Occupational and environmental exposures to heavy metals: Risk factors for male infertility in Lebanon?

2008 ◽  
Vol 25 (2) ◽  
pp. 203-212 ◽  
Author(s):  
Marcia C. Inhorn ◽  
Luke King ◽  
Jerome O. Nriagu ◽  
Loulou Kobeissi ◽  
Najwa Hammoud ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heavy Metals ◽  
Male Infertility ◽  
Environmental Exposures

scholarly journals 745 Risk Factors of Incident Renal Stones in Indian Population: A Hospital-Based Case-Control Study

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
S Singh ◽  
S Gupta ◽  
T S Mishra ◽  
B D Banerjee ◽  
T Sharma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heavy Metals ◽  
Case Control Study ◽  
Dietary Habits ◽  
Renal Stones ◽  
Tertiary Hospital ◽  
Case Control ◽  
The Body ◽  
Increased Risk ◽  
Control Study

Abstract Introduction Nephrolithiasis is pathological calcification in the excretory passages of the body and is prevalent among 7.6% of Indians. We aimed to study the various risk factors associated with renal stones from India. Method It was a hospital-based case-control study conducted over 18 months in a tertiary hospital in Delhi. Cases were defined as patients with renal stones diagnosed on the basis of history and radiological examination. Controls were similar to cases in all respects except for the diagnosis and selected from the hospital. A total of 18 risk factors, including age, gender, heavy metals, stress, metabolic factors, alcohol intake, dietary habits, co-morbidities, etc. were assessed. Logistic regression analysis was performed to calculate the strength of the risk associations. Results In the analysis of 60 cases and controls, we found 6 times, 5.5 times, and 2.4 times increased odds of renal stones in patients with increased arsenic, cadmium, and lead concentrations in blood, respectively. Similarly, there are 3 times increased odds of renal stones in patients suffering from stress. Conclusions Exposure to smoke, occupation dust, and contaminated water may lead to an increased ingestion/inhalation of heavy metals like cadmium, arsenic, and predisposing people to an increased risk of renal stones.

A Comparison of Symptoms of Behavioral Disturbances in Yoruba and African American Individuals With Dementia

2000 ◽  
Vol 12 (S1) ◽  
pp. 403-408 ◽  
Author(s):  
Hugh C. Hendrie ◽  
Sujuan Gao ◽  
Olusegun Baiyewu
Keyword(s):  
Risk Factors ◽  
Genetic Variation ◽  
African American ◽  
Comparative Studies ◽  
Environmental Exposures ◽  
Cross Cultural ◽  
Industrialized Countries ◽  
Behavioral Disturbances ◽  
Great Opportunity ◽  
Similarities And Differences

Comparative cross-cultural studies represent a great opportunity for delineating risk factors for the dementias by providing a much wider diversity of both environmental exposures and genetic variation than studies within industrialized countries. Similarly, studies of the behavioral disturbances of dementia that allow for identification of similarities and differences may be useful both in understanding the etiology of these disorders and in determining the best approach to management. So far, few such comparative studies exist.

scholarly journals Environmental and Nutritional Aspect in Male Infertility

1970 ◽  
Vol 10 (1) ◽  
pp. 16-19 ◽  
Author(s):  
Hamida Begum ◽  
ABM Moniruddin ◽  
Khairun Nahar
Keyword(s):  
Heavy Metals ◽  
Male Infertility ◽  
Sperm Count ◽  
Sperm Production ◽  
Male And Female ◽  
Exogenous Estrogen ◽  
Sperm Counts ◽  
And Function ◽  
Nutritional Aspect ◽  
Anatomical Defects

Male and female partner of a couple must be standard and fit to have the capacity to procreate. Studies confirm that male sperm counts are declining and environmental factors as pesticides, exogenous estrogen, heavy metals negatively impact spermatogenesis without any obvious anatomical defects. So, a number of nutritional therapies have been shown to improve sperm count and motility as carnitine, arginine, zinc, selenium and vitamin B12. Numerous anitioxidants have prove beneficial in treating male infertility as Vitamin C, Vitamin E, Glutathione and Coenzyme Q10. This article aims to highlight the correction of nutritional imbalances to encourage optimum sperm production and function, when there is idiopathic impaired spermatogenesis.   doi:10.3329/jom.v10i1.1997   J Medicine 2009; 10: 16-19   

scholarly journals Environment as a Risk Factor for Male Infertility

2001 ◽  
Vol 1 ◽  
pp. 576-578 ◽  
Author(s):  
Luc Multigner ◽  
Alejandro Oliva
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Male Infertility ◽  
Sperm Production ◽  
Western Countries ◽  
Infertile Couples

Infertility affects 15% of couples in Western countries. Infertility is defined as the inability to conceive after 1 year of attempts without contraception, but it is not synonymous with sterility. Between 30 and 50% of infertile couples are infertile due to male reasons, mainly due to sperm production disorders. Although some risk factors, most of which are infectious, have been identified, there is still much uncertainty about the origins of male infertility.

scholarly journals Epigenetic Biomarkers for Environmental Exposures and Personalized Breast Cancer Prevention

2020 ◽  
Vol 17 (4) ◽  
pp. 1181 ◽  
Author(s):  
Hannah Lui Park
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Alcohol Consumption ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Hormone Therapy ◽  
Environmental Exposures ◽  
Breast Cancers ◽  
Prevention Strategies ◽  
Epigenetic Biomarkers

Environmental and lifestyle factors are believed to account for >80% of breast cancers; however, it is not well understood how and when these factors affect risk and which exposed individuals will actually develop the disease. While alcohol consumption, obesity, and hormone therapy are some known risk factors for breast cancer, other exposures associated with breast cancer risk have not yet been identified or well characterized. In this paper, it is proposed that the identification of blood epigenetic markers for personal, in utero, and ancestral environmental exposures can help researchers better understand known and potential relationships between exposures and breast cancer risk and may enable personalized prevention strategies.

scholarly journals Metal Dyshomeostasis and Inflammation in Alzheimer’s and Parkinson’s Diseases: Possible Impact of Environmental Exposures

2013 ◽  
Vol 2013 ◽  
pp. 1-19 ◽  
Author(s):  
Oddvar Myhre ◽  
Hans Utkilen ◽  
Nur Duale ◽  
Gunnar Brunborg ◽  
Tim Hofer
Keyword(s):  
Risk Factors ◽  
Elevated Serum ◽  
Environmental Exposures ◽  
Serum Copper ◽  
Copper Binding ◽  
Intracellular Iron ◽  
Disease Outcomes ◽  
Age Related ◽  
Parkinson’S Diseases ◽  
Iron And Zinc

A dysregulated metal homeostasis is associated with both Alzheimer’s (AD) and Parkinson’s (PD) diseases; AD patients have decreased cortex and elevated serum copper levels along with extracellular amyloid-beta plaques containing copper, iron, and zinc. For AD, a putative hepcidin-mediated lowering of cortex copper mechanism is suggested. An age-related mild chronic inflammation and/or elevated intracellular iron can trigger hepcidin production followed by its binding to ferroportin which is the only neuronal iron exporter, thereby subjecting it to lysosomal degradation. Subsequently raised neuronal iron levels can induce translation of the ferroportin assisting and copper binding amyloid precursor protein (APP); constitutive APP transmembrane passage lowers the copper pool which is important for many enzymes. Usingin silicogene expression analyses, we here show significantly decreased expression of copper-dependent enzymes in AD brain and metallothioneins were upregulated in both diseases. Although few AD exposure risk factors are known, AD-related tauopathies can result from cyanobacterial microcystin andβ-methylamino-L-alanine (BMAA) intake. Several environmental exposures may represent risk factors for PD; for this disease neurodegeneration is likely to involve mitochondrial dysfunction, microglial activation, and neuroinflammation. Administration of metal chelators and anti-inflammatory agents could affect disease outcomes.

Sign in / Sign up

Export Citation Format

Share Document