Relationship of antecedent stressful life events to childhood and family history of anxiety and the course of panic disorder

BackgroundThere is a limitation of data about factors associated with treatment response in panic disorder (PD) patients at long-term follow-up period. The aim of this study was to evaluate the long-term treatment response of pharmacotherapy-resistant patients with PD after 5 years of cognitive-behavior group therapy (CBGT) and to identify factors that predict this outcome.MethodSixty-four patients who completed 12 sessions of CBGT were followed for 5-year. Outcome measures were evaluated by the Clinical Global Impression (CGI) and quality of life (QoL) using WHOQOL-bref. Demographic and clinical features, stressful life events were the variables investigated as predictors of CBGT response across follow-up period.ResultsTreatment was associated with significant reduction in symptoms severity (agoraphobia, anticipatory anxiety and panic attacks) with maintenance of gains at 5-year of follow-up (p < 0.05). Twenty-four (40%) of the sample remained in remission after 5 years, 12 (20%) relapsed during the follow-up period and 24 (40%) were non-responder to CBGT. The poor CBGT response had an important negative impact in QoL. Regression analyzes showed that comorbidity with dysthymia (p = 0.017) and stressful life events (p = 0.012) as the most important predictors to worse response.ConclusionsThe improvement in all evaluations suggested that brief CBGT for pharmacotherapy-resistant patients could be an alternative as next-step strategy for residual symptoms with maintenance of the gains after 5 years as assessed across follow-up period. New strategies should be tried for resistant patients, such as those with dysthymia comorbidity, and some specific tool in order to cope with adverse events.

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Impact of stressful life events on the course of panic disorder in adults

Journal of Affective Disorders ◽

10.1016/j.jad.2011.05.029 ◽

2011 ◽

Vol 134 (1-3) ◽

pp. 373-376 ◽

Cited By ~ 14

Author(s):

Ethan Moitra ◽

Ingrid Dyck ◽

Courtney Beard ◽

Andri S. Bjornsson ◽

Nicholas J. Sibrava ◽

...

Keyword(s):

Panic Disorder ◽

Life Events ◽

Stressful Life Events ◽

Stressful Life

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Stressful life events among individuals with a history of eating disorders: a case-control comparison

BMC Psychiatry ◽

10.1186/s12888-021-03499-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Selma Ø. Lie ◽

Cynthia M. Bulik ◽

Ole A. Andreassen ◽

Øyvind Rø ◽

Lasse Bang

Keyword(s):

Eating Disorders ◽

Sexual Assault ◽

Binge Eating ◽

Life Events ◽

Emotional Abuse ◽

Stressful Life Events ◽

Case Control ◽

Stressful Life ◽

Close Relative ◽

History Of

Abstract Background Experiencing stressful life events (SLEs) can negatively impact mental health and increase risk for psychiatric disorders including eating disorders (EDs). Previous research has shown that childhood sexual abuse is associated with some EDs, but less is known about the association between other non-sexual SLEs and EDs. Method A case-control study of individuals with (n = 495, age mean ± SD = 29.1 ± 9.8 years) and without (n = 395, age = 30.2 ± 11.7) self-reported lifetime history of EDs was conducted to compare history of self-reported SLEs. Participants reported history of sexual (e.g., rape, other sexual assault) and non-sexual (e.g., emotional abuse, assault, bereavement) life events using an adaptation of the Stressful Life Events Screening Questionnaire. Individuals with EDs were divided into ED subtypes along the restricting – binge eating/purging spectrum to examine subtype differences. Logistic regressions were conducted for each SLE and ED subtype to obtain odds ratios (ORs). We report p-values corrected for multiple comparisons. Results Exposure to any SLE was significantly more common in individuals with EDs than in controls (OR = 2.47, p < .001). Specifically, rape, other sexual assault, and emotional abuse were significantly more common among individuals with a history of binge-eating/purging ED subtypes (ORs = 2.15–3.58, p’s < .01) compared with controls. Furthermore, history of life-threatening disease and loss of a close relative/partner/friend were associated with some ED subtypes. The association between SLEs and EDs was stronger for individuals who had experienced multiple SLEs. Conclusion By investigating a range of different SLEs, we showed that both sexual and non-sexual SLEs were more common in individuals with a history of EDs (binge-eating/purging subtypes) than controls. Results highlight the importance of assessing a variety of past SLEs in risk assessment for different EDs.

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Major stressful life events and risk of developing lung cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.1575 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 1575-1575 ◽

Cited By ~ 2

Author(s):

Syed Hasan Raza Jafri ◽

Faisal Ali ◽

Arash Mollaeian ◽

Syed Mojiz Hasan ◽

Rahat Hussain ◽

...

Keyword(s):

Lung Cancer ◽

Risk Factor ◽

Life Events ◽

Stressful Life Events ◽

Stressful Life Event ◽

Smoking Status ◽

Stressful Life ◽

Life Event ◽

The Past ◽

History Of

1575 Background: Lung cancer is the leading cause of cancer-related mortality linked with smoking, though only 6-18% of heavy smokers die of lung cancer. We hypothesized that major stressful life events are a risk factor for developing lung cancer. Methods: In our matched case-control study, cases (CA) were lung cancer patients diagnosed within past 12 months. Controls (CO) were patients without a prior history of malignancy. CA and CO were matched for age, gender and smoking status. Smokers had at least 10 packs/years history of smoking. Data was collected using standardized research questionnaire on 11 major stressful life events using Holmes and Rahe stress scale. The primary endpoint was odds of having a major stressful life event. A sample of 360 patients (120 CA and 240 CO), was needed to achieve 80% power to detect an odds ratio (OR) of 2.00 using Chi-Square test with a P = 0.05 significance. The study was IRB approved at each institution. Results: Between May 2015 and December 2016, 324 patients were enrolled (23 were excluded due to prior cancer history or incomplete information). 301 (CA = 102; CO = 199) were included in the final analysis. The two groups were well matched in median age (CA = 64.4 years; CO = 63.9years), gender (CA-Male = 48%; CO-Male = 49.2%) and smoking status (ever smoker, CA = 86%; CO = 85%). There was no difference in lifetime stressful life event between CA and CO (95% vs 93.9% P = 0.68%). However, CA were significantly more likely to have had a major stressful life event within the past 5 years than controls (CA = 77.4% vs CO = 65.8%, P = 0.03, (OR = 1.78). Serious life-threatening illness of an immediate family member (P = 0.04) and retirement (P = 0.07) within the past 5 years were noticeably more common among CA. Holmes-Rahe stress score in the last 5 years was higher in men (86.3 vs 63.3, P = 0.07) and those > 65 years old (82.4 vs 57.2,P = 0.04) as compared with CO and in those with squamous histology than with adenocarcinoma (115.6 vs 63.4, P = 0.005). Conclusions: Patients with lung cancer (CA) were significantly more likely to have had a major stressful life event within the past 5 years than the matched controls (CO), especially in older men with squamous histology. Major stressful life events should be considered a risk factor for developing lung cancer.

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Suicidal Attempts and Life Events Among Depressive Adult Outpatients

European Psychiatry ◽

10.1016/s0924-9338(09)70840-5 ◽

2009 ◽

Vol 24 (S1) ◽

pp. 1-1

Author(s):

G. Amara ◽

A. Braham ◽

S. Ben Nasr ◽

B. Ben Hadj Ali

Keyword(s):

Life Events ◽

Stressful Life Events ◽

Stressful Life ◽

Major Depressive ◽

Suicidal Attempts ◽

History Of ◽

Dsm Iv ◽

The Mean ◽

Psychiatric Department ◽

Early Life Events

Aims:Although a relationship between experience of problematic life events and suicidal behaviour has been recognized during last decades, few studies of life events have been realized among depressive adults.The aim of this study was to determine the correlations between life events and suicidal attempts among depressive adult patients.Methods:Eighty adult outpatients were recruited from the psychiatric department of Farhat Hached hospital of sousse (in Tunisia). All patients were followed up for a Major Depressive Disorder (MDD) according to the DSM IV criteria. They also were in remission for at least four weeks. For life events we used the EVE scale of Ferreri which permitted to assess event nature, event number and patient strategies in front of stressful life events.Results:The gender ratio of the sample was 1.35 and the mean age was 44.4 ± 12.9 years.Twenty five percent of the sample have committed at least one suicidal attempt.Suicidal attempts were positively correlated with the total number of life events (p = 0.001), the number of early life events (p = 0.024) and the number of stressful life events (p < 0.001). Patients with a history of suicidal attempts were more likely to cope negatively with life events (p < 0.001).Conclusion:To prevent suicide, psychotherapies focusing on stress coping could be a good therapeutic alternative among patients with MDD.

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Relationship of Stressful Life Events and Adolescents' Employment

Psychological Reports ◽

10.2466/pr0.1980.47.3f.1195 ◽

1980 ◽

Vol 47 (3_suppl) ◽

pp. 1195-1198

Author(s):

Iliana M. Castillo

Keyword(s):

Life Events ◽

Stressful Life Events ◽

Psychiatric Patients ◽

Stressful Life ◽

Frequency Of Occurrence ◽

Work Study ◽

Occupational Programs ◽

Study Programs ◽

Relationship Of ◽

The Relationship

The relationship between stressful life events and adolescents' employment was studied using Coddington's Social Readjustment Rating Questionnaire for Adolescents. The amount of stress reported by those 52 health care and industrial work-study occupational programs was significantly greater than that of 31 unemployed students and 43 students in other work-study programs. The results are compared with data from previous studies of adolescent normal and psychiatric patients. Frequency of occurrence and positive and negative connotations of the life events are also discussed.

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