New concepts in cyclosporine pharmacokinetic and dynamic monitoring: the impact of concomitant immunosuppression on target C2 concentrations

2004 ◽  
Vol 36 (2) ◽  
pp. S437-S441 ◽  
Author(s):  
M Brunet ◽  
O Millán ◽  
O Jiménez ◽  
J.M Campistol ◽  
E Vidal ◽  
...  
Keyword(s):  
Dynamic Monitoring ◽  
New Concepts ◽  
The Impact

scholarly journals Silencing and Oblivion of Psychological Trauma, Its Unconscious Aspects, and Their Impact on the Inflation of Vajrayāna. An Analysis of Cross-Group Dynamics and Recent Developments in Buddhist Groups Based on Qualitative Data

Religions ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 622 ◽  
Author(s):  
Anders
Keyword(s):  
Group Dynamics ◽  
Interdisciplinary Approach ◽  
Psychological Trauma ◽  
Ongoing Research ◽  
Psychological Mechanisms ◽  
Teacher Student ◽  
New Concepts ◽  
Recent Developments ◽  
Student Relationship ◽  
The Impact

The commercialization of Buddhist philosophy has led to decontextualization and indoctrinating issues across groups, as well as abuse and trauma in that context. Methodologically, from an interdisciplinary approach, based on the current situation in international Buddhist groups and citations of victims from the ongoing research, the psychological mechanisms of rationalizing and silencing trauma were analyzed. The results show how supposedly Buddhist terminology and concepts are used to rationalize and justify economic, psychological and physical abuse. This is discussed against the background of psychological mechanisms of silencing trauma and the impact of ignoring the unconscious in that particular context. Inadequate consideration regarding the teacher–student relationship, combined with an unreflective use of Tibetan honorary titles and distorted conceptualizations of methods, such as the constant merging prescribed in so-called 'guru yoga', resulted in giving up self-responsibility and enhanced dependency. These new concepts, commercialized as 'karma purification' and 'pure view', have served to rationalize and conceal abuse, as well as to isolate the victims. Therefore, we are facing societal challenges, in terms of providing health and economic care to the victims and implementing preventive measures. This use of language also impacts on scientific discourse and Vajrayāna itself, and will affect many future generations.

scholarly journals Expressionism in European and Chinese painting (late XIX – early XXI centuries)

2020 ◽  
pp. 27-46
Author(s):  
Jitai Wang
Keyword(s):  
Comparative Analysis ◽  
Mutual Influence ◽  
Cultural Factors ◽  
Chinese Painting ◽  
Oil Painting ◽  
New Concepts ◽  
Similarities And Differences ◽  
The Individual ◽  
The Impact

This article examines the impact of Chinese traditional painting upon the formation of Western expressionism, as well as interprets the influence of Western expressionism upon Chinese painting in expressionist manner of different periods. The author reveals the mutual influence, similarities and differences between Western expressionism and Chinese painting in expressionist manner, Chinese imagery oil painting, Chinese colored ink painting, and Chinese imagery painting in Western style. Based on correlation between the spiritual ideology of painting and artistic form, the author carries out a comparative analysis of spiritual and formal factors of Chinese and Western painting systems for the purpose of determination of their mutual influence, and how it affects the emergence of new concepts in painting. The structure of brush stroke of the artist defines his aesthetic spirit. The article determines the “cyclic” nature of interinfluence processes between Chinese and Western painting systems that stimulate the development of human civilization. The analysis of corresponding cultural factors allows assessing the individual artistic characteristics of painting. Both, Chinese and Western painting systems entered the period when spiritual ideology of painting interacts with the artistic forms, opening the era of “globalization” of the language of painting.

scholarly journals The Quest to solve the HL-LHC data access puzzle

2020 ◽  
Vol 245 ◽  
pp. 04027
Author(s):  
X. Espinal ◽  
S. Jezequel ◽  
M. Schulz ◽  
A. Sciabà ◽  
I. Vukotic ◽  
...  
Keyword(s):  
Data Storage ◽  
Working Group ◽  
Data Access ◽  
Current Data ◽  
Resource Needs ◽  
Lake Model ◽  
New Concepts ◽  
Depth Analysis ◽  
Group Members ◽  
The Impact

HL-LHC will confront the WLCG community with enormous data storage, management and access challenges. These are as much technical as economical. In the WLCG-DOMA Access working group, members of the experiments and site managers have explored different models for data access and storage strategies to reduce cost and complexity, taking into account the boundary conditions given by our community.Several of these scenarios have been evaluated quantitatively, such as the Data Lake model and incremental improvements of the current computing model with respect to resource needs, costs and operational complexity.To better understand these models in depth, analysis of traces of current data accesses and simulations of the impact of new concepts have been carried out. In parallel, evaluations of the required technologies took place. These were done in testbed and production environments at small and large scale.We will give an overview of the activities and results of the working group, describe the models and summarise the results of the technology evaluation focusing on the impact of storage consolidation in the form of Data Lakes, where the use of streaming caches has emerged as a successful approach to reduce the impact of latency and bandwidth limitation.We will describe the experience and evaluation of these approaches in different environments and usage scenarios. In addition we will present the results of the analysis and modelling efforts based on data access traces of the experiments.

scholarly journals Restarting elective endoscopy safely amidst an evolving pandemic and the impact of patient perception

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Christopher Nguyen ◽  
Kevin T. Kline ◽  
Shehzad Merwat ◽  
Sheharyar Merwat ◽  
Gurinder Luthra ◽  
...  
Keyword(s):  
Risk Mitigation ◽  
Mitigation Strategies ◽  
Transmission Risk ◽  
Dynamic Monitoring ◽  
Successful Model ◽  
Outpatient Procedures ◽  
Risk Patients ◽  
Risk Mitigation Strategies ◽  
Spread Of Infection ◽  
The Impact

Abstract Background The COVID-19 pandemic has led to disruptions in elective and outpatient procedures. Guidance from the Centers for Medicare and Medicaid Services provided a framework for gradual reopening of outpatient clinical operations. As the infrastructure to restart endoscopy has been more clearly described, patient concerns regarding viral transmission during the procedure have been identified. Moreover, the efficacy of the measures in preventing transmission have not been clearly delineated. Methods We identified patients with pandemic-related procedure cancellations from 3/16/2020 to 4/20/2020. Patients were stratified into tier groups (1–4) by urgency. Procedures were performed using our hospital risk mitigation strategies to minimize transmission risk. Patients who subsequently developed symptoms or tested for COVID-19 were recorded. Results Among patients requiring emergent procedures, 57.14% could be scheduled at their originally intended interval. COVID-19 concerns represented the most common rescheduling barrier. No patients who underwent post-procedure testing were positive for COVID-19. No cases of endoscopy staff transmission were identified. Conclusions Non-COVID-19 related patient care during the pandemic is a challenging process that evolved with the spread of infection, requiring dynamic monitoring and protocol optimization. We describe our successful model for reopening endoscopy suites using a tier-based system for safe reintroduction of elective procedures while minimizing transmission to patients and staff. Important barriers included financial and transmission concerns that need to be addressed to enable the return to pre-pandemic utilization of elective endoscopic procedures.

Using Indicators to Monitor Security Risk in Systems of Systems

2012 ◽  
pp. 256-292 ◽  
Author(s):  
Olav Skjelkvåle Ligaarden ◽  
Atle Refsdal ◽  
Ketil Stølen
Keyword(s):  
Power Supply ◽  
System Of Systems ◽  
Dynamic Monitoring ◽  
Security Risk ◽  
Dynamic Nature ◽  
Systems Of Systems ◽  
It Service ◽  
The Impact

Systems of systems are collections of systems interconnected through the exchange of services. Their often complex service dependencies and very dynamic nature make them hard to analyze and predict with respect to quality in general, and security in particular. In this chapter, the authors put forward a method for the capture and monitoring of impact of service dependencies on the security of provided services. The method is divided into four main steps focusing on documenting the system of systems and IT service dependencies, establishing the impact of service dependencies on risk to security of provided services, identifying measureable indicators for dynamic monitoring, and specifying their design and deployment, respectively. The authors illustrate the method in an example-driven fashion based on a case within power supply.

scholarly journals Requirements for Electric Machine Design based on Operating Points from Real Driving Data in Cities

2019 ◽  
Vol 10 (4) ◽  
pp. 60
Author(s):  
Svenja Kalt ◽  
Lucas Brenner ◽  
Markus Lienkamp
Keyword(s):  
Time Pressure ◽  
Early Stage ◽  
Driving Cycle ◽  
Driving Cycles ◽  
New Concepts ◽  
The Difference ◽  
Electric Machine Design ◽  
The Impact ◽  
Operating Points

Increasing environmental awareness leads to the necessity for more efficient powertrains in the future. However, the development of new vehicle concepts generates a trend towards ever shorter development cycles. Therefore, new concepts must be tested and validated at an early stage in order to meet the increasing time pressure. This requires the determination of real driving data in fleet tests in order to generate realistic driving cycles, which correspond as closely as possible to the actual driving behavior of the applications use case. Within the scope of this paper, real driving data are analyzed and used to create a representative driving cycle. The resulting driving cycle based on real driving characteristics is then used to investigate the impact of application-based design for powertrains on the design of electric machines, by illustrating the difference between synthetic operating points and real driving data.

Genotype×environment interactions and some considerations of their implications for wheat breeding in Australia This review is one of a series commissioned by the Advisory Committee of the Journal.

1998 ◽  
Vol 49 (2) ◽  
pp. 153 ◽  
Author(s):  
K. E. Basford ◽  
M. Cooper
Keyword(s):  
Genetic Material ◽  
Wheat Breeding ◽  
Breeding Programs ◽  
Specific Adaptation ◽  
New Concepts ◽  
Statistical Studies ◽  
Definition Of ◽  
Level Of Understanding ◽  
The Impact

Genotype×environment (G×E) interactions complicate selection forbroad adaptation, while their nature and causes need to be understood toutilise and exploit them in selection for specific adaptation. This invitedreview combines an assessment of the literature with the experience we havegained from involvement in wheat breeding and associated research programs toassess (1) the implications of G×E interactions for wheat breeding inAustralia, (2) the impact that research into G E interactions has had onbreeding strategy, and (3) the evidence for impact from this research efforton genetic improvement of crop adaptation. The role of analytical methodologyin this process is considered and some important issues are discussed.There are sufficient examples drawn from wheat breeding in Australia tosuggest that progress in dealing with G×E interactions can be made andseveral of these are presented. They show that impact in plant breedingfollows from achieving an appropriate level of understanding of theenvironmental and genetic factors causing the interactions as well as anassessment of their importance in the target genotype-environment system. Anaccurate definition of the environmental factor(s) contributing to theG×E interactions has been particularly important in determining therelevance of observed differences in plant adaptation to the target populationof environments. From the combination of biological and statistical studies, amore comprehensive understanding of G×E interactions has emerged andcontributed to new concepts and procedures for dealing with them.Distinguishing between what are repeatable and non-repeatable interactions isa key step. Genuine cases of positive specific adaptation observed inmulti-environment trials (METs) can be exploited by appropriately targetedselection strategies, while non-repeatable interactions are accommodated byselection for broad adaptation.The investigation of G×E interactions for grain yield of wheat inAustralia has matured to the point where an understanding of some of theircauses has enabled wheat breeders to exploit positive components of specificadaptation. The experience that has been gained in achieving these advancesindicates the importance of establishing a MET system that is relevant to thetarget population of environments of the breeding program. The investment ofadequate resources into effective design, conduct, analysis, andinterpretation of METs remains critical to continued progress from selectionin complex genotype-environment systems that present large G× Einteractions. Wheat breeders who understand their genetic material and thetarget population of environments can then use the generated information baseto achieve impact from their breeding programs.

Honoring the 75th anniversary of the American Association of Neurological Surgeons

2008 ◽  
Vol 108 (1) ◽  
pp. 184
Author(s):  
Edward R. Laws
Keyword(s):  
American Association ◽  
75Th Anniversary ◽  
Harvey Cushing ◽  
Parent Organization ◽  
New Concepts ◽  
Publishing Group ◽  
Scientific Technical ◽  
The Many ◽  
The Impact ◽  
Paradigm Shifting

Ever since the Journal of Neurosurgery (JNS) published its first volume in 1944, the journal has reflected the scientific, technical, and clinical evolution of our specialty and parent organization, first called the Harvey Cushing Society and later the American Association of Neurological Surgeons. The JNS has been an uncompromising arbiter of progress in our specialty, and its superb editorial stewardship has led to its recognition as the premier journal in the field. The impact rating of JNS and its wide circulation among neurosurgeons worldwide are two of the many reasons why most of the truly innovative and paradigm-shifting advances in neurosurgery have been published in its pages. As part of the 75th anniversary of the American Association of Neurological Surgeons celebration, the JNS Publishing Group has initiated a project of reviewing papers published over the years that have had the highest impact factor and greatest scientific interest: papers that have heralded new knowledge, new concepts, and new techniques that have been at the heart of modern neurosurgery and its continuing excitement and progress. We hope you will enjoy these articles and the accompanying commentaries. In this issue we present the next paper in this series.

New concepts: development of a survivorship programme for patients with a functionally univentricular heart

2011 ◽  
Vol 21 (S2) ◽  
pp. 77-79 ◽  
Author(s):  
David J. Goldberg ◽  
Kathryn Dodds ◽  
Jack Rychik
Keyword(s):  
Fontan Operation ◽  
Univentricular Heart ◽  
Plastic Bronchitis ◽  
Complete Understanding ◽  
Protein Losing Enteropathy ◽  
New Concepts ◽  
Fontan Physiology ◽  
The Impact ◽  
Valuable Service

AbstractChildren with functionally univentricular hearts are now surviving into their third and fourth decades of life. Although survival alone is a remarkable achievement, a lot must still be done to improve the quality and duration of life after the Fontan operation. Challenges that may be faced by these patients include the impact of the Fontan operation on the liver and the density of bone, protein-losing enteropathy, and plastic bronchitis. Paediatric cardiologists are familiar with the haemodynamic issues inherent in Fontan physiology; however, training in cardiology is often not sufficient to give us a complete understanding of the pathophysiology of the complications or of the options for treatment. Collaboration with other subspecialists including gastroenterologists, endocrinologists, and pulmonologists is essential in order to provide the rigorous and nuanced care that our patients need and deserve. A clinic in which a patient can see multiple subspecialists, and in which the subspecialists, as a group, can discuss each patient, can provide a unique and valuable service for patients with a functionally univentricular heart.

scholarly journals Most Preferred Business Banking Product of HDFC Bank in Trichy City

2011 ◽  
Vol 2 (4) ◽  
pp. 177-185
Author(s):  
Uma Rani T.
Keyword(s):  
Risk Management ◽  
Constant Factor ◽  
Asset Liability Management ◽  
Liability Management ◽  
New Concepts ◽  
The World ◽  
The Face ◽  
The Impact ◽  
Insight Into ◽  
Rapid Transformation

Change is the only constant factor in this dynamic world and banking is not an exception. The changes staring in the face of bankers relates to the fundamental way of banking-which is undergoing rapid transformation in the world of today, in response to the forces of completion productivity and efficiency of operations, reduced operating margins better asset/liability management, risk management, any time and any where banking. The major challenge faced by banks today is to protect the falling margins due to the impact of competition. Another significant impact of banks today is the technology issue. In this study the business banking products of HDFC bank, that best suits the needs of the borrower were analysed. The Customer feels that loans to be obtained require a process that is extremely complicating and time consuming. This calls for an ombudsman setup separately for the domain. The observation and findings of the study have helped to give useful recommendation to bank. The implementation of the suggestion can help to improve strategies and build competencies over that of their competitors. This study has there by helped me by giving exposure into new concepts in today’s banking scenario as the interface shifts from service to products. There has also been some insight into competency recognition.

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