scholarly journals 625 Contribution of miRNAs as epigenetic regulators of retinol efficacy in the skin dermis

2021 ◽  
Vol 141 (5) ◽  
pp. S108
Author(s):  
V. Bardey ◽  
N. Pelletier ◽  
L. Danoux ◽  
L. Philip ◽  
C. Reymermier
Keyword(s):  
Epigenetic Regulators

scholarly journals A Systems Biology Approach to Identify Essential Epigenetic Regulators for Specific Biological Processes in Plants

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 364
Author(s):  
Rachel M. McCoy ◽  
Russell Julian ◽  
Shoban R. V. Kumar ◽  
Rajeev Ranjan ◽  
Kranthi Varala ◽  
...  
Keyword(s):  
Machine Learning ◽  
Network Inference ◽  
Root Apical Meristem ◽  
Environmental Cues ◽  
Biological Processes ◽  
Learning Network ◽  
Meristem Development ◽  
Epigenetic Regulator ◽  
Gene Regulatory ◽  
Epigenetic Regulators

Upon sensing developmental or environmental cues, epigenetic regulators transform the chromatin landscape of a network of genes to modulate their expression and dictate adequate cellular and organismal responses. Knowledge of the specific biological processes and genomic loci controlled by each epigenetic regulator will greatly advance our understanding of epigenetic regulation in plants. To facilitate hypothesis generation and testing in this domain, we present EpiNet, an extensive gene regulatory network (GRN) featuring epigenetic regulators. EpiNet was enabled by (i) curated knowledge of epigenetic regulators involved in DNA methylation, histone modification, chromatin remodeling, and siRNA pathways; and (ii) a machine-learning network inference approach powered by a wealth of public transcriptome datasets. We applied GENIE3, a machine-learning network inference approach, to mine public Arabidopsis transcriptomes and construct tissue-specific GRNs with both epigenetic regulators and transcription factors as predictors. The resultant GRNs, named EpiNet, can now be intersected with individual transcriptomic studies on biological processes of interest to identify the most influential epigenetic regulators, as well as predicted gene targets of the epigenetic regulators. We demonstrate the validity of this approach using case studies of shoot and root apical meristem development.

Abstract 2084: Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress response

2021 ◽  
Author(s):  
Kevin C. Johnson ◽  
Kevin J. Anderson ◽  
Elise T. Courtois ◽  
Amit D. Gujar ◽  
Floris P. Barthel ◽  
...  
Keyword(s):  
Stress Response ◽  
Environmental Stress ◽  
Single Cell ◽  
Cellular Plasticity ◽  
Environmental Stress Response ◽  
Epigenetic Regulators

Epigenetic function in neurodevelopment and cognitive impairment

Neuroforum ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mira Jakovcevski ◽  
Geraldine Zimmer-Bensch
Keyword(s):  
Brain Development ◽  
Neuronal Migration ◽  
Treatment Options ◽  
Regulation Of Gene Expression ◽  
Noncoding Rnas ◽  
Molecular Processes ◽  
High Prevalence ◽  
Genes Encoding ◽  
Epigenetic Regulators ◽  
Epigenetic Processes

Abstract Brain development comprises a fine-tuned ensemble of molecular processes that need to be orchestrated in a very coordinated way throughout time and space. A wide array of epigenetic mechanisms, ranging from DNA methylation and histone modifications to noncoding RNAs, have been identified for their major role in guiding developmental processes such as progenitor proliferation, neuronal migration, and differentiation through precise regulation of gene expression programs. The importance of epigenetic processes during development is reflected by the high prevalence of neurodevelopmental diseases which are caused by a lack or mutation of genes encoding for transcription factors and other epigenetic regulators. Most of these factors process central functions for proper brain development, and respective mutations lead to severe cognitive defects. A better understanding of epigenetic programs during development might open new routes toward better treatment options for related diseases.

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