In our study, rats were subjected to Oxymetazoline hydrochloride treatment
and Rhinitis medicamentosa (RM) was formed and then autophagy gene expression
levels were determined after the application of an antioxidant agent
erdosteine (ED). The rats were divided into three groups; Group 1 was the
control group. Group 2 (RM) and group 3 (RM+ED) rats received two spray puffs
of 0.05% oxymetazoline into the nasal cavities three times daily for eight
weeks. After determination of RM in the rats, the RM group were killed. The
ED+RM group received 10 mg/kg of an ED suspension. At the end of seven days,
these rats were also killed. All groups? hippocampus tissues were obtained
for the measurement of autophagy gene expressions. In rhinitis medicamentosa
group Atg5, Atg7 and Atg10 gene expressions in the left hippocampus were
reduced as compared to control group (p=0.01, p>0.05, p=0.01, respectively).
Also, erdosteine treatments were restored mRNA expression of autophagy genes.
In right hippocampus of rhinitis medicamentosa group, Atg5 and Atg10 gene
expressions was found to be down-regulated as compared to control group
(p>0.05, p<0.05, respectively). Both BECN1 and ULK genes expression were
found to be reduced in left hippocampus of rhinitis medicamentosa group.
Erdosteine applications was restored the expression of these genes (p=0.03,
p=0.03, respectively). Additionally, in right hippocampus, Erdosteine
application was restored the expression of ULK gene (p=0.01). This is the
first report that evaluated the expression autophagy genes in RM rat models
and the changes observed after erdosteine applications.