The interaction of 4-thiazolidinone derivatives containing indolin-2-one moiety with P-glycoprotein studied using K562 cell lines

2015 ◽  
Vol 101 ◽  
pp. 126-132 ◽  
Author(s):  
Feng Wang ◽  
Zijian Liu ◽  
Jian Wang ◽  
Jun Tao ◽  
Ping Gong ◽  
...  
Keyword(s):  
Cell Lines ◽  
K562 Cell ◽  
P Glycoprotein

scholarly journals Comparative evaluation of S9788, verapamil, and cyclosporine A in K562 human leukemia cell lines and in P-glycoprotein-expressing samples from patients with hematologic malignancies

Blood ◽  
1994 ◽  
Vol 84 (1) ◽  
pp. 262-269 ◽  
Author(s):  
JL Merlin ◽  
A Guerci ◽  
S Marchal ◽  
N Missoum ◽  
C Ramacci ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cyclosporine A ◽  
K562 Cell ◽  
Simultaneous Detection ◽  
Leukemia Cell ◽  
Hematologic Malignancies ◽  
Clinical Samples ◽  
Human Leukemia ◽  
P Glycoprotein ◽  
Complete Reversal

Abstract The activity of S9788, recently synthetized as a modulator of multidrug resistance (MDR), was compared with verapamil and cyclosporine A in normal sensitive and MDR K562 cell lines, then in samples from 33 patients with hematological malignancies, using flow cytometry with simultaneous detection of P-glycoprotein and determination of intracellular daunorubicin fluorescence. This technique was compared and correlated with a tritiated daunorubicin accumulation method. In K562 cell lines, S9788 exhibited a significantly higher reversing activity than verapamil and cyclosporine A, and allowed a complete restoration of the accumulation of daunorubicin when used at 5 mumol/L. In the clinical samples, the three compounds were evaluated at equimolar concentration (5 mumol/L) using concomitant exposure to daunorubicin and to the reversing agent. In P-glycoprotein-negative samples, no significant effect on intracellular daunorubicin fluorescence of any of the reversing agents was noted. In the 15 P- glycoprotein-positive samples, a significant increase in daunorubicin fluorescence, by at least one reversing agent, was seen in 10 cases, among which S9788 reversing activity was higher than that of the two other agents in seven cases. Complete reversal was only achieved in one case with S9788.

scholarly journals Comparative evaluation of S9788, verapamil, and cyclosporine A in K562 human leukemia cell lines and in P-glycoprotein-expressing samples from patients with hematologic malignancies

Blood ◽  
1994 ◽  
Vol 84 (1) ◽  
pp. 262-269
Author(s):  
JL Merlin ◽  
A Guerci ◽  
S Marchal ◽  
N Missoum ◽  
C Ramacci ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cyclosporine A ◽  
K562 Cell ◽  
Simultaneous Detection ◽  
Leukemia Cell ◽  
Hematologic Malignancies ◽  
Clinical Samples ◽  
Human Leukemia ◽  
P Glycoprotein ◽  
Complete Reversal

The activity of S9788, recently synthetized as a modulator of multidrug resistance (MDR), was compared with verapamil and cyclosporine A in normal sensitive and MDR K562 cell lines, then in samples from 33 patients with hematological malignancies, using flow cytometry with simultaneous detection of P-glycoprotein and determination of intracellular daunorubicin fluorescence. This technique was compared and correlated with a tritiated daunorubicin accumulation method. In K562 cell lines, S9788 exhibited a significantly higher reversing activity than verapamil and cyclosporine A, and allowed a complete restoration of the accumulation of daunorubicin when used at 5 mumol/L. In the clinical samples, the three compounds were evaluated at equimolar concentration (5 mumol/L) using concomitant exposure to daunorubicin and to the reversing agent. In P-glycoprotein-negative samples, no significant effect on intracellular daunorubicin fluorescence of any of the reversing agents was noted. In the 15 P- glycoprotein-positive samples, a significant increase in daunorubicin fluorescence, by at least one reversing agent, was seen in 10 cases, among which S9788 reversing activity was higher than that of the two other agents in seven cases. Complete reversal was only achieved in one case with S9788.

scholarly journals Increase in the Level of P-Glycoprotein mRNA Expression in Multidrug-resistant K562 Cell Lines Treated with Sodium Butyrate Is Not Accompanied with Erythroid Differentiation

1990 ◽  
Vol 81 (12) ◽  
pp. 1214-1217 ◽  
Author(s):  
Hiroyuki Shibata ◽  
Ryunosuke Kanamaru ◽  
Toshiaki Sato ◽  
Chikashi Ishioka ◽  
Yukari Konishi ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Cell Lines ◽  
Sodium Butyrate ◽  
K562 Cell ◽  
Erythroid Differentiation ◽  
Multidrug Resistant ◽  
P Glycoprotein

scholarly journals Retraction Note: Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
S. Mohana ◽  
M. Ganesan ◽  
N. Rajendra Prasad ◽  
D. Ananthakrishnan ◽  
D. Velmurugan
Keyword(s):  
Multidrug Resistance ◽  
Wnt Signaling ◽  
Cell Lines ◽  
P Glycoprotein ◽  
Overexpressing Cell

An amendment to this paper has been published and can be accessed via the original article.

Comparison of Furosemide and Vinblastine Secretion from Cell Lines Overexpressing Multidrug Resistance Protein (P-Glycoprotein) and Multidrug Resistance-Associated Proteins (MRP1 and MRP2)

Pharmacology ◽  
2002 ◽  
Vol 64 (3) ◽  
pp. 126-134 ◽  
Author(s):  
Shawn D. Flanagan ◽  
Carolyn L. Cummins ◽  
Miki Susanto ◽  
Xiaoli Liu ◽  
Lori H. Takahashi ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cell Lines ◽  
Multidrug Resistance Protein ◽  
P Glycoprotein ◽  
Associated Proteins ◽  
Resistance Protein

Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines

2013 ◽  
Vol 86 ◽  
pp. 208-217 ◽  
Author(s):  
Milka Jadranin ◽  
Milica Pešić ◽  
Ivana S. Aljančić ◽  
Slobodan M. Milosavljević ◽  
Nina M. Todorović ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Drug Resistant ◽  
P Glycoprotein
Sign in / Sign up

Export Citation Format

Share Document