Baseline periodontal risk calculator score is strongly associated with alveolar bone loss and tooth loss 3, 9, and 15 years later in non-transient men

The purpose of this paper is two-fold: (1) to review the evidence that osteoporosis and post-menopausal estrogen deficiency are associated with progressive alveolar bone loss and an elevated risk of tooth loss; and (2) to propose the use of tetracyclines, specifically low-dose doxycycline (LDD) (and, perhaps in the future, the chemically modified tetracyclines), to mitigate alveolar bone loss in post-menopausal osteoporotic/osteopenic women. Design concepts for a randomized clinical trial to study the effects of LDD on progressive alveolar bone loss in this patient population are reviewed. Since osteoporosis affects over 20 million people in the United States, progressive alveolar bone loss in this patient group represents a potentially significant public health problem unique from common adult periodontitis. Stopping progressive alveolar bone loss is essential to prevent both tooth loss and micro-architectural deterioration of alveolar bone.

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Continuous Periosteal Strapping Sutures for Stabilization of Osseous Grafts With Resorbable Membranes for Buccal Ridge Augmentation: A Technique Report

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-17-00060 ◽

2017 ◽

Vol 43 (4) ◽

pp. 283-290 ◽

Cited By ~ 3

Author(s):

Tamir H Shalev ◽

Gregori M Kurtzman ◽

Alon H Shalev ◽

Deborah K Johnson ◽

Mark Elias M Kersten

Keyword(s):

Bone Loss ◽

Tooth Loss ◽

Alveolar Bone ◽

Effective Means ◽

Alveolar Bone Loss ◽

Socket Preservation ◽

Ridge Structure ◽

Ridge Augmentation ◽

Novel Technique ◽

Bone Height

Alveolar bone loss occurs after extraction with loss of a premolar or anterior tooth; the residual supporting alveolar bone loss averages 1.53 mm of crestal bone height and 3.87 mm of buccolingual width, with most of the bone loss occurring at the facial plate. Socket preservation does not completely preserve the original ridge contours but can be an effective means of reducing bone loss following extraction. Attempts to rebuild the alveolar ridge structure after tooth loss often employ the concept of guided bone regeneration, a technique-sensitive procedure that routinely involves placement of particulate bone with or without fixation screws and either a resorbable or a nonresorbable membrane. We present a novel technique for stabilizing a resorbable membrane and underlying particulate graft allowing for predictable bone grafting across multiple edentulous sites.

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Evaluation of the relationship between periodontal risk and carotid artery calcifications on panoramic radiographs

European Journal of Dentistry ◽

10.4103/1305-7456.172614 ◽

2015 ◽

Vol 09 (04) ◽

pp. 483-489 ◽

Cited By ~ 4

Author(s):

Gulen Kamak ◽

Eren Yildirim ◽

Emin Rencber

Keyword(s):

Carotid Artery ◽

Bone Loss ◽

Tooth Loss ◽

Alveolar Bone ◽

Significant Relation ◽

Panoramic Radiographs ◽

Carotid Artery Calcification ◽

Periodontal Risk ◽

The Relationship ◽

Carotid Calcification

ABSTRACT Objective: To evaluate if there is a relationship between findings of carotid artery calcification (CAC) and periodontal risk in nonsmoker subjects by using panoramic radiographs (DPR). Materials and Methods: A total of 1146 DPRs were investigated. Gender, age, severity of bone loss, tooth loss, periodontal risk, and findings of carotid calcification were recorded. The periodontal risk was evaluated and classified according to the degree of alveolar bone loss. Results: CAC was diagnosed in %13.6 (n: 156) of DPRs. Of 1146 patients, 338 (29.5%) had low, 668 (60%) had moderate, and 120 (10.5%) had high periodontal risk. A statistically significant relation was observed between carotid calcification and periodontal risk. Conclusion: Positive findings of carotid calcification may be related with periodontal problems. Clinicians must be careful about diagnosing CACs on DPRs during routine examinations. In the case of positive findings of CAC and periodontitis together, the patient may be consulted to a specialist for further investigation.

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ALVEOLAR BONE LOSS AND TOOTH LOSS IN MALE CIGAR AND PIPE SMOKERS

The Journal of the American Dental Association ◽

10.14219/jada.archive.1999.0029 ◽

1999 ◽

Vol 130 (1) ◽

pp. 57-64 ◽

Cited By ~ 68

Author(s):

ELIZABETH A. KRALL ◽

ARTHUR J. GARVEY ◽

RAUL I. GARCIA

Keyword(s):

Bone Loss ◽

Tooth Loss ◽

Alveolar Bone ◽

Alveolar Bone Loss

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Alveolar bone loss and tooth loss are associated with COVID-19 severity but are not independent risk factors. An explorative study

Advances in Oral and Maxillofacial Surgery ◽

10.1016/j.adoms.2021.100223 ◽

2021 ◽

pp. 100223

Author(s):

H.C.M. Donders ◽

J.M. van der Sleen ◽

Y.J. Kleinbergen ◽

N. Su ◽

J. de Lange ◽

...

Keyword(s):

Risk Factors ◽

Bone Loss ◽

Tooth Loss ◽

Alveolar Bone ◽

Alveolar Bone Loss ◽

Explorative Study ◽

Independent Risk Factors

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Metacarpal Cortical Bone Area Predicts Tooth Loss in Men

JDR Clinical & Translational Research ◽

10.1177/2380084416668155 ◽

2016 ◽

Vol 2 (2) ◽

pp. 179-186 ◽

Cited By ~ 2

Author(s):

E.K. Kaye ◽

P. Vokonas ◽

R.I. Garcia

Keyword(s):

Bone Loss ◽

Cortical Bone ◽

Tooth Loss ◽

Alveolar Bone ◽

Metacarpal Bone ◽

Alveolar Bone Loss ◽

Bone Area ◽

Number Of Teeth

The relationship between bone mineral density and tooth loss in men is unclear. The aim of this retrospective cohort study was to determine if relative metacarpal bone area (MCA) predicts tooth loss in a cohort of 273 male participants in the Dental Longitudinal Study and Normative Aging Study of the Department of Veterans Affairs. Outer and inner cortical bone widths of the middle metacarpal of the nondominant hand were measured on anteroposterior hand radiographs approximately 11 y apart. Baseline MCA was computed and categorized into quartiles. The men were followed from 1971 to 2015. Incident tooth loss during 2 intervals was examined: concurrent with the MCA measurements and long term over the total follow-up (17 ± 7 y). Radiographic alveolar bone loss (ABL) was measured on periapical radiographs as a percentage of the distance from the cementoenamel junction to root apex, and the number of teeth with ABL >40% was computed. Negative binomial generalized linear regression models estimated the mean number of teeth with ABL >40% and the number lost (concurrent and total), controlling for age, smoking, number of teeth at baseline, percentage teeth with ≥1 decayed/filled surface, and years of follow-up. At baseline, MCA was inversely related to number of teeth with >40% ABL. Men in the lowest MCA quartile (Q1) lost the most teeth, both concurrent with MCA measurements and long term, but the association differed by caries level (≤55% or >55% decayed/filled teeth). At the low caries level, the numbers lost in Q1 were 29% greater than in the highest MCA quartile (Q4). At the high caries level, the numbers lost in Q1 were more than twice those in Q4. Associations were attenuated when further controlled for number of teeth with ABL>40%. These findings suggest that systemic bone status plays a role in tooth loss and that the association may be mediated by alveolar bone loss. Knowledge Transfer Statement: Low relative metacarpal bone area was related to loss of alveolar bone and incident tooth loss in men. This information extends previous research, primarily studies of women, showing that osteoporosis adversely affects oral health. Knowledge of a patient’s systemic bone status may be important for managing his or her periodontal disease. Tooth loss in the absence of periodontal inflammation may signify systemic bone loss. Interprofessional communication is central to maintaining optimal oral and bone health.

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B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection

Interdisciplinary Perspectives on Infectious Diseases ◽

10.1155/2009/864359 ◽

2009 ◽

Vol 2009 ◽

pp. 1-6 ◽

Cited By ~ 18

Author(s):

Pamela J. Baker ◽

Nicole Ryan Boutaugh ◽

Michaela Tiffany ◽

Derry C. Roopenian

Keyword(s):

T Cells ◽

B Cells ◽

Bone Loss ◽

B Cell ◽

Tooth Loss ◽

Alveolar Bone ◽

Oral Infection ◽

Alveolar Bone Loss ◽

Oral Colonization ◽

Deficient Mice

Periodontal disease is one of the most common infectious diseases of humans. Immune responses to infection trigger loss of alveolar bone from the jaw and eventual tooth loss. We investigated the contribution of B cell IgD to alveolar bone loss by comparing the response of B cell normal BALB/cJ mice and IgD deficient BALB/c-Igh-5−/−Jmice to oral infection withPorphyromonas gingivalis, a gram-negative periodontopathic bacterium from humans.P. gingivalis-infected normal mice lost bone. Specific antibody toP. gingivaliswas lower and oral colonization was higher in IgD deficient mice; yet bone loss was completely absent. Infection increased the proportion of CD69+activated B cells and CD4+T cells in immune normal mice compared to IgD deficient mice. These data suggest that IgD is an important mediator of alveolar bone resorption, possibly through antigen-specific coactivation of B cells and CD4+T cells.

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Sclerostin and DKK1 Inhibition Preserves and Augments Alveolar Bone Volume and Architecture in Rats with Alveolar Bone Loss

Journal of Dental Research ◽

10.1177/0022034518766874 ◽

2018 ◽

Vol 97 (9) ◽

pp. 1031-1038 ◽

Cited By ~ 11

Author(s):

M. Liu ◽

P. Kurimoto ◽

J. Zhang ◽

Q.T. Niu ◽

M. Stolina ◽

...

Keyword(s):

Bone Loss ◽

Tooth Loss ◽

Alveolar Bone ◽

Alveolar Bone Loss ◽

Bone Volume ◽

Bone Biomechanics ◽

Ovariectomized Rats ◽

Structural Support ◽

Maxillary Molar ◽

Molar Extraction

Alveolar bone is a mechanosensitive tissue that provides structural support for teeth. Alveolar bone loss is common with aging, menopause, tooth loss, and periodontitis and can lead to additional tooth loss, reduced denture fixation, and challenges in placing dental implants. The current studies suggest that sclerostin and DKK1, which are established osteocyte-derived inhibitors of bone formation, contribute to alveolar bone loss associated with estrogen ablation and edentulism in rats. Estrogen-deficient ovariectomized rats showed significant mandibular bone loss that was reversed by systemic administration of sclerostin antibody (SAB) alone and in combination with DKK1 antibody (DAB). Osteocytes in the dentate and edentulous rat maxilla expressed Sost (sclerostin) and Dkk1 (DKK1) mRNA, and molar extraction appeared to acutely increase DKK1 expression. In a chronic rat maxillary molar extraction model, systemic SAB administration augmented the volume and height of atrophic alveolar ridges, effects that were enhanced by coadministering DAB. SAB and SAB+DAB also fully reversed bone loss that developed in the opposing mandible as a result of hypo-occlusion. In both treatment studies, alveolar bone augmentation with SAB or SAB+DAB was accompanied by increased bone mass in the postcranial skeleton. Jaw bone biomechanics showed that intact sclerostin-deficient mice exhibited stronger and denser mandibles as compared with wild-type controls. These studies show that sclerostin inhibition, with and without DKK1 coinhibition, augmented alveolar bone volume and architecture in rats with alveolar bone loss. These noninvasive approaches may have utility for the conservative augmentation of alveolar bone.

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