Adult life events increase the risk of Cardiovascular Disease and Depressiveness among those with childhood adversities

2008 ◽  
Vol 23 ◽  
pp. S85
Author(s):  
K. Korkeila ◽  
J. Korkeila ◽  
J. Vahtera ◽  
L. Sillanmäki ◽  
M. Koskenvuo
Keyword(s):  
Cardiovascular Disease ◽  
Life Events ◽  
Adult Life ◽  
Childhood Adversities

scholarly journals Every Night and Every Morn: Effect of Variation in CLOCK Gene on Depression Depends on Exposure to Early and Recent Stress

2021 ◽  
Vol 12 ◽  
Author(s):  
Dorka Gyorik ◽  
Nora Eszlari ◽  
Zsofia Gal ◽  
Dora Torok ◽  
Daniel Baksa ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Linkage Disequilibrium ◽  
Life Events ◽  
Negative Life Events ◽  
Population Sample ◽  
Brief Symptom Inventory ◽  
Additive Models ◽  
Outcome Variable ◽  
Childhood Adversities ◽  
Increased Risk

The role of circadian dysregulation is increasingly acknowledged in the background of depressive symptoms, and is also a promising treatment target. Similarly, stress shows a complex relationship with the circadian system. The CLOCK gene, encoding a key element in circadian regulation has been implicated in previous candidate variant studies in depression with contradictory findings, and only a few such studies considered the interacting effects of stress. We investigated the effect of CLOCK variation with a linkage-disequilibrium-based clumping method, in interaction with childhood adversities and recent negative life events, on two phenotypes of depression, lifetime depression and current depressive symptoms in a general population sample.Methods: Participants in NewMood study completed questionnaires assessing childhood adversities and recent negative life events, the Brief Symptom Inventory to assess current depressive symptoms, provided data on lifetime depression, and were genotyped for 1054 SNPs in the CLOCK gene, 370 of which survived quality control and were entered into linear and logistic regression models with current depressive symptoms and lifetime depression as the outcome variable, and childhood adversities or recent life events as interaction variables followed by a linkage disequilibrium-based clumping process to identify clumps of SNPs with a significant main or interaction effect.Results: No significant clumps with a main effect were found. In interaction with recent life events a significant clump containing 94 SNPs with top SNP rs6825994 for dominant and rs6850524 for additive models on current depression was identified, while in interaction with childhood adversities on current depressive symptoms, two clumps, both containing 9 SNPs were found with top SNPs rs6828454 and rs711533.Conclusion: Our findings suggest that CLOCK contributes to depressive symptoms, but via mediating the effects of early adversities and recent stressors. Given the increasing burden on circadian rhythmicity in the modern lifestyle and our expanding insight into the contribution of circadian disruption in depression especially as a possible mediator of stress, our results may pave the way for identifying those who would be at an increased risk for depressogenic effects of circadian dysregulation in association with stress as well as new molecular targets for intervention in stress-related psychopathologies in mood disorders.

Preterm Birth as a Risk Factor for Metabolic Syndrome and Cardiovascular Disease in Adult Life: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 210 ◽  
pp. 69-80.e5 ◽  
Author(s):  
Panagiota Markopoulou ◽  
Eleni Papanikolaou ◽  
Antonis Analytis ◽  
Emmanouil Zoumakis ◽  
Tania Siahanidou
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Risk Factor ◽  
Preterm Birth ◽  
Meta Analysis ◽  
Adult Life

The Diet of Girls and Young Women at the Beginning of the Century

1993 ◽  
Vol 9 (1) ◽  
pp. 15-23 ◽  
Author(s):  
J. Fellague Ariouat ◽  
D.J.P. Barker
Keyword(s):  
Cardiovascular Disease ◽  
Young Women ◽  
Cardiovascular Mortality ◽  
Maternal Nutrition ◽  
Adult Life ◽  
Cardiovascular Death ◽  
Early Growth ◽  
Fetal Life ◽  
Fertility Rates ◽  
Death Rates

Recent research has shown that retarded growth during fetal life and infancy is linked to the development of cardiovascular disease (coronary heart disease and stroke) in adult life. Maternal nutrition has an important effect on early growth and the diets of young women may therefore influence cardiovascular disease in the next generation. Samples of women aged 80 years and over were interviewed in six areas of England and Wales with different cardiovascular death rates. The women, 281 in total, were asked about their diets when they were aged 10 to 15 years. Those who grew up in areas which now have low cardiovascular mortality tended to eat four meals a day rather than three, to live in households which had gardens, kept hens or livestock, and to go into domestic service, where diets were generally good. Those who grew up in areas which now have high cardiovascular mortality tended to eat less red meat, to live in houses without gardens, to enter industrial occupations and have higher fertility rates.

scholarly journals Possible Health Implications and Low Vitamin D Status during Childhood and Adolescence: An Updated Mini Review

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Dimitrios Papandreou ◽  
Pavlos Malindretos ◽  
Zacharoula Karabouta ◽  
Israel Rousso
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Developing Countries ◽  
Life Span ◽  
Vitamin D Deficiency ◽  
Chronic Diseases ◽  
Adult Life ◽  
Childhood And Adolescence ◽  
Vitamin D Status ◽  
Calcium Insufficiency

Vitamin D deficiency is common in the developing countries and exists in both childhood and adult life. The great importance of Vitamin D is the moderation of calcium (Ca) and phosphorus (P) homeostasis as well as the absorption of Ca. While insufficiency of vitamin D is a significant contributing factor to risk of rickets in childhood, it is possible that a more marginal deficiency of vitamin D during life span contribute to osteoporosis as well as potentially to the development and various other chronic diseases such as cardiovascular disease, cancer and diabetes. This paper reviews the metabolism, epidemiology, and treatment of vitamin D and calcium insufficiency as well as its relation to various diseases during childhood and adolescence.

scholarly journals Which psychological, psychophysiological, and anthropometric factors are connected with life events, depression, and quality of life in patients with cardiovascular disease

2017 ◽  
Vol Volume 13 ◽  
pp. 2093-2104 ◽  
Author(s):  
Milos Slepecky ◽  
Antonia Kotianova ◽  
Jan Prasko ◽  
Ivan Majercak ◽  
Erika Gyorgyova ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cardiovascular Disease ◽  
Life Events

scholarly journals The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life.

BMJ ◽  
1993 ◽  
Vol 306 (6875) ◽  
pp. 422-426 ◽  
Author(s):  
D J Barker ◽  
C Osmond ◽  
S J Simmonds ◽  
G A Wield
Keyword(s):  
Cardiovascular Disease ◽  
Head Circumference ◽  
Adult Life ◽  
Small Head

scholarly journals Threats to Belonging—Stressful Life Events and Mental Health Symptoms in Aging Men—A Longitudinal Cohort Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Jutta Lindert ◽  
Lewina O. Lee ◽  
Marc G. Weisskopf ◽  
Martin McKee ◽  
Susanne Sehner ◽  
...  
Keyword(s):  
Cohort Study ◽  
Life Events ◽  
Life Stress ◽  
Stressful Life Events ◽  
Adult Life ◽  
Stressful Life ◽  
Symptoms Of Depression ◽  
The Past ◽  
Aging Men ◽  
The Impact

Objectives: Stressful life events, especially relationship events, are frequent in adult life. We investigated the impact of a variety of stressful life events on symptoms of depression, anxiety, and hostility.Methods: We analyzed data from a large prospective cohort study of men (n = 1,437) in the Boston area (assessed in 1985, 1988, and 1991). Main outcomes were measures of depression, anxiety and hostility symptoms. We used the Elders Life Stress Inventory (ELSI) to measure stressful life events in the past 12 months and examine their association with symptoms of depression, anxiety and hostility. First, we analyzed the association of stressful life events with symptom changes; second, we categorized stressful life events into finance/work, health, relationships, loss, living situations events; and third, we estimated the specific association between relationship events and depression, anxiety and hostility symptoms using multilevel models.Results: The most frequent stressful life events were health, relationship, and financial events. Depression, anxiety, and hostility symptoms were relatively stable among men who did not experience these life events. However, those who reported life events in the past 12 months had a greater increase in symptoms of depression (+0.05; 95% CI: 0.01 to 0.10) and of hostility (+0.05; 95% CI: 0.01 to 0.09) than those who did not. Additionally, we found a significant decrease in hostility (−0.05; 95% CI: −0.08 to −0.01) in those experiencing no life events.Conclusion: Relationship events were more important than any other type of events, and were significantly associated with increased depression and hostility in aging men. Although the effects were small, the results point to a need to understand better the impact of relationships on psychopathology in the aging population.

Elastic Properties of the Human Umbilical Cord in Preeclampsia

2011 ◽  
Author(s):  
Reuben B. Dodson ◽  
Kendall S. Hunter ◽  
Virginia L. Ferguson
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
High Fat Diet ◽  
Adult Life ◽  
Circulatory System ◽  
Human Umbilical Cord ◽  
High Fat ◽  
Epidemiological Evidence ◽  
Fetal Origins ◽  
Genetically Determined

Maternal diseases of pregnancy have been found to detrimentally affect the fetal circulatory system, with consequences lasting well into adulthood. In 1995, Barker introduced the idea that major disorders of adult life (including coronary heart disease, hypertension, stroke and diabetes) arise not only through an interaction between factors in our lifestyle, such as a high-fat diet, obesity and smoking, and a genetically determined susceptibility but also through development in utero [1]. Epidemiological evidence continues to support the notion that adult cardiovascular disease (CVD) has fetal origins [2–5].

Fetal Nutrition and Cardiovascular Disease in Adult Life

2001 ◽  
pp. 253-268 ◽  
Author(s):  
David J. P. Barker ◽  
Keith M. Godfrey
Keyword(s):  
Cardiovascular Disease ◽  
Adult Life ◽  
Fetal Nutrition
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