scholarly journals Physiological and metabolic effects of healthy female aging on exhaled breath biomarkers

iScience ◽  
2022 ◽  
pp. 103739
Author(s):  
Pritam Sukul ◽  
Simon Grzegorzewski ◽  
Celine Broderius ◽  
Phillip Trefz ◽  
Thomas Mittlmeier ◽  
...  
Keyword(s):  
Metabolic Effects ◽  
Exhaled Breath ◽  
Healthy Female ◽  
Female Aging

scholarly journals Comprehensive Two-Dimensional Gas Chromatography–Mass Spectrometry Analysis of Exhaled Breath Compounds after Whole Grain Diets

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2667
Author(s):  
Kaisa Raninen ◽  
Ringa Nenonen ◽  
Elina Järvelä-Reijonen ◽  
Kaisa Poutanen ◽  
Hannu Mykkänen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Metabolic Effects ◽  
Mass Spectrometry Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Wheat Bread ◽  
Exhaled Breath ◽  
Two Dimensional ◽  
Whole Grain ◽  
Chromatography Mass Spectrometry

Exhaled breath is a potential noninvasive matrix to give new information about metabolic effects of diets. In this pilot study, non-targeted analysis of exhaled breath volatile organic compounds (VOCs) was made by comprehensive two-dimensional gas chromatography–mass spectrometry (GCxGC-MS) to explore compounds relating to whole grain (WG) diets. Nine healthy subjects participated in the dietary intervention with parallel crossover design, consisting of two high-fiber diets containing whole grain rye bread (WGR) or whole grain wheat bread (WGW) and 1-week control diets with refined wheat bread (WW) before both diet periods. Large interindividual differences were detected in the VOC composition. About 260 VOCs were detected from exhaled breath samples, in which 40 of the compounds were present in more than half of the samples. Various derivatives of benzoic acid and phenolic compounds, as well as some furanones existed in exhaled breath samples only after the WG diets, making them interesting compounds to study further.

scholarly journals Similar neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats

2021 ◽  
Vol 11 (6) ◽  
pp. 320-334
Author(s):  
Myroslava Hrytsak ◽  
Daria Popovych ◽  
Nataliya Badiuk ◽  
Ivanna Hrytsan ◽  
Walery Zukow
Keyword(s):  
Tap Water ◽  
Physiological Activity ◽  
Experimental Studies ◽  
Mineral Waters ◽  
Female Rats ◽  
Metabolic Effects ◽  
Control Group ◽  
Healthy Female ◽  
Sodium Magnesium ◽  
Female Wistar Rats

Background. In order to expand the hydro-mineral base of Truskavets’ spa by diluting brine (130 g/L), two new sulphate-chloride sodium-magnesium mineral waters "Myroslava" (5 g/L) and "Khrystyna" (10 g/L) were created. This report is the first in a series of experimental studies of their physiological activity in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats 220-300 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The day after the completion of the drinking course in all rats assessed the state of autonomous regulation by parameters of the HRV. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine and testosterone (by the ELISA); as well as electrolytes, nitric metabolites, lipid peroxidation products and antioxidant enzymes as well as cholesterol, glucose, amylase and middle mass molecules. Most of the listed parameters of metabolism as well as 17-ketosteroids were determined in daily urine. In the adrenal glands the thickness of glomerular, fascicular, reticular and medullar zones was measured. Results. To identify exactly those parameters, the set of which three groups of animals differ significantly from each other, the information field of the registered parameters was subjected to discriminant analysis. The program included in the model 6 endocrine and 11 metabolic parameters, as well as glomerular filtration. Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water.

scholarly journals Metabolic effects of inhaled salbutamol determined by exhaled breath analysis

2017 ◽  
Vol 11 (4) ◽  
pp. 046004 ◽  
Author(s):  
Martin T Gaugg ◽  
Anna Engler ◽  
Yvonne Nussbaumer-Ochsner ◽  
Lukas Bregy ◽  
Anna S Stöberl ◽  
...  
Keyword(s):  
Breath Analysis ◽  
Metabolic Effects ◽  
Exhaled Breath ◽  
Exhaled Breath Analysis ◽  
Inhaled Salbutamol

scholarly journals Adverse effects of COVID-protective face-masks and wearing durations onto respiratory-haemodynamic physiology and exhaled breath constituents

2021 ◽  
Author(s):  
Pritam Sukul ◽  
Julia Bartels ◽  
Patricia Fuchs ◽  
Phillip Trefz ◽  
Rasmus Remy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiac Output ◽  
Adverse Effects ◽  
Short Chain Fatty Acids ◽  
Metabolic Effects ◽  
Exhaled Breath ◽  
Elderly Age ◽  
Peripheral Oxygen Saturation ◽  
Haemodynamic Parameters ◽  
Surgical Masks

Abstract While protecting against the coronavirus transmission, face-masks may have adverse effects on respiratory-haemodynamic parameters. We investigated immediate and progressive effects of FFP2 and surgical masks on exhaled breath constituents and physiological attributes in 30 healthy volunteers at rest. We continuously monitored exhaled breath profiles in the mask space in elderly (age: 60–80 years) and adults (age: 20–60 years) over a period of 30 min by high-resolution real-time mass-spectrometry (PTR-ToF-MS). Peripheral oxygen saturation, respiratory- and haemodynamic parameters were measured (non-invasively) continuously in parallel. Profound and consistent decrease in SpO2 and increase in pET-CO2 indicates ascending deoxygenation and inadequate ventilation in subjects. Cardiac output and MAP changed as secondary. Exhalation of blood-borne volatile metabolites mirrored behaviour of cardiac output, MAP, SpO2, respiratory rate and pET-CO2. FFP2 masks affected more pronouncedly than surgical masks. Elderly cohort was more vulnerable to those effects. Exhaled humidity increased and exhaled oxygen decreased significantly over time. Breath profiles of endogenous aldehydes, hemiterpene, organosulfur, short-chain fatty acids, alcohols and ketone indicated cross-talks between physio-metabolic effects such as hypoxia, oxidative stress, hypoventilation, compartmental vasoconstriction, altered systemic bacterial activity and energy homeostasis. Concentrations of exogenous VOCs such as aromatics, nitrile and monoterpene depicted compartmental storage and washout. Breathomics allows unique physio-metabolic insights into side effects of face-mask wearing. Mask induced deoxygenation, oxidative stress, CO2 rebreathing, vasoconstriction and blood pressure fluctuations in elderly were clinically concerning (as leading towards hypoxia and hypoventilation). Intelligible global-pandemic policies should reconsider the type and wearing durations of recommended face-masks, based upon age and/or cardio-pulmonary conditions.

scholarly journals Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3098 ◽  
Author(s):  
Jorge A. M. Pereira ◽  
Priscilla Porto-Figueira ◽  
Ravindra Taware ◽  
Pritam Sukul ◽  
Srikanth Rapole ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
Diagnostic Procedures ◽  
Medical Diagnostics ◽  
Metabolic Effects ◽  
Exhaled Breath ◽  
Oral Diseases ◽  
Monitoring Tool ◽  
Non Invasive ◽  
New Frontier ◽  
Volatile Organic

Fostered by the advances in the instrumental and analytical fields, in recent years the analysis of volatile organic compounds (VOCs) has emerged as a new frontier in medical diagnostics. VOCs analysis is a non-invasive, rapid and inexpensive strategy with promising potential in clinical diagnostic procedures. Since cellular metabolism is altered by diseases, the resulting metabolic effects on VOCs may serve as biomarkers for any given pathophysiologic condition. Human VOCs are released from biomatrices such as saliva, urine, skin emanations and exhaled breath and are derived from many metabolic pathways. In this review, the potential of VOCs present in saliva will be explored as a monitoring tool for several oral diseases, including gingivitis and periodontal disease, dental caries, and oral cancer. Moreover, the analytical state-of-the-art for salivary volatomics, e.g., the most common extraction techniques along with the current challenges and future perspectives will be addressed unequivocally.

scholarly journals Peculiarities of neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats

2021 ◽  
Vol 11 (9) ◽  
pp. 862-875
Author(s):  
Myroslava Hrytsak ◽  
Dariya Popovych ◽  
Nataliya Badiuk ◽  
Ivanna Hrytsan
Keyword(s):  
Uric Acid ◽  
Tap Water ◽  
Mineral Waters ◽  
Female Rats ◽  
Metabolic Effects ◽  
Control Group ◽  
Healthy Female ◽  
Sodium Magnesium ◽  
Female Wistar Rats ◽  
Daily Urine

Background. Earlier we found that the newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water. The aim of this study is to elucidate the effects of these mineral waters on the neuroendocrine status and metabolism of these animals. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days injected a tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The day after the completion of the drinking course in all rats, at first, assessed the state of autonomous regulation by parameters of the HRV. The plasma levels of the hormones of adaptation were determined: corticosterone, triiodothyronine and testosterone (by the ELISA) as well as electrolytes: calcium, magnesium, phosphates, chloride, sodium and potassium; nitric metabolites: creatinine, urea, uric acid, medium molecular polypeptides, bilirubin; lipid peroxidation products and antioxidant enzymes, as well as cholesterol, amylase and glucose. Most of the listed parameters of metabolism were also determined in daily urine. In the adrenals the thickness of glomerular, fascicular, reticular and medullar zones was measured. Results. To identify exactly those parameters, the set of which all four groups of animals differ significantly from each other, the information field of the registered parameters was subjected to discriminant analysis. The program included in the model 8 endocrine and 16 metabolic parameters, information about which is condensed into three roots. The first root reflects directly the SOD and corticosterone and inversely the reticular zone as well as plasma uric acid and glucose. The second root contains information about Nap/Kp ratio, natrihistia, amylasemia, magnesiumuria as well as inversely about kaliemia. The third root reflects directly the triiodothyronine, parathyroid activity, plasma Ca, natriuria and chloriduria as well as urine malondyaldehide. Inversely displays the root information about the testosterone, Ku/Nau ratio, glomerular zone, plasma katalase and Na as well as uricosuria and amylasuria. In the information space of the three discriminant roots, all four groups are quite clearly distinguished. Classification accuracy is 94% (three errors). Conclusion. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets resort have specific endocrine and metabolic effects on healthy old female rats with weekly use. This provides a basis for preclinical studies.

Abstract #203 The Real Life Effectiveness; Metabolic Effects and Tolerability of Hydroxychloroquine Once Daily in the Treatment of Type-2 Diabetes Mellitus

2018 ◽  
Vol 24 ◽  
pp. 28-29
Author(s):  
Hemant Thacker ◽  
Rupal Shrimanker ◽  
Banshi Saboo ◽  
Diabetologist ◽  
Anuj Maheshwari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Real Life ◽  
Metabolic Effects ◽  
Life Effectiveness ◽  
Once Daily ◽  
The Real

The Draw-A-Person Test and Body Image

2014 ◽  
Vol 35 (1) ◽  
pp. 3-22 ◽  
Author(s):  
Jonathan E. Handelzalts ◽  
Yael Ben-Artzy-Cohen
Keyword(s):  
Body Mass Index ◽  
Body Image ◽  
Body Mass ◽  
Significant Relationship ◽  
Diet Group ◽  
Female Students ◽  
Self Report ◽  
Body Image Scale ◽  
Healthy Female

The Draw-A-Person (DAP) test has been the center of a long-lasting debate regarding its validity. This study investigated the DAP indices of height, width (size), and inclusion/omission of details and their relation to body image as measured by a self-report scale (Gray’s body image scale) and manifested by the diet behaviors and body mass index of 55 healthy female students. Although the drawings of the diet group were smaller, there was no significant relationship between figure size and diet behaviors. However, body image as measured by a self-report scale did result in significant differences between groups. Moreover, there was a significant correlation between the size of the figure drawn and body image as measured by a self-report scale (larger figures correlated with better body image). No significant results were found for the omission/inclusion indices of the DAP. These results are discussed in light of previous findings regarding the DAP.

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