scholarly journals Drug Delivery: Self‐Propelled Micro/Nanomotors for Tumor Targeting Delivery and Therapy (Adv. Healthcare Mater. 1/2021)

2021 ◽  
Vol 10 (1) ◽  
pp. 2170001
Author(s):  
Ruyi Lin ◽  
Wenqi Yu ◽  
Xianchun Chen ◽  
Huile Gao
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Targeting Delivery

Biomimetic Drug Delivery Systems Oriented by Biological Function in Tumor Targeting

2021 ◽  
Vol 22 ◽  
Author(s):  
Rui Wang ◽  
Xianyi Sha
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Biological Function ◽  
Delivery Systems ◽  
Biological Functions ◽  
Simple Preparation ◽  
Targeting Delivery ◽  
Clinical Transformation ◽  
Endogenous Substances

: The emergence of nanoscale drug delivery systems provides new opportunities for targeting delivery of chemotherapeutic drugs and has achieved excellent results. In recent years, with the arising of the concept of intelligent drug delivery systems, the design and preparation of carriers have become more and more complicated, which is not conducive to clinical transformation. Researchers are gradually focusing on biomimetic nanoscale drug delivery systems, trying to combine the physicochemical properties of nanoscale carriers with the natural biological functions of endogenous substances, so as to boost tumor targeting delivery. In this article, we first classify and introduce biomimetic nanoscale drug delivery systems, and then emphasize their unique biological functions. The biomimetic nanoscale drug delivery systems have the advantages of simple preparation, powerful functions, and low immunogenicity, having a good application prospect.

Redox stimuli-responsive hollow mesoporous silica nanocarriers for targeted drug delivery in cancer therapy

2016 ◽  
Vol 1 (6) ◽  
pp. 480-487 ◽  
Author(s):  
Ye Tian ◽  
Ranran Guo ◽  
Yunfeng Jiao ◽  
Yangfei Sun ◽  
Shun Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Targeted Drug Delivery ◽  
Tumor Targeting ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Disulfide Linkages ◽  
Targeting Delivery ◽  
Targeted Drug ◽  
Hollow Mesoporous Silica

Transferrin-capped hollow mesoporous silica nanoparticles through disulfide linkages realize tumor-targeting delivery and glutathione-induced drug release.

Influence of nanomedicine mechanical properties on tumor targeting delivery

2020 ◽  
Vol 49 (8) ◽  
pp. 2273-2290 ◽  
Author(s):  
Zheng Li ◽  
Chen Xiao ◽  
Tuying Yong ◽  
Zifu Li ◽  
Lu Gan ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tumor Targeting ◽  
Antitumor Efficacy ◽  
Efficacy And Safety ◽  
Targeting Delivery ◽  
Delivery Efficiency

This tutorial review summarizes the influence of nanomedicine mechanical properties on drug delivery efficiency, antitumor efficacy and safety.

Outer membrane vesicles derived from E. coli as novel vehicles for transdermal and tumor targeting delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (36) ◽  
pp. 18965-18977 ◽  
Author(s):  
Ting-Wei Gu ◽  
Mao-Ze Wang ◽  
Jie Niu ◽  
Yang Chu ◽  
Ke-Ran Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Outer Membrane ◽  
Transdermal Drug Delivery ◽  
Tumor Targeting ◽  
Membrane Vesicles ◽  
Outer Membrane Vesicles ◽  
E Coli ◽  
First Pass ◽  
Targeting Delivery

Transdermal drug delivery is favored in clinical therapy because of its ability to overcome the shortcomings of the first pass elimination of the liver caused by traditional oral administration and the irreversibility of the injection.

Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

2019 ◽  
Vol 25 (37) ◽  
pp. 3917-3926
Author(s):  
Sajjad Molavipordanjani ◽  
Seyed Jalal Hosseinimehr
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Medical Imaging ◽  
Cancer Diagnosis ◽  
Carbon Nanoparticles ◽  
Tumor Targeting ◽  
Polymeric Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Active Targeting ◽  
Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

“Smart” Nanocarriers: A New Paradigm for Tumor Targeting Drug Delivery Systems

2011 ◽  
Vol 1 (1) ◽  
pp. 67-84
Author(s):  
Zhigang Hu ◽  
Fei Huo ◽  
Yi Zhang ◽  
Chunyang Chen ◽  
Kehua Tu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Paradigm

scholarly journals Recent Advances in pH- or/and Photo-Responsive Nanovehicles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 725
Author(s):  
Yuseon Shin ◽  
Patihul Husni ◽  
Kioh Kang ◽  
Dayoon Lee ◽  
Sehwa Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Design ◽  
Solid Tumors ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Efficacy And Safety ◽  
Stimulus Responsive ◽  
External Signals

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

A Controlled-Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocation for Drug Delivery

2013 ◽  
Vol 52 (29) ◽  
pp. 7487-7491 ◽  
Author(s):  
Zilong Zhao ◽  
Hongmin Meng ◽  
Nannan Wang ◽  
Michael J. Donovan ◽  
Ting Fu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Tumor Targeting ◽  
Ph Value ◽  
Extracellular Ph

Adoptive CD8+T-cell grafted with liposomal immunotherapy drugs to counteract the immune suppressive tumor microenvironment and enhance therapy for melanoma

Nanoscale ◽  
2021 ◽  
Author(s):  
Simeng Liu ◽  
Huimin Liu ◽  
Xiaoshuang Song ◽  
Ailing Jiang ◽  
Yuchuan Deng ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Tumor Microenvironment ◽  
Cell Viability ◽  
Tumor Targeting ◽  
Cd8 T Cell ◽  
Targeting Delivery ◽  
Immunosuppressive Tumor Microenvironment

Efficient tumor-targeting delivery of CpG or BMS-202 by adoptive T-cells coupled with drug loaded liposomes reversed the immunosuppressive tumor microenvironment, restoring T cell viability and effectively inhibiting the growth of melanoma.

scholarly journals Phosphorylcholine oligomer-grafted graphene oxide for tumor-targeting doxorubicin delivery

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41675-41685 ◽  
Author(s):  
Yu Qin ◽  
Changyu Wang ◽  
Yun Jiang ◽  
Tao Liu ◽  
Jianyong Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Tumor Targeting ◽  
Doxorubicin Delivery

Phosphorylcholine oligomer-grafted, folic acid-labeled and doxorubicin-loaded graphene oxide was found to be a potential versatile platform for biomarker-directed drug delivery with optimal biocompatibility.

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