Alkyl polyglucoside-based adapalene-loaded microemulsions for targeted dermal delivery: Structure, stability and comparative biopharmaceutical characterization with a conventional dosage form

2019 ◽  
Vol 54 ◽  
pp. 101245 ◽  
Author(s):  
Nataša Bubić Pajić ◽  
Tanja Ilić ◽  
Ines Nikolić ◽  
Vladimir Dobričić ◽  
Ivana Pantelić ◽  
...  
Keyword(s):  
Dosage Form ◽  
Structure Stability ◽  
Dermal Delivery ◽  
Alkyl Polyglucoside ◽  
Conventional Dosage

Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies

RSC Advances ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 10001-10010 ◽  
Author(s):  
Prakash Chandra Bhatt ◽  
Pranay Srivastava ◽  
Preeti Pandey ◽  
Washim Khan ◽  
Bibhu Prasad Panda
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Pc12 Cells ◽  
Solid Lipid Nanoparticles ◽  
Dosage Form ◽  
Lipid Nanoparticles ◽  
Brain Delivery ◽  
Solid Lipid ◽  
Biological Studies ◽  
Conventional Dosage

Astaxanthin nanoformulation was found appropriate in all measures with strong antioxidant activity against H2O2induced oxidative stress in PC12 cells. Biodistribution and brain delivery was also found to be superior to conventional dosage form.

Nanocarriers Based Novel Drug Delivery as Effective Drug Delivery: A Review

2019 ◽  
Vol 4 (2) ◽  
pp. 71-83 ◽  
Author(s):  
Nitin R. Shirsath ◽  
Ajaygiri K. Goswami
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Patient Compliance ◽  
Delivery System ◽  
Drug Targeting ◽  
Dosage Form ◽  
Effective Drug ◽  
Delivery Technique ◽  
Health Related ◽  
Conventional Dosage

Background:A lot of people are facing some health-related problems in day to day life. The conventional drug delivery is not able to cure it alone, moreover, some drugs have poor solubility, low half-life and show lesser bioavailability. It is necessary to conduct research on carrier-based nanoparticulate drug delivery, this is an alternative approach to alter/eliminate the problem of conventional dosing for better effectiveness, patient compliance, and effective drug targeting.Objective:To develop a carrier-based nanoparticulate drug delivery system for the elimination of problems associated with conventional dosage form.Method:In this review, different problems associated with conventional dosage form as well as potential advantages of the nanoparticulate delivery systems have been discussed. We also discussed their different route for administration such as oral, intranasal, ocular, transdermal, vaginal etc. for effective drug targeting. It has been found that different nanocarriers based drug delivery have been able to enhance the bioavailability, solubility, minimized adverse effect as well as effective in Gene delivery also. Ionic gelation, Solvent evaporation, emulsification, homogenization, lyophilisation, etc. are techniques used for their development.Conclusion:The carrier-based drug delivery technique act as an effective drug delivery system for the treatment of various diseases/disorders as well as provides better efficiency, bioavailability and improve patient compliance.

scholarly journals Topical Dosage Form & Delivery System for Pigmentation Control: A Review

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1341-1349
Author(s):  
Yap Vi Lien ◽  
Mogana R ◽  
Sasikala Chinnappan ◽  
Ashok Kumar Janakiraman ◽  
Tan Lee Fang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Skin Penetration ◽  
Dosage Forms ◽  
Brown Pigment ◽  
Tyrosinase Enzyme ◽  
Novel Drug ◽  
Conventional Dosage

Hyperpigmentation is one of the most commonly seen skin disorders which is not a concerning health issues but it may affect the psychological aspect of a person. Hyperpigmentation is caused by the presence of excess melanin, which is the brown pigment of the skin. Products that aimed to reduce the pigmentations act by inhibiting the tyrosinase enzyme, which is the rate-limiting enzyme in the synthesis of melanin. There are many products that are currently available in the market that aims to reduce pigmentation of the skin. These products are conventionally formulated into different dosage forms such as cream, lotion and emulgel, which gains popularity due to its convenience on application. However, due to the drawbacks that these dosage forms possess such as poor stability and absorption, new formulations are presented which incorporate novel drug delivery system into the conventional dosage forms. These novel drug delivery systems are, inter alia, liposome, niosomes and microsphere. They carry benefits of controlled drug delivery, enhanced skin penetration and reduce drug toxicity as compared to the conventional dosage form, which resulted in the increase in marketed product diving into this pathway. This present article will discuss the various dosage forms, drug delivery system, its advantages, disadvantages and marketed product for pigmentation control.

scholarly journals AN OVERVIEW OF TRANSDERMAL DELIVERY SYSTEM

2017 ◽  
Vol 10 (10) ◽  
pp. 36 ◽  
Author(s):  
Reshmi Jayaprakash ◽  
Jahnara Hameed ◽  
Anupriya Anupriya
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Dosage Form ◽  
Systemic Circulation ◽  
Oral Dosage ◽  
Transdermal Drug Delivery System ◽  
Different Types ◽  
Conventional Dosage

Recently, most widely using conventional dosage form such as tablet, capsules, and injections but due to some case we are preferable to choose transdermal drug delivery system (TDDS) because conventional oral dosage form undergo first pass metabolism. In TDDS, skin is the effective medium for the penetration of drug into systemic circulation. This system required very low dose for the effective result or action. One of the major disadvantages of TDDS is penetration rate is very low through the stratum corneum. Nowadays, different types of skin penetration enhancement techniques are used for increasing the penetration. These types of techniques can be also increase the bioavailability. The patients have more preferable to choose this type of drug delivery system because it has more advantages than conventional dosage form. This article is discuses about the anatomy and physiology of skin and its drug penetration capacity, polymers used in transdermal drug delivery and different types of TDDS.

scholarly journals Most promising solid dispersion technique of oral dispersible tablet

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Vikrant K. Nikam ◽  
Shubham K. Shete ◽  
Jyoti P. Khapare
Keyword(s):  
Solid Dispersion ◽  
Dosage Form ◽  
Solid Dispersions ◽  
Review Article ◽  
Two Component System ◽  
Dispersible Tablet ◽  
Oral Disintegrating Tablet ◽  
Materials Used ◽  
Dispersion Technique ◽  
Conventional Dosage

Abstract Background The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet. Oral dispersible tablet is also called as mouth dissolving tablet, fast dissolving tablet, or oral disintegrating tablet. Oral dispersible tablet has advantage as it quickly disintegrates into saliva when it is put on the tongue. The faster the drug disintegrates or is dissolved, the faster the absorption and the quicker the therapeutic effect of drug will be attained. Main text This review article focuses on the progress in methods of manufacturing and various latest technologies involved in the development of oral disintegrating tablet. The solid dispersion technique is one of the novel techniques to manufacturing the oral dispersible tablet. Solid dispersion is basically a drug polymer two component system. Conclusion This review article focuses on advantages, disadvantages, materials used as carrier for solid dispersions, methods of preparation of solid dispersion, classification of solid dispersion, promising drugs that can be incorporated into oral disintegrating tablet by solid dispersion techniques, and recent research in solid dispersion technique using polymers as carriers.

Development and Psychometric Evaluation of a Revised Sense of Coherence Scale

2018 ◽  
Vol 34 (3) ◽  
pp. 206-215 ◽  
Author(s):  
Rahel Bachem ◽  
Andreas Maercker
Keyword(s):  
Posttraumatic Growth ◽  
Factor Structure ◽  
Sense Of Coherence ◽  
Psychological Health ◽  
Psychometric Evaluation ◽  
Health Indicators ◽  
Structure Stability ◽  
Confirmatory Factor Analyses ◽  
Reliability Factor ◽  
Two Samples

Abstract. The present study introduces a revised Sense of Coherence (SOC) scale, a new conceptualization and operationalization of the resilience indicator SOC. It outlines the scale development and aims for testing its reliability, factor structure, and validity. Literature on Antonovsky’s SOC (SOC-A) was critically reviewed to identify needs for improving the scale. The scale was investigated in two samples. Sample 1 consisted of 334 bereaved participants, Sample 2 of 157 healthy controls. The revised SOC Scale, SOC-A, and theoretically relevant questionnaires were applied. Explorative and confirmatory factor analyses established a three-factor structure in both samples. The revised SOC Scale showed significant but discriminative associations with related constructs, including self-efficacy, posttraumatic growth, and neuroticism. The revised measure was significantly associated with psychological health indicators, including persistent grief, depression, and anxiety, but not to the extent as the previous SOC-A. Stability over time was sufficient. The study provides psychometric support for the revised SOC conceptualization and scale. It has several advantages over the previous SOC-A scale (unique variance, distinct factor structure, stability). The scale could be used for clinical and health psychological testing or research into the growing field of studies on resilience over the life span.

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