scholarly journals Clinical profile of dengue infection at a teaching hospital in North India

2011 ◽  
Vol 6 (07) ◽  
pp. 551-554 ◽  
Author(s):  
Ritu Karoli ◽  
Jalees Fatima ◽  
Zeba Siddiqi ◽  
Khursheed I Kazmi ◽  
Amit R Sultania
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Indian Subcontinent ◽  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
North India ◽  
World Health ◽  
Health Concern ◽  
Neurological Involvement ◽  
Atypical Manifestations

Introduction: Dengue viral infections are among the most important mosquito-borne diseases of the Indian subcontinent and have become a major global public health concern. Spread of disease has led to increased recognition of atypical manifestations apart from the classical clinical features of dengue infection. Methodology: A cross-sectional study of admitted patients suspected to have dengue infection was conducted during the monsoon and post-monsoon seasons in the year 2010. Patients who had serological confirmation of dengue infection were classified according to World Health Organization definitions of dengue fever and dengue hemorrhagic fever. Clinical and biochemical parameters were compared between the two groups. Results: Out of 356 patients with suspected dengue fever enrolled in the study, 138 (39%) had serologically confirmed dengue infection. Eighty (58%) patients were males and 58 (42%) were females. Ninety-six (70%) patients had classical dengue fever while 42 (30%) had dengue hemorrhagic fever. The most common symptoms were headache (105, 76%), abdominal pain (87, 63%), vomiting (80, 58%), rash (36, 26%), and cutaneous hypersensitivity (22, 16%). Hemorrhagic manifestations were present in 55 (40%) patients. Atypical manifestations were recorded. Notably, 14% of patients had neurological involvement and 4% had acute hepatic failure. Overall mortality was 6% and all fatal cases were due to multi-organ failure. Conclusion: Dengue infection poses a huge burden to the health-care system; its spectrum ranges from mild self-limiting illness to severe fatal disease. It can have varied and multi-systemic manifestations which can go unrecognized. Clinicians should have a high index of suspicion for atypical manifestations.

scholarly journals ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICES REGARDING DENGUE FEVER AMONG ADULT POPULATION OF DISTRICT DIR LOWER, KHYBER PAKHTUNKHWA, PAKISTAN

2017 ◽  
Vol 7 (2) ◽  
pp. 71-74
Author(s):  
Aminullah ◽  
Soaib Ali Hassan ◽  
Ashfaq Ahmed Khawaja Khail ◽  
Abdul Waris ◽  
Gul Alam ◽  
...  
Keyword(s):  
Sample Size ◽  
Dengue Fever ◽  
Adult Population ◽  
Hemorrhagic Fever ◽  
World Health ◽  
Health Concern ◽  
Cross Sectional ◽  
Viral Pathogen ◽  
Tropical Regions ◽  
Preventive Practices

Background: Dengue is a major public-health concern throughout globe especially tropical and sub-tropical regions. Dengue fever is transmitted by bite of female mosquito caused by human viral pathogen that belongs to the genus Flavivirus of the family Flaviviridae. World Health Organization (WHO) estimates that 50-100 million dengue infections occur each year and that almost half the world's population lives in countries where dengue is endemic. The first confirmed dengue hemorrhagic fever outbreak in Pakistan occurred in 1994. Since then, epidemics of dengue fever have been reported in the region with increasing frequency and expanding geographic distribution.Objectives: To assess the knowledge, attitudes and preventive practices regarding dengue fever among adult population.Methods: This study was a Cross sectional descriptive survey conducted among adult population in Union council Ouch and Chakdarah district Dir Lower, KPK province Pakistan. The study was collected in the months of October to December 2015. Sample size was calculated through sample size formula calculation and total of 419 subjects including male and females were interviewed using a pre-tested structured questionnaire selected through simple random sampling technique.Results: Majority of study population were males (79.3%) and living in houses made of bricks (68.3%). Majority of population was unaware regarding dengue fever transmission, its sign and symptoms and treatment (58.9%). Respondents' main source of information was TV and radio. The study participants consider dengue as a fatal disease and the preventive practices from mosquito bite were recorded as, full clothing (24.4%) followed by use of repellents (10%). Around half of the respondents were using bed net for dengue prevention in which 36% got it from various NGOs working in the district.Conclusion: There is lack of knowledge about dengue fever among the communities. Preventive practices can be improved by increasing knowledge and its translation into sustainable practices.

scholarly journals Serum levels of interleukin-6, tumor necrosis factor-alpha and interferon-gama in infants with and without dengue

2008 ◽  
Vol 41 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Berta Nelly Restrepo ◽  
Diana María Isaza ◽  
Clara Lina Salazar ◽  
Ruth Ramírez ◽  
Marta Ospina ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Primary Infection ◽  
Secondary Infection ◽  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
Serum Levels ◽  
Tnf Alpha ◽  
Necrosis Factor Alpha ◽  
Ifn Gamma

This study compared the serum levels of IL-6, TNF-alpha and IFN-gamma, in children under 1 year of age with and without dengue. Sera were collected from a total of 41 children living in the Department of Antioquia, Colombia (27 patients with dengue and 14 controls). The results showed higher cytokine levels in children with dengue than without dengue, with statistically significant differences for IL-6 and IFN-gamma. No statistically significant differences were found between clinical forms, although IL-6 and IFN-gamma levels were higher in dengue fever cases than in dengue hemorrhagic fever cases. On the other hand, TNF-alpha levels were higher in dengue hemorrhagic fever than in dengue fever. The levels of IL-6 and TNF-alpha were higher in secondary infection than in primary infection, although IFN-gamma levels were higher in primary infection. These results suggest that IL-6, TNF-alpha and IFN-gamma are involved in dengue infection independently of the clinical form.

scholarly journals SIADH (Syndrome of Inappropriate ADH Secretion): Perplexing Look of Dengue Fever

2021 ◽  
pp. 1-4
Author(s):  
Richmond Ronald Gomes ◽  
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Animal Studies ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
World Health ◽  
Fluid Extravasation ◽  
Health Organization ◽  
Expanded Dengue Syndrome

Dengue is a mosquito-borne disease (female mosquitoes of the Aedes genus, principally Aedes aegypti) caused by any one of four closely related dengue viruses. It is endemic in tropical and subtropical continent. World health organization (WHO) currently estimates there may be 50 -100 million dengue infections worldwide every year with over 2.5 billion people at risk of dengue. Symptomatic dengue virus infection may manifests as undifferentiated fever, classical dengue fever (with or without unusual hemorrhages), and dengue hemorrhagic fever (with or without shock). Isolated organopathy or expanded dengue syndrome (EDS) was coined by WHO in the year 2012 to describe cases, which do not fall into either dengue shock syndrome or dengue hemorrhagic fever. The atypical manifestations noted in expanded dengue are multisystemic and multifaceted with organ involvement, such as liver, brain, heart, kidney, central/peripheral nervous system, gastrointestinal tract, lympho reticular system. Dengue virus has long been considered as a non-neurotropic virus, as animal studies have shown that virus does not cross blood brain barrier. Hyponatremia may be found in association with dengue fever and is thought to be caused by peripheral fluid extravasation and resulting intravascular hypovolaemia. But hyponatremia due to syndrome of inappropriate secretion of anti-diuretic hormone (SIADH) in Dengue fever is rare. We report a 40 years old male who was diagnosed as Dengue fever (Dengue Ns1Ag positive) with thrombocytopenia and hyponatremia. He was admitted and further investigations revealed SIADH. He responded well to cautious sodium replacement and addition of tolvaptan. He recovered completely and was discharged after one week. Thus, all clinicians should keep in mind the possibility of SIADH as a part of expanded dengue syndrome.

scholarly journals Clinico-haematological profile of dengue virus infection at rural tertiary care centre in North India

2017 ◽  
Vol 5 (8) ◽  
pp. 3329
Author(s):  
Vidyasagar Ram ◽  
Khwaja Saifullah Zafar ◽  
Manoj Kumar ◽  
Ganga Prasad Vaishya ◽  
Ejaz Ahmad ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Fever ◽  
Indian Subcontinent ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Laboratory Data ◽  
North India ◽  
Dengue Virus Infection ◽  
Haematological Profile

Background: In India, dengue epidemics are becoming more frequent. Dengue viral infections are among the most important mosquito-borne disease of the Indian subcontinent. The study aimed to compare the clinical and haematological profile of all patients diagnosed with dengue viral infection. Patient with confirmed infection with dengue virus were prospectively evaluated for disease progression and to determine their final clinical outcome. The objective of the study was to study the clinico-haematological profile of dengue infection at rural tertiary care centre.Methods: This prospective study included 456 clinically suspected cases of dengue infection of ages more than 14 years of age. Dengue was confirmed by serological methods. Confirmed cases of dengue infection were analyzed according to age, sex and education. Clinical and hematological data were compared between dengue fever and dengue hemorrhagic fever.Results: Serologic dengue infection was positive in 220 (48%) out of 456 clinically suspected cases of the dengue infection. 127 (57.73%) patients were males and 93 (42.27%) were females. 149 (67.72%) patient had dengue fever while 71 (32.27%) had dengue hemorrhagic fever. The proportion of dengue cases was highest among male aged 15 to 24 years-old. A gradual decrease occurred in the percentage of dengue cases in the population aged 44 years-old or more. Common clinical symptoms were fever, headache, abdominal pain, myalgia, joint pain and retro-orbital pain. Common haematological abnormalities were thrombocytopenia, leukopenia and elevated alanine aminotransferase (SGOT).Conclusions: Differences in the clinical, biochemical and haematological profile of dengue virus infection, indicative of a variation in disease severity from DF to DHF. In this study, we present recent data on readily obtained clinical and laboratory data that can be used for early diagnosis and earlier appropriate treatment of dengue virus infection.

scholarly journals Dengue fever in the Indian subcontinent: an overview

2010 ◽  
Vol 5 (04) ◽  
pp. 239-247 ◽  
Author(s):  
Ummar Raheel ◽  
Muhammad Faheem ◽  
Mohammad Nasir Riaz ◽  
Naghmana Kanwal ◽  
Farakh Javed ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Infectious Diseases ◽  
Economic Impact ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Preventive Measures ◽  
Indian Subcontinent ◽  
Hemorrhagic Fever ◽  
Economic Loss ◽  
Pivotal Role

The Indian Subcontinent has emerged as a scene of many mosquito-borne infectious diseases, including malaria and dengue fever. After the 1990s, the rate of malaria declined owing largely to preventive measures, but at the same time dengue fever (DF) and dengue hemorrhagic fever (DHF) were increasing in the region. Outbreaks were recorded in all countries of the Indian Subcontinent with India, Pakistan, Bangladesh and Sri Lanka on the forefront and suffering from the largest number of cases and deaths. We discuss annual cases of DF/DHF in these four countries and possible factors involved in DF outbreaks. We also discuss prevalent serotypes in this region where data suggest the emergence of DEN2 and DEN3 as the most dominant and lethal serotypes. Climate is an important factor influencing DF outbreaks, and rainfall, temperature and humidity play a pivotal role in DF outbreaks. Finally the economic impact of DF/DHF cases is discussed showing that direct and indirect economic loss due to DF/DHF reaches millions of USD each year.

scholarly journals Importance of Platelet Count and Hematocrit in Dengue Fever in Children

2021 ◽  
Vol 44 (2) ◽  
pp. 74-77
Author(s):  
Farhana Rahat ◽  
Morsheda Khanam ◽  
Kazi Iman ◽  
UK Ghosh ◽  
NK Ghosh
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Care Hospital ◽  
Pediatric Age Group

Background: Dengue fever has become one of the most important public health concerns now a day due to increasing complications and fatal outcomes. Dengue hemorrhagic fever and dengue shock syndrome are life threatening but reversible complications of dengue fever. Objectives: This study was performed to evaluate the relationship between platelet count and hematocrit with the severity of dengue infection in pediatric age group. Materials & Methods: This was a prospective observational study which included 280 dengue seropositive children of 1 month to 15 years, conducted during 1st June to 30th November, 2018 in a tertiary care hospital of Dhaka. Results: Out of 280 dengue cases, 187(66.78%) had thrombocytopenia and 88(47%) had raised hematocrit. Among the thrombocytopenic patients 44% had dengue fever, 47% had dengue hemorrhagic fever and 9% dengue shock syndrome. A significant co-relation was observed between the severities of thrombocytopenia and raised hematocrit with the appearance of dengue warning signs in case of dengue hemorrhagic fever. Conclusion: Thrombocytopenia and raised hematocrit were related to the severity of dengue hemorrhagic fever. Bangladesh J Child Health 2020; VOL 44 (2) :74-77

scholarly journals Gene Expression Profiling of Early Acute Febrile Stage of Dengue Infection and Its Comparative Analysis With Streptococcus pneumoniae Infection

2021 ◽  
Vol 11 ◽  
Author(s):  
Leena H. Bajrai ◽  
Sayed S. Sohrab ◽  
Thamir A. Alandijany ◽  
Mohammad Mobashir ◽  
Muddassir Reyaz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Streptococcus Pneumoniae ◽  
Infectious Diseases ◽  
Gene Expression Profiling ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Expression Profiling ◽  
Antigen Processing ◽  
Dengue Infection ◽  
Hemorrhagic Fever

Infectious diseases are the disorders caused by organisms such as bacteria, viruses, fungi, or parasites. Although many of them are permentantly hazardous, a number of them live in and on our bodies and they are normally harmless or even helpful. Under certain circumstances, some organisms may cause diseases and these infectious diseases may be passed directly from person to person or via intermediate vectors including insects and other animals. Dengue virus and Streptococcus pneumoniae are the critical and common sources of infectious diseases. So, it is critical to understand the gene expression profiling and their inferred functions in comparison to the normal and virus infected conditions. Here, we have analyzed the gene expression profiling for dengue hemorrhagic fever, dengue fever, and normal human dataset. Similar to it, streptococcus pneumoniae infectious data were analyzed and both the outcomes were compared. Our study leads to the conclusion that the dengue hemorrhagic fever arises in result to potential change in the gene expression pattern, and the inferred functions obviously belong to the immune system, but also there are some additional potential pathways which are critical signaling pathways. In the case of pneumoniae infection, 19 pathways were enriched, almost all these pathways are associated with the immune system and 17 of the enriched pathways were common with dengue infection except platelet activation and antigen processing and presentation. In terms of the comparative study between dengue virus and Streptococcus pneumoniae infection, we conclude that cell adhesion molecules (CAMs), MAPK signaling pathway, natural killer cell mediated cytotoxicity, regulation of actin cytoskeleton, and cytokine-cytokine receptor interaction are commonly enriched in all the three cases of dengue infection and Streptococcus pneumoniae infection, focal adhesion was enriched between classical dengue fever — dengue hemorrhagic fever, dengue hemorrhagic fever—normal samples, and SP, and antigen processing and presentation and Leukocyte transendothelial migration were enriched in classical dengue fever —normal samples, dengue hemorrhagic fever—normal samples, and Streptococcus pneumoniae infection.

scholarly journals Assessment of World Health Organization definition of dengue hemorrhagic fever in North India

2010 ◽  
Vol 4 (03) ◽  
pp. 150-155 ◽  
Author(s):  
Prashant Gupta ◽  
Vineeta Khare ◽  
Sanjeev Tripathi ◽  
Vijaya Lakshmi Nag ◽  
Rashmi Kumar ◽  
...  
Keyword(s):  
World Health Organization ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Hemorrhagic Fever ◽  
World Health ◽  
Who Criteria ◽  
Age Related ◽  
Definition Of ◽  
Health Organization

Background: Classification of symptomatic dengue according to current World Health Organization (WHO) criteria is not straightforward. In this prospective study of dengue infection during an epidemic in India in 2004, we applied the WHO classification of dengue to assess its usefulness for our patients. Methodology: The study included 145 clinically suspected cases of dengue infection of all ages. Dengue was confirmed by serological methods (IgM ELISA and HI test). WHO criteria were applied to classify dengue positive patients into Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Clinical and laboratory parameters were compared between dengue patients with bleeding and those without bleeding. Results: Out of the 50 serologically positive cases of dengue enrolled in the study, only 3 met the WHO criteria for DHF and 1 met the criteria for DSS; however, 21 (42%) cases had one or more bleeding manifestations. Conclusion: By using WHO criteria of DHF on Indian patients, all severe cases of dengue cannot be correctly classified. A new definition of DHF that considers geographic and age-related variations in laboratory and clinical parameters is urgently required.

scholarly journals Dengue Fever: Clinical Characteristics of A Tertiary Care Hospital Study

2020 ◽  
Vol 44 (1) ◽  
pp. 30-33
Author(s):  
Mohammed Rizwanul Ahsan ◽  
Manzoor Hussain ◽  
SK Azimul Hoque ◽  
Al Amin Mridha ◽  
Sabrina Makbul
Keyword(s):  
Renal Impairment ◽  
Dengue Fever ◽  
Urban Areas ◽  
Clinical Characteristics ◽  
Hepatic Dysfunction ◽  
Dengue Infection ◽  
Tertiary Care ◽  
World Health ◽  
Health Concern ◽  
Care Hospital

Background: Incidence of dengue infection has increased worldwide and has become a significant public health concern. Clinical suspicion based on the frequency of symptoms is very important for early diagnosis. Objectives: To observe the clinical characteristics of serologically confirmed hospitalized cases of dengue fever. Material and Methods: This cross-sectional study was done among admitted children with dengue infection in Dhaka Shishu (Children) Hospital from July 2018 to October 2018. The diagnosis of dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) were established according to the World Health Organization (WHO) classification criteria. Cases who were NS1 antigen and IgM dengue antibody positive included in this study. Results: Among 51 serologically confirmed dengue fever patients, mean age was 6.66 ± 3.69 years. Majority of the cases (74.5%) were less than 10 years of age, 60.8% were male, 39.2% were female, and 88.23% of patients came from urban areas. Classic DF was found in 74.5% of patients, while 25.49% of patients DHF, and 11.7% DSS. Fever was the most common (72.55%) symptom followed by headache, vomiting and myalgia. Hemorrhagic manifestations found in 21.57% of cases. The most common complications were hepatic dysfunction (47.09%) followed by renal impairment, encephalopathy, multi-organ failure, and ARDS. Conclusion: The majorities of dengue cases were from urban areas, below ten years of age and classical DF. Besides fever other common symptoms were headache, vomiting and myalgia. The most common complications were hepatic dysfunction, renal impairment and encephalopathy. Bangladesh J Child Health 2020; VOL 44 (1) :30-33

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