Genotoxicity and sperm defects induced by 5-FU in male mice and the possible protective role of Pentas lanceolata-iridoids

2020 ◽  
Vol 850-851 ◽  
pp. 503145
Author(s):  
Maha A. Fahmy ◽  
Howaida I. Abd-Alla ◽  
Entesar E. Hassan ◽  
Zeinab M. Hassan ◽  
Heba-tollah M. Sweelam
Keyword(s):  
Protective Role ◽  
Male Mice ◽  
Pentas Lanceolata

The possible protective role of curcumin on the toxic effect of nicotine in the lung of adult male mice

2012 ◽  
Vol 35 (4) ◽  
pp. 805-811
Author(s):  
Dorria A.M. Zaghloul ◽  
Esam Salah Kamel ◽  
Hekmat O. Abd el-Aziz ◽  
Mohammed A. Mahmoud
Keyword(s):  
Toxic Effect ◽  
Adult Male ◽  
Protective Role ◽  
Male Mice

scholarly journals Chronic rapamycin treatment causes diabetes in male mice

2014 ◽  
Vol 307 (4) ◽  
pp. R434-R443 ◽  
Author(s):  
Christine E. Schindler ◽  
Uttara Partap ◽  
Bonnie K. Patchen ◽  
Steven J. Swoap
Keyword(s):  
Glucose Intolerance ◽  
Mammalian Target Of Rapamycin ◽  
Protective Role ◽  
Metabolic Effects ◽  
Current Evidence ◽  
Male Mice ◽  
Rapamycin Treatment ◽  
Female Mice ◽  
Glucose Levels

Current evidence indicates that the mammalian target of rapamycin inhibitor rapamycin both increases longevity and, seemingly contradictorily, impairs glucose homeostasis. Most studies exploring the dimensions of this paradox have been based on rapamycin treatment in mice for up to 20 wk. We sought to better understand the metabolic effects of oral rapamycin over a substantially longer period of time in HET3 mice. We observed that treatment with rapamycin for 52 wk induced diabetes in male mice, characterized by hyperglycemia, significant urine glucose levels, and severe glucose and pyruvate intolerance. Glucose intolerance occurred in male mice by 4 wk on rapamycin and could be only partially reversed with cessation of rapamycin treatment. Female mice developed moderate glucose intolerance over 1 yr of rapamycin treatment, but not diabetes. The role of sex hormones in the differential development of diabetic symptoms in male and female mice was further explored. HET3 mice treated with rapamycin for 52 wk were gonadectomized and monitored over 10 wk. Castrated male mice remained glucose intolerant, while ovariectomized females developed significant glucose intolerance over the same time period. Subsequent replacement of 17β-estradiol (E2) in ovariectomized females promoted a recovery of glucose tolerance over a 4-wk period, suggesting the protective role of E2against rapamycin-induced diabetes. These results indicate that 1) oral rapamycin treatment causes diabetes in male mice, 2) the diabetes is partially reversible with cessation of treatment, and 3) E2plays a protective role against the development of rapamycin-induced diabetes.

scholarly journals Protective Role of Different Local Spices on Lambda Cyhalothrin Induced Nephrotoxicity in Male Mice

2021 ◽  
pp. 61-70
Author(s):  
Eme Efioanwan Orlu ◽  
Adetutu Olubunmi Obulor
Keyword(s):  
Experimental Design ◽  
Total Protein ◽  
Protective Role ◽  
Male Mice ◽  
Lambda Cyhalothrin ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Animal House

Aim: This study was aimed at evaluating the protective role of different local spices on lambda cyhalothrin induced nephrotoxicity in male mice Experimental Design: A completely randomized experimental design using standard methods for analysis. Place and Duration of Study: This study was carried out in the Animal house, Department of Animal and Environmental Biology of Rivers State University, Nkpolu-Oroworukwo Port Harcourt, Nigeria. GPS 4o47'50''N 6o58'49''E. This study lasted for 35days. Methodology: The experimental animals were separated into 6 groups (A-F) of seven mice each. Group A served as the control and Group B – F served as the test groups. At the end of the 35 day treatment period, feed was withdrawn from the mice 24 hours before termination of the experiment. Blood samples for analysis of kidney function test were collected from each mouse by ocular puncture into plain tubes. The blood was allowed to clot and centrifuged at 2500g to separate the serum from the cells. Total protein was analyzed using the spectrophotometric method of biuret, Bradford and erythrosine – b, albumin was estimated, creatinine and urea was done using enzymatic method. Vital organs were removed and weighed for organosomatic indices. Histological sections of the kidney were mounted on slides, stained with hematoxylin and eosin (H&E). Photomicrographs were generated. Results: There is no significant difference (P=0.05) between the organ weight and bodyweight in group A compared with the treatment groups. The values of Albumin, total protein, urea, creatinine and total bilirubin increased significantly in group B administered lambda cyhalothrin alone but decreased in groups administered the local spices. Histopathological analysis of the kidney shows the regular structure of the kidney architecture in group A, tubular degeneration and several vacuolations were observed in group B. However, less degeneration of the epithelial cells, regeneration of renal tubular epithelium were observed in groups C- F. Conclusion: Based on the results from liver biomarkers and histological micrographs from this study, pronounced degeneration was observed in the kidney cells exposed to lambda-cyhalothrin only. Moreover, all spices used had a regenerating ability on the kidney tubules. It is advocated therefore that consumption of this spices either singly or in combination should be encouraged especially for those exposed to insecticides poisoning

Genetic background affects the mucosal SIgA levels, parasite burden, lung inflammation and susceptibility of male mice to Ascaris suum infection.

2021 ◽  
Author(s):  
Luciana Maria de Oliveira ◽  
Denise Silva Nogueira ◽  
Ricardo Marcelo Geraldi ◽  
Fernando Sérgio Barbosa ◽  
Chiara Cássia Oliveira Amorim ◽  
...  
Keyword(s):  
Immune Response ◽  
Ascaris Suum ◽  
Parasite Burden ◽  
Protective Role ◽  
Male Mice ◽  
Socioeconomic Impacts ◽  
Cellular Immune ◽  
Time Point ◽  
Synergetic Action

Ascariasis is a neglected tropical disease, widespread in the world and causing important socioeconomic impacts. The presence of various stages of worm development in the pulmonary and intestinal mucosa induces a humoral and cellular immune response. However, although there is much evidence of the protective role of mucosal immunity against various pathogens, including helminthes, there is still a gap in the knowledge about the immune response and the mechanisms of action that are involved in protection against diseases, especially in the initial phase of ascariasis. Then, the aim of this study was to evaluate the kinetic aspects of the immune parasitological parameters in intestinal and pulmonary mucosa in male mice with early ascariasis. Therefore, two mice strains showed a different susceptibility to ascariasis (BALB/c and C57BL6/j), when experimentally infected with 2,500 infective eggs of Ascaris suum from time-point 0 and the immune parasitological parameters evaluated each two days after infection, during the period of 12 days. The results were suggestive of a synergetic action of intestinal and pulmonary SIgA contributing for the protection against early ascariasis by reducing the amount of migrating larval as well as the influx of leukocytes in the lung and the consequent impair of the pulmonary capacity.

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