Relationship of visceral adipose tissue to metabolic risk factors for coronary heart disease: Is there a contribution of subcutaneous fat cell hypertrophy?

Metabolism ◽  
1999 ◽  
Vol 48 (3) ◽  
pp. 355-362 ◽  
Author(s):  
P. Imbeault ◽  
S. Lemieux ◽  
D. Prud'homme ◽  
A. Tremblay ◽  
A. Nadeau ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Visceral Adipose Tissue ◽  
Subcutaneous Fat ◽  
Metabolic Risk ◽  
Fat Cell ◽  
Visceral Adipose ◽  
Relationship Of

scholarly journals Visceral Adipose Tissue Cutoffs Associated With Metabolic Risk Factors for Coronary Heart Disease in Women

Diabetes Care ◽  
2003 ◽  
Vol 26 (5) ◽  
pp. 1413-1420 ◽  
Author(s):  
B. J. Nicklas ◽  
B. W.J.H. Penninx ◽  
A. S. Ryan ◽  
D. M. Berman ◽  
N. A. Lynch ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Visceral Adipose Tissue ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Visceral Adipose

scholarly journals Association between visceral adipose tissue volume, measured using computed tomography, and cardio-metabolic risk factors

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Wook Yi ◽  
Keunyoung Kim ◽  
Myungsoo Im ◽  
Soree Ryang ◽  
Eun Heui Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Computed Tomography ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Metabolic Risk Factors ◽  
Metabolic Parameters ◽  
Oral Glucose ◽  
Slice Thickness ◽  
Metabolic Risk ◽  
Visceral Adipose

AbstractWe evaluated the associations between metabolic parameters with visceral adipose tissue (VAT) volume in women with prediabetes or type 2 diabetes (T2DM), and we compared the VAT volume with the VAT area. We enrolled women aged > 20 years with prediabetes or T2DM, who underwent oral glucose tolerance test and whose VAT was evaluated using computed tomography (CT) at our institution between 2017 and 2019. All participants underwent unenhanced spiral CT with a 3-mm slice thickness from the level of the diaphragm to the level of the mid-thigh. The two VAT areas were defined as the free drawn area on the levels of the umbilicus and L2 vertebra. The VAT areas were also manually drawn from the level of the diaphragm to the level of the pelvic floor and were used to calculate the VAT volumes by summing all areas with a slice thickness of 3 mm after setting the attenuation values from −45 to −195 Hounsfield Unit. All metabolic characteristics, except blood pressure, were significantly correlated with the VAT volume. The VAT areas measured at the level of the L2 vertebra and umbilicus were correlated with serum triglyceride, high-density lipoprotein cholesterol, and Framingham steatosis index alone. Multivariable regression analyses revealed that the VAT volume was significantly associated with several metabolic parameters. In conclusion, in women with prediabetes and T2DM, the VAT volume acquired from CT-based calculation has more significant correlations with metabolic risk factors compared with the VAT area.

Visceral adipose tissue as a predictor for metabolic risk factors in the Korean population

2007 ◽  
Vol 0 (0) ◽  
pp. 071119221323003-??? ◽  
Author(s):  
J. H. Han ◽  
H. S. Park ◽  
S. M. Kim ◽  
S. Y. Lee ◽  
D. J. Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Metabolic Risk Factors ◽  
Korean Population ◽  
Metabolic Risk ◽  
Visceral Adipose

Independent associations between liver fat, visceral adipose tissue, and metabolic risk factors in men

2007 ◽  
Vol 32 (2) ◽  
pp. 265-272 ◽  
Author(s):  
Kathleen P. McMillan ◽  
Jennifer L. Kuk ◽  
Timothy S. Church ◽  
Steven N. Blair ◽  
Robert Ross
Keyword(s):  
Risk Factors ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Metabolic Profile ◽  
Univariate Analysis ◽  
Density Lipoprotein ◽  
Metabolic Risk Factors ◽  
Liver Fat ◽  
Metabolic Risk ◽  
Visceral Adipose

The independent associations between liver fat, visceral adipose tissue (AT), and metabolic risk factors are unclear. Although it has been reported that visceral AT is the strongest predictor of metabolic risk, liver fat has also been reported as a strong independent associate of a deleterious metabolic profile. We examined the independent associations between liver fat, visceral AT, and metabolic risk factors in a sample of 293 men varying widely in adiposity. Liver fat and abdominal AT were measured by computed tomography (CT). Univariate analysis revealed that liver fat was associated (p < 0.05) with triglycerides (TG), systolic blood pressure (SBP), and total cholesterol (TC), but not with glucose or high-density lipoprotein cholesterol (HDLC). Liver fat remained a significant correlate (p < 0.05) of TG and TC after control for age and subcutaneous AT or cardiorespiratory fitness (CRF), but not after adjustment for visceral AT alone. Conversely, visceral AT remained significantly associated with TG, SBP, glucose, HDLC (p < 0.01), and TC (p = 0.05) independent of liver fat, subcutaneous AT, CRF, and age. Both liver fat and visceral AT were associated with metabolic risk in men. However, when controlled for each other, visceral AT was the only independent associate of metabolic risk.

scholarly journals Impacts of Visceral Adipose Tissue and Subcutaneous Adipose Tissue on Metabolic Risk Factors in Middle-aged Japanese

Obesity ◽  
2010 ◽  
Vol 18 (1) ◽  
pp. 153-160 ◽  
Author(s):  
Rie Oka ◽  
Katsuyuki Miura ◽  
Masaru Sakurai ◽  
Koshi Nakamura ◽  
Kunimasa Yagi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Middle Aged ◽  
Visceral Adipose ◽  
Subcutaneous Adipose

Abstract 5822: Atherosclerotic Plaque Inflammation Synchronize With Inflammatory Activity OF Visceral Fat

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Eung Ju Kim ◽  
Hong Seog Seo ◽  
Sungeun Kim ◽  
Jin Oh Na ◽  
Jae Hyoung Park ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Atherosclerotic Plaque ◽  
Visceral Adipose Tissue ◽  
Visceral Fat ◽  
Subcutaneous Fat ◽  
Fdg Uptake ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
Plaque Inflammation ◽  
Visceral Adipose

Background: Visceral adipose tissue is thought to confer increased cardiovascular risk through leukocyte infiltration and increased adipose macrophage activity. Previous positron emission tomography (PET) studies using fluorodeoxyglucose (FDG) demonstrated that increased FDG uptake could reflect the severity of inflammation in atherosclerotic plaque. We hypothesized that active atherosclerotic change in the major arteries would accompany increased inflammation within visceral fat and it could be detected in humans using combined FDG PET/computed tomography (CT). Methods: We observed 44 consecutive subjects with cardiovascular disease. For all of them, an one-hour PET/CT (from brain to foot) was performed after injection of FDG (370–555 MBq). FDG uptake in the aorta or its major branches was evaluated visually and semiquantitatively. Maximal standard uptake values (SUV) of the highest regions of interest were calculated in the subcutaneous fat and visceral fat area, separately. Results: Significant FDG uptake in the arterial wall was noted in 21 patients (plaque positive; PP group), all of whom have experienced acute cardiovascular events (acute coronary syndrome or ischemic stroke) within a week. The other 23 patients (plaque negative; PN group) had chronic stable angina or asymptomatic carotid stenosis. Visceral fat SUV was significantly higher as compared to subcutaneous fat SUV (0.49± 0.15 vs. 0.15± 0.05, p< 0.001) in PP group, whereas there was no significant difference in PN group (0.18± 0.07 vs. 0.16± 0.03, p= 0.622). When we compared two groups, PP group showed higher visceral fat SUV than PN group (p< 0.001). In terms of subcutaneous fat SUV, the results were similar in two groups (p= 0.773). Conclusions: We demonstrated that atherosclerotic plaque inflammation was associated with increased inflammation within visceral fat. Our results need to be confirmed by comparison with histologic or other imaging findings. Further evaluation to determine whether metabolic activity of visceral adipose tissue is a marker or mediator of vascular inflammation is also needed.

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