Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study

Abstract To investigate the relationship between perceived physical and mental fatigability and physical performance in community-dwelling very old adults (≥80 years). We examined the association in one retired community in Beijing including 404 very old adults. Pittsburgh Fatigability Scale (PFS), Chinese version, was used to assess perceived fatigability in physical domain (PFS-P) and mental domain (PFS-M). High fatigability is defined as PFS-P ≥ 15, and PFS-M ≥ 13. Physical performance measures include grip strength, usual gait speed, chair stand and Short Physical Performance Battery (SPPB) test. Women have higher PFS scores (both PFS-P & PFS-M) and higher prevalence of high fatigability than men. After adjusting for sex, usual gait speed and SPPB scores were significantly associated with PFS-P & PFS-M, while grip strength and chair stand performance were significantly associated with PFS-P only. After multivariable adjustment, usual gait speed (B=-3.745, P=0.021) and chair stand performance (B=0.335, P=0.005) were significantly associated with PFS-P, while usual gait speed (B=-2.656, P=0.006) and SPPB scores (B=-0.214, P=0.029) were significantly associated with PFS-M. Perceived physical and mental fatigability is highly prevalent in very older adults and they differ by sex. The significant associations between PFS scores and performance measures suggest that PFS is of potential clinical importance, especially when testing performance measures are not feasible. Utilization of PFS score can assist in identifying target populations who are at risk of reduced physical functions, such as older with depression, older women. Interventions to improve usual gait speed are likely to reduce both perceived physical and mental fatigability.

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Low protein intake, muscle strength and physical performance in the very old: The Newcastle 85+ Study

Clinical Nutrition ◽

10.1016/j.clnu.2017.11.005 ◽

2018 ◽

Vol 37 (6) ◽

pp. 2260-2270 ◽

Cited By ~ 26

Author(s):

Antoneta Granic ◽

Nuno Mendonça ◽

Avan Aihie Sayer ◽

Tom R. Hill ◽

Karen Davies ◽

...

Keyword(s):

Muscle Strength ◽

Physical Performance ◽

Protein Intake ◽

Very Old ◽

Low Protein

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Effect of Dietary Patterns on Muscle Strength and Physical Performance in the Very Old: Findings from the Newcastle 85+ Study

PLoS ONE ◽

10.1371/journal.pone.0149699 ◽

2016 ◽

Vol 11 (3) ◽

pp. e0149699 ◽

Cited By ~ 27

Author(s):

Antoneta Granic ◽

Carol Jagger ◽

Karen Davies ◽

Ashley Adamson ◽

Thomas Kirkwood ◽

...

Keyword(s):

Muscle Strength ◽

Physical Performance ◽

Dietary Patterns ◽

Very Old

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Effects of calcifediol versus cholecalciferol on 25(OH)D3 serum levels, appendicular muscle strength, and physical performance in post-menopausal women

Bone Abstracts ◽

10.1530/boneabs.5.op1 ◽

2016 ◽

Author(s):

Antimo Moretti ◽

Sire Alessandro de ◽

Dario Calafiore ◽

Raffaele Gimigliano ◽

Francesca Gimigliano ◽

...

Keyword(s):

Muscle Strength ◽

Physical Performance ◽

Serum Levels ◽

Menopausal Women ◽

Post Menopausal

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Association between muscle strength and physical performance in Japanese elderly: The Fujiwara-kyo Study

10.24816/jcgg.2018.v9i2.03 ◽

2018 ◽

Vol 9 (2) ◽

pp. 44-51 ◽

Cited By ~ 1

Keyword(s):

Muscle Strength ◽

Physical Performance ◽

Japanese Elderly

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Faculty Opinions recommendation of Variations in the vitamin D receptor gene are not associated with measures of muscle strength, physical performance, or falls in elderly men. Data from MrOS Sweden.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.739057747.793580276 ◽

2020 ◽

Author(s):

Rebecca Mason

Keyword(s):

Vitamin D ◽

Muscle Strength ◽

Physical Performance ◽

Vitamin D Receptor ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Elderly Men ◽

Falls In Elderly

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Impact of Malnutrition Status on Muscle Parameter Changes over a 5-Year Follow-Up of Community-Dwelling Older Adults from the SarcoPhAge Cohort

Nutrients ◽

10.3390/nu13020407 ◽

2021 ◽

Vol 13 (2) ◽

pp. 407

Author(s):

Laetitia Lengelé ◽

Olivier Bruyère ◽

Charlotte Beaudart ◽

Jean-Yves Reginster ◽

Médéa Locquet

Keyword(s):

Older Adults ◽

Muscle Strength ◽

Physical Performance ◽

Community Dwelling ◽

Timed Up And Go ◽

P Values ◽

Student’S T ◽

The Impact ◽

Community Dwelling Older Adults

This study aimed to assess the impact of malnutrition on the 5-year evolution of physical performance, muscle mass and muscle strength in participants from the SarcoPhAge cohort, consisting of community-dwelling older adults. The malnutrition status was assessed at baseline (T0) according to the “Global Leadership Initiatives on Malnutrition” (GLIM) criteria, and the muscle parameters were evaluated both at T0 and after five years of follow-up (T5). Lean mass, muscle strength and physical performance were assessed using dual X-ray absorptiometry, handgrip dynamometry, the short physical performance battery test and the timed up and go test, respectively. Differences in muscle outcomes according to nutritional status were tested using Student’s t-test. The association between malnutrition and the relative 5-year change in the muscle parameters was tested using multiple linear regressions adjusted for several covariates. A total of 411 participants (mean age of 72.3 ± 6.1 years, 56% women) were included. Of them, 96 individuals (23%) were diagnosed with malnutrition at baseline. Their muscle parameters were significantly lower than those of the well-nourished patients both at baseline and after five years of follow-up (all p-values < 0.05), except for muscle strength in women at T5, which was not significantly lower in the presence of malnutrition. However, the 5-year changes in muscle parameters of malnourished individuals were not significantly different than those of well-nourished individuals (all p-values > 0.05).

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Physical and functional performance assessment in pediatric oncology: a systematic review

Pediatric Research ◽

10.1038/s41390-021-01523-5 ◽

2021 ◽

Author(s):

Regine Söntgerath ◽

Julia Däggelmann ◽

Sabine V. Kesting ◽

Corina S. Rueegg ◽

Torge-Christian Wittke ◽

...

Keyword(s):

Systematic Review ◽

Muscle Strength ◽

Physical Performance ◽

Cardiorespiratory Fitness ◽

Pediatric Cancer ◽

Motor Performance ◽

Performance Test ◽

Functional Mobility ◽

Cancer Type ◽

And Function

Abstract Background Research indicates reduced physical performance from diagnosis into survivorship of pediatric cancer patients. However, there is no systematic information or guideline available on the methods to assess physical performance and function in this population. The purpose was to systematically compile and describe assessments of physical performance and function in patients and survivors of pediatric cancer, including cardiorespiratory fitness, muscle strength, speed, balance, flexibility, functional mobility, gait and motor performance test batteries. Methods We searched the databases PubMed, SPORTDiscus, and Cochrane Database and performed abstract and full-text selection of 2619 articles according to the Cochrane Handbook of Systematic Reviews. Information on patients characteristics, assessments, information on validity and reliability, and relevant references was extracted. Results In summary, 63 different assessments were found in 149 studies including 11639 participants. Most studies evaluated cardiorespiratory fitness and muscle strength with the majority conducted off treatment. Some outcomes (e.g. speed) and diagnoses (e.g. neuroblastoma) were severely underrepresented. With the exception of gait, leukemia patients represented the largest group of individuals tested. Conclusions Insufficient data and patient heterogeneity complicate uniform recommendations for assessments. Our results support researchers and practitioners in selecting appropriate assessment to meet their specific research questions or individual daily practice needs. Impact This systematic review includes 149 studies and provides a comprehensive summary of 63 assessments to evaluate cardiorespiratory fitness, muscle strength, speed, balance, flexibility, functional mobility, gait or motor performance test batteries in patients and survivors of pediatric cancer. We present the most studied fields within the pediatric cancer population, which are cardiorespiratory fitness and muscle strength, off treatment phase, and leukemia patients. We propose research priorities by identification of subgroups in terms of cancer type, phase of treatment, and outcome of interest that are underrepresented in studies currently available.

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Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Acta Endocrinologica ◽

10.1530/eje-10-0703 ◽

2011 ◽

Vol 164 (2) ◽

pp. 189-196 ◽

Cited By ~ 37

Author(s):

Diana G Taekema ◽

Carolina H Y Ling ◽

Gerard Jan Blauw ◽

Carel G Meskers ◽

Rudi G J Westendorp ◽

...

Keyword(s):

Muscle Strength ◽

Physical Performance ◽

Handgrip Strength ◽

Oldest Old ◽

Muscle Growth ◽

Serum Levels ◽

Middle Aged ◽

Cross Sectional ◽

The Relationship ◽

Circulating Levels

ObjectiveIn aging populations, poor handgrip strength has been associated with physical disability and mortality. IGF1 is an important mediator of muscle growth and regeneration affecting muscle function. We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged- and oldest-old subjects.DesignCross-sectional analysis in two different cohorts composed of middle-aged- (n=672, mean 63.9±6.7 years) and oldest-old subjects (n=272, all 89 years).MethodsHandgrip strength, functional performance and ability, and serum levels of IGF1 and IGFBP3 were measured in all subjects and analyzed by linear regression for men and women separately.ResultsIGF1 and IGFBP3 levels declined with chronological age and were positively associated with handgrip strength in middle-aged- and oldest-old women (both, P<0.05), but not in men of either age group. Furthermore, higher serum levels of IGF1 were associated with slower walking speed in oldest-old men (P=0.012), and serum levels of IGFBP3 were positively associated with activities of daily living in the oldest-old women (P=0.002).ConclusionThe significant relationship between IGF1 levels and muscle strength found in women but not in men suggests a gender-specific influence of IGF1 on muscle strength. Further studies are necessary to test the relationship with physical performance.

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