In vitro and in vivo studies on the antioxidant activities of the aqueous extracts of Douchi (a traditional Chinese salt-fermented soybean food)

2008 ◽  
Vol 107 (4) ◽  
pp. 1421-1428 ◽  
Author(s):  
Dong Wang ◽  
Li-jun Wang ◽  
Feng-xue Zhu ◽  
Ji-ye Zhu ◽  
Xiao Dong Chen ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
In Vivo Studies ◽  
Aqueous Extracts ◽  
Fermented Soybean ◽  
Soybean Food

scholarly journals An Overview of Structural Aspects and Health Beneficial Effects of Antioxidant Oligosaccharides

2020 ◽  
Vol 26 (16) ◽  
pp. 1759-1777 ◽  
Author(s):  
Tatiane F. Vieira ◽  
Rúbia C. G. Corrêa ◽  
Rosely A. Peralta ◽  
Regina F. Peralta-Muniz-Moreira ◽  
Adelar Bracht ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Sugar Content ◽  
Animal Health ◽  
Monosaccharide Composition ◽  
Degree Of Polymerization ◽  
Chemical Diversity ◽  
In Vivo Studies

Background: Non-digestible oligosaccharides are versatile sources of chemical diversity, well known for their prebiotic actions, found naturally in plants or produced by chemical or enzymatic synthesis or by hydrolysis of polysaccharides. Compared to polyphenols or even polysaccharides, the antioxidant potential of oligosaccharides is still unexplored. The aim of the present work was to provide an up-to-date, broad and critical contribution on the topic of antioxidant oligosaccharides. Methods: The search was performed by crossing the words oligosaccharides and antioxidant. Whenever possible, attempts at establishing correlations between chemical structure and antioxidant activity were undertaken. Results: The most representative in vitro and in vivo studies were compiled in two tables. Chitooligosaccharides and xylooligosaccharides and their derivatives were the most studied up to now. The antioxidant activities of oligosaccharides depend on the degree of polymerization and the method used for depolymerization. Other factors influencing the antioxidant strength are solubility, monosaccharide composition, the type of glycosidic linkages of the side chains, molecular weight, reducing sugar content, the presence of phenolic groups such as ferulic acid, and the presence of uronic acid, among others. Modification of the antioxidant capacity of oligosaccharides has been achieved by adding diverse organic groups to their structures, thus increasing also the spectrum of potentially useful molecules. Conclusion: A great amount of high-quality evidence has been accumulating during the last decade in support of a meaningful antioxidant activity of oligosaccharides and derivatives. Ingestion of antioxidant oligosaccharides can be visualized as beneficial to human and animal health.

scholarly journals Nutraceutical Activity in Osteoarthritis Biology: A Focus on the Nutrigenomic Role

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1232
Author(s):  
Stefania D’Adamo ◽  
Silvia Cetrullo ◽  
Veronica Panichi ◽  
Erminia Mariani ◽  
Flavio Flamigni ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Antioxidant Activities ◽  
Synergistic Effects ◽  
National Health System ◽  
Bioactive Molecules ◽  
Joint Disease ◽  
In Vivo Studies ◽  
Wide Range

Osteoarthritis (OA) is a disease associated to age or conditions that precipitate aging of articular cartilage, a post-mitotic tissue that remains functional until the failure of major homeostatic mechanisms. OA severely impacts the national health system costs and patients’ quality of life because of pain and disability. It is a whole-joint disease sustained by inflammatory and oxidative signaling pathways and marked epigenetic changes responsible for catabolism of the cartilage extracellular matrix. OA usually progresses until its severity requires joint arthroplasty. To delay this progression and to improve symptoms, a wide range of naturally derived compounds have been proposed and are summarized in this review. Preclinical in vitro and in vivo studies have provided proof of principle that many of these nutraceuticals are able to exert pleiotropic and synergistic effects and effectively counteract OA pathogenesis by exerting both anti-inflammatory and antioxidant activities and by tuning major OA-related signaling pathways. The latter are the basis for the nutrigenomic role played by some of these compounds, given the marked changes in the transcriptome, miRNome, and methylome. Ongoing and future clinical trials will hopefully confirm the disease-modifying ability of these bioactive molecules in OA patients.

scholarly journals Natural Nrf2 Activators from Juices, Wines, Coffee, and Cocoa

Beverages ◽  
2020 ◽  
Vol 6 (4) ◽  
pp. 68
Author(s):  
Mallique Qader ◽  
Jian Xu ◽  
Yuejun Yang ◽  
Yuancai Liu ◽  
Shugeng Cao
Keyword(s):  
Oxidative Stress ◽  
Defense Mechanisms ◽  
Target Genes ◽  
Antioxidant Activities ◽  
Reactive Oxygen ◽  
Polyphenolic Compounds ◽  
Cellular Systems ◽  
In Vivo Studies

Juices, wine, coffee, and cocoa are rich sources of natural polyphenolic compounds that have potent antioxidant activities proven by in vitro and in vivo studies. These polyphenolic compounds quench reactive oxygen and nitrogen species (RONS) or reactive free radicals and act as natural antioxidants which are also able to protect against reactive oxygen species (ROS)-mediated oxidative damage, which elevates cellular antioxidant capacity to induce antioxidant defense mechanisms by modulating transcription factors. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcription factor encoded in humans. It is activated as a result of oxidative stress and induces the expression of its target genes. This is one of the most important cellular defense mechanisms against oxidative stress. However, the oxidative stress alone is not enough to activate Nrf2. Hence phytochemicals, especially polyphenolics, act as natural Nrf2 activators. Herein, this review discusses the natural products identified in juices, coffee, cocoa and wines that modulate Nrf2 activity in cellular systems.

scholarly journals Antimicrobial, Antioxidant, and Immunomodulatory Properties of Essential Oils: A Systematic Review

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2786 ◽  
Author(s):  
Magdalena Valdivieso-Ugarte ◽  
Carolina Gomez-Llorente ◽  
Julio Plaza-Díaz ◽  
Ángel Gil
Keyword(s):  
Essential Oils ◽  
Animal Feed ◽  
Antioxidant Activities ◽  
Dose Range ◽  
Food Preservation ◽  
In Vivo Studies ◽  
Resistant Bacteria ◽  
Immunomodulatory Properties

Essential oils (EOs) are a mixture of natural, volatile, and aromatic compounds obtained from plants. In recent years, several studies have shown that some of their benefits can be attributed to their antimicrobial, antioxidant, anti-inflammatory, and also immunomodulatory properties. Therefore, EOs have been proposed as a natural alternative to antibiotics or for use in combination with antibiotics against multidrug-resistant bacteria in animal feed and food preservation. Most of the results come from in vitro and in vivo studies; however, very little is known about their use in clinical studies. A systematic and comprehensive literature search was conducted in PubMed, Embase®, and Scopus from December 2014 to April 2019 using different combinations of the following keywords: essential oils, volatile oils, antimicrobial, antioxidant, immunomodulation, and microbiota. Some EOs have demonstrated their efficacy against several foodborne pathogens in vitro and model food systems; namely, the inhibition of S. aureus, V. cholerae, and C. albicans has been observed. EOs have shown remarkable antioxidant activities when used at a dose range of 0.01 to 10 mg/mL in cell models, which can be attributed to their richness in phenolic compounds. Moreover, selected EOs exhibit immunomodulatory activities that have been mainly attributed to their ability to modify the secretion of cytokines.

scholarly journals Antioxidant activities of aqueous extracts from 12 Chinese edible flowers in vitro and in vivo

2016 ◽  
Vol 61 (1) ◽  
pp. 1265324 ◽  
Author(s):  
Feng Wang ◽  
Miao Miao ◽  
Hui Xia ◽  
Li-Gang Yang ◽  
Shao-Kang Wang ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Aqueous Extracts

scholarly journals Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review

Biomedicines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 3 ◽  
Author(s):  
Abu Bakar ◽  
Pin-Chuan Yao ◽  
Valendriyani Ningrum ◽  
Cheng-Tzu Liu ◽  
Shih-Chieh Lee
Keyword(s):  
Systematic Review ◽  
Oral Mucositis ◽  
Wound Repair ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
In Vivo Studies ◽  
Potential Use ◽  
Anti Inflammation

The aim of this review was to provide an updated overview of studies on the medical-biological activities of Cinnamomum osmophloeum (C. osmophloeum) in vitro and in vivo and the potential therapeutic use of natural agents prepared from this plant for the alleviation of oral mucositis (OM). Reported articles were collected using web search engine tools. The systematic review was organized according to the preferred reporting items for reviews and meta-analyses (PRISMA) statement. Additional sources were identified through cross-referencing to identify the potential use of C. osmophloeum in the alleviation of OM. The results disclosed that C. osmophloeum is comprised of bioactive ingredients that could act diversely as a reagent in anti-inflammation, antibacterial, antioxidant, anti-hyperglycemic, antidyslipidemia, anti-cancer, renal disease therapy and anti-hyperuricemia capacities. Recent studies revealed that the overall effects on anti-inflammation, wound repair, and the antibacterial and antioxidant activities of its constituents would act as a potential remedy for oral mucositis. Up-to-date in vitro and in vivo studies on the medical-biological activities of C. osmophloeum suggested that C. osmophloeum and its constituents could be promising remedies as adjuvants in OM therapy and warrant further investigation.

Does the melatonin supplementation decrease the severity of the outcomes in COVID-19 patients? A mini review of observational data in the in vivo and in vitro studies

2021 ◽  
Vol 4 (2) ◽  
pp. 348-359
Author(s):  
Mohammad Gholizadeh ◽  
Faezeh Abaj ◽  
Hossein Hasani ◽  
Atieh Mirzababaei ◽  
Khadijeh Mirzaei
Keyword(s):  
Molecular Level ◽  
Antioxidant Activities ◽  
Early Stage ◽  
Specific Treatment ◽  
Case Series ◽  
Lung Damage ◽  
In Vivo Studies ◽  
Critical Conditions

The Coronavirus Disease 2019 (COVID-19) is a global pandemic and there is no specific treatment for reducing the severity of this disease up to date. The majority of the treatments remain supportive and empirical. The aim of present study is to assess the relationship between melatonin supplementation and its effect on the severity of the outcomes in covid-19 patients. All published studies up to April 4 of 2021 were searched by using the databases of PubMed, ISI Web of Science, SCOPUS and Google Scholar.  Finally, 201 studies have been acquired.      After screening titles, abstracts and justifying the inclusion criteria, eight studies were finally selected in our study. Four studies were observational and case series with total 216,792 participants. Three studies performed on laboratory in the molecular level and one was carried out in mice. The results have suggested that melatonin decreases the severity of the outcomes of COVID-19 patients in their early stage or even in their critical conditions. Furthermore, the melatonin decreases pneumonia and reduces the ground glass lung damage observed in the image findings. Also, it plays an important role as anti-inflammatory, anti-viral and antioxidant activities. Melatonin inhibits the main protease of sares-cov-2 virus and decreases the viral load in molecular level. Regarding the in vivo studies, melatonin is more effective for reducing acute lung injury than other treatments. Although, further clinical studies are required.

Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies

2018 ◽  
Vol 199 ◽  
pp. 141-149 ◽  
Author(s):  
Makoto Anraku ◽  
Janusz M. Gebicki ◽  
Daisuke Iohara ◽  
Hisao Tomida ◽  
Kaneto Uekama ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
In Vivo Studies
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