Population-Based Analysis of the Relationship of Whole Bone Strength Indices and Fall-Related Loads to Age- and Sex-Specific Patterns of Hip and Wrist Fractures

2007 ◽  
Vol 2007 ◽  
pp. 327-328
Author(s):  
B.L. Clarke
Keyword(s):  
Bone Strength ◽  
Population Based ◽  
Wrist Fractures ◽  
Relationship Of ◽  
The Relationship ◽  
Age And Sex

scholarly journals Population-Based Analysis of the Relationship of Whole Bone Strength Indices and Fall-Related Loads to Age- and Sex-Specific Patterns of Hip and Wrist Fractures

2005 ◽  
Vol 21 (2) ◽  
pp. 315-323 ◽  
Author(s):  
B Lawrence Riggs ◽  
L Joseph Melton ◽  
Richard A Robb ◽  
Jon J Camp ◽  
Elizabeth J Atkinson ◽  
...  
Keyword(s):  
Bone Strength ◽  
Population Based ◽  
Wrist Fractures ◽  
Relationship Of ◽  
The Relationship ◽  
Age And Sex

Analysis of Maximum Expiratory Flow Volume Curves Using Canonical Correlation Analysis

1985 ◽  
Vol 24 (02) ◽  
pp. 91-100 ◽  
Author(s):  
W. van Pelt ◽  
Ph. H. Quanjer ◽  
M. E. Wise ◽  
E. van der Burg ◽  
R. van der Lende
Keyword(s):  
Correlation Analysis ◽  
Canonical Correlation Analysis ◽  
Canonical Correlation ◽  
Flow Volume ◽  
Non Linear ◽  
Maximum Expiratory Flow ◽  
Expiratory Flow ◽  
Relationship Of ◽  
The Relationship ◽  
Age And Sex

SummaryAs part of a population study on chronic lung disease in the Netherlands, an investigation is made of the relationship of both age and sex with indices describing the maximum expiratory flow-volume (MEFV) curve. To determine the relationship, non-linear canonical correlation was used as realized in the computer program CANALS, a combination of ordinary canonical correlation analysis (CCA) and non-linear transformations of the variables. This method enhances the generality of the relationship to be found and has the advantage of showing the relative importance of categories or ranges within a variable with respect to that relationship. The above is exemplified by describing the relationship of age and sex with variables concerning respiratory symptoms and smoking habits. The analysis of age and sex with MEFV curve indices shows that non-linear canonical correlation analysis is an efficient tool in analysing size and shape of the MEFV curve and can be used to derive parameters concerning the whole curve.

scholarly journals Serum IGF1, metabolic syndrome, and incident cardiovascular disease in older people: a population-based study

2013 ◽  
Vol 168 (3) ◽  
pp. 393-401 ◽  
Author(s):  
Christa C van Bunderen ◽  
Mirjam M Oosterwerff ◽  
Natasja M van Schoor ◽  
Dorly J H Deeg ◽  
Paul Lips ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Older People ◽  
Population Based ◽  
Mortality Data ◽  
The Metabolic Syndrome ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Definition Of ◽  
Relationship Of ◽  
The Relationship

ObjectiveHigh as well as low levels of IGF1 have been associated with cardiovascular diseases (CVD). The relationship of IGF1 with (components of) the metabolic syndrome could help to clarify this controversy. The aims of this study were: i) to investigate the association of IGF1 concentration with prevalent (components of) the metabolic syndrome; and ii) to examine the role of (components of) the metabolic syndrome in the relationship between IGF1 and incident CVD during 11 years of follow-up.MethodsData were used from the Longitudinal Aging Study Amsterdam, a cohort study in a representative sample of the Dutch older population (≥65 years). Data were available in 1258 subjects. Metabolic syndrome was determined using the definition of the US National Cholesterol Education Program Adult Treatment Panel III. CVD were ascertained by self-reports and mortality data.ResultsLevels of IGF1 in the fourth quintile were associated with prevalent metabolic syndrome compared with the lowest quintile (odds ratio: 1.59, 95% confidence interval (CI) 1.09–2.33). The middle up to the highest quintile of IGF1 was positively associated with high triglycerides in women. Metabolic syndrome was not a mediator in the U-shaped relationship of IGF1 with CVD. Both subjects without the metabolic syndrome and low IGF1 levels (hazard ratio (HR) 1.75, 95% CI 1.12–2.71) and subjects with the metabolic syndrome and high IGF1 levels (HR 2.28, 95% CI 1.21–4.28) demonstrated increased risks of CVD.ConclusionsIn older people, high-normal IGF1 levels are associated with prevalent metabolic syndrome and high triglycerides. Furthermore, this study suggests the presence of different pathomechanisms for both low and high IGF1 levels and incident CVD.

scholarly journals 2315. The Relationship of Pre-Hospital Functional Status and Clinical Outcomes in Patients with Laboratory-Confirmed RSV Infection: Active Population-Based Surveillance, 2017–2019

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S794-S794
Author(s):  
Angela Branche ◽  
Lisa Saiman ◽  
Edward E Walsh ◽  
Ann R Falsey ◽  
William Sieling ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Functional Status ◽  
Clinical Outcomes ◽  
Demographic Data ◽  
Patient Characteristics ◽  
Population Based ◽  
Active Population ◽  
Rsv Infection ◽  
Relationship Of ◽  
The Relationship

Abstract Background Respiratory syncytial virus (RSV) infection is a common cause of acute respiratory infection (ARI) in adults. Prospective surveillance enables collection of representative data on demographic and clinical characteristics. Few data of this kind are available for adults hospitalized with RSV infection. We used active population-based surveillance to identify patients with laboratory-confirmed RSV infection and evaluated demographic characteristics and clinical outcomes. Methods Hospitalized adults ≥ 18 years old residing in a predefined catchment area with ≥ 2 ARI symptoms or exacerbation of underlying cardiopulmonary disease were screened for eligibility during October 2017–April 2018 and October 2018–April 2019 in 3 hospitals in Rochester, NY and New York City. Respiratory specimens were tested for RSV using PCR assays. Clinical and demographic data were abstracted from the medical record. Multivariate analysis was used to evaluate the relationship of patient characteristics with clinical outcomes. Results 8,217 hospitalized adults were screened and 9.4% positive for RSV infection. Preliminary clinical and demographic data were available for 348 patients including 14% 18–49 years, 28% 50–64 years and 58% > 65 years. Mean age was 68 years and 60% were female (Figure 1). Patients had a mean of 3 co-morbidities, with diabetes (40%), chronic obstructive pulmonary disease (30%), chronic kidney disease (28%), congestive heart failure (28%), coronary artery disease (25%) and asthma (24%) the most common co-morbidities (Figure 2). Median hospital length of stay was 6 days (IQR 4–10), 13% of patients were admitted to the ICU, 5% were mechanically ventilated and 5% died during admission and 12% within 6 months. In multivariate analysis having > 3 comorbidities, cardiac disease or a lower baseline functional status measured by activities of daily living scores was significantly associated with 6-month mortality. Conclusion The majority of hospitalized patients with RSV infection were older adults with ≥ 3 chronic comorbid conditions. Baseline functional status may be predictive of worse clinical outcomes in patients with RSV infection. These insights into patient characteristics and clinical outcomes will provide information for prevention programs. Disclosures All authors: No reported disclosures.

scholarly journals Validation of Surrogates of Urine Osmolality in Population Studies

2017 ◽  
Vol 46 (1) ◽  
pp. 26-36 ◽  
Author(s):  
Sonia Youhanna ◽  
Lise Bankir ◽  
Paul Jungers ◽  
David Porteous ◽  
Ozren Polasek ◽  
...  
Keyword(s):  
Metabolic Diseases ◽  
Large Population ◽  
Urine Osmolality ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Urine Concentration ◽  
Total N ◽  
Mean Differences ◽  
Relationship Of ◽  
The Relationship

Background: The importance of vasopressin and/or urine concentration in various kidney, cardiovascular, and metabolic diseases has been emphasized recently. Due to technical constraints, urine osmolality (Uosm), a direct reflect of urinary concentrating activity, is rarely measured in epidemiologic studies. Methods: We analyzed 2 possible surrogates of Uosm in 4 large population-based cohorts (total n = 4,247) and in patients with chronic kidney disease (CKD, n = 146). An estimated Uosm (eUosm) based on the concentrations of sodium, potassium, and urea, and a urine concentrating index (UCI) based on the ratio of creatinine concentrations in urine and plasma were compared to the measured Uosm (mUosm). Results: eUosm is an excellent surrogate of mUosm, with a highly significant linear relationship and values within 5% of mUosm (r = 0.99 or 0.98 in each population cohort). Bland-Altman plots show a good agreement between eUosm and mUosm with mean differences between the 2 variables within ±24 mmol/L. This was verified in men and women, in day and night urine samples, and in CKD patients. The relationship of UCI with mUosm is also significant but is not linear and exhibits more dispersed values. Moreover, the latter index is no longer representative of mUosm in patients with CKD as it declines much more quickly with declining glomerular filtration rate than mUosm. Conclusion: The eUosm is a valid marker of urine concentration in population-based and CKD cohorts. The UCI can provide an estimate of urine concentration when no other measurement is available, but should be used only in subjects with normal renal function.

scholarly journals Incidence, prevalence, mortality and chronic renal damage of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a 20-year population-based cohort

2018 ◽  
Vol 34 (9) ◽  
pp. 1508-1517 ◽  
Author(s):  
Alvise Berti ◽  
Emilie Cornec-Le Gall ◽  
Divi Cornec ◽  
Marta Casal Moura ◽  
Eric L Matteson ◽  
...  
Keyword(s):  
Renal Damage ◽  
Survival Rates ◽  
Population Based ◽  
Incidence Rates ◽  
Annual Incidence ◽  
Incident Cohort ◽  
The Relationship ◽  
True Population ◽  
Age And Sex ◽  
Incidence Prevalence

Abstract Background True population-based clinical and outcomes data are lacking for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis (AAGN). Therefore we aimed to estimate the incidence, prevalence and mortality of AAGN, as well as the relationship between the grade of chronic renal damage at presentation and renal and non-renal outcomes. Methods Patients with AAGN were identified among a population-based incident cohort of 57 Olmsted County residents diagnosed with ANCA-associated vasculitis (AAV) in 1996–2015. Incidence rates were age and sex adjusted to the 2010 US white population. Age- and sex-adjusted prevalence was calculated for 1 January 2015. Survival rates were compared with expected rates in the Minnesota population. Chronic renal damage was assessed by chronicity score (CS) on biopsies performed at diagnosis. Results Thirty-four (60%) patients had AAGN. Of these, 65% had microscopic polyangiitis (MPA) and 74% were myeloperoxidase (MPO)-ANCA positive. The annual incidence of AAGN was 2.0/100 000 population [95% confidence interval (CI) 1.3–2.7] and the overall prevalence was 35/100 000 (95% CI 24–47). Mortality for AAGN was increased (P < 0.001), whereas mortality for AAV without glomerulonephritis did not differ from the general population. Minimal to mild CS predicted recovery of renal function at 1 year; clinical diagnosis (granulomatosis with polyangiitis versus MPA) and ANCA specificity (proteinase 3 versus MPO) did not. This observation was replicated in an independent cohort of 38 newly diagnosed AAGN patients seen at our centre over the 1999–2014 period. Conclusions The annual incidence and prevalence of AAGN in Minnesota are 2.0/100 000 and 35/100 000, respectively. Mortality is worse compared with AAV patients without glomerulonephritis. More advanced renal damage at diagnosis predicts less renal recovery.

scholarly journals State Digitalzation Policy as a Factor of Sustainable Inclusive Growth and Development of Russian Regions

2020 ◽  
Vol 208 ◽  
pp. 08031
Author(s):  
Rustam Sharafutdinov ◽  
Vladislav Gerasimov ◽  
Elvir Akhmetshin ◽  
Hilary Okagbue ◽  
Asiyat Tagibova
Keyword(s):  
Russian Federation ◽  
Growth And Development ◽  
Population Based ◽  
Steady Increase ◽  
Inclusive Growth ◽  
The Social ◽  
Security Infrastructure ◽  
The Russian Federation ◽  
Relationship Of ◽  
The Relationship

This research paper addresses the need for digitalization of the economy in socially important areas of the Russian Federation, particularly its regions. The purpose of the study is to examine the relationship of digitalization with the processes of inclusive growth and regional development. The study identifies the main directions of the digitalization policy, its overall effectiveness, as well as those processes that make certain public goods more accessible for the population, namely: education, healthcare, security, infrastructure and their possible impact on inequality and the level of income of the population. Problems are identified in the existing national and regional digitalization policy, which is not able to ensure a steady increase in citizens’ incomes, high-quality and affordable higher education, as well as reduce the social tension of the population. Based on the foregoing, the authors offer recommendations for resolving these problems in terms of a digitalization approach and an improved digitalization policy with a view to sustainable inclusive socio-economic growth and development of the Russian Federation regions.

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