CN1 Patterns of Utilization and Implementation Experiences of Oncology Monoclonal Antibodies (MABS) Biosimilars in the U.S.: From BOTH Payers and Healthcare Professionals (HCPS) Perspectives

2021 ◽  
Vol 24 ◽  
pp. S3
Author(s):  
J. Yang ◽  
K. Blinzler ◽  
J. Lankin ◽  
M. Maculaitis ◽  
A. Shelbaya
Keyword(s):  
Monoclonal Antibodies ◽  
Healthcare Professionals ◽  
Patterns Of Utilization ◽  
The U.S

scholarly journals Identification, Characterization, and Relatedness of Luteovirus Isolates from Forage Legumes

1999 ◽  
Vol 89 (5) ◽  
pp. 374-379 ◽  
Author(s):  
V. D. Damsteegt ◽  
A. L. Stone ◽  
A. J. Russo ◽  
D. G. Luster ◽  
F. E. Gildow ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Coat Protein ◽  
Subterranean Clover ◽  
Polyclonal Antiserum ◽  
Pea Aphid ◽  
Forage Legumes ◽  
Soybean Dwarf Virus ◽  
Virus Isolates ◽  
Genomic Relatedness ◽  
The U.S

Virus isolates from forage legumes collected from eight different states were identified as luteoviruses closely related to soybean dwarf luteovirus dwarfing (SbDV-D) and yellowing (SbDV-Y) described in Japan. All isolates produced reddened leaf margins in subterranean clover and were transmitted in a persistent manner by Acrythosiphon pisum, but not by Aulacorthum solani. Specific monoclonal antibodies raised against SbDV-Y were differentially reactive with endemic isolates. Immunoblots probed with a SbDV-D polyclonal antiserum showed single 26-kDa coat protein bands, confirming close serological relatedness to SbDV. Analyses of genomic and subgenomic double-stranded RNAs and northern blot analyses confirmed genomic relatedness to SbDV. Based on our results, we conclude that the U.S. luteovirus isolates studied comprise a strain or strains of the soybean dwarf virus that have clovers as common hosts and the pea aphid as a common vector.

scholarly journals Onasemnogene Abeparvovec-xioi: World’s most expensive and approved therapy for spinal muscular atrophy

2021 ◽  
pp. 145-149
Author(s):  
Vinod Bairagi
Keyword(s):  
United States ◽  
Gene Therapy ◽  
Spinal Muscular Atrophy ◽  
Healthcare Professionals ◽  
Muscular Atrophy ◽  
The United States ◽  
Severe Form ◽  
Expensive Drug ◽  
The U.S ◽  
Experience Difficulty

On May 24, 2019, the U.S. Food and Drug Administration approved Onasemnogene Abeparvovec-xioi (Zolgensma), the first gene therapy approved to treat children less than two years of age with spinal muscular atrophy (SMA), the most severe form of SMA and a leading genetic cause of infant mortality. It is priced in the United States at $2.1m (£1.6m; €1.9m) the world’s most expensive drug. Children with SMA experience difficulty performing essential functions of life. Most children with this disease do not survive past early childhood due to respiratory failure. Patients with SMA now have another treatment option to minimize the progression of SMA and improve survival. This review summarized the clinical guidelines for the Onasemnogene Abeparvovec-xioi use and may be useful to healthcare professionals.

scholarly journals Emerging Monoclonal Antibodies for the Treatment of Multiple Myeloma

2020 ◽  
Author(s):  
Hanley N. Abramson
Keyword(s):  
Multiple Myeloma ◽  
Monoclonal Antibodies ◽  
Checkpoint Inhibitors ◽  
Antibody Drug Conjugate ◽  
B Cell Maturation ◽  
Fda Approval ◽  
Therapeutic Measures ◽  
Fundamental Shift ◽  
Future Status ◽  
The U.S

Therapeutic measures designed to treat multiple myeloma (MM) have undergone a fundamental shift over the past two decades as a number of small molecules that attack this cancer by different mechanisms, including proteasome blockade, immunomodulation, and histone deacetylase (HDAC) inhibition, have been introduced. The insertion of monoclonal antibodies (mAbs) into the mix began in 2015 with the U.S. Food and Drug Administration (FDA) approval of daratumumab and elotuzumab, which target CD38 and SLAMF7, respectively. In 2020, they were joined by another anti-CD38 mAb, isatuximab, and the bispecific antibody-drug conjugate (ADC) belantamab mafodotin, which targets the B-cell maturation antigen (BCMA). This review focuses on additional mAbs currently under clinical study for MM. These include several BCMAxCD3-directed bispecifics (AMG 420, AMG 701, REGN5458, REGN5459, teclistamab, and TNB-383B), the ADCs indatuximab ravtansine and STRO-001, and checkpoint inhibitors, although the future status of the latter is in a state of flux due to toxicity issues that arose in trials in which these drugs, especially PD-1 or PD-L1 blockers, were combined with immunomodulators.

scholarly journals OŚWIADCZENIA ‘PRO FUTURO’ ‒ DYLEMATY PRAWNE

2016 ◽  
Vol 14 (4) ◽  
pp. 171
Author(s):  
Jolanta Pacian
Keyword(s):  
Advance Directives ◽  
Healthcare Professionals ◽  
Legal Framework ◽  
Living Will ◽  
European Countries ◽  
Loss Of Consciousness ◽  
Advance Statements ◽  
Methods Of Treatment ◽  
The U.S

Advance Directives: Legal DilemmasSummaryThe experience of the European countries and the U.S. has shown that, although in practice the use of advance statements is giving rise to problems for healthcare professionals and patients alike, both legal and medical in nature, they are undoubtedly a manifestation of patients’ independence and a sign of respect for their wishes when life or health is at stake. The regulations regarding the introduction of the living will into the Polish legal framework should take into account the patient’s choice only with regard to preferred methods of treatment in the event of his loss of consciousness and inability to inform the physician of his preferences of treatment.

Disability, Health Status, and Utilization of Health Services

1980 ◽  
Vol 10 (4) ◽  
pp. 657-676 ◽  
Author(s):  
Saad Z. Nagi ◽  
Judith Marsh
Keyword(s):  
Independent Living ◽  
Unmet Needs ◽  
Adult Population ◽  
Relative Importance ◽  
Important Indicator ◽  
Utilization Of Services ◽  
Utilization Of Health Services ◽  
Patterns Of Utilization ◽  
Policies And Programs ◽  
The U.S

Change in the patterns of utilization of services is an important indicator of the influence of policies and programs concerning health care. This paper focuses on these patterns as revealed in a survey of a probability sample of the U.S. adult population conducted in 1972. The analysis sought to assess the influence of a number of health dimensions, as well as economic and sociodemographic characteristics, on utilization. Coverage through insurance or other payment plans constituted one of the independent factors in the analysis. The dimensions of health included indicators of disabilities in work and independent living, limitations in physical and emotional performance, and the existence and severity of pathology and impairment. A discriminant analysis was employed to assess the relative importance of these variables in their influence upon the utilization of services. Finally, the paper presents information about unmet needs for care.

Progress in oncology biosimilars till 2020: Scrutinizing comparative studies of biosimilar monoclonal antibodies

2021 ◽  
pp. 107815522110160
Author(s):  
Aqsa Safdar ◽  
Muhammad Hammad Butt ◽  
Abrar Ahmad ◽  
Muhammad Zaman
Keyword(s):  
Monoclonal Antibodies ◽  
Comparative Studies ◽  
Healthcare Professionals ◽  
Reference Product ◽  
Point Of View ◽  
Biological Drugs ◽  
Regulatory Aspects ◽  
The World ◽  
Clinical Point ◽  
Different Parts

Stupendous elevation in the healthcare costs has followed with the inception of the current unconventional options of treatment available for cancer patients. There is a dire need of innovative financing approaches to lessen the financial load on healthcare system. Biosimilars are biological drugs consisting of an active ingredient from a reference biological drug that has a great potential of relieving financial load. Strict requirements from regulatory point of view are required as biosimilars are exceedingly similar to but not identical to the reference product. This provides with a certainty that no consequential differences from clinical point of view as compared to the respective biologics exists with regards to efficacy, safety and purity. Safety and effectiveness of biosimilars have been disclosed since more than 10 years of affirmations. However, there is a need to educate the healthcare professionals to abolish potential misconceptions and coalesce biosimilars into regular clinical practice. The present review focuses on providing an overview of regulatory aspects and requirements for biosimilars, the main challenges in the selection and development of biosimilars and the economic impact and financial savings observed in recent studies carried out in different parts of the world. In addition, we have discussed the different successful comparative studies which have been done in different parts of the world to depict the biosimilarity for monoclonal antibodies such as bevacizumab, trastuzumab and rituximab.

scholarly journals Vietnamese Families' Strength and Resilience and Healthcare Professionals’ Role During the Pandemic

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 358-359
Author(s):  
Christina Miyawaki ◽  
Minhui Liu ◽  
Kyriakos Markides
Keyword(s):  
Social Exchange ◽  
Low Socioeconomic Status ◽  
Life Stress ◽  
Social Exchange Theory ◽  
Healthcare Professionals ◽  
Care Recipient ◽  
Logistic Regression Models ◽  
Care Recipients ◽  
Positive Caregiving ◽  
The U.S

Abstract Traumatic escape from Vietnam in 1975 brought 1.3 million Vietnamese refugees to the U.S. Today, Vietnamese are the largest Asian subethnic group in Houston, Texas (81,000+), making Houston the 3rd largest Vietnamese-populated city in the U.S. Despite these numbers, health research on Vietnamese population is limited. To address this gap, we developed the Vietnamese Aging and Care Survey and collected data on Vietnamese older adults (≥65 years) and their caregivers (N=199). The purpose of this study was to examine the association between caregivers’ caregiving characteristics and care recipients’ mental health (N=58 dyads). Descriptive statistics and logistic regression models were used. Caregivers were on average 53 years-old, Vietnam-born (97%), and working (66%). The majority (84%) lived with their care recipients and provided care for 20+ hours/week (69%) in good/excellent health (76%). Care recipients were on average 75 years-old, Vietnam-born (100%) in fair/poor health (81%). Regression results showed stressed caregivers with more-depressed care recipients (OR=1.47, 95%CI:1.02, 2.13) but positive caregiving experiences (OR=0.85, 95%CI:0.74, 0.97) and burdened caregivers (OR=0.79, 95%CI:0.65, 0.96) with less-depressed care recipients. We found the association between stressed caregivers and depressed care recipients (Life Stress Paradigm), but care recipients becoming a “helpful company” reduces caregiver burden and care recipients’ depression (Social Exchange Theory). Vietnamese families live in multigenerational households within ethnic enclaves and remain a tightly-knit family unit showing resilience to their low socioeconomic status (≤25K, 91%). Leveraging a family as their strength, healthcare professionals should take a caregiver-care recipient dyad approach when planning COVID-19 pandemic interventions in Vietnamese communities.

scholarly journals HEALTH STATUS OF OLDER VIETNAMESE REFUGEES: RESULTS FROM THE VIETNAMESE AGING AND CARE SURVEY (VACS)

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S375-S376
Author(s):  
Christina E Miyawaki ◽  
Nai-Wei Chen ◽  
Oanh L Meyer ◽  
Mindy Thy Tran ◽  
Kyriakos S Markides
Keyword(s):  
Health Status ◽  
Vietnam War ◽  
Social Services ◽  
Healthcare Professionals ◽  
Health Data ◽  
High School Education ◽  
Health Conditions ◽  
Vietnamese Refugees ◽  
Care Survey ◽  
The U.S

Abstract Over 1.3 million Vietnamese including refugees migrated to the U.S., after the Vietnam War. Vietnamese are the 4th largest Asian ethnic group in the U.S. Despite the number, little is known about their health conditions. To fill this gap, the Vietnamese Aging and Care Survey (VACS) was developed, and sociodemographic and health data on 132 refugees (≥65 years) were collected in Houston, Texas. They were on average 75.4 years-old, retired (77%), married (58%), female (55%) with less than high school education (86%) in poor/fair health (76%). They immigrated around age 49 years-old, and have hypertension (74%), arthritis (48%), and diabetes (41%). They manage their lives by living in a multi-generation tightly-knit enclaves, and show resilience to their low sociodemographic status (≤25K, 94%). Findings suggest healthcare professionals to introduce more social services such as adult daycare programs in culturally-sensitive ways to ease their transition to new lives in the U.S.

scholarly journals DEVELOPING POSITIVE IMAGE OF HEALTHCARE PROFESSIONALS IN THE U.S. SOCIAL MEDIA DISCOURSE

2018 ◽  
Vol 9 (2) ◽  
pp. 5
Author(s):  
Svetlana Yurievna Zhdanova ◽  
Svetlana Valentinovna Polyakova ◽  
Anna Victorovna Pecherkina ◽  
Liubava Olegovna Puzureva
Keyword(s):  
Social Media ◽  
Healthcare Professionals ◽  
Media Discourse ◽  
Positive Image ◽  
The U.S

Одним из ключевых показателей эффективности системы здравоохранения является уровень удовлетворенности населения качеством предоставляемых медицинских услуг. Данный показатель является результатом соотношения ожиданий пациентов и субъективной оценки оказанной медицинской помощи. В настоящей статье рассматривается образ врачей, фармацевтов и других медицинских работников в американских группах в Facebook и других социальных сетях.Целью данной работы является изучение репрезентации образа врачей, фармацевтов и других специалистов в области здравоохранения в социальных сетях. Анализируются основные методы разработки позитивных образов и восприятия медицинских работников на примере сообщества Американской медицинской ассоциации в Facebook.Методология и методики исследования. В исследовании использованы методы систематического поиска, сравнительного анализа и когнитивно-дискурсивный анализ для определения того, какие категории в репрезентации образа медицинского и фармацевтического работника представлены в текстах. Коэффициент φ-углового преобразования Фишера, коэффициент корреляции φ и кластерный анализ были включены в группу методов статистической обработки.Результаты и научная новизна. В результатах исследования было показано, что основными компонентами образа профессионала здравоохранения на большинстве связанных с ним специальных сайтов американской медицинской ассоциации являются успешная устойчивость отношений между врачом и пациентом, модель формирования команды, ценностная опора в уходе за пациентами и практика непрерывного повышения квалификации врача посредством специальной подготовки и обучения на программах, предлагаемых американской медицинской ассоциацией.

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