Impacts of fish oil on the gut microbiota of rats with alcoholic liver damage

2020 ◽  
Vol 86 ◽  
pp. 108491
Author(s):  
Ya-Ling Chen ◽  
Hitoshi Shirakawa ◽  
Nien-Shan Lu ◽  
Hsiang-Chi Peng ◽  
Qian Xiao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fish Oil ◽  
Liver Damage

Effects of Fish Oil with a High Content of n-3 Polyunsaturated Fatty Acids on Mouse Gut Microbiota

2014 ◽  
Vol 45 (3) ◽  
pp. 195-202 ◽  
Author(s):  
Hai-Ning Yu ◽  
Jing Zhu ◽  
Wen-sheng Pan ◽  
Sheng-Rong Shen ◽  
Wei-Guang Shan ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Mouse Gut Microbiota

scholarly journals Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0186216 ◽  
Author(s):  
Chenxi Cui ◽  
Yanyan Li ◽  
Hang Gao ◽  
Hongyan Zhang ◽  
Jiaojiao Han ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fish Oil ◽  
High Fat Diet ◽  
Krill Oil ◽  
High Fat ◽  
Diet Induced Obesity

Gut microbiota maintains FXR activation and protects from fatal liver damage in a murine model of primary sclerosing cholangitis

2020 ◽  
Vol 73 ◽  
pp. S81
Author(s):  
Kai Markus Schneider ◽  
Lena Candels ◽  
Antje Mohs ◽  
Carsten Elfers ◽  
Annika Wahlström ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Primary Sclerosing Cholangitis ◽  
Liver Damage ◽  
Murine Model ◽  
Sclerosing Cholangitis ◽  
Fatal Liver

scholarly journals Fish Oil Can Significantly Reshape Diet-Based Gut Microbiota in Mice

2020 ◽  
Author(s):  
Han Sun ◽  
Dan Chen ◽  
Yingyue Yang ◽  
Bei Tan ◽  
Changzhi Huang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fish Oil ◽  
Microbial Diversity ◽  
Beneficial Effects ◽  
Proinflammatory Effect ◽  
Anti Inflammatory ◽  
Microbiota Diversity

Abstract Background Studies have demonstrated the influence of diet on the gut microbiota, and recent evidence has revealed the beneficial effects of fish oil supplements on the gut microbiota. The goal of the present study was to investigate the influence of fish oil on diet-based gut microbiota changes in mice. Results AIN-93M significantly decreased the gut microbial diversity of mice, increasing the abundances of Bacteroides and Parabacteroides and decreasing the abundance of Odoribacter. In contrast, gut microbial diversity was maintained in mice fed a fish oil-intensive diet, where the Firmicutes: Bacteroidetes ratio was increased, the abundance of Parabacteroides was increased and that of Odoribacter was decreased. In contrast, the VSL#3 intervention had little influence on gut microbiota diversity, decreasing the abundance of Firmicutes. Conclusions AIN-93M can decrease gut microbiota diversity, which may be associated with a potential proinflammatory effect. Fish oil may have anti-inflammatory effects by restoring and maintaining microbial diversity.

scholarly journals Dietary Lipid Effects on Gut Microbiota of First Feeding Atlantic Salmon (Salmo salar L.)

2021 ◽  
Vol 8 ◽  
Author(s):  
Eleni Nikouli ◽  
Konstantinos Ar. Kormas ◽  
Yang Jin ◽  
Yngvar Olsen ◽  
Ingrid Bakke ◽  
...  
Keyword(s):  
16S Rrna ◽  
Atlantic Salmon ◽  
Gut Microbiota ◽  
Fish Oil ◽  
Salmo Salar ◽  
Vegetable Oil ◽  
Early Life ◽  
Dietary Lipid ◽  
Rrna Gene ◽  
First Feeding

Decline in fish oil and fish meal availability has forced the aquaculture sector to investigate alternative and sustainable aquafeed ingredients. Despite that several studies have evaluated the effect of fish oil replacement in aquaculture fish species, there is a knowledge gap on the effects of alternative dietary lipid sources on the gut microbiota in early life stages of Salmo salar. The present study evaluated the influence of dietary administration of two different lipid sources (fish oil and vegetable oil) on the intestinal microbiota of first feeding Atlantic salmon (S. salar) up to 93 days post first feeding (dpff). The two diets used in this study, FD (fish oil diet) and VD (blend of rapeseed, linseed and palm oils diet), were formulated to cover the fish nutritional requirements. Apart from the lipid source, the rest of the feed components were identical in the two diets. Hindgut samples were collected at 0, 35, 65, and 93 dpff. Moreover, fertilized eggs, yolk sac larvae, rearing water and feed were also collected in order to assess a possible contribution of their microbiota to the colonization and bacterial succession of the fish intestines. To analyze the bacterial communities, amplicon sequencing was used targeting the V3–V4 region of the 16S rRNA gene. The findings indicate that feeding on either fish oil or vegetable oil-based diet, fish growth variables (mean wet weight and total length) did not differ significantly during the experiment (p > 0.05). No significant differences were also found between the two dietary groups, regarding their gut bacteria composition, after the analysis of the 16S rRNA sequencing data. Instead, gut microbiota changed with age, and each stage was characterized by different dominant bacteria. These operational taxonomic units (OTUs) were related to species that provide different functions and have been isolated from a variety of environments. The results also show little OTUs overlap between the host and rearing environment microbiota. Overall, this study revealed the occurrence of a core microbiota in early life of Atlantic salmon independent of the feed-contained oil origin.

scholarly journals Trem-2 modulation of gut microbiota is blunted during hepatotoxic injury and uncoupled from liver repair responses

2019 ◽  
Author(s):  
Inês Coelho ◽  
Nádia Duarte ◽  
Maria Paula Macedo ◽  
Carlos Penha-Gonçalves
Keyword(s):  
Gut Microbiota ◽  
Liver Damage ◽  
Liver Tissue ◽  
Innate Immune ◽  
Microbiota Composition ◽  
Wild Type ◽  
Immune Receptors ◽  
Microbiota Diversity ◽  
Gut Microbiota Composition

AbstractThe involvement of gut microbiota in liver disease has been addressed in the context of the “leaky gut hypothesis” postulating that dysbiosis allow microbial components to elicit liver inflammatory responses and hepatic tissue damage. Conversely, commensal gut microbiota acting on innate immune receptors protect against hepatotoxic insults. Given that mice deficient for the triggering receptor expressed on myeloid cells-2 (Trem-2) show increased vulnerability to experimental drug-induced hepatic damage we explored the possibility that Trem-2 is a modulator of gut microbiota composition.We found that microbiota composition in untreated Trem-2 KO mice differs from the wild-type showing overall decrease in microbiota diversity and increased representation of Verrucomicrobia. Interestingly, induction of liver damage with hepatotoxic drugs blunted this microbiota diversity difference and altered phyla composition with increased representation of Verrucomicrobia during acute hepatic injury and Proteobacteria during chronic challenge. Furthermore, co-housing experiments that homogenized microbiota diversity showed that the increased liver tissue vulnerability to hepatotoxic insults in Trem-2 KO mice was not dependent on microbiota composition. This work uncouples Trem-2 dependent alterations in gut commensal microbiota from Trem-2 pro-recovery effects in the damaged liver tissue. These findings support the possibility that unlinked actions of innate immune receptors contribute to disease association with microbiota alterations, particularly with the Verrucomicrobia phylum.ImportanceTrem-2 is a mammalian innate immunity receptor involved in development and resolution of tissue damage, namely in the brain and in the liver. Nevertheless, it is not known whether gut microbiota is contributing to these Trem-2 mediated phenotypes. We found that Trem-2 KO mice spontaneously display different gut microbiota composition as compared to wild-type mice, namely with increased abundance of the phylum Verrucomicrobia. Notably these differences do not impact the control of Trem-2 on liver tissue vulnerability to hepatotoxic insults. This work uncouples Trem-2 modulation of gut microbiota and the role of Trem-2 on responses to liver damage. This work brings new insights on role of innate immune receptors on the association of organic and systemic diseases with gut microbiota.

scholarly journals A High-Fish Oil Diet Can Significantly Reshape The Gut Microbiota In Mice

2021 ◽  
Author(s):  
Han Sun ◽  
Dan Chen ◽  
Yingyun Yang ◽  
Bei Tan ◽  
Changzhi Huang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fish Oil ◽  
Microbial Diversity ◽  
Essential Role ◽  
Dextran Sulphate ◽  
Beneficial Effects ◽  
Proinflammatory Effect ◽  
Fish Oil Diet ◽  
High Fish ◽  
Microbiota Diversity

Abstract Background: Gut microbiota plays an essential role for human health and recent evidence has revealed the beneficial effects of fish oil supplements on the gut microbiota. The present study was to investigate the influence of fish oil on diet-based gut microbiota changes and colitis in mice and whether pyroptosis plays a role in this process.Results: A high-fish oil diet alleviated colitis, resulted in less weight loss and improved pathological scores. Caspase-1, activated in the dextran sulphate sodium (DSS) group, was suppressed by a high-fish oil diet. AIN-93M significantly decreased the gut microbial diversity of mice, increasing the abundances of Bacteroides and Parabacteroides and decreasing the abundance of Odoribacter. In contrast, gut microbial diversity was maintained in mice fed a high-fish oil diet; the Firmicutes: Bacteroidetes ratio was increased, the abundance of Parabacteroides was increased, and that the abundance of Odoribacter was decreased.Conclusion: AIN-93M can decrease gut microbiota diversity, which may be associated with a potential proinflammatory effect. Fish oil has anti-inflammatory effects. It can also restore and maintain microbial diversity and suppress pyroptosis activation.

Metagenomics analysis of gut microbiota in response to diet intervention and gestational diabetes in overweight and obese women: a randomised, double-blind, placebo-controlled clinical trial

Gut ◽  
2020 ◽  
pp. gutjnl-2020-321643 ◽  
Author(s):  
Kati Mokkala ◽  
Niklas Paulin ◽  
Noora Houttu ◽  
Ella Koivuniemi ◽  
Outi Pellonperä ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Gut Microbiota ◽  
Fish Oil ◽  
Bacterial Species ◽  
Combination Group ◽  
Controlled Clinical Trial ◽  
Oral Glucose ◽  
Obese Women ◽  
Double Blind ◽  
Metabolic Complications

ObjectiveGut microbiota and diet are known to contribute to human metabolism. We investigated whether the metagenomic gut microbiota composition and function changes over pregnancy are related to gestational diabetes mellitus (GDM) and can be modified by dietary supplements, fish oil and/or probiotics.DesignThe gut microbiota of 270 overweight/obese women participating in a mother–infant clinical study were analysed with metagenomics approach in early (mean gestational weeks 13.9) and late (gestational weeks 35.2) pregnancy. GDM was diagnosed with a 2 hour 75 g oral glucose tolerance test.ResultsUnlike women with GDM, women without GDM manifested changes in relative abundance of bacterial species over the pregnancy, particularly those receiving the fish oil + probiotics combination. The specific bacterial species or function did not predict the onset of GDM nor did it differ according to GDM status, except for the higher abundance of Ruminococcus obeum in late pregnancy in the combination group in women with GDM compared with women without GDM. In the combination group, weak decreases over the pregnancy were observed in basic bacterial housekeeping functions.ConclusionsThe specific gut microbiota species do not contribute to GDM in overweight/obese women. Nevertheless, the GDM status may disturb maternal gut microbiota flexibility and thus limit the capacity of women with GDM to respond to diet, as evidenced by alterations in gut microbiota observed only in women without GDM. These findings may be important when considering the metabolic complications during pregnancy, but further studies with larger populations are called for to verify the findings.

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