Atopic dermatitis of the face, scalp, and neck: Type I reaction to the yeast Pityrosporum ovale?

1992 ◽  
Vol 89 (1) ◽  
pp. 44-51 ◽  
Author(s):  
E JENSENJAROLIM ◽  
L POULSEN ◽  
H WITH ◽  
M KIEFFER ◽  
V OTTEVANGER ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Type I ◽  
Pityrosporum Ovale ◽  
The Face

Molecular pathogenesis and clinical implications of eczema herpeticum

2008 ◽  
Vol 10 ◽  
Author(s):  
Caroline Bussmann ◽  
Wen-Ming Peng ◽  
Thomas Bieber ◽  
Natalija Novak
Keyword(s):  
Atopic Dermatitis ◽  
Age Of Onset ◽  
Current Knowledge ◽  
Allergen Challenge ◽  
Skin Lesions ◽  
Molecular Pathogenesis ◽  
Type I Interferons ◽  
Total Serum ◽  
Type I ◽  
Eczema Herpeticum

A subgroup of patients with atopic dermatitis develops one or more episodes of a severe viral skin infection caused by herpes simplex virus superimposed on eczematous skin lesions. This condition is named atopic dermatitis complicated by eczema herpeticum. Characteristic features of patients developing eczema herpeticum include an early age of onset of atopic dermatitis with a persistent and severe course into adulthood, predilection for eczematous skin lesions in the head and neck area, elevated total serum IgE levels and increased allergen sensitisation. Deficiencies at the level of both the innate and the adaptive immune system, which have been identified in atopic dermatitis, are much more pronounced in this subgroup. Predisposing cellular factors include a reduced number of plasmacytoid dendritic cells in the epidermis and a modified capacity of these cells to produce type I interferons after allergen challenge. In addition, lower levels of antimicrobial peptides in the skin of atopic dermatitis patients, resulting in part from a Th2-prone micromilieu, contribute to the lack of an effective defence against viral attack. In this review, we summarise the current knowledge of the molecular pathogenesis of eczema herpeticum.

Treatment of Leg and Face Veins with a Cryogen Spray, Variable Pulse Width 1064 nm Nd:Yag Laser—A Prospective Study of 47 Patients

2002 ◽  
Vol 19 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Cindy Y. Li ◽  
Sorin Eremia
Keyword(s):  
Prospective Study ◽  
Nd:Yag Laser ◽  
Pulse Width ◽  
Skin Type ◽  
Type I ◽  
High Fluences ◽  
Vein Segment ◽  
The Face ◽  
A Prospective Study ◽  
Reticular Veins

Objective: Throughout the 1990s, laser treatment of leg veins was a challenge. Newer, longer wavelength lasers capable of delivering high fluences with larger spot sizes with a variable pulse width have shown promising preliminary results. Experience with these lasers for treatment of facial telangiectasia and periorbital reticular veins is even more scant. To our knowledge this is the first prospective study to evaluate a variable pulse width, cryogen spray—equipped 1064 nm Nd:Yag laser for both the treatment of leg and face veins, including larger periorbital reticular veins. Materials and Methods: Forty-seven volunteers aged 32–67 years (30 with skin type I-V with leg telangiectasia and reticular veins, and 17 with skin type I-IV with face telangiectasia and reticular periorbital veins) were treated with the Nd:Yag laser. For leg vein patients, 2–3 sets of different leg veins were treated with a maximum of 3 treatments. Patients were examined 1 week after each treatment and at 1, 2, and 3 months after the last treatment. All face vein patients received 1 treatment and were examined at 1 month posttreatment. Treatment parameters for both leg and face veins varied with the size of vessels being treated. Pre- and posttreatment 35 mm photos were taken. Improvement was judged by 2 experienced physicians both visually on patients and by comparison of pre- and posttreatment photos. Results were graded as percent resolution in 5 groups: 0%, 0–25%, 25–50%, 50–75%, and 75–100%. Results: Twenty-three of 30 patients completed the leg vein segment of the study. A total of 41 leg vein sites were treated. Greater than 75% improvement was observed at 85% of the treated sites. Greater than 50% improvement was observed at 95% of the treated sites. Less than 25% improvement was observed at 5% of the treated sites. Seventeen of 17 patients completed the face vein segment of the study, and 32 sites were treated (24 cheeks, noses, and chin telangiectasia and 8 periorbital reticular veins). Greater than 75% improvement was observed at 97% of the treated sites. Greater than 50% improvement was observed at 100% of the treated sites. Notably, 100% of the facial reticular veins treated had essentially 100% resolution. Pain during treatment was variably perceived by patients, but was occasionally sufficient for patients to decline further treatment. Transient hemosiderin pigmentation, as seen with sclerotherapy, was common with larger vessels. Conclusion: The cryogen spray-equipped 1064 nm Nd: Yag laser was remarkably effective and safe for skin type I-V patients. Excellent results for leg veins, approaching sclerotherapy outcomes, were obtained for both 0.3–1.5 mm telangiectasia and larger 1.5–3.0 mm reticular veins. Furthermore, this 1064 Nd:Yag laser is also an outstanding tool for treatment of facial telangiectasia with little if any risk of purpura. For the first time we appear to have a safe and effective treatment for 1–2 mm periorbital reticular veins. The use of topical anesthesia may be needed for some patients.

scholarly journals Eczema herpeticum in an infant – a case report

2020 ◽  
Vol 16 (3) ◽  
pp. 320-324
Author(s):  
Lesya Besh ◽  
◽  
Oksana Matsyura ◽  
Olesya Besh ◽  
Olga Troyanovska ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Case Report ◽  
Clinical Case ◽  
Allergic Inflammation ◽  
The Body ◽  
Preventive Effect ◽  
Herpesvirus Infection ◽  
Eczema Herpeticum ◽  
The Face ◽  
Ulcerative Lesions

Eczema herpeticum is a chronic dermatosis with erosive and ulcerative lesions of the skin in children of a predominantly young age. The clinical case presented in this article shows the severe course of herpesvirus infection combined with atopic dermatitis in a 5-month infant. A rash in the form of vesicles and pustules throughout the body with a predominant localisation on the skin of the face, the scalp, neck, and chest was found in the course of the examination of the child. Influence of infections on the course of allergic processes is an ambiguous and complicated issue. It has been proved that an infection can contribute to the development of allergies and exacerbate the course of already existing allergic inflammation. In recent years, an increasing number of studies have shown the preventive effect of infection on the development of allergic pathology in children, especially during the first years of life.

scholarly journals An Optimal Model of Financial Distress Prediction: A Comparative Study between Neural Networks and Logistic Regression

Risks ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 200
Author(s):  
Youssef Zizi ◽  
Amine Jamali-Alaoui ◽  
Badreddine El Goumi ◽  
Mohamed Oudgou ◽  
Abdeslam El Moudden
Keyword(s):  
Neural Networks ◽  
Logistic Regression ◽  
Financial Distress ◽  
Prediction Models ◽  
Type I ◽  
Return On Assets ◽  
Logistic Regression Models ◽  
The Face ◽  
One Year ◽  
Type Ii Errors

In the face of rising defaults and limited studies on the prediction of financial distress in Morocco, this article aims to determine the most relevant predictors of financial distress and identify its optimal prediction models in a normal Moroccan economic context over two years. To achieve these objectives, logistic regression and neural networks are used based on financial ratios selected by lasso and stepwise techniques. Our empirical results highlight the significant role of predictors, namely interest to sales and return on assets in predicting financial distress. The results show that logistic regression models obtained by stepwise selection outperform the other models with an overall accuracy of 93.33% two years before financial distress and 95.00% one year prior to financial distress. Results also show that our models classify distressed SMEs better than healthy SMEs with type I errors lower than type II errors.

scholarly journals FACIAL ARTERY ON FACE - A STUDY ON SOUTH INDIAN CADAVERS AND SPECIMENS

2013 ◽  
Vol 03 (03) ◽  
pp. 072-076
Author(s):  
Lydia S. Quadros ◽  
Arathy Babu ◽  
Antony Sylvan D'souza
Keyword(s):  
Facial Artery ◽  
Type I ◽  
Type Ii ◽  
Type Iii ◽  
Medical College ◽  
South Indian ◽  
Inferior Angle ◽  
The Face ◽  
Formalin Fixed ◽  
Left Hemi

Abstract Context: Facial artery is usually the main artery supplying the face. It gives three named branches on the face, the inferior labial, the superior labial and the lateral nasal and continues as the angular artery. Face is also supplied by the transverse facial artery and the arteries accompanying the cutaneous nerves. Aim: In the present study, variations of facial artery on face were observed. Settings & design: Department of Anatomy, Kasturba Medical College, Manipal. Material & method: The present study was performed on 38 males and 12 females' formalin-fixed hemi-faces. Diameter of facial artery was noted at two specific points using a fine microcaliper. Results: The variations were divided into 3 categories. Out of 38 male hemi-faces, 100% right and 78% left hemi-faces belonged to type I category; 22% left hemi-faces belonged to Type III category. Out of 12 female hemi-faces, 80% right and 80% left hemi-faces belonged to Type I category, 18% left hemi-faces belonged to Type II category and 20% right and 2% left hemi-faces belonged to Type III category. Premasseteric branch was observed in 4 hemi-faces; a duplex with a prominent lateral angular branch was observed in 4 hemi-faces and anenlarged transverse facial artery was seen in 2 hemi-faces. The diameter of facial artery at its origin and at the antero-inferior angle of masseter muscle was larger in males. Conclusion: This study shows that the variations in the branches and the diameter of the facial artery were relatively larger in males when compared to females.

A New and Simpler Approximation for ANOVA Under Variance Heterogeneity

1994 ◽  
Vol 19 (2) ◽  
pp. 91-101 ◽  
Author(s):  
Ralph A. Alexander ◽  
Diane M. Govern
Keyword(s):  
Type I Error ◽  
Order Approximation ◽  
Error Rates ◽  
Type I ◽  
Type Ii ◽  
Type Ii Error ◽  
Tail Probabilities ◽  
Type I Error Rates ◽  
Heterogeneity Of Variance ◽  
The Face

A new approximation is proposed for testing the equality of k independent means in the face of heterogeneity of variance. Monte Carlo simulations show that the new procedure has Type I error rates that are very nearly nominal and Type II error rates that are quite close to those produced by James’s (1951) second-order approximation. In addition, it is computationally the simplest approximation yet to appear, and it is easily applied to Scheffé (1959) -type multiple contrasts and to the calculation of approximate tail probabilities.

scholarly journals Case Report: Aicardi-Goutières Syndrome Caused by Novel TREX1 Variants

2021 ◽  
Vol 9 ◽  
Author(s):  
De Wu ◽  
Liwei Fang ◽  
Ting Huang ◽  
Songcheng Ying
Keyword(s):  
White Matter ◽  
Type I Interferons ◽  
Enzyme Linked Immunosorbent Assay ◽  
Type I ◽  
White Matter Volume ◽  
Elevated Type ◽  
Chinese Girl ◽  
The Face ◽  
Exonuclease 1 ◽  
First Time

TREX1 (three prime repair exonuclease 1) gene encodes DNA 3′ end repair exonuclease that plays an important role in DNA repair. Mutations in TREX1 gene have been identified as the cause of a rare autoimmune neurological disease, Aicardi-Goutières syndrome (AGS). Here, we report an AGS case of a 6-month-old Chinese girl with novel TREX1 variants. The patient had mild rashes on the face and legs, increased muscle tensions in the limbs, and positive cervical correction reflex. Cranial magnetic resonance imaging showed that there were patches of slightly longer T1 and T2 signals in the bilateral cerebral hemisphere and brainstem white matter, mainly in the frontotemporal lobe, together with decreased white matter volume, enlarged ventricles, and widened sulcus fissure. Total exon sequencing showed that the TREX1 gene of the child had mutations of c.137_138insC and c.292_293insA, which had not been reported before. In addition, elevated type I interferons were detected by using enzyme-linked immunosorbent assay in the patient's serum. Together, our study demonstrated that novel TREX1 variants (c.137_138insC and c.292_293insA) cause AGS for the first time.

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