Oxidative Balance in Fetal Life and Allergic Disease Risk in Adolescence: Investigating the role of Prenatal Nutrient Intakes and Potential Sources of Oxidative Stress in Utero

The role of oxidative stress, an imbalance between reactive oxygen species production (ROS) and antioxidants, has been described in several patho-physiological conditions, including cardiovascular, neurological diseases and cancer, thus impacting on individuals’ lifelong health. Diet, environmental pollution, and physical activity can play a significant role in the oxidative balance of an organism. Even if physical training has proved to be able to counteract the negative effects caused by free radicals and to provide many health benefits, it is also known that intensive physical activity induces oxidative stress, inflammation, and free radical-mediated muscle damage. Indeed, variations in type, intensity, and duration of exercise training can activate different patterns of oxidant–antioxidant balance leading to different responses in terms of molecular and cellular damage. The aim of the present review is to discuss (1) the role of oxidative status in athletes in relation to exercise training practice, (2) the implications for muscle damage, (3) the long-term effect for neurodegenerative disease manifestations, (4) the role of antioxidant supplementations in preventing oxidative damages.

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Peripheral chemoreceptors respond to hypoxia in pontine-lesioned fetal lambs in utero

Journal of Applied Physiology ◽

10.1152/jappl.1993.75.3.1027 ◽

1993 ◽

Vol 75 (3) ◽

pp. 1027-1034 ◽

Cited By ~ 21

Author(s):

B. M. Johnston ◽

P. D. Gluckman

Keyword(s):

Acute Hypoxia ◽

In Utero ◽

Fetal Life ◽

Peripheral Chemoreceptors ◽

Fetal Breathing Movements ◽

Pontine Lesion ◽

Regulation Of Breathing ◽

Peripheral Arterial ◽

Stimulation Of

Acute hypoxia inhibits, rather than stimulates, fetal breathing movements (FBM), but there has been controversy as to the activity and role of the peripheral arterial chemoreceptors in the regulation of breathing movements in the unanesthetized fetus in utero. However, after midcollicular brain stem transection or lateral pontine lesion, hypoxia causes FBM to become continuous and stimulated in rate and depth. To determine whether this stimulatory response involves peripheral chemoreceptors, we used a two-stage approach to examine the response to hypoxia after peripheral chemodenervation in lateral pontine-lesioned fetal lambs. The lateral pons was lesioned at 119–121 days, and the response to hypoxia was tested in the unanesthetized fetus 4 days afterward. Fourteen fetuses in which hypoxia stimulated FBM underwent either peripheral chemodenervation or sham denervation in a second operation. Hypoxia had no effect when the fetus was tested 4–5 days after peripheral chemodenervation, and the basal incidence of FBM was significantly lower. The stimulatory response was unchanged by sham denervation. We conclude that the peripheral chemoreceptors are active in fetal life and that they mediate the stimulation of FBM seen in response to hypoxia after removal of the lateral pontine inhibition. In addition, after pontine lesion there is evidence of tonic chemoreceptor-mediated influences on FBM, which are normally overriden in the intact fetus.

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Redox physiology in animal function: The struggle of living in an oxidant environment

Current Zoology ◽

10.1093/czoolo/56.6.687 ◽

2010 ◽

Vol 56 (6) ◽

pp. 687-702 ◽

Cited By ~ 19

Author(s):

David Costantini

Keyword(s):

Oxidative Stress ◽

Life Histories ◽

Evolutionary Ecology ◽

Life History Strategies ◽

Ecological Studies ◽

Oxidative Balance ◽

Fitness Traits ◽

Trade Offs ◽

Strong Focus

Abstract A strong focus of ecological research for several decades has been to understand the factors underlying the variation in animal life-histories. In recent times, ecological studies have begun to show that oxidative stress may represent another important modulator of competitive trade-offs among fitness traits or of positively integrated patterns of traits. Therefore, incorporating mechanisms underlying oxidative physiology into evolutionary ecology has the potential to help understand variation in life-history strategies. In this review, I provide a general overview of oxidative stress physiology, and subsequently focus on topics that have been neglected in previous ecological reviews on oxidative stress. Specifically, I introduce and discuss the adaptations that animals have evolved to cope with oxidative stress; the environmental stressors that can generate changes in oxidative balance; the role of reactive species in transduction of environmental stimuli and cell signaling; and the range of hormetic responses to oxidative stress.

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Undernutrition and Overnutrition Burden for Diseases in Developing Countries: The Role of Oxidative Stress Biomarkers to Assess Disease Risk and Interventional Strategies

Antioxidants ◽

10.3390/antiox6020041 ◽

2017 ◽

Vol 6 (2) ◽

pp. 41 ◽

Cited By ~ 6

Author(s):

Francesca Mastorci ◽

Cristina Vassalle ◽

Kyriazoula Chatzianagnostou ◽

Claudio Marabotti ◽

Khawer Siddiqui ◽

...

Keyword(s):

Oxidative Stress ◽

Developing Countries ◽

Disease Risk ◽

Oxidative Stress Biomarkers ◽

Stress Biomarkers

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HIV, Metabolic Syndrome X, Inflammation, Oxidative Stress, and Coronary Heart Disease Risk : Role of Protease Inhibitor Exposure

Cardiovascular Toxicology ◽

10.1385/ct:4:3:303 ◽

2004 ◽

Vol 4 (3) ◽

pp. 303-316 ◽

Cited By ~ 25

Author(s):

Barry E. Hurwitz ◽

Nancy G. Klimas ◽

Maria M. Llabre ◽

Kevin J. Maher ◽

Jay S. Skyler ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Coronary Heart Disease ◽

Heart Disease ◽

Protease Inhibitor ◽

Coronary Heart Disease Risk ◽

Disease Risk ◽

Syndrome X ◽

Heart Disease Risk

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Role of Oxidative Stress in the Mechanisms of Anthracycline-Induced Cardiotoxicity: Effects of Preventive Strategies

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/8863789 ◽

2021 ◽

Vol 2021 ◽

pp. 1-16

Author(s):

Rodrigo Carrasco ◽

Rodrigo L. Castillo ◽

Juan G. Gormaz ◽

Montserrat Carrillo ◽

Paaladinesh Thavendiranathan

Keyword(s):

Oxidative Stress ◽

Treatment Strategies ◽

Redox Balance ◽

Therapeutic Interventions ◽

Preventive Strategies ◽

Stress Injury ◽

Oxidative Balance ◽

Protective Strategies ◽

Antioxidant Effects

Anthracycline-induced cardiotoxicity (AIC) persists as a significant cause of morbidity and mortality in cancer survivors. Although many protective strategies have been evaluated, cardiotoxicity remains an ongoing threat. The mechanisms of AIC remain unclear; however, several pathways have been proposed, suggesting a multifactorial origin. When the central role of topoisomerase 2β in the pathophysiology of AIC was described some years ago, the classical reactive oxygen species (ROS) hypothesis shifted to a secondary position. However, new insights have reemphasized the importance of the role of oxidative stress-mediated signaling as a common pathway and a critical modulator of the different mechanisms involved in AIC. A better understanding of the mechanisms of cardiotoxicity is crucial for the development of treatment strategies. It has been suggested that the available therapeutic interventions for AIC could act on the modulation of oxidative balance, leading to a reduction in oxidative stress injury. These indirect antioxidant effects make them an option for the primary prevention of AIC. In this review, our objective is to provide an update of the accumulated knowledge on the role of oxidative stress in AIC and the modulation of the redox balance by potential preventive strategies.

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In utero exposure to tobacco and alcohol modifies neurobehavioral development in mice offspring: consideration a role of oxidative stress

Pharmacological Research ◽

10.1016/j.phrs.2003.11.002 ◽

2004 ◽

Vol 49 (5) ◽

pp. 467-473 ◽

Cited By ~ 34

Author(s):

Y Li

Keyword(s):

Oxidative Stress ◽

In Utero ◽

In Utero Exposure ◽

Neurobehavioral Development

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Role of Dietary Antioxidants in Neurodegenerative Diseases: Where are We Standing?

Current Pharmaceutical Design ◽

10.2174/1381612826666200107143619 ◽

2020 ◽

Vol 26 (7) ◽

pp. 714-729 ◽

Cited By ~ 2

Author(s):

Sena Bakir ◽

Gizem Catalkaya ◽

Fatma D. Ceylan ◽

Haroon Khan ◽

Burcu Guldiken ◽

...

Keyword(s):

Oxidative Stress ◽

Neurodegenerative Diseases ◽

Natural Antioxidants ◽

Spongiform Encephalopathy ◽

Preventive Effect ◽

Dietary Antioxidants ◽

Oxidative Balance ◽

The Relationship ◽

Lateral Sclerosis

: This review presents the potential effects of dietary antioxidants on neurodegenerative diseases. The relationship between autoimmunity and antioxidants, and their preventive effect on neurodegenerative diseases are evaluated. The driven factors of neurodegeneration and the potential effects of natural antioxidants are summarized for Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, spongiform encephalopathy, Huntington’s disease, and amyotrophic lateral sclerosis. The effect of oxidative stress on neurodegenerative diseases and regulative effect of antioxidants on oxidative balance is discussed. This review provides beneficial information for the possible cure of neurodegenerative diseases with dietary intake of antioxidants.

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