iflazoglu Mutlu ◽  
Ismail Seven ◽  
Gozde Arkali ◽  
Nurgul Birben ◽  
Aslihan Sur Arslan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ellagic Acid ◽  
Lead Toxicity ◽  
Productive Performance ◽  
Laying Quail

scholarly journals Ellagic Acid Suppresses the Oxidative Stress Induced by Dietary-Oxidized Tallow

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Alam Zeb ◽  
Adnan Akbar
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Ellagic Acid ◽  
Animal Studies ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Thiobarbituric Acid ◽  
Rabbit Heart ◽  
The Body ◽  
Margaric Acid

Dietary tallow was thermally oxidized at 180°C in an open fryer. The oxidized tallow (OT) and unoxidized tallow were characterized for oxidation parameters and fatty acid composition using GC-MS. Tallow samples were fed to rabbits along with 50, 100, and 150 mg/kg/day of ellagic acid (EA) for three weeks. Results revealed that the peroxide value (PV) and thiobarbituric acid reactive substances (TBARS) significantly increased, while radical scavenging activity (RSA) of the tallow decreased significantly with oxidation. GC-MS analysis showed eight fatty acids in the tallow samples, where palmitic acid (48.5-49.7 g/100 g), linoleic acid (18.7-23.7 g/100 g), stearic acid (13.5-15.6 g/100 g), and margaric acid (6.32-6.42 g/100 g) were the major fatty acids. Animal studies showed that oxidized tallow (OT) alone or in combination with EA significantly altered the body weight of the rabbits. Serum biochemical parameters and renal function tests were affected by OT and ameliorated by EA. The toxic effects of OT on haematological indices were minimized by EA. The supplementation of OT alone had significant effects on the liver structure and functions. The coadministration of EA reduced the toxic properties of OT on the liver, by increasing the antioxidant (GSH) system. The rabbit heart was also affected by the OT, which was ameliorated by EA supplementation. These results suggested that the supplementation of EA was beneficial against the OT-induced oxidative stress and may be considered for foods containing oxidized lipids.

scholarly journals Ellagic Acid ameliorates Streptozotocin-Induced Diabetic Hyperalgesia in Rat: Involvement of Oxidative Stress

2021 ◽  
Author(s):  
Siamak Shahidi ◽  
◽  
Alireza Komaki ◽  
Safoura Raoufi ◽  
Iraj Salehi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ellagic Acid ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Antinociceptive Effect ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Tail Flick ◽  
Stress Markers ◽  
Total Antioxidant

Background/Aim: Hyperalgesia is one of the current complications of diabetes mellitus that Oxidative stress and inflammation have principal role in its development. Ellagic Acid (EA) as a herbal component, has some biological activities, including antioxidant and anti-inflammatory effects. This study was designed to evaluate the possible beneficial effect of EA on hyperalgesia in streptozotocin (STZ)-induced diabetic rat. Materials and Methods: Rats were divided into control(vehicle received), diabetic, EA (25, 50 mg/kg)-treated control and EA(25, 50 mg/kg)-treated diabetic groups. Diabetes was induced by a single intraperitoneal (IP) injection of streptozotocin (STZ) (60 mg/Kg). EA was administered daily by oral gavage for 4 weeks. Hyperalgesia was assessed using tail flick (TF) and hot plate (HP) tests. Also, oxidative stress markers including malondialdehyde (MDA), total oxidant status (TOS) and total antioxidant capacity (TAC) in the serum were evaluated. Results: Diabetic animals showed marked reductions in TF and HP latencies, elevation of serum MDA level and TOS and diminution of serum TAC compared to controls significantly. Treatment of Diabetic rats with EA ameliorated reduction of TF latency at the dose of 25 mg/kg and HP latency at the dose of 50 mg/kg. Furthermore EA significantly increased TAC and decreased MDA level at dose of 50 mg/kg and reduced TOS at both doses in the serum of diabetic animals. In EA treated normal rats we could see no significant alterations in the parameters studied. Conclusion: These results displayed potent antinociceptive effect of EA in diabetic rats via attenuating oxidative stress. This proposes therapeutic potential of EA for damping diabetic hyperalgesia.

scholarly journals Effect of replacement different levels of sesame meal as a protein source to replace soybean meal on the productive performance and reproductive of laying quail: تأثير استبدال مستويات مختلفة من كسبة السمسم كمصدر بروتيني محل كسبة فول الصويا على الأداء الإنتاجي والتناسلي لطائر السمان البياض

2021 ◽  
Vol 5 (3) ◽  
pp. 70-58
Author(s):  
Duraid Thonnon Younis, Khalid Hadi Mustafa Al-Sofee Duraid Thonnon Younis, Khalid Hadi Mustafa Al-Sofee
Keyword(s):  
Soybean Meal ◽  
Feed Intake ◽  
Egg Production ◽  
Protein Source ◽  
Egg Mass ◽  
Average Weight ◽  
Productive Performance ◽  
Sesame Meal ◽  
Laying Quail ◽  
Different Levels

The study was conducted in the poultry field in the Animal Production Department/ College of Agriculture and Forestry/ University of Mosul, for the period from 18/ 2/ 2020 until 13/ 4/ 2020. The experiment aimed to study the effect of replacement different levels of sesame meal (SSM) as a protein source to replace soybean meal (SBM) on the productive performance and reproductive of laying quail, 360 quail birds (240 females and 120 males) were used, at the age of 49 days, distributed randomly into five treatments, each treatment with eight replicates, ( 9 birds in each replicate 6 females and 3 males). The treatments were as follows: the first was the control (0% SSM), the second, third, fourth, and the fifth replaced SSM by SBM with level (25, 50, 75 and 100%) respectively, feed and water was ad libitum during the trial period of 8 weeks. The results of the statistical analysis showed there is a significant statistical difference at a level (P≤0.05) in the fifth treatment (100% SSM) as compared to control and other treatments in total egg number, average egg weight, total egg mass, Hen day egg production percentage (% HD), feed intake, feed conversion ratio, fertility, and hatching percentage of total eggs, average weight of hatched chicks, and a significant increase in the embryo mortality. The results also showed a significant decrease at a level (P≤0.05) in the feed intake for the fourth treatment (75% SSM) compared to the control, while no significant differences were observed for the other treatments in all the studied traits. The results of this study showed the possibility of using sesame meal as a protein source at (75%) to replace soybean meal in laying quail bird diets.

Reduction of oxidative stress and apoptosis in hyperlipidemic rabbits by ellagic acid

2005 ◽  
Vol 16 (11) ◽  
pp. 675-681 ◽  
Author(s):  
Ya-Mei Yu ◽  
Weng-Cheng Chang ◽  
Chieh-Hsi Wu ◽  
Su-Yin Chiang
Keyword(s):  
Oxidative Stress ◽  
Ellagic Acid

scholarly journals Oxidative Stress, Antioxidant Capabilities, and Bioavailability: Ellagic Acid or Urolithins?

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 707 ◽  
Author(s):  
Silvana Alfei ◽  
Barbara Marengo ◽  
Guendalina Zuccari
Keyword(s):  
Oxidative Stress ◽  
Ellagic Acid ◽  
Functional Foods ◽  
Fruits And Vegetables ◽  
Human Diseases ◽  
Natural Polyphenols ◽  
Extreme Variability ◽  
Therapeutic Alternatives

Oxidative stress (OS), triggered by overproduction of reactive oxygen and nitrogen species, is the main mechanism responsible for several human diseases. The available one-target drugs often face such illnesses, by softening symptoms without eradicating the cause. Differently, natural polyphenols from fruits and vegetables possess multi-target abilities for counteracting OS, thus representing promising therapeutic alternatives and adjuvants. Although in several in vitro experiments, ellagitannins (ETs), ellagic acid (EA), and its metabolites urolithins (UROs) have shown similar great potential for the treatment of OS-mediated human diseases, only UROs have demonstrated in vivo the ability to reach tissues to a greater extent, thus appearing as the main molecules responsible for beneficial activities. Unfortunately, UROs production depends on individual metabotypes, and the consequent extreme variability limits their potentiality as novel therapeutics, as well as dietary assumption of EA, EA-enriched functional foods, and food supplements. This review focuses on the pathophysiology of OS; on EA and UROs chemical features and on the mechanisms of their antioxidant activity. A discussion on the clinical applicability of the debated UROs in place of EA and on the effectiveness of EA-enriched products is also included.

scholarly journals Improvement of endothelial function by Gunnera tinctoria extract with antioxidant properties

2020 ◽  
Vol 53 (1) ◽  
Author(s):  
Constanza Sabando ◽  
Maité Rodríguez-Díaz ◽  
Walther Ide ◽  
Edgar Pastene ◽  
Marcia Avello ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Function ◽  
Ellagic Acid ◽  
Methanolic Extract ◽  
Umbilical Vein ◽  
Chemical Constituents ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Antioxidant Power ◽  
Quercetin Derivatives

Abstract Background Gunnera tinctoria has been collected by Mapuche-Pewenche people for food and medicinal purposes. The high polyphenol content of methanolic extract from G. tinctoria leaves with chemical constituents such as ellagic acid and quercetin derivatives suggests its application to prevent endothelial dysfunction and oxidative stress. The aim of this study was to provide evidence of the protective effect of this extract on endothelial function by reducing oxidative stress induced by high d-glucose and H2O2, as well as by stimulating nitric oxide (NO) levels in human umbilical vein endothelial cells (HUVECs). Results A methanolic extract with a high content of polyphenols (520 ± 30 mg gallic acid equivalents/g dry extract) was obtained from G. tinctoria leaves. Its main constituent was ellagic acid. The results of Ferric reducing antioxidant power and 2,2-diphenyl-1-picrylhydrazyl radical scavenging assays of the extract confirmed its antioxidant activity by inhibition pathway of radical species. The incubation of HUVECs with the extract decreased the apoptosis and reactive oxygen species (ROS) synthesis induced by high extracellular concentration of d-glucose or hydrogen peroxide. The extract increased endothelial NO levels and reduced vasoconstriction in human placental vessels. Conclusions This study provides evidence about the antioxidant and endothelial protective properties of methanolic G. tinctoria leaf extract. The extract improves the availability of NO in HUVECs, inhibiting the production of ROS and vasoconstriction.

Ellagic acid alleviates clozapine‑induced oxidative stress and mitochondrial dysfunction in cardiomyocytes

2020 ◽  
pp. 1-9
Author(s):  
Roya Ahangari ◽  
Saleh Khezri ◽  
Asal Jahedsani ◽  
Saba Bakhshii ◽  
Ahmad Salimi
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Ellagic Acid
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