scholarly journals The correlation between depression and anxiety with cognitive function of nurse in isolation room for Coronavirus disease-19 in RSUP HJ. Adam Malik Medan

2021 ◽  
Vol 429 ◽  
pp. 119881
Author(s):  
Ranintha Surbakti ◽  
Iskandar Nasution ◽  
Fasihah Fitri
Keyword(s):  
Cognitive Function ◽  
Depression And Anxiety ◽  
Isolation Room

Measuring the outcomes of care in older people: a non-critical review of patient-based measures. II. Mental status, depression and psychological wellbeing instruments

2000 ◽  
Vol 10 (2) ◽  
pp. 123-132 ◽  
Author(s):  
P. Kliempt ◽  
D. Ruta ◽  
M. McMurdo
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Cognitive Function ◽  
Older People ◽  
Mental Status ◽  
Psychological Wellbeing ◽  
Depression And Anxiety ◽  
General Health Status ◽  
Outcomes Of Care

This is the second in a series of three papers reviewing 69 patient-based outcome measures that have been developed specifically for use with older people, or that have been administered to populations that include older people. The first paper described how the measures were identified, and provided a brief description of 17 measures of general health status and quality of life. This paper reviews nine measures of mental status and cognitive function, 10 measures of depression and anxiety, and seven psychological wellbeing measures (see Tables 1-3).

Abstract 135: Change in Cognition, Depression, and Anxiety Following Catheter Ablation

2014 ◽  
Vol 7 (suppl_1) ◽  
Author(s):  
Jane S Saczynski ◽  
Heather M Richardson ◽  
Alexandra Hajduk ◽  
Catarina I Kiefe ◽  
Robert J Goldberg ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Function ◽  
Catheter Ablation ◽  
Psychosocial Factors ◽  
Medical Center ◽  
Depression And Anxiety ◽  
Patient Centered ◽  
Symptoms Of Depression ◽  
Post Procedure ◽  
Clinical Benefits

Background: Patients with atrial fibrillation (AF) commonly experience symptoms such as palpitations, shortness of breath and chest discomfort. The severity of AF-related symptoms is associated with psychosocial factors such as anxiety and depression. Limited data suggests that catheter ablation, a treatment option in symptomatic patients with AF, reduces depression and anxiety but its effect on cognitive function remains unclear. Methods: Participants were 38 AF patients (mean age = 63 years ±8; 68% male, 66% paroxysmal AF) undergoing an index catheter ablation for AF at the University of Massachusetts Medical Center and interviewed pre-ablation and post ablation (1-week, 1 month and 3 months) as part of an ongoing study of AF treatment and psychosocial factors. A total of 150 ablation patients will be included in the final sample. Cognitive function was assessed using the Montreal Cognitive Assessment Battery (impairment = score <27 on the 30 point scale), depression by the Patient Health Questionnaire (PHQ) and anxiety by the Generalized Anxiety Score (GAD). Trajectories of depressive symptoms, anxiety and cognitive function were modeled before and after catheter ablation using linear mixed models adjusting for age, sex, AF type (paroxysmal vs other), and history of coronary artery disease or diabetes. Results: Patients reported high levels of depressive symptoms and anxiety and many (>50%) were cognitively impaired prior to ablation. Cognitive function increased following ablation, with improvements observed as early as one week after catheter ablation and continued to improve at 3-months post procedure (Table). Symptoms of depression and anxiety declined immediately following ablation and continued to decline through 3-months post procedure but changes were not statistically significant and may have been limited by power. Conclusions: Catheter-based ablation was associated with improved symptoms of depression and anxiety as well as cognitive function among patients with symptomatic AF. Knowledge of the patient-centered, as well as clinical, benefits of the various treatments for AF will guide patients, their families and their physicians make informed treatment choices.

scholarly journals Effect of Physical Activity on Cognitive Function and Neurogenesis: Roles of BDNF and Oxidative Stress

Thrita ◽  
2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Elham Shakouri ◽  
Mohammad Ali Azarbayjani ◽  
Seyed Behnamedin Jameie ◽  
Maghsoud Peeri ◽  
Mona Farhadi
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Cognitive Function ◽  
Cognitive Disorders ◽  
Depression And Anxiety ◽  
Beneficial Effects ◽  
The Central Nervous System ◽  
Poor Nutrition ◽  
Enhanced Learning ◽  
Lifestyle Patterns

Context: Cognitive disorders are one of the most common neurological problems that can be caused by lifestyle patterns, especially sedentary lifestyle, poor nutrition, exposure to a variety of toxins or diseases. Evidence Acquisition: There are various strategies recommended for the prevention and treatment of these disorders, including drug therapy, psychological therapy, dietary pattern changes, and physical activity. Results: It seems that physical activity with biological mechanisms can have beneficial effects on the central nervous system and improve cognitive function, including enhanced learning and memory, as well as reduced depression and anxiety. Conclusions: Of the major mechanisms that physical activity can affect cognitive function include increased neurogenic factors, decreased oxidative stress, decreased inflammatory mediators, and mitochondrial biogenesis. Therefore, it is recommended that people with cognitive impairments can use physical activity as an appropriate strategy to prevent and treat cognitive impairment problems.

scholarly journals Personality traits in post-COVID syndrome

2021 ◽  
Author(s):  
Cristina Delgado-Alonso ◽  
María Valles-Salgado ◽  
Alfonso Delgado-Álvarez ◽  
Natividad Gómez-Ruiz ◽  
Miguel Yus ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Sleep Quality ◽  
Personality Traits ◽  
Neuropsychiatric Symptoms ◽  
Emotional Stability ◽  
Olfactory Function ◽  
Therapeutic Interventions ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Personality Profiles

Abstract Background. We aimed to evaluate personality traits in patients with postCOVID syndrome, as well as the association with neuropsychiatric symptoms present in this disorder. Methods. The Big Five Structure Inventory was administered to 93 consecutive patients with a diagnosis of post-COVID syndrome and to matched controls. We also performed a comprehensive evaluation of depression, anxiety, fatigue, sleep quality, cognitive function, and olfactory function. Results. Patients with post-COVID syndrome scored lower for emotional stability, equanimity, positive mood, and self-control. Extraversion, emotional stability, and openness correlated negatively with anxiety and depression levels. Conscientiousness correlated negatively with anxiety. No statistically significant correlations were observed between personality traits and cognitive function, sleep quality, olfactory function, or fatigue. Personality scores explained 36.3% and 41% of the variance in scores on the anxiety and depression scales, respectively. Two personality profiles with lower levels of emotional stability were associated with depression and anxiety. Conclusions. Our study shows higher levels of neuroticism in patients with post-COVID syndrome. Personality traits were predictive of the presence of depression and anxiety, but not cognitive function, sleep quality, or fatigue, in the context of post-COVID syndrome. These findings may have implications for the detection of patients at risk of depression and anxiety in post-COVID syndrome, and for the development of preventive and therapeutic interventions.

scholarly journals Tryptophan supplementation and serotonin function: genetic variations in behavioural effects

2018 ◽  
Vol 77 (2) ◽  
pp. 174-188 ◽  
Author(s):  
E. L. Gibson
Keyword(s):  
Amino Acid ◽  
Cognitive Function ◽  
Negative Affect ◽  
Affective Disorders ◽  
Promoter Region ◽  
Kynurenine Pathway ◽  
Insufficient Data ◽  
Depression And Anxiety ◽  
Behavioural Effects ◽  
Induced Mood

The neurotransmitter serotonin has a role in affective disorders such as depression and anxiety, as well as sleep, cognitive function and appetite. This review examines the evidence that serotonin-related genotypes may moderate the behavioural effects of supplementation with the serotonin precursor amino acidl-tryptophan (TRP), on which synthesis of serotonin (or 5-hydroxytryptamine; 5-HT) depends. However, 95 % of serotonin is synthesised and used in the periphery, and TRP is also metabolised via non-5-HT routes such as the kynurenine pathway. Moreover, understanding of genotypes involved in regulation of serotonin raises questions over the generalisability of TRP effects on behaviour across individuals with varied serotonergic genotypes. To date, only differences between variants of the 5-HT transporter-linked promoter region (5-HTTLPR) have been investigated in relation to behavioural effects of TRP supplementation. Effects of 5-HTTLPR genotypes are usually compared between the alleles that are either high (L/L′) or low (S/S′) expressing of mRNA for the 5-HT transporter receptor. Yet, another key genetic variable is sex: in women, the S/S′ genotype predicts sensitivity to improved mood and reduced cortisol by TRP supplementation, during stressful challenges, whereas the L/L′ genotype protects against stress-induced mood deterioration. In men, the L/L′ genotype may confer risk of stress-induced increases in negative affect; there are insufficient data to assess effects on male S/S′ genotypes. However, better-powered studies to detect sex by genotype by stress by TRP interactions, as well as consideration of more genotypes, are needed before strong conclusions and recommendations for behavioural effects of TRP treatment can be reached.

scholarly journals Genetic polymorphisms and haplotypes of ERCC1 and ERCC2 associated with quality of life, depression, and anxiety status among patients with lung cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yunxiang Tang ◽  
Ruike Zhang ◽  
Yinan Li ◽  
Shuyu Xu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Cognitive Function ◽  
Emotional Functioning ◽  
Life Questionnaire ◽  
Depression And Anxiety ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
The Relationship

Abstract Background Patients with lung cancer (LC) have a poor quality of life (QoL) and easily suffer from psychological diseases. Previous studies focused less on the relationship between genetic factors and QoL, depression, and anxiety status in LC patients. The current study is intended to explore the relationship between SNPs and haplotypes of ERCC1 and ERCC2 and the QoL, depression and anxiety status of patients with LC. Methods QoL, depression and anxiety status were assessed in 291 LC patients using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30), EORTC Quality of Life Questionnaire-Lung Cancer 13 (QLQ-LC13), SDS and SAS. Nine tag SNPs of ERCC1 and ERCC2 were detected using an improved multiplex ligation detection reaction (iMLDR) technique. Haplotype analysis was conducted using the software Haploview 4.2. The association between SNPs or haplotypes and QoL or depression or anxiety in LC patients was analyzed by regression analysis. Results ERCC1 rs11615 was associated with emotional functioning (P = 0.027), and ERCC1 rs3212986 was associated with anxiety scores (P = 0.018). ERCC1 rs762562-rs3212986 haplotype was associated with cognitive function (P = 0.029), somatic function (P = 0.014) and dysphagia (OR = 3.32, P = 0.044). Patients with ERCC1 rs3212986-rs11615 AG haplotype had worse cognitive function (adjusted Beta = − 5.42) and somatic function (adjusted Beta = − 6.55) and had severer symptoms of loss of appetite (adjusted OR = 1.67) and dysphagia (adjusted OR = 4.43) (All adjusted P < 0.05). ERCC2 rs13181-rs3916874-rs238416 haplotype was associated with emotional functioning (P = 0.035), pain at other sites (OR 1.88, P = 0.014), chest pain (OR 0.42, P = 0.02), dysphagia (OR 2.82, P = 0.048), and anxiety status (OR 0.23, P = 0.009). Conclusion After adjustment for environmental factors, SNPs and haplotypes of ERCC1 and ERCC2 were associated with different domains of QoL, depression and anxiety in LC patients.

scholarly journals The Impact of the Virtual Cognitive Health Program on the Cognition and Mental Health of Older Adults: Pre-Post 12-Month Pilot Study (Preprint)

2018 ◽  
Author(s):  
Shefali Kumar ◽  
Jennifer LA Tran ◽  
Heidi Moseson ◽  
Caroline Tai ◽  
Jordan M Glenn ◽  
...  
Keyword(s):  
Mental Health ◽  
Older Adults ◽  
At Risk ◽  
Cognitive Function ◽  
Health Program ◽  
Depression And Anxiety ◽  
Web Based ◽  
Cognitive Health ◽  
Anxiety Levels ◽  
The Impact

BACKGROUND Face-to-face multidomain lifestyle interventions have shown to be effective for improving or maintaining cognitive function in older adults at risk for dementia. Remotely delivered interventions could increase access to such solutions but first require evidence to support that these programs can successfully impact health outcomes. OBJECTIVE The objective of this study was to evaluate the impact of a remotely delivered multidomain lifestyle intervention, the virtual cognitive health (VC Health) program, on the cognitive function and mental health of older adults with subjective cognitive decline (SCD). METHODS A 52-week, prospective, single-arm, pre-post, remote nationwide clinical trial was conducted to measure the change in cognitive function, depression, and anxiety levels for older adults at risk of developing dementia who participated in the VC Health program. A Web-based study platform was used to screen, consent, and enroll participants across the United States. Participants completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) test and Web-based assessments (which included the Patient Health Questionnaire [PHQ-9] and Generalized Anxiety Disorder [GAD-7] surveys) at baseline and weeks 12, 24, and 52; all data were collected remotely. Changes in RBANS, PHQ-9, and GAD-7 were assessed using 2-tailed paired t tests and nonparametric signed-rank tests. RESULTS Participants (N=82) were, on average, aged 64 years (range 60.0-74.9 years), 74% (61/82) female, 88% (72/82) white, and 67% (55/82) had a college degree or higher. At baseline, participants had a mean and median RBANS Total Index score of 95.9 (SD 11.1) and 95.5 (interquartile range, IQR=13). Participants experienced a mean and median increase of 5.8 (SD 7.4) and 6 (IQR=11) in RBANS Total Index score from baseline to week 52 (P<.001). Participants had a mean and median PHQ-9 score of 8.5 (SD 4.9) and 8 (IQR=6) at baseline and experienced a mean and median decrease of 3.8 (SD 4.1) and 4 (IQR=6) units in PHQ-9 score from baseline to week 52 (P<.001). At baseline, participants had a mean and median GAD-7 score of 6.2 (SD 4.5) and 5.5 (IQR=6) and experienced a mean and median decrease of 2.9 (SD 4.1) and 2 (IQR=5) units in GAD-7 score from baseline to week 52 (P<.001). Participants were engaged and very satisfied with various program components. CONCLUSIONS In this study, older adults with SCD who were at risk for dementia experienced statistically significant improvements in their cognitive function, depression, and anxiety levels. These findings serve as initial evidence for the overall feasibility and effectiveness of the VC Health program to improve or maintain cognitive function in older adults who are experiencing SCD. Further research should be conducted to understand the degree to which the improvements are attributable to specific components of the intervention. CLINICALTRIAL ClinicalTrials.gov NCT02969460; https://clinicaltrials.gov/ct2/show/NCT02969460 (Archived by WebCite at http://www.webcitation.org/73XOph9Qm)

Exploring Associations Between a Biological Marker of Chronic Stress and Reported Depression and Anxiety in People With Aphasia

2019 ◽  
Vol 62 (11) ◽  
pp. 4119-4130 ◽  
Author(s):  
Rebecca Hunting Pompon ◽  
Alissa N. Smith ◽  
Carolyn Baylor ◽  
Diane Kendall
Keyword(s):  
Cognitive Function ◽  
Chronic Stress ◽  
Cortisol Level ◽  
Hair Sample ◽  
Biological Marker ◽  
Depression And Anxiety ◽  
Future Health ◽  
Psychological Constructs ◽  
Post Hoc

Purpose Living with the communication impairment of aphasia can be stressful. Chronic stress, depression, and anxiety are intimately linked, may be more pervasive in people with poststroke aphasia than the general population, and may influence cognitive function and treatment outcomes. In this project, we explored the psychological constructs of depression and anxiety and their associations with a biomarker measure of chronic stress in people with aphasia. Method Fifty-seven participants with aphasia completed measures of depression and anxiety and provided a hair sample from which to extract the stress hormone cortisol. Pearson product–moment correlational analyses were used to identify associations between depression, anxiety, and long-term level of cortisol via hair sample. Results While cortisol level was not associated with depression and anxiety across this sample of people with aphasia, a post hoc analysis showed a significant, positive correlation between a subset of participants with moderate and higher levels of depression and elevated cortisol level. Conclusions Chronic stress, depression, and anxiety have been little explored in people with aphasia to date, yet they are associated with future health consequences and impaired cognitive function, motivating further research as well as consideration of these factors in aphasia rehabilitation.

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