Prevalence and control of the type 2 DM in a health area

2009 ◽  
Vol 137 ◽  
pp. S48
Author(s):  
GREGORIO MEDIAVILLA ◽  
JESUS ITURRALDE ◽  
ALFONSO A. RODRÍGUEZ ◽  
JAVIER MARTINEZ ◽  
AMAYA RUIZ DE LOIZAGA ◽  
...  
Keyword(s):  
Type 2 Dm ◽  
Health Area ◽  
And Control

scholarly journals Reduced Serum Adiponectin Levels in Type 2 Diabetic Patients in Zaria

2018 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Serum Adiponectin ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Mean Values ◽  
Control Subjects ◽  
Type 2 Dm ◽  
And Control ◽  
Biochemical Assessment ◽  
Type 2 Diabetic

Background: Adiponectin is a collagen-like plasma protein secreted by adipocytes that has been suggested to play a causal role in the development of insulin resistance. Even though hypoadiponectinaemia is reported to be closely associated with obesity-related diseases such as ACVD, type 2 DM, dyslipidaemia, report from our environment is lacking. Materials and Methods: Serum adiponectin, insulin and glucose were measured in 90 type 2 diabetic and control subjects respectively. The patients were known diabetics attending the diabetic clinic at the ABUTH, Zaria. The control subjects were apparently healthy individuals within the hospital and Zaria environs. Results: Mean serum adiponectin levels were significantly lower (P<0.05) in the diabetic patients than in the control subjects. On the other hand, the mean values of insulin and glucose were significantly higher (P<0.05) in the diabetic patients than in the controls. Conclusion: Measurement of serum adiponectin as an adjunct in the biochemical assessment of type 2 DM is suggested.

scholarly journals Relationship between TP53 and interleukin-6 gene variants and the risk of types 1 and 2 diabetes mellitus development in the Kermanshah province

2021 ◽  
Vol 14 (1) ◽  
pp. 37-44
Author(s):  
Lida Haghnazari ◽  
◽  
Ramin Sabzi ◽  
◽  
Keyword(s):  
Diabetes Mellitus ◽  
Tp53 Gene ◽  
Control Group ◽  
Control Groups ◽  
Codon 72 ◽  
Type 2 Dm ◽  
And Control ◽  
Type 1 Dm

Diabetes mellitus (DM) is a metabolic disorder that results from insufficient secretion or insulin resistance, or both. Insulin secretion deficiency leads to chronic hyperglycemia along with impaired metabolism of proteins, lipids, and carbohydrates. This study aimed to investigate the TP53 gene SNP (single nucleotide polymorphism) rs1042522 genotype and the interleukin-6 (IL-6) gene SNP rs1800795 genotype in DM and control groups. This study was performed on 70 patients with type 1 DM, 100 patients with type 2 DM without related complications, 66 control subjects for type 1 DM, and 95 control subjects for type 2 DM. The control groups were matched regarding age and gender and did not have a familial relationship with the patient groups. All the subjects were residents of Kermanshah, located in the western part of Iran. Polymorphisms of TP53 and IL-6 genes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Lipid profile, fasting blood glucose, and HbA1c were measured using the ELISA and immunoturbidometric methods. The frequency of genotypes (CC, CG, GG) of the TP53 gene codon 72 in type 1 DM and its control group were significantly different (P= 0.013). Likewise, the frequency of genotypes (CC, CG, GG) of the TP53 gene codon 72 was significantly different between type 2 DM and control groups (P <0.001). The frequency of genotypes (GG, GC, CC) of G174C polymorphisms in the IL-6 gene was different between type 1 DM and control group as well as between type 2 DM and its control group, but it was not statistically significant. SNP rs1042522 genotypes in the dominant form (CG + GG vs. CC) (OR= 3.880; P < 0.001) and alleles G vs. C alleles (OR= 0.384; P < 0.001) increased the risk of type 2 DM significantly. There was no significant difference between type 1 and type 2 DM groups and respected control groups regarding the frequency of the IL-6 gene SNP rs1800795 alleles. The G allele of SNP rs1042522 encoding the TP53 gene increases the risk of developing DM in the population of the Kermanshah province, Iran.

scholarly journals Pola makan dan obesitas sebagai faktor risiko diabetes mellitus tipe 2 di Rumah Sakit Sanglah Denpasar

2007 ◽  
Vol 4 (1) ◽  
pp. 1
Author(s):  
Ni Komang Wiardani ◽  
Hamam Hadi ◽  
Emy Huriyati
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Dietary Patterns ◽  
Animal Protein ◽  
Fiber Intake ◽  
High Fat ◽  
Dietary Fiber Intake ◽  
Type 2 Dm ◽  
And Control

Background: Diabetes Mellitus (DM) is a chronic disease with its increasing prevalence worldwide, including in Indonesia and in Bali province especially among adult group. The increasing prevalence of DM is followed by the increasing prevalence of obesity affected by changes in lifestyle and unhealthy dietary patterns.Objective: The study was conducted to investigate relations between dietary patterns and obesity with type 2 DM in Sanglah Hospital, Denpasar.Method: The study was observational analytic with matched case control study. Subject of the study was divided into two groups, i.e. case and control with comparison case and control 1:2 which matched to age and sex. The cases were type 2 DM patients who had recently diagnosed on first visited in Sanglah Hospital. Control 1 was outpatients of non-type 2 DM in Sanglah Hospital and control 2 were taken from the case-neighboring household. Total subject were 147, taken by consecutive method. Collected data were subject identity, dietary patterns, physical activity, weight, height, waist circumference and fasting blood sugar. Dietary patterns were collected using Food Frequency Questionnaire (FFQ), physical activity was collected using modified International Physical Activity Questionnaire (IPAQ), and fasting blood sugar were estimated using biosensor of glucose. Multiple logistic regression models were used to identify risk factors associated with type 2 DM.Result: This study showed that there were 5 variables significantly related with type 2 DM, i.e. interaction of overall obesity with the dietary fiber intake (OR:10.7; 95% CI: 3.5-33.7), family history (OR:5.5, 95% CI: 2.2-13.3), source of high fat animal protein (OR:4.9, 95% CI:1.5-16.1), source of low fat animal protein (OR:0.1, 95% CI: 0-0.5), hypertension (OR:3.7, 95% CI:1.4-9.9)Conclusion: The interaction between overall obesity with dietary fiber intake, family history, source of high fat animal protein, source of low fat animal protein and hypertension were the risk factors of type 2 DM occurrence in Sanglah Hospital, Denpasar.

scholarly journals Human Visceral Adipose Tissue (VAT) Inflammation Is Not Associated With Perforin Deficiency in Type 2 Diabetes Mellitus (DM) Subjects as Compared to Health Controls

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A15-A16
Author(s):  
Ravindra Kumar Shukla ◽  
Ramkaran Choudhary ◽  
Mahendra Lodha ◽  
Mahaveer singh Rodha ◽  
Nitin Bajpai ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
T Cell ◽  
Nk Cells ◽  
Single Cell ◽  
Stromal Vascular Fraction ◽  
Healthy Controls ◽  
Type 2 Dm ◽  
And Control

Abstract Introduction: Role of T cells in VAT inflammation is poorly characterised. Perforin deficiency is associated with autoimmune inflammatory diseases like Hemophagocytosis Lymphohistiocytosis,as also in context of type 1 DM pathogenesis. Data from animal models suggest that perforin deficiency leads to VAT inflammation1Objective: We hypothesized CD8+/perf+ and CD56+/perf+ cells to be decreased in type 2 DM as compared to healthy controls. The present study also explored the difference in activation of T/NK cells between two groups Methods: 2×2 cm omental tissue was obtained from subjects undergoing elective abdominal surgery. The sample was transported in RPMI solution and stored in -80 ℃. Processing involved thawing, incubation at 37.6 ℃ for 24 hours with type IV Collagenase (1 mg/ml, Sigma Aldrich) 1ml/g of tissue,centrifuge (32g for 10 min at 10℃). The resultant Stromal Vascular fraction (SVF) was suspended in phosphate buffer saline (PBS), passed through cell strainer to make single cell suspension. It was again centrifuged and tagged with CD markers of interest. Fc block was added and single cell solution with FACS fluid prepared. It was run in BD CANTO-2 flow cytometer as described2Results: Of seventeen samples analysed, twelve samples of type 2 diabetes subjects were compared with five healthy controls. All results are presented in median. The diabetics had higher HbA1c (8.1 % vs 6%), higher BMI (28 kg/m2 vs 24 kg/m2), hsCRP(2.1 mg/dl Vs 0.9 mg/dl) but there was no difference in HOMA-Ir (5 vs 5.2 mU/L/mg/dl). The percentage of CD4+ + CD8+ cells/g of VAT was similar in both cases and control (20 × 103 Vs 23× 103). CD8+/CD45+/perf+ and CD56+/CD45+/perf+ could not be identified in any of the samples. Although CD8+/CD45+/perf-- and CD56+/CD45+/perf-- cells were identified. Next, we analysed the same cells for cytotoxic activation by 107a. The percentage of 107a positivity was low in CD 8+ (7% and 4 % respectively in cases and control) and CD 56+ cells (10% and 9 % respectively in cases and control),Although clinically type 2 DM subjects were obese and had inflammation (i.e higher hsCRP), there was no difference in VAT activation of immune cells studied. Also, we could not delineate perforin in any of the samples. Conclusion: Taken together this work suggests VAT T cell immune milieu in human Type 2 DM is different from mouse model. It is neither characterised by perforin deficiency nor activation of T cell/NK cell. This study points towards the probability that, the role of T cell/NK cells in human VAT infiltration could be fundamentally different from mice models. Further studies should be focussed on functional characteristics of these cells and interaction with VAT macrophages. References 1. Xavier S. Revelo et al Diabetes 2015;64:90–103 2. Wetzels S et al J Vis Exp. 2018 Mar 6;(133):57319.

scholarly journals Effectiveness of Line application and telephone-based counseling to improve medication adherence: A randomized control trial study among uncontrolled type 2 diabetes patients

2021 ◽  
Vol 11 (4) ◽  
pp. 438-443
Author(s):  
Jukkrit Wungrath ◽  
Nattapong Autorn
Keyword(s):  
Type 2 Diabetes ◽  
Health Care ◽  
Medication Adherence ◽  
Control Group ◽  
Control Groups ◽  
Type 2 Dm ◽  
And Behavior ◽  
And Control ◽  
Experimental Group

Background: More than 4.2 million cases of diabetes mellitus (DM) were reported in Thailand during 2019. Medication adherence is necessary to delay disease progression and prevent complications among uncontrolled type 2 DM patients. The objective of this research was to study how education via the Line application and telephone-based counseling impacted medication adherence knowledge by analyzing the behavior of uncontrolled type 2 diabetic patients. Methods: Uncontrolled type 2 DM patients in Doi Saket Hospital, Doi Saket district, Chiang Mai province, Thailand. were included in the study. The sample was divided into an experimental (n=30) and control group (n=30). Patients who met the inclusion criteria of having uncontrolled type 2 diabetes diagnosed by a physician for at least one year, capable of communicating in Thai, possessing a mobile phone with the Line application and able to partake in activities for eight weeks were recruited in the parallel-group randomized trial. The experimental group participated in the developed education program, while the control group received standard routine health education activities provided by their health care providers. The intervention was based on the 5Rs principle as right medicine, right dose, right route, right patient and right time and included activities via the Line application and telephone-based counseling. Participants were evaluated for their medication adherence knowledge and behavior. Results: After eight weeks of education through the Line application and telephone-based counseling, posttest mean scores of medication adherence knowledge of the experimental and control groups were 18.03 (SD=0.28) and 12.37 (SD=0.62), while posttest mean scores of medication adherence behavior of the experimental and control groups were 49.28 (SD=3.77) and 33.84 (SD=3.81), respectively. Results revealed that the experimental group had statistically significant (P<0.01) higher medication adherence knowledge and behavior mean scores. Conclusion: Education using the Line application and telephone-based counseling program improved medication adherence knowledge and behavior among uncontrolled type 2 DM patients. Other outcomes of social media interactions such as patient engagement, patient behavior and attitudes, and the efficacy of patient-health care provider communication levels are possible areas for future study.

scholarly journals Study of the Association between Serum Ferritin Levels and HbA1c in Patient with Type 2 Diabetes Mellitus in Jordanian Population Sample

2021 ◽  
pp. 1-5
Author(s):  
Saad AL-Fawaeir ◽  
Haytham M. Daradka ◽  
Ali Ahmad Abu Siyam
Keyword(s):  
Serum Ferritin ◽  
Population Sample ◽  
Positive Association ◽  
Control Group ◽  
Diabetic Patients ◽  
Biochemical Tests ◽  
Type 2 Dm ◽  
Significant Difference ◽  
And Control

Background/ aim: The most common endocrine disorder in the world is type 2 DM, affecting 85-90% of all people with diabetes. Several studies have found an association between serum ferritin levels and HbA1c, so the current study was undertaken to examine the association between serum ferritin levels and HbA1c in Jordanian patient’s sample with type 2 DM. Method:  120 patients with type 2 DM were enrolled into the current study, and control group consist of 20 healthy individuals, blood samples were collected after 14 h of fasting, 5 ml of fasting sample for FBS and ferritin, 4 ml whole blood taken in EDTA tube for Hb and HbA1c, sample centrifuged and biochemical tests were done in the same day. Results: The mean of serum ferittin was significantly higher in patients group (213.87±114.23 ng/ml) than control group (98.34±18.45 ng/ml, P < 0.05). There was a positive association between serum ferritin and HbA1c (P < 0.05). Also there was a significant correlation between serum ferritin and FBS P < 0.05. Among the two groups there was no significant difference regarding demographic features (sex, age and BMI). Conclusion: collected data showed that there is a significantly association between ferittin and type 2 DM, it was higher in comparison with healthy group, so it can give an indication of glycemic  control in diabetic patients.

Yoga Practice in People with Diabetes

2003 ◽  
Vol 13 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Nora Mercuri ◽  
Ercilia Olivera ◽  
Alicia Souto ◽  
María Guidi
Keyword(s):  
Physical Activity ◽  
Personal Information ◽  
Treatment Schedule ◽  
La Plata ◽  
Metabolic Characteristics ◽  
Breathing Exercises ◽  
Type 2 Dm ◽  
National University ◽  
And Control

The aim of this study was to evaluate the clinical and metabolic changes observed immediately and 3 months after daily Yoga practices in a group of people with diabetes mellitus (DM). The study included sixteen women(3 with Type 1 DM, 12 with Type 2 DM, and 1 with type 2 DM treated with insulin; mean age 61 ± 11 years; DM history 21 ± 14 years) attending the Physical Activity Program at CENEXA – Center of Experimental and Applied Endocrinology (UNLP-CONICET, PAHO/WHO Collaborating Center), National University of La Plata School of Medicine, La Plata, Argentina. Group Yoga practices consisted in âsanas (postures), prânâyâma(breathing exercises), relaxation, and meditation techniques performed twice a week (27 sessions in all), complemented by daily individual sessions practiced at home the remaining days of the week. Data recorded at the beginning and at the end of the study included personal information, clinical and metabolic characteristics, type of treatment and control, and complications. Blood pressure(BP), heart rate (HR), and glycemia also were recorded at the beginning and end of 13 alternate sessions. Both attendance and compliance with the proposed schedule were high (&gt; 80%), excepting 2 people who deserted but completed 50% of the study. There were no overall significant differences (beginning vs. end of the study) in BMI, HbA1, lipid profile, dietary plan, habitual physical activity practice, BP, and treatment schedule. Conversely, there was a significant decrease in HR (8 sessions; p &lt; 0.03) and glycemia (10 sessions; p &lt; 0.03) immediately after the Yoga sessions. The immediate positive effect of Yoga practices on glycemia and HR suggests that such practices would be beneficial for the treatment of people with DM.

scholarly journals Ramadan Intermittent Fasting Affects Adipokines and Leptin/Adiponectin Ratio in Type 2 Diabetes Mellitus and Their First-Degree Relatives

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Khaldoon Abdullah ◽  
Molham AL-Habori ◽  
Ekram Al-Eryani
Keyword(s):  
Diabetes Mellitus ◽  
Intermittent Fasting ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Control Groups ◽  
Ramadan Fasting ◽  
Type 2 Dm ◽  
Hs Crp ◽  
And Control

Background. In view of the association of Ramadan intermittent fasting with profound changes in lifestyle both in nondiabetic and diabetic patients, the aim of this study was to investigate the effect of Ramadan fasting on adiponectin, leptin and leptin to adiponectin ratio (LAR), growth hormone (GH), human-sensitive C-reactive protein (hs-CRP), and diabetic and metabolic syndrome factors in patients with Type 2 Diabetes Mellitus (Type 2 DM), their first-degree relatives (FDRs), and healthy controls. Methods. This cohort study involved 98 Yemeni male subjects aged 30-70 years old: 30 Type 2 DM, 37 FDRs of Type 2 diabetic patients, and 31 healthy control subjects. Subjects’ body mass index (BMI), waist circumference (WC), and blood pressure (BP) were measured, and venous blood samples were collected twice: the first samples were collected a couple of days prior to Ramadan fasting (baseline) and the second samples after 3 weeks of fasting. Results. Ramadan fasting did not affect BMI, WC, and BP in Type 2 DM and their FDRs with respect to the baseline levels prior to Ramadan, whereas triglyceride and cholesterol were borderline significantly decreased in Type 2 DM with no effect in FDRs. Fasting blood glucose was not affected in Type 2 DM but was significantly increased in FDRs and control groups, whereas glycated haemoglobin (HbA1c) was slightly decreased in Type 2 DM, FDRs, and healthy controls. C-peptide, insulin, and insulin resistance (HOMA-IR) were significantly increased in Type 2 DM and FDRs, with no effect in the control group, whereas β-cell function (HOMA-β) was significantly decreased in FDRs and controls with no change in Type 2 DM. Ramadan fasting significantly decreased GH in both FDRs and control groups, and significantly increased hs-CRP in the control with no effect in Type 2 DM and FDRs. Adiponectin was significantly decreased, and leptin and LAR were significantly increased in Type 2 DM, FDRs, and control groups. Conclusion. Ramadan intermittent fasting decreased adiponectin and increased leptin, LAR, insulin, and insulin resistance in both Type 2 DM and FDRs as well as decreased GH in both FDRs and healthy controls and increased hs-CRP in healthy controls. Moreover, Ramadan intermittent fasting neither worsens a patient’s glycemic parameters nor improves it, with the exception of a slight improvement in HbA1c in Type 2 DM, FDRs, and healthy controls.

scholarly journals Correlative analysis of blood pressure and other biochemical parameters with type 2 DM subjects

2015 ◽  
Vol 5 (1) ◽  
pp. 306-308
Author(s):  
Jannatul Ferdous ◽  
Runa Laila ◽  
Shamim Ahmed ◽  
Nasreen Begum ◽  
Ismat Ara Begum ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Plasma Glucose ◽  
Biochemical Parameters ◽  
Study Group ◽  
Healthy Controls ◽  
Type 2 Dm ◽  
Significant Difference ◽  
And Control

Objective : To determine the association of blood pressure and other biochemical parameters with type 2 DM subjects.Methodology : This was an observational study with case control design was conducted in the Biomedical Research Group, Research Division, Bangladesh Institute of Research and Rehabilitation in Diabetes ,Endocrine Metabolic Disorders (BIRDEM), Dhaka Bangladesh, during the period of July 2008 to June 2009. A total of 153 subjects were included in study of which 63 belonged to T2 Diabetes Mellitus group and 90 were healthy Controls. Insulin glucose ratio were assayed in patients and controls and identified the association, using standardized assay methods. We also assessed the type – 2 diabetic patients who had significantly raised Fasting blood sugar, insulin HOMA-B %= B cell function assessed by homeostasis model assessment to compared with the healthy controls. Correlation analysis of HOMA-B % with biochemical parameters, blood pressure, fasting and post prandial glucose also analysed.Results : Age of Control and type 2 DM subjects ( Mean±SD),P-value] were (46 ± 8.31) and (47 ±7.58), (P=0.326) respectively and BMI, among subject and control (kg/m2), (Mean ± SD), (24 ± 3.96, 25 ± 2.72 p=0.754). WHR [cm, (Mean±SD), p=<0.001], showed significant difference between T2 DM and healthy subjects. The median (range) of the glucose and insulin ratio of the study group, there was significant difference between Control vs. T2DM (p<0.001). Systolic blood pressure[S-BP, mean±SD] & Diastolic blood pressure [D-BP, mean±SD] were significant in T2DM as compared to control subjects {( p= 0.008) ( p= 0.003)} respectively ; Fasting plasma glucose levels [mmol/l, (Mean± SD)] , post prandial plasma glucose level [mmol/l, (Mean± SD)]and the HOMA%B level median (range) among subject and control of the study group[(8.27±2.19) , (11.79 ± 2.69), {71 ( 4.90 - 391.30)}] were a significant difference in between Control vs type2 DM {(p <0.001), (p <0.001)and. (p <0.001)} respectively.Conclusion : In this study, boty systolic and diastolic blood pressure, blood glucose level and insulin status and WHR were found the significant parameters for maintaining type to DM under control condition. Development of hypertension cardio vascular disease and other complication can be prevented on keeping these parameters in normal level.Northern International Medical College Journal Vol.5(1) 2013: 306-308

scholarly journals Study ABO / Rh Systems with IL-18 & IL-33 in Iraqi Patients with Diabetes Mellitus Type II

2014 ◽  
Vol 11 (3) ◽  
pp. 1136-1144
Author(s):  
Baghdad Science Journal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Serum Level ◽  
Blood Group ◽  
Inflammatory Markers ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Type 2 Dm ◽  
And Control

Type 2 diabetes mellitus (DM) is a group of metabolic disorder disease. The inflammatory markers act as a new risk factor for development of type 2 diabetes with a possible association with ABO/Rh blood groups. Human ABO genes are located on chromosome 9q34.1-q34.2. The aim of this study was to investigate the possible association between inflammatory markers, interleukin (IL) -18 and IL-33 in type 2DM and ABO blood groups. Sixty four patients with newly diagnosed type2 DM and control group consist of twenty healthy Iraqi individual. Laboratory test were include ABO blood groups using standard serological procedures and detection IL-18 and IL-33 in serum by ELISA kits. The Present data showed a significant increase in the serum level of IL-18 between type 2 DM patients and control, while there was no significant difference in the serum level of IL-33. At the same time both study blood groups O patients & control showed lowest level of serum IL-18, while blood group A with allele A showed less concentration of IL-33 in patients & control. Blood group O showed the highest percentage in patients & control, also Rh positive showed higher percentage. In conclusion, positive relation between IL-18 concentration and risk of type 2 DM, thus may be a predictor for newly diagnostic diabetic patient, while Serum levels of IL-33 might be a predictor marker of disease progression. No associations were found between ABO & Rh groups with type 2 DM.

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