P1-517: VALIDITY AND RELIABILITY OF THE 10/66 DEMENTIA RESEARCH GROUP COGNITIVE TEST BATTERY FOR EARLY IDENTIFICATION OF COGNITIVE DECLINE IN MEXICO

Background: Down syndrome (DS), the most common genetic cause of intellectual disability, is associated with an ultra-high risk of developing Alzheimer’s disease. However, there is individual variability in the onset of clinical dementia and in baseline cognitive abilities prior to decline, particularly in memory, executive functioning, and motor coordination. The LonDownS Consortium aims to determine risk and protective factors for the development of dementia and factors relating to cognitive abilities in people with DS. Here we describe our cognitive test battery and related informant measures along with reporting data from our baseline cognitive and informant assessments. Methods: We developed a cognitive test battery to assess general abilities, memory, executive function, and motor coordination abilities in adults with DS, with informant ratings of similar domains also collected, designed to allow for data on a broad range of participants. Participants (n=305) had a range of ages and abilities, and included adults with and without a clinical diagnosis of dementia. Results: Results suggest the battery is suitable for the majority of adults with DS, although approximately half the adults with dementia were unable to undertake any cognitive task. Many test outcomes showed a range of scores with low floor and ceiling effects. Non-verbal age-adjusted IQ scores had lower floor effects than verbal IQ scores. Before the onset of any cognitive decline, females aged 16-35 showed better verbal abilities compared to males. We also identified clusters of cognitive test scores within our battery related to visuospatial memory, motor coordination, language abilities, and processing speed / sustained attention. Conclusions: Our further studies will use baseline and longitudinal assessments to explore factors influencing cognitive abilities and cognitive decline related to ageing and onset of dementia in adults with DS.

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Kognitive Defizite bei Schizophren Erkrankten

Zeitschrift für Klinische Psychologie und Psychotherapie ◽

10.1026/1616-3443/a000288 ◽

2015 ◽

Vol 44 (2) ◽

pp. 106-120 ◽

Cited By ~ 2

Author(s):

Almut Carolus ◽

Petia Popova ◽

Brigitte Rockstroh

Keyword(s):

Test Battery ◽

Cognitive Test ◽

Kognitive Defizite ◽

Kognitive Funktionen

Zusammenfassung. Theoretischer Hintergrund: Kognitive Funktionseinschränkungen sind zentrales Merkmal schizophrener Erkrankungen und werden entsprechend im Behandlungskonzept berücksichtigt. Kognitive Remediationsprogramme gelten als wirksam, Effektstärken als moderat. Trainingsvarianten werden zur Effektoptimierung erprobt. Fragestellung: Ist gezieltes Funktionstraining in neuroplastizitäts-orientiertem Lernkontext effektiver als breitgefächertes Behandlungsprogramm und werden Effekte durch das Erkrankungsstadium moduliert? Methode: Bei 59 chronisch und 31 ersthospitalisierten schizophren Erkrankten wurden kognitive Defizite über Testleistungen der MATRICS Consensus Cognitive Test Battery gegenüber 25 gesunder Kontrollpersonen erfasst. Testleistungen vor, nach 4-wöchiger Interventionsphase mit zwei spezifischen Trainings oder Standardbehandlung und 3-monatiger Katamnese prüften den Einfluss von Interventionstypus und Erkrankungsstadium auf Leistungsverbesserung. Ergebnisse: Sowohl chronische wie erstmals behandelte Patienten aller Behandlungsgruppen verbesserten sich signifikant über die Messzeitpunkte, obwohl Defizite relativ zu Kontrollen fortbestanden. Schlussfolgerungen: Spezifisches Training verbessert kognitive Funktionen nicht über Zeit/Remissionseffekte hinaus.

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P1-390: Lower Gait Speed is Independently Associated with Increased Mortality Risk Among People with Dementia in Low- and Middle-Income Countries: Results from The 10/66 Dementia Research Group Population-Based Cohort Study

Alzheimer s & Dementia ◽

10.1016/j.jalz.2016.06.1142 ◽

2016 ◽

Vol 12 ◽

pp. P582-P582 ◽

Cited By ~ 1

Author(s):

Ronaldo D. Piovezan ◽

Daysi Acosta ◽

Mariella Guerra ◽

Y. Huang ◽

Juan J. Llibre Rodriguez ◽

...

Keyword(s):

Cohort Study ◽

Mortality Risk ◽

Research Group ◽

Gait Speed ◽

Population Based ◽

Middle Income ◽

Middle Income Countries ◽

People With Dementia ◽

Dementia Research ◽

Group Population

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A Randomized, Multicenter, Crossover Psychometric Evaluation Study of an iPad-administered Cognitive Test Battery in Participants with Major Depressive Disorder Who Responded to Treatment with Oral Antidepressants

Journal of Affective Disorders ◽

10.1016/j.jad.2021.05.046 ◽

2021 ◽

Author(s):

Jennifer Bogert ◽

Hany Rofael ◽

Kenneth Mosca ◽

Rachel Ochs Ross ◽

Geert Callaerts ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Psychometric Evaluation ◽

Evaluation Study ◽

Test Battery ◽

Cognitive Test ◽

Major Depressive

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Dementia in Developing Countries

International Psychogeriatrics ◽

10.1017/s1041610201007797 ◽

2001 ◽

Vol 13 (4) ◽

pp. 389-393 ◽

Cited By ~ 7

Author(s):

Martin Prince

Keyword(s):

Health Care ◽

Developing Countries ◽

Social Welfare ◽

Research Group ◽

Research Evidence ◽

Population Based ◽

Normal Part ◽

Social Welfare Services ◽

Low Profile ◽

Dementia Research

The 10/66 Dementia Research Group (2000a) has drawn attention to the uneven distribution of research evidence worldwide; although two thirds (66%) of all persons with dementia live in developing countries, 10% or less of population-based research has been conducted in those regions. The study by Vas and colleagues on dementia in Mumbai, India, published in this issue of International Psychogeriatrics is therefore most welcome. Dementia has a very low profile in most developing countries. Families often view it as a normal part of aging, and few seek help despite experiencing significant strain (Pate1 & Prince, 2001; Shaji et al., in press). Unsurprisingly therefore it is accorded a low priority by policymakers in the developing world, and there is little sign of attention being given to the development of more responsive health care or social welfare services. Population-based research, well disseminated, can play an important role in increasing awareness at all levels of society.

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Differences in quantitative methods for measuring subjective cognitive decline – results from a prospective memory clinic study

International Psychogeriatrics ◽

10.1017/s1041610216000272 ◽

2016 ◽

Vol 28 (9) ◽

pp. 1513-1520 ◽

Cited By ~ 16

Author(s):

Asmus Vogel ◽

Lise Cronberg Salem ◽

Birgitte Bo Andersen ◽

Gunhild Waldemar

Keyword(s):

Depressive Symptoms ◽

Cognitive Decline ◽

Quantitative Methods ◽

Cognitive Status ◽

Cognitive Test ◽

Subjective Cognitive Decline ◽

Linear Regression Models ◽

Memory Clinic ◽

Subjective Memory ◽

Wide Range

ABSTRACTBackground:Cognitive complaints occur frequently in elderly people and may be a risk factor for dementia and cognitive decline. Results from studies on subjective cognitive decline are difficult to compare due to variability in assessment methods, and little is known about how different methods influence reports of cognitive decline.Methods:The Subjective Memory Complaints Scale (SMC) and The Memory Complaint Questionnaire (MAC-Q) were applied in 121 mixed memory clinic patients with mild cognitive symptoms (mean MMSE = 26.8, SD 2.7). The scales were applied independently and raters were blinded to results from the other scale. Scales were not used for diagnostic classification. Cognitive performances and depressive symptoms were also rated. We studied the association between the two measures and investigated the scales’ relation to depressive symptoms, age, and cognitive status.Results:SMC and MAC-Q were significantly associated (r = 0.44, N = 121, p = 0.015) and both scales had a wide range of scores. In this mixed cohort of patients, younger age was associated with higher SMC scores. There were no significant correlations between cognitive test performances and scales measuring subjective decline. Depression scores were significantly correlated to both scales measuring subjective decline. Linear regression models showed that age did not have a significant contribution to the variance in subjective memory beyond that of depressive symptoms.Conclusions:Measures for subjective cognitive decline are not interchangeable when used in memory clinics and the application of different scales in previous studies is an important factor as to why studies show variability in the association between subjective cognitive decline and background data and/or clinical results. Careful consideration should be taken as to which questions are relevant and have validity when operationalizing subjective cognitive decline.

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