GW25-e5211 The relationship between serum TNF-α and sICAM levels and the severity of coronary artery diseases

Abstract Coronary artery ectasia (CAE) is defined by a ≥1.5-fold expansion coronary artery vessel diameter, with respect to the adjacent coronary artery vessel. Atherosclerosis and extracellular matrix changes are thought to play an important role in CAE development. Lysyl oxidase (LOX) is part of an important enzyme family involved in the regulation of connective tissue. LOX deficiency has been associated with aortic aneurysm, fold, and dissection. Our study aimed to investigate the relationship between LOX gene G473A (rs1800449) polymorphism and CAE. Eighty-eight patients diagnosed with CAE and 75 healthy individuals were included in the study. The CAE group demonstrated significantly higher hyperlipidemia (p=0.01), male sex incidence (p=0.06), serum TNF-α (p=0.03), and sE-selectin (p=0.02). The LOX genotype and allele distribution showed no significant difference between the groups. Notably, patients with CAE carrying the LOX-CT genotype demonstrated significantly higher TNF-α (p=0.04) and sP-selectin (p=0.02) levels than those carrying the LOX-CC genotype. Higher TNF-α values and hyperlipidemia were associated with the risk of CAE. Further, we observed that TNF-α levels were higher in patients with right coronary artery (RCA) ectasia. Additional large-scale studies to include other LOX gene polymorphisms may support our findings and further elucidate their relationship to CAE.

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Variants of D9N, G188A, N291S, and 93 T/G Genes in patients with Coronary Artery Diseases

Medical Science and Discovery ◽

10.36472/msd.v8i12.636 ◽

2021 ◽

Vol 8 (12) ◽

pp. 698-705

Author(s):

Mohamed S Daoud

Keyword(s):

Coronary Artery ◽

Coronary Artery Diseases ◽

Control Groups ◽

Pcr Rflp ◽

Strong Relation ◽

Diagnostic Coronary Angiography ◽

And Control ◽

The Relationship ◽

Behavioral Markers ◽

Saudi Patients

Objective: Our work aimed to study the relationship between LPL variants D9N, G188A, N291S, and 93 T/G genes and CAD in Saudi patients. Materials and Methods: We recruited 253 CAD patients, who underwent diagnostic coronary angiography, and 207 control subjects. Several biochemical and behavioral markers were obtained, and different genotypes of LPL variants, D9N, G188E, N291S, and 93 T/G, were detected using The PCR-RFLP method. Results: The current study found D9N genotypes, AA, AG, and GG in 71.14%, 23.72%, and 5.14% in CAD patients, respectively. the AA, AG, and GG control genotypes were found in 81.64%, 16.43%, and 1.93%, respectively. The OR of the D9N AA versus AG genotype with a 95% CI was determined to be 1.65 (1.04–2.65), (p = 0.035). The OR of the D9N AA versus AG + GG genotype with a 95% CI was 1.80 (1.16–2.81), (p = 0.009). A strong relation of the D9N AA was observed with CAD. For the G188E, N291S, 93T/G variants insignificant were observed in both CAD and control groups. Conclusion: This study revealed the D9N variant has an association with CAD; however, no relation was detected between CAD and G188E, N291S, and 93T/G variants in the Saudi patients.

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The Relationship between Coronary Artery Diseases and Magnesium Deficiency, with Regard to Coronary Artery Spasms

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1993.tb38747.x ◽

1993 ◽

Vol 676 (1 Nutrition in) ◽

pp. 334-337

Author(s):

HIDEKI MORI ◽

HIDETOSHI NARITA ◽

YOSHIKI HOSHI ◽

TAKEMICHI KANAZAWA ◽

KOGO ONODERA ◽

...

Keyword(s):

Coronary Artery ◽

Magnesium Deficiency ◽

Coronary Artery Diseases ◽

The Relationship

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The Relationship of Anger Expression and Alexithymia with Coronary Artery Stenosis in Patients with Coronary Artery Diseases

Yonsei Medical Journal ◽

10.3349/ymj.2004.45.2.181 ◽

2004 ◽

Vol 45 (2) ◽

pp. 181 ◽

Cited By ~ 3

Author(s):

Kyung Bong Koh ◽

Seung Yun Cho ◽

Jang Woo Kim ◽

Kyu Sik Rho ◽

Sang Hyuk Lee ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Stenosis ◽

Anger Expression ◽

Artery Stenosis ◽

Coronary Artery Diseases ◽

Relationship Of ◽

The Relationship

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Novel insights in the relationship of gut microbiota and coronary artery diseases

Critical Reviews in Food Science and Nutrition ◽

10.1080/10408398.2020.1868397 ◽

2021 ◽

pp. 1-13

Author(s):

Inmaculada Ramírez-Macías ◽

Esteban Orenes-Piñero ◽

Anny Camelo-Castillo ◽

José Miguel Rivera-Caravaca ◽

Cecilia López-García ◽

...

Keyword(s):

Coronary Artery ◽

Gut Microbiota ◽

Coronary Artery Diseases ◽

Relationship Of ◽

The Relationship

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Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

Clinical Science ◽

10.1042/cs20190999 ◽

2019 ◽

Vol 133 (22) ◽

pp. 2283-2299

Author(s):

Apabrita Ayan Das ◽

Devasmita Chakravarty ◽

Debmalya Bhunia ◽

Surajit Ghosh ◽

Prakash C. Mandal ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Chronic Inflammation ◽

Ex Vivo ◽

Human Subjects ◽

Critical Role ◽

Atherosclerotic Cardiovascular Disease ◽

Tnf Α ◽

Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

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Inhibition of Pro-Inflammatory Cytokine Secretion by Select Antioxidants in Human Coronary Artery Endothelial Cells

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000520 ◽

2020 ◽

Vol 90 (1-2) ◽

pp. 103-112 ◽

Cited By ~ 1

Author(s):

Michael J. Haas ◽

Marilu Jurado-Flores ◽

Ramadan Hammoud ◽

Victoria Feng ◽

Krista Gonzales ◽

...

Keyword(s):

Endothelial Cells ◽

Ascorbic Acid ◽

Coronary Artery ◽

Inflammatory Cytokines ◽

Inflammatory Cytokine ◽

Culture Media ◽

Cytokine Secretion ◽

Human Coronary Artery ◽

Tnf Α ◽

Pro Inflammatory Cytokines

Abstract. Inflammatory and oxidative stress in endothelial cells are implicated in the pathogenesis of premature atherosclerosis in diabetes. To determine whether high-dextrose concentrations induce the expression of pro-inflammatory cytokines, human coronary artery endothelial cells (HCAEC) were exposed to either 5.5 or 27.5 mM dextrose for 24-hours and interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor α (TNF α) levels were measured by enzyme immunoassays. To determine the effect of antioxidants on inflammatory cytokine secretion, cells were also treated with α-tocopherol, ascorbic acid, and the glutathione peroxidase mimetic ebselen. Only the concentration of IL-1β in culture media from cells exposed to 27.5 mM dextrose increased relative to cells maintained in 5.5 mM dextrose. Treatment with α-tocopherol (10, 100, and 1,000 μM) and ascorbic acid (15, 150, and 1,500 μM) at the same time that the dextrose was added reduced IL-1β, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1β, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. However, ebselen treatment reduced IL-1β, IL-6, and IL-8 levels in cells maintained in either 5.5 or 27.5 mM dextrose. IL-2 and TNF α concentrations in culture media were below the limit of detection under all experimental conditions studied suggesting that these cells may not synthesize detectable quantities of these cytokines. These results suggest that dextrose at certain concentrations may increase IL-1β levels and that antioxidants have differential effects on suppressing the secretion of pro-inflammatory cytokines in HCAEC.

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Unprotected Left Main Coronary Artery Percutaneous Coronary Intervention-Our Experiences at a Tertiary Hospital

Cardiovascular Journal ◽

10.3329/cardio.v6i2.18349 ◽

2014 ◽

Vol 6 (2) ◽

pp. 107-111

Author(s):

S Munwar ◽

AHMW Islam ◽

S Talukder ◽

AQM Reza ◽

T Ahmed ◽

...

Keyword(s):

Percutaneous Coronary Intervention ◽

Coronary Artery ◽

Left Main Coronary Artery ◽

Coronary Intervention ◽

Drug Eluting Stent ◽

Bare Metal ◽

Coronary Artery Diseases ◽

Left Main ◽

Percutaneous Coronary ◽

Drug Eluting

Background: Aim of the study was to evaluate the primary procedural success of percutaneous coronary intervention of unprotected left main coronary artery stenosis using either Bare-metal stents or drug eluting stent. Methods: Total 33 patients were enrolled in this very preliminary non-randomized prospective cohort study. Among them, Male: 25 and Female: 8. Total 35 stents were deployed. Mean age were for Male: 59 yrs, for Female: 62 yrs. Associated coronary artery diseases risk factors were dyslipidemia, High Blood pressure, Diabetes Mellitus, Positive family history for coronary artery diseases and smoking. Results: Among the study group; 26 (78%) were Dyslipidemic, 24(70%) were hypertensive; 17 (51.5%) patients were Diabetic, 11(33%) were smoker and 7(21%) patients had family history of Ischaemic heart disease. Female patients were more obese (BMI M 26: F 27) and developed coronary artery diseases in advance age. Common stented territory were left main: 20 (60%), Left main to left anterior descending artery 7 (22%) and Left main to left circumflex artery 6 (18%). Average length and diameter of stent was 3.5 and 18 mm respectively. Stent used: Bare Metal Stent 5 (15%), Drug Eluting Stent: 28 (85%). Among the different Drug Eluting Stents, Everolimus eluting stents were 11 (39.3%), Sirolimus eluting 10(35.7%), Paclitaxel eluting 3 (10.7%), Biolimus eluting 3 (10.7%) and Zotarolimus eluting1 (3.6%). In the present study, overall survival outcome was 94% (31 patient), mortality of cardiac cause 3% (1 patient) and 1 patient (3%) died of hepatocellular carcinoma. Conclusion: Our study has shown that percutaneous coronary intervention of the unprotected left main is a safe and effective alternative to Coronary Artery Bypass Graft (CABG). DOI: http://dx.doi.org/10.3329/cardio.v6i2.18349 Cardiovasc. j. 2014; 6(2): 107-111

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