Study on the Thermal Characteristics of Fe3O4 Nanoparticles and Gelatin Compound for Magnetic Fluid Hyperthermia in Radiofrequency Magnetic Field

2014 ◽  
Vol 50 (11) ◽  
pp. 1-4 ◽  
Author(s):  
Jiangtao Li ◽  
Zheng Liang ◽  
Xu Zhong ◽  
Zhijie Zhao ◽  
Jianhao Li
Keyword(s):  
Magnetic Field ◽  
Magnetic Fluid ◽  
Thermal Characteristics ◽  
Magnetic Fluid Hyperthermia

On the in Vitro Hyperthermia of Magnetic Fluid in AC Magnetic Field

2009 ◽  
Author(s):  
Junfeng Jiang ◽  
Ruoyu Hong ◽  
Xiaohui Zhang ◽  
Hongzhong Li
Keyword(s):  
Magnetic Field ◽  
Magnetic Fluid ◽  
Volume Fraction ◽  
Maximum Temperature ◽  
Magnetic Fluid Hyperthermia ◽  
Ac Magnetic Field ◽  
Hyperthermia Therapy ◽  
Good Biocompatibility ◽  
High Chemical Stability

Hyperthermia therapy for cancer has attracted much attention nowadays. The study on the heat transfer in the magnetic fluid and the tumor is crucial for the successful application of magnetic fluid hyperthermia (MFH). Water-based Fe3O4 magnetic fluid is expected to be a most appropriate candidate for MFH due to the good biocompatibility, high saturation magnetization, super-paramagnetization and high chemical stability. In this paper, we explore the heat generation and transfer in magnetic fluid which is placed under an AC magnetic field. It is found that the amplitude and the frequency of alternating magnetic field, particle size and volume fraction have a pronounce influence on maximum temperature of hyperthermia.

MAGNETIC FLUID HYPERTHERMIA IN A CYLINDRICAL GEL CONTAINS WATER FLOW

2015 ◽  
Vol 15 (05) ◽  
pp. 1550088 ◽  
Author(s):  
MORTEZA HEYDARI ◽  
MEHRDAD JAVIDI ◽  
MOHAMMAD MAHDI ATTAR ◽  
ALIREZA KARIMI ◽  
MAHDI NAVIDBAKHSH ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Experimental Data ◽  
Fluid Flow ◽  
Magnetic Fluid ◽  
Blood Perfusion ◽  
Temperature Function ◽  
Magnetic Fluid Hyperthermia ◽  
Frequency Magnetic Field ◽  
Complicated Part ◽  
Cancerous Cells

In magnetic fluid hyperthermia (MFH), nanoparticles are injected into a diseased tissue and then subjected to an alternating high frequency magnetic field. The produced heat may have a key asset to destroy the cancerous cells. The blood flow in a tissue is considered as the most complicated part of the MFH which should be taken into account in the analysis of the MFH. This study was aimed to perform an experimental study to investigate the heat transfer of agar gel which contains fluid flow. Fe 3 O 4 as a nanoparticle was injected into the center of a cylindrical gel. It was also embedded with other cylindrical gels and subjected to an alternating magnetic field of 7.3 (kA/m) and a frequency of 50 (kHz) for 3600 (s). The temperature of the gel was measured at three points. The temperature distribution was measured via the experimental data. Moreover, specific absorption rate (SAR) was quantified with time differential temperature function at t = 0 by means of experimental data. Finite element method (FEM) was employed to establish a model to validate the SAR function. Results revealed the effects of fluid flow and accuracy of the SAR function for heat production in gel. The proposed function have implications in hyperthermia studies as a heat generation source. Finally, the condition of experimental setup was simulated to find the blood perfusion.

scholarly journals Towards improved magnetic fluid hyperthermia: major-loops to diminish variations in local heating

2017 ◽  
Vol 19 (22) ◽  
pp. 14527-14532 ◽  
Author(s):  
Cristina Munoz-Menendez ◽  
David Serantes ◽  
Juan M. Ruso ◽  
Daniel Baldomir
Keyword(s):  
Magnetic Field ◽  
Magnetic Fluid ◽  
Applied Magnetic Field ◽  
Local Heating ◽  
Anisotropy Constant ◽  
Field Amplitude ◽  
Magnetic Fluid Hyperthermia ◽  
Magnetic Field Amplitude

A low anisotropy constant allows us to decrease local heating dispersion for a given applied magnetic field amplitude.

Characteristics of a magnetic fluid heat transport device Part 1: Numerical simulation of flow and heat transport phenomena

2000 ◽  
Vol 214 (4) ◽  
pp. 549-561 ◽  
Author(s):  
H Yamaguchi ◽  
I Kobori ◽  
N Kobayashi
Keyword(s):  
Magnetic Field ◽  
Numerical Analysis ◽  
Heat Transport ◽  
Magnetic Fluid ◽  
Numerical Study ◽  
Thermal Characteristics ◽  
Geometrical Model ◽  
Flow State ◽  
Vortex Zone ◽  
Transport Device

A numerical analysis is conducted in order to study the flow state and thermal characteristics of a magnetic fluid heat transport device. A simple geometrical model of the device is considered in the present numerical study. The highly simplified marker-and-cell (HSMAC) method is adopted for the numerical analysis, where the transient solutions are obtained in the two-dimensional axisymmetric computational plane. From results of the numerical calculation it can be shown that the vortex zone appears when a magnetic field is applied and the configuration of flow associated with the vortex zone changes for variation in the magnetic field, increasing or decreasing the heat transport capability dependent upon the conditions of the device.

scholarly journals Assessing the hyperthermic properties of magnetic heterostructures: the case of gold–iron oxide composites

2016 ◽  
Vol 6 (6) ◽  
pp. 20160058 ◽  
Author(s):  
Elvira Fantechi ◽  
Paula M. Castillo ◽  
Erika Conca ◽  
Francesca Cugia ◽  
Claudio Sangregorio ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Magnetic Fluid ◽  
Potassium Citrate ◽  
Alternating Magnetic Field ◽  
X Ray Diffraction ◽  
Experimental Conditions ◽  
Magnetic Fluid Hyperthermia ◽  
Transmission Electron ◽  
Oxide Composites

Gold–iron oxide composites were obtained by in situ reduction of an Au(III) precursor by an organic reductant (either potassium citrate or tiopronin) in a dispersion of preformed iron oxide ultrasmall magnetic (USM) nanoparticles. X-ray diffraction, transmission electron microscopy, chemical analysis and mid-infrared spectroscopy show the successful deposition of gold domains on the preformed magnetic nanoparticles, and the occurrence of either citrate or tiopronin as surface coating. The potential of the USM@Au nanoheterostructures as heat mediators for therapy through magnetic fluid hyperthermia was determined by calorimetric measurements under sample irradiation by an alternating magnetic field with intensity and frequency within the safe values for biomedical use. The USM@Au composites showed to be active heat mediators for magnetic fluid hyperthermia, leading to a rapid increase in temperature under exposure to an alternating magnetic field even under the very mild experimental conditions adopted, and their potential was assessed by determining their specific absorption rate (SAR) and compared with the pure iron oxide nanoparticles. Calorimetric investigation of the synthesized nanostructures enabled us to point out the effect of different experimental conditions on the SAR value, which is to date the parameter used for the assessment of the hyperthermic efficiency.

Magnetic Field Synthesis in the Design of Inductors for Magnetic Fluid Hyperthermia

2010 ◽  
Vol 46 (8) ◽  
pp. 2931-2934 ◽  
Author(s):  
Paolo Di Barba ◽  
Fabrizio Dughiero ◽  
Elisabetta Sieni
Keyword(s):  
Magnetic Field ◽  
Magnetic Fluid ◽  
Magnetic Fluid Hyperthermia

scholarly journals Numerical Model for Magnetic Fluid Hyperthermia in a Realistic Breast Phantom: Calorimetric Calibration and Treatment Planning

2019 ◽  
Vol 20 (18) ◽  
pp. 4644 ◽  
Author(s):  
Arkadiusz Miaskowski ◽  
Mahendran Subramanian
Keyword(s):  
Magnetic Field ◽  
Treatment Planning ◽  
Magnetic Fluid ◽  
Heat Dissipation ◽  
Current Effect ◽  
Magnetic Fluid Hyperthermia ◽  
Safety Issues ◽  
Tissue Interactions ◽  
Eddy Current Effect ◽  
The Magnetic Field

This paper aims to apply a proposed, based on calorimetric measurements, a reliable numerical model for magnetic fluid hyperthermia (MFH) treatment planning of breast cancer. Furthermore, we perform a comparative analysis of magnetic nanoparticles (MNPs) and tumour tissue interactions by means of the magnetic-field-dependent Néel and Brownian relaxation times. The analysis was based on an anatomically correct breast model (developed in-house) and a modified linear response theory, which was applied to investigate the heat dissipation from the magnetic nanoparticles dispersed in the breast tumour. The calculations of the single-domain magnetic power losses were conducted for a case where the magnetic field value and the applied frequency were known, but also for the different concentrations of the MNPs in the tumour. Two scenarios were considered: The MNPs mobilised and immobilised in the tumour. In parallel, the eddy currents effect, together with the related temperature distributions, were considered in order to analyse safety issues. By changing the MNP concentration in the tumour, the corresponding temperature distributions were calculated. The eddy current effect, together with the related temperature distribution, were considered in order to analyse safety issues. Varying the MNP concentration in the tumour, the corresponding temperature distribution was calculated. Moreover, the cumulative equivalent minutes at 43   ℃ were analysed. In the anatomically correct breast phantoms, the tissue location can lead to “hot spots” due to the eddy current effect and subsequently to the high gradients of the temperature. That is why the analysis of safety issues related to the overheating side effect should be taken into consideration during the treatment planning of magnetic fluid hyperthermia. The phenomenon of heat dissipation from MNPs is very sophisticated and depends on their concentration, the distribution and the relaxation mechanism in the tumour, together with magnetic field strength and frequency. Furthermore, we inferred that the phenomenon of heat dissipation from MNPs equally depends on MNP-tissue interactions, and it can lead to 30% differences in the power assessment. Nevertheless, the aforementioned factors should be considered in parallel using anatomical, volume-dependent models to enhance the efficiency of in vivo treatment.

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