Point of care diagnosis of plant virus: Current trends and prospects

2021 ◽  
pp. 101779
Author(s):  
Kalishwaralal Kalimuthu ◽  
Jaison Arivalagan ◽  
Manikandan Mohan ◽  
Johnson Retnaraj Samuel Selvan Christyraj ◽  
Jesu Arockiaraj ◽  
...  
Keyword(s):  
Plant Virus ◽  
Point Of Care ◽  
Current Trends

Current trends of functionalized nanomaterial-based sensors in point-of-care diagnosis

2022 ◽  
pp. 337-353
Author(s):  
S. Nandini ◽  
S. Nalini ◽  
S. Bindhu ◽  
S. Sandeep ◽  
C.S. Karthik ◽  
...  
Keyword(s):  
Point Of Care ◽  
Current Trends

scholarly journals Current Trends of Nanobiosensors for Point-of-Care Diagnostics

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Naumih M. Noah ◽  
Peter M. Ndangili
Keyword(s):  
Health Care ◽  
Care Management ◽  
Early Stage ◽  
Point Of Care ◽  
Health Care Management ◽  
Disease Onset ◽  
Disease Diagnosis ◽  
Point Of Care Testing ◽  
Quality Health Care ◽  
Current Trends

In order to provide better-quality health care, it is very important that high standards of health care management are achieved by making timely decisions based on rapid diagnostics, smart data analysis, and informatics analysis. Point-of-care testing ensures fast detection of analytes near to the patients facilitating a better disease diagnosis, monitoring, and management. It also enables quick medical decisions since the diseases can be diagnosed at an early stage which leads to improved health outcomes for the patients enabling them to start early treatment. In the recent past, various potential point-of-care devices have been developed and they are paving the way to next-generation point-of-care testing. Biosensors are very critical components of point-of-care devices since they are directly responsible for the bioanalytical performance of an essay. As such, they have been explored for their prospective point-of-care applications necessary for personalized health care management since they usually estimate the levels of biological markers or any chemical reaction by producing signals mainly associated with the concentration of an analyte and hence can detect disease causing markers such as body fluids. Their high selectivity and sensitivity have allowed for early diagnosis and management of targeted diseases; hence, facilitating timely therapy decisions and combination with nanotechnology can improve assessment of the disease onset and its progression and help to plan for treatment of many diseases. In this review, we explore how nanotechnology has been utilized in the development of nanosensors and the current trends of these nanosensors for point-of-care diagnosis of various diseases.

Protein biochip systems for the clinical laboratory

2005 ◽  
Vol 43 (12) ◽  
Author(s):  
Anne Marie Dupuy ◽  
Sylvain Lehmann ◽  
Jean Paul Cristol
Keyword(s):  
Clinical Laboratory ◽  
Point Of Care ◽  
Sample Volume ◽  
Small Sample ◽  
Throughput Capacity ◽  
Great Promise ◽  
Current Trends ◽  
Biomedical Diagnosis ◽  
Multiplexed Immunoassay ◽  
Spotted Array

AbstractClassical methods of protein analysis such as electrophoresis, ELISA and liquid chromatography are generally time-consuming, labor-intensive and lack high-throughput capacity. In addition, all existing methods used to measure proteins necessitate multiple division of the original sample and individual tests carried out for each substance, with an associated cost for each test. The chip system allows several tests to be performed simultaneously without dividing the original patient sample. This system facilitates the development of multiplexed assays that simultaneously measure many different analytes in a small sample volume. These emerging technologies fall into two categories: 1) spotted array-based tools, and 2) microfluidic-based tools. Miniaturized and multiplexed immunoassays allow a great deal of information to be obtained from a single sample. These analytical systems are referred to as “lab-on-a-chip” devices. This article presents current trends and advances in miniaturized multiplexed immunoassay technologies, reviewing different systems from research to point-of-care assays. We focus on a subset of chip-based assays that may be used in a clinical laboratory and are directly applicable for biomedical diagnosis. Recent advances in biochip assays combine the power of miniaturization, microfluidics, micro- to nanoparticles, and quantification. A number of applications are just beginning to be explored. The power of biochip assays offers great promise for point-of-care clinical testing and monitoring of many important analytes.

scholarly journals Current Trends in the Development and Use of Personalized Implants: Engineering Concepts and Regulation Perspectives for the Contemporary Oral and Maxillofacial Surgeon

2021 ◽  
Vol 11 (24) ◽  
pp. 11694
Author(s):  
Alessandro Tel ◽  
Alessandra Bordon ◽  
Marco Sortino ◽  
Giovanni Totis ◽  
Lorenzo Fedrizzi ◽  
...  
Keyword(s):  
3D Printing ◽  
Task Force ◽  
Point Of Care ◽  
Facial Skeleton ◽  
Medical Software ◽  
Current Trends ◽  
Oral And Maxillofacial Surgeon ◽  
The Impact ◽  
Cultural Gaps ◽  
Medical Device Regulation

The recently adopted Medical Device Regulation (MDR) has finally entered into force on 26 May 2021. As innovation and especially the advent of customized prostheses has deeply modified many surgical procedures in our discipline, it is imperative for the contemporary surgeon to become aware of the impact that the MDR will have on many aspects, including the choice of the manufacturer, the evaluation of the devices, point-of-care 3D printing labs, and medical software. In this paper, the authors tried to identify the cultural gaps in clinical practice that the MDR is supposed to fill. To achieve this purpose, a task force of experts was reunited, including CMF surgeons with direct expertise in medical software and 3D printing, mechanical and material engineers, facing the topic of the MDR from a multidimensional perspective. In this article, surgeons and engineers review many crucial aspects concerning the points of the regulation that mostly affect the field of implantable devices for the cranio-maxillo-facial skeleton. The result of interdisciplinary research is a paper aiming to provide surgeons with the knowledge on the fundamental processes of additive manufacturing, increasing the clinician’s awareness on the evaluation of a customized implant before surgery and on the underlying regulatory framework.

scholarly journals Point of care ultrasonography from the emergency department to the internal medicine ward: current trends and perspectives

2020 ◽  
Vol 15 (3) ◽  
pp. 395-408 ◽  
Author(s):  
Antonio Leidi ◽  
Frédéric Rouyer ◽  
Christophe Marti ◽  
Jean-Luc Reny ◽  
Olivier Grosgurin
Keyword(s):  
Internal Medicine ◽  
Emergency Department ◽  
Point Of Care ◽  
Internal Medicine Ward ◽  
Current Trends ◽  
Point Of Care Ultrasonography

Search mode for rapid detection of virus particles

1991 ◽  
Vol 49 ◽  
pp. 286-287
Author(s):  
O. E. Bradfute
Keyword(s):  
Electron Microscopy ◽  
Rapid Detection ◽  
Plant Virus ◽  
Low Dose ◽  
Search Mode ◽  
Virus Diseases ◽  
Virus Particles ◽  
Focus Image ◽  
Time Required ◽  
Rapid Switching

Electron microscopy is frequently used in preliminary diagnosis of plant virus diseases by surveying negatively stained preparations of crude extracts of leaf samples. A major limitation of this method is the time required to survey grids when the concentration of virus particles (VPs) is low. A rapid survey of grids for VPs is reported here; the method employs a low magnification, out-of-focus Search Mode similar to that used for low dose electron microscopy of radiation sensitive specimens. A higher magnification, in-focus Confirm Mode is used to photograph or confirm the detection of VPs. Setting up the Search Mode by obtaining an out-of-focus image of the specimen in diffraction (K. H. Downing and W. Chiu, private communications) and pre-aligning the image in Search Mode with the image in Confirm Mode facilitates rapid switching between Modes.

Current Trends in the Training and Utilization of Paraprofessionals in Speech and Language Programs

1991 ◽  
Vol 22 (2) ◽  
pp. 51-59 ◽  
Author(s):  
Kathy L. Coufal ◽  
Allen L. Steckelberg ◽  
Stanley F. Vasa
Keyword(s):  
Selection Criteria ◽  
Job Descriptions ◽  
Paraprofessional Training ◽  
Language Programs ◽  
Program Administrators ◽  
Current Trends ◽  
Training And Supervision ◽  
Communicative Disorders ◽  
Supervision Practices ◽  
A Current

Administrators of programs for children with communicative disorders in 11 midwestern states were surveyed to assess trends in the training and utilization of paraprofessionals. Topics included: (a) current trends in employment, (b) paraprofessional training, (c) use of ASHA and state guidelines, and (d) district policies for supervision. Selection criteria, use of job descriptions, training programs, and supervision practices and policies were examined. Results indicate that paraprofessionals are used but that standards for training and supervision are not consistently applied across all programs. Program administrators report minimal training for supervising professionals.

The Graduate Dysphagia Course: Opening the Door to New Frontiers

2016 ◽  
Vol 1 (13) ◽  
pp. 104-112
Author(s):  
Karen A. Ball ◽  
Luis F. Riquelme
Keyword(s):  
Graduate Student ◽  
Paradigm Shifts ◽  
Speech Language Pathology ◽  
Approaches To Teaching ◽  
Graduate Level ◽  
Graduate Curriculum ◽  
Current Trends ◽  
Language Pathology

A graduate-level course in dysphagia is an integral part of the graduate curriculum in speech-language pathology. There are many challenges to meeting the needs of current graduate student clinicians, thus requiring the instructor to explore alternatives. These challenges, suggested paradigm shifts, and potential available solutions are explored. Current trends, lack of evidence for current methods, and the variety of approaches to teaching the dysphagia course are presented.

“Aspirin - resistance”? A few critical considerations on definition, terminology, diagnosis, clinical value, natural course of atherosclerotic disease, and therapeutic consequences

VASA ◽  
2011 ◽  
Vol 40 (6) ◽  
pp. 429-438 ◽  
Author(s):  
Berent ◽  
Sinzinger
Keyword(s):  
Platelet Function ◽  
Point Of Care ◽  
Aspirin Resistance ◽  
Point Of View ◽  
Evidence Based ◽  
Platelet Function Tests ◽  
Clinical Value ◽  
Vascular Events ◽  
Therapeutic Consequences ◽  
Function Tests

Based upon various platelet function tests and the fact that patients experience vascular events despite taking acetylsalicylic acid (ASA or aspirin), it has been suggested that patients may become resistant to the action of this pharmacological compound. However, the term “aspirin resistance” was created almost two decades ago but is still not defined. Platelet function tests are not standardized, providing conflicting information and cut-off values are arbitrarily set. Intertest comparison reveals low agreement. Even point of care tests have been introduced before appropriate validation. Inflammation may activate platelets, co-medication(s) may interfere significantly with aspirin action on platelets. Platelet function and Cox-inhibition are only some of the effects of aspirin on haemostatic regulation. One single test is not reliable to identify an altered response. Therefore, it may be more appropriate to speak about “treatment failure” to aspirin therapy than using the term “aspirin resistance”. There is no evidence based justification from either the laboratory or the clinical point of view for platelet function testing in patients taking aspirin as well as from an economic standpoint. Until evidence based data from controlled studies will be available the term “aspirin resistance” should not be further used. A more robust monitoring of factors resulting in cardiovascular events such as inflammation is recommended.

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