Co-associations Between IL10 Genetic Variants, IL 10 Production And Helminth Infection In A Tropical Population Of Brazil With High Prevalence Of Asthma

2012 ◽  
Vol 129 (2) ◽  
pp. AB62
Author(s):  
C.A. Figueiredo ◽  
M.L. Barreto ◽  
N.M. Alcantara-Neves ◽  
P.J. Cooper ◽  
L.C. Rodrigues ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Helminth Infection ◽  
High Prevalence

scholarly journals Helminth infection in southern Laos: high prevalence and low awareness

2013 ◽  
Vol 6 (1) ◽  
pp. 328 ◽  
Author(s):  
Khampheng Phongluxa ◽  
Vilavanh Xayaseng ◽  
Youthanavanh Vonghachack ◽  
Kongsap Akkhavong ◽  
Peter van Eeuwijk ◽  
...  
Keyword(s):  
Helminth Infection ◽  
High Prevalence

scholarly journals Short Communication: Prevalence and risk factors of soil-transmitted helminth infection among farmers in Gelgel Village, Klungkung District, Bali, Indonesia

2020 ◽  
Vol 21 (4) ◽  
Author(s):  
Budiapsari Putu indah ◽  
ANAK AGUNG GEDE INDRANINGRAT ◽  
HENY ARWATI ◽  
YOES PRIJATNA DACHLAN
Keyword(s):  
Risk Factors ◽  
Short Communication ◽  
Helminth Infection ◽  
Significant Risk ◽  
Personal Hygiene ◽  
High Risk Population ◽  
Modified Technique ◽  
Hygiene Factors ◽  
High Prevalence ◽  
Regression Test

Abstract. Apsari PIB, Indraningrat AAG, Arwati H, Dachlan YP. 2020. Short Communication: Prevalence and risk factors of soil-transmitted helminth infection among farmers in Gelgel Village, Klungkung District, Bali, Indonesia. Biodiversitas 21: 1535-1540. Soil-transmitted helminths infection remains a problem in tropical and subtropical regions worldwide. Indonesia is one of the tropical countries with a high prevalence of STH infection in children and high-risk population such as farmers. This study aimed to assess the prevalence and risk factors of STH infection from farmers. STH infection was diagnosed by Kato-Katz modified technique, while risk factors relevant to STH infection were assessed by a questionnaire. Data were analyzed by logistic regression and multiple regression test. A total of 162 fecal-samples and questionnaires were obtained from 250 participants. Twenty-two subjects (13.5%) were positive, and 140 subjects (86.5%) were negative for STH infection giving the prevalence rate of 13.5% among farmers. Several significant risk factors for STH infection were age, gender, level of study, income, eating fresh unwashed vegetable, hand washing without soap, defecation site, without wearing hand gloves and protective cloth, bare walking foot, and the use of synthetic fertilizer. So we can conclude that personal hygiene factors were the most contributed factors for STH infection.

scholarly journals Helminth parasites in the intestinal tract of indigenous poultry in parts of Kenya : short communication

2004 ◽  
Vol 75 (1) ◽  
Author(s):  
L.W. Irungu ◽  
R.N. Kimani ◽  
S.M. Kisia
Keyword(s):  
Health Status ◽  
Infection Control ◽  
Intestinal Tract ◽  
Short Communication ◽  
Helminth Infection ◽  
Helminth Parasites ◽  
Ascaridia Galli ◽  
The Poor ◽  
High Prevalence ◽  
Syngamus Trachea

A study was carried out on 456 indigenous poultry intestinal specimens from various towns in Kenya to determine the occurrence and distribution of helminth parasites in the intestinal tract of the birds. Of the specimens examined, 414 had parasites whereas the remaining 42 had none, which is an infection rate of 90.78 %. The main species of helminths found in the intestines were Raillietina sp. (47.53 %), Heterakis gallinarum (21.33 %), Ascaridia galli (10.03 %), Strongyloides avium (9.96 %), Choanotaenia infundibulum (4.61 %), Cotugnia digonopora (3.6 %), Capillaria sp. (1.5 %), Trichostrongylus tenius (1.04 %) and Syngamus trachea (0.40 %). Most helminths were present in both the mid- and hindguts. Syngamus trachea and C. digonopora were only found in the foregut and midgut, respectively. Although chickens from which the specimens were collected appeard healthy, the high prevalence of helminthiasis observed shows the poor level of helminth infection control practiced by the indigenous poultry keepers in the country, which might affect the health status of the birds and their growth rates. Poultry keepers should be encouraged to prevent, control and treat such cases.

High prevalence of GB-C/hepatitis G virus in a Brazilian population with helminth infection

1998 ◽  
Vol 56 (4) ◽  
pp. 310-315 ◽  
Author(s):  
P. Gallian ◽  
V. Rodrigues ◽  
J. F. Cantaloube ◽  
H. Dessein ◽  
P. de Micco ◽  
...  
Keyword(s):  
Helminth Infection ◽  
Brazilian Population ◽  
Hepatitis G Virus ◽  
High Prevalence ◽  
Hepatitis G

scholarly journals Genotypes and Phenotypes: A Review of Pulmonary Hypertension in Genetic Syndromes

2021 ◽  
Vol 20 (5) ◽  
pp. 150-156
Author(s):  
Rachel T Sullivan ◽  
Eric D Austin
Keyword(s):  
Pulmonary Hypertension ◽  
Genetic Variants ◽  
Current Knowledge ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
Pulmonary Vascular Disease ◽  
Disease Phenotype ◽  
Genetic Syndromes ◽  
High Prevalence ◽  
Pulmonary Arterial ◽  
Genetic Makeup

There has been significant advancement in the understanding of the genetics of pulmonary hypertension (PH), particularly in those with heritable or idiopathic pulmonary arterial hypertension. In addition to genetic variants with a primarily pulmonary vascular disease phenotype, the prevalence of PH in other genetic syndromes is increasingly recognized. We will review the current knowledge of PH associated with multisystem genetic syndromes. There is high prevalence of coexisting cardiac and pulmonary disease, making it challenging to discern whether PH is secondary to these processes or underlying genetic makeup. There is a paucity of data on response to PH-targeted therapy and implications on overall prognosis.

Review: Genetics of helminth resistance in sheep

2014 ◽  
Vol 94 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Niel A. Karrow ◽  
Katherine Goliboski ◽  
Nancy Stonos ◽  
Flavio Schenkel ◽  
Andrew Peregrine
Keyword(s):  
Genetic Variants ◽  
Helminth Infection ◽  
Anthelmintic Resistance ◽  
Genetic Selection ◽  
Economic Loss ◽  
Helminth Parasites ◽  
Selection Strategies ◽  
Gastrointestinal Helminth ◽  
The World ◽  
Selection For

Karrow, N. A., Goliboski, K., Stonos, N., Schenkel, F. and Peregrine, A. 2014. Review: Genetics of helminth resistance in sheep. Can. J. Anim. Sci. 94: 1–9. Gastrointestinal helminth parasites are an important source of economic loss to sheep producers. A rapid increase in anthelmintic resistance has occurred around the globe; therefore, the industry is exploring alternative strategies such as genetic selection to control losses attributed to helminth infection. Since helminths have co-evolved with sheep for millions of years, natural selection for enhanced helminth resistance has occurred within certain breeds from various parts of the world. These breeds of sheep are being used to better understand the genetic aspects of helminth resistance. If the genetic variants that contribute to this phenotype can be identified, it may be possible to use selection strategies to introduce resistance alleles into other breeds or to increase their frequency within breeds. This review will provide an up-to-date overview of the pathology of helminth disease, the immune response to helminth infection, and the search for genes that confer helminth resistance.

scholarly journals Genetic Determinants of Clozapine-Induced Metabolic Side Effects

2016 ◽  
Vol 62 (2) ◽  
pp. 138-149 ◽  
Author(s):  
Kamini Vasudev ◽  
Yun-Hee Choi ◽  
Ross Norman ◽  
Richard B. Kim ◽  
Ute I. Schwarz
Keyword(s):  
Metabolic Syndrome ◽  
Side Effects ◽  
Genetic Variants ◽  
Serotonin Receptor ◽  
Leptin Receptor ◽  
Linear Regression Analysis ◽  
Cytochrome P450 Enzymes ◽  
Metabolic Side Effects ◽  
Genetic Predictors ◽  
High Prevalence

Objective: Atypical antipychotics are linked to a higher incidence of metabolic side effects, including weight gain, dyslipidemia, and diabetes. In this study, we examined the prevalence and potential genetic predictors of metabolic side effects in 60 adult patients on clozapine. Method: Genetic variants of relevance to clozapine metabolism, clearance, and response were assessed through targeted genotyping of cytochrome P450 enzymes CYP1A2 and CYP2C19, the efflux transporter ABCB1, the serotonin receptor (HTR2C), leptin (LEP), and leptin receptor (LEPR). Clozapine levels and other potential confounders, including concurrent medications, were also included in the analysis. Results: More than half of the patients were obese (51%), had metabolic syndrome (52.5%), and 30.5% were overweight. There was a high prevalence of antipsychotic polypharmacy (61.9%). With multivariable linear regression analysis, LEP –2548G>A, LEPR c.668A>G, and HTR2C c.551-3008 C>G were identified as genetic predictors of body mass index (BMI) after considering effects of clozapine dose, blood level, and concurrent medications (adjusted R2 = 0.305). Metabolic syndrome was found to be significantly associated with clozapine level and CYP2C19*2 and LEPR c.668 G alleles. Clozapine levels in patients with metabolic syndrome were significantly higher compared to those without metabolic syndrome (1886 ± 895 vs. 1283 ± 985 ng/mL, P < 0.01) and were associated with the CYP2C19*2 genotype. No association was found between the genetic variants studied and lipid or glucose levels. Conclusion: This study confirms a high prevalence of metabolic side effects with clozapine and suggests higher clozapine level and pharmacogenetic markers in CYP2C19, LEP, LEPR, and HTR2C receptors as important predictors of BMI and metabolic syndrome.

scholarly journals VITAMINS FOR PREGNANT, ACTIVE FOLATES WITH 100% ABSORPTION

2017 ◽  
pp. 48-50 ◽  
Author(s):  
E. G. Khilkevich ◽  
O. I. Yazykova
Keyword(s):  
Folic Acid ◽  
Genetic Variants ◽  
Congenital Malformations ◽  
The Body ◽  
Natural Food ◽  
Study Objective ◽  
Study Results ◽  
High Prevalence ◽  
Sufficient Degree ◽  
Folate Cycle

Study objective. To study the efficacy of folic acid drugs, in particular metafolin, at the stage of pregravid preparation and during pregnancy to prevent congenital malformations and complications of pregnancy.Material and methods. We conducted a search of the literature sources by the keywords «folic acid», «folates», «metafolin», «pregnancy», «methyltetrahydrofolate» in domestic and foreign databases: elibrary, Medline/PubMed, Embase, CINAHL. 23 sources were selected.Study results. One of the main challenges that the obstetrician faces is the prevention of pregnancy complications and congenital malformations of the fetus. In the literature there is considerable amount of evidence about the effectiveness of folic acid. However, the natural food folates and folic acid preparations may not be absorbed to a sufficient degree by the body in women with defects in folate-converting enzymes, the incidence rate of which reaches 50%.Conclusion. All women at the stage of pregravid preparation and during pregnancy should take folates to prevent complications of pregnancy and congenital malformations in the fetus. Given the high prevalence of mutations in genes responsible for folateconverting enzymes, in clinical practice it is recommended to use folates able to be absorbed by the body regardless of genetic variants of the folate cycle enzymes. 

High prevalence of genetic variants previously associated with Brugada syndrome in new exome data

2013 ◽  
Vol 84 (5) ◽  
pp. 489-495 ◽  
Author(s):  
B Risgaard ◽  
R Jabbari ◽  
L Refsgaard ◽  
AG Holst ◽  
S Haunsø ◽  
...  
Keyword(s):  
Brugada Syndrome ◽  
Genetic Variants ◽  
Exome Data ◽  
High Prevalence

Identification of Novel Genes Associated to Major Mental Disease by Whole Exome Sequencing in Families with High Prevalence

2017 ◽  
Vol 41 (S1) ◽  
pp. S98-S99
Author(s):  
J. Pol Fuster ◽  
L. Ruiz Guerra ◽  
B. Ortega Vila ◽  
A. Medina Dols ◽  
B. Bisbal Carrió ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Genetic Variants ◽  
Mental Disease ◽  
Psychotic Symptoms ◽  
Disease Etiology ◽  
New Genes ◽  
Whole Exome ◽  
High Prevalence ◽  
Rare Genetic Variants

IntroductionThe identification of new genetic variants underlying psychosis is crucial to improve its molecular diagnosis and to determine the disease etiology, which is necessary to develop new therapeutic targets.AimTo identify novel rare genetic variants associated to mental disorders, using whole exome sequencing (WES).MethodsTwo families with high prevalence of mental disease were genotyped using WES. The first family has 5 members affected, the mother with a bipolar disorder, three sons, two with schizophrenia and one with schizoaffective disorder, and a cousin with major depression and psychotic symptoms. The second family is constituted by 38 members affected by major mental diseases in three generations. Key affected members of each family were genotyped by WES. Shared rare variants, with allelic frequencies below 0.5% in general population, were identified among the affected members of the family. The segregation of those variants was confirmed by Sanger sequencing.ResultsIn family 1, thirty-seven genetic variants related to neurodevelopment were identified. Two of those variants in the genes TRIP12 and RNF25 segregated with psychosis. In family 2, seven rare genetic variants contained in genes related to neurodevelopment were identified. A mutation in the gene ARHGAP19 segregated with psychosis.ConclusionsThree new genes have been found to be associated with psychosis. TRIP12 and RNF25 encode two E3-ubiquitin ligases which modulate the Wnt pathway, mutations in which lead to neurodevelopmental defects. ARHGAP19 encodes a GTPase which regulates the RhoA protein, involved in the regulation of the cytoskeleton.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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