Changes in plasma levels of ghrelin, leptin, and other hormonal and metabolic parameters following standardized breakfast, lunch, and physical exercise before and after a multidisciplinary weight-reduction intervention in obese adolescents

AbstractLifestyle changes are important factors for managing dyslipidemia before considering blood lipid-lowering drugs. However, genetic factors can influence the response outcome.We aimed to determine a dyslipidemia management strategy in obese adolescents.: A total of 60 dyslipidemic obese adolescents received physical exercise and the NCEP step II diet for 28 days. Apolipoprotein E (apo E) genotypes and blood lipid levels were compared before and after interventions.The apoApo E alleles might influence improvement in lipid profiles after diet and exercise interventions. These results could inform personalized dyslipidemia management in obese adolescents, to determine which subjects would benefit from blood lipid-lowering drugs.

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Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in major depression

European Psychiatry ◽

10.1016/s0924-9338(11)72609-8 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 904-904

Author(s):

F.D. Garcia ◽

Q. Coquerel ◽

E. Kiive ◽

P. Déchelotte ◽

J. Harro ◽

...

Keyword(s):

Major Depression ◽

Physical Exercise ◽

Plasma Levels ◽

Plasma Cortisol ◽

Cortisol Response ◽

Cortisol Secretion ◽

Mild Depression ◽

Moderate Depression ◽

Before And After ◽

Underlying Mechanisms

IntroductionAbnormal vasopressin (VP) and oxytocin (OT) signaling may contribute to the altered activity of the hypothalamo-pituitary-adrenal (HPA) axis in major depression; the underlying mechanisms remain uncertain.ObjectiveThis study characterized plasma levels and affinities of OT-and VP-reactive autoantibodies (autoAbs) with relation to disease severity and plasma cortisol response to physical exercise in patients with mild and moderate depression and healthy controls.MethodsPhysical exercise was used to elicit plasma cortisol response in 23 male depressive and 20 healthy subjects. All subjects were evaluated by the MADRS. Plasma levels VP-and OT-reactive IgG, IgA and IgM autoAbs were measured by ELISA, before and after the exercise, and affinity was measured by plasmon resonance.ResultsPlasma levels of OT-and VP-reactive total IgG autoAbs were lower in patients with moderate depression vs. controls and patients with mild depression. Both OT- and VP- free IgG autoAbs levels were negatively correlated with MADRS scores. Affinity values displayed 100 fold variability in both groups. Patients with moderate depression displayed blunted response of cortisol secretion to physical exercise. Baseline levels of VP total IgG and IgM autoAbs correlated negatively and of VP free IgG autoAbs correlated positively with plasma cortisol after physical exercise.ConclusionThese data show that changes of levels but not affinity of OT- and VP- reactive autoantibodies can be associated with the altered mood in subjects with moderate depression and that levels of VP-reactive autoAbs are associated with cortisol secretion.

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Impact of Smoking, Physical Training and Weight Reduction on FVII, PAM and Hemostatic Markers in Sedentary Men

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647350 ◽

1990 ◽

Vol 64 (04) ◽

pp. 516-520 ◽

Cited By ~ 38

Author(s):

Jean-Christophe Gris ◽

Jean-François Schved ◽

Olivier Feugeas ◽

Patricia Aguilar-Martinez ◽

Anne Arnaud ◽

...

Keyword(s):

Smoking Cessation ◽

Physical Exercise ◽

Training Program ◽

Physical Training ◽

Weight Reduction ◽

Plasma Levels ◽

Fibrinopeptide A ◽

Hemostatic Markers ◽

Exercise Induced ◽

Pai 1

SummaryThe variations of FVII, PAI-1, TAT complexes, fibrinopeptide A, D-Dimers and beta thromboglobulin plasma levels were studied on 30 sedentary men, smokers and non-smokers, who were admitted to a 6 months’ program of physical training and smoking cessation. After 3 months of intervention, sustained physical training was associated with the decrease of FVII and PAI-1 levels. Mild exercise performed during a second 3-month period could maintain normal FVII and PAI-1 activities but participants who stopped the training increased their FVII and PAI-1 plasma levels. FVII was not influenced by smoking habits. Smoking cessation seemed to slightly potentiate the decrease of PAI-1 levels associated with mild exercise. Overweight, FVII and PAI-1 levels were correlated and the weight reduction induced by training was related to the changes in the factors. In smokers, physical exercise was associated with a significant increase of hemostatic markers. This exercise-induced variation disappeared after 3 months of intervention in participants who stopped smoking and reappeared in those who smoked again after 6 months of intervention. This finding was not influenced by the physical training program.

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Prevalence of Thyroid Dysfunction in Obese Children and Adolescents before and after Weight Reduction and Its Relation to Other Metabolic Parameters

Hormone Research ◽

10.1159/000197872 ◽

2009 ◽

Vol 71 (3) ◽

pp. 155-161 ◽

Cited By ~ 48

Author(s):

S. Shalitin ◽

M. Yackobovitch-Gavan ◽

M. Phillip

Keyword(s):

Children And Adolescents ◽

Weight Reduction ◽

Thyroid Dysfunction ◽

Metabolic Parameters ◽

Obese Children ◽

Before And After

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Weekly Exercise Consistently Reinstates Positive Mood

European Psychologist ◽

10.1027/1016-9040.3.4.271 ◽

1998 ◽

Vol 3 (4) ◽

pp. 271-280 ◽

Cited By ~ 12

Author(s):

Hannah Steinberg ◽

Briony R. Nicholls ◽

Elizabeth A. Sykes ◽

N. LeBoutillier ◽

Nerina Ramlakhan ◽

...

Keyword(s):

Physical Exercise ◽

Negative Mood ◽

Real Life ◽

Positive Mood ◽

Field Investigation ◽

Single Bout ◽

Before And After ◽

Exercise Class ◽

Negative Feelings ◽

Over Time

Mood improvement immediately after a single bout of exercise is well documented, but less is known about successive and longer term effects. In a “real-life” field investigation, four kinds of exercise class (Beginners, Advanced, Body Funk and Callanetics) met once a week for up to 7 weeks. Before and after each class the members assessed how they felt by completing a questionnaire listing equal numbers of “positive” and “negative” mood words. Subjects who had attended at least five times were included in the analysis, which led to groups consisting of 18, 20, 16, and 16 subjects, respectively. All four kinds of exercise significantly increased positive and decreased negative feelings, and this result was surprisingly consistent in successive weeks. However, exercise seemed to have a much greater effect on positive than on negative moods. The favorable moods induced by each class seemed to have worn off by the following week, to be reinstated by the class itself. In the Callanetics class, positive mood also improved significantly over time. The Callanetics class involved “slower,” more demanding exercises, not always done to music. The Callanetics and Advanced classes also showed significantly greater preexercise negative moods in the first three sessions. However, these differences disappeared following exercise. Possibly, these two groups had become more “tolerant” to the mood-enhancing effects of physical exercise; this may be in part have been due to “exercise addiction.”

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Effect of Adherence to Physical Exercise on Cardiometabolic Profile in Postmenopausal Women

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18020656 ◽

2021 ◽

Vol 18 (2) ◽

pp. 656

Author(s):

Valentina Bucciarelli ◽

Francesco Bianco ◽

Francesco Mucedola ◽

Andrea Di Blasio ◽

Pascal Izzicupo ◽

...

Keyword(s):

Physical Exercise ◽

Diastolic Function ◽

Postmenopausal Women ◽

Serum Glucose ◽

Moderate Intensity ◽

Adherence Rate ◽

Before And After ◽

Estrogen Depletion ◽

The Impact ◽

Cardiometabolic Profile

Background: Menopause is associated with negative cardiovascular adaptations related to estrogen depletion, which could be counteracted by physical exercise (PhE). However, the impact of total adherence-rate (TA) to PhE and sedentary time (SedT) on cardiometabolic profile in this population has not been elucidated. Methods: For 13-weeks, 43 women (57.1 ± 4.7 years) participated in a 4-days-a-week moderate-intensity walking training. They underwent laboratory, anthropometric and echocardiographic assessment, before and after training (T0–T1). Spontaneous physical activity (PhA) was assessed with a portable multisensory device. The sample was divided according to TA to PhE program: <70% (n = 17) and ≥70% (n = 26). Results: TA ≥ 70% group experienced a significant T1 improvement of relative wall thickness (RWT), diastolic function, VO2max, cortisol, cortisol/dehydroandrostenedione-sulphate ratio and serum glucose. After adjusting for SedT and 10-min bouts of spontaneous moderate-to-vigorous PhA, TA ≥ 70% showed the most significant absolute change of RWT and diastolic function, body mass index, weight and cortisol. TA ≥ 70% was major predictor of RWT and cortisol improvement. Conclusions: In a group of untrained, postmenopausal women, a high TA to a 13-weeks aerobic PhE program confers a better improvement in cardiometabolic profile, regardless of SedT and PhA levels.

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Weight-Reduction Optimization Design for Milling Planer Bed Based on Finite Element Analysis

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.490-495.2785 ◽

2012 ◽

Vol 490-495 ◽

pp. 2785-2789

Author(s):

Dong Sun ◽

Xu Dong Yang

Keyword(s):

Finite Element Analysis ◽

Finite Element ◽

Weight Reduction ◽

Optimization Design ◽

Weak Link ◽

Three Dimensional ◽

Production Costs ◽

Element Analysis ◽

Before And After ◽

Improvement Scheme

The milling planer bed is one of the most important foundational parts for the entire machine, sufficient stiffness is required. The posterior segment of a certain milling planer bed is regarded as the optimization object in this paper. Three-dimensional modeling method is used to calculate the exact weight of the bed and then finite element analysis is used to research the static and dynamic characteristics before and after weight-reduction. The weak link of the bed is found out and a improvement scheme is put forward ensuring lower production costs under the premise of sufficient rigidity.

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SECRETION OF DIHYDROTESTOSTERONE BY HUMAN PROSTATE IN BENIGN PROSTATIC HYPERTROPHY

Acta Endocrinologica ◽

10.1530/acta.0.0770401 ◽

1974 ◽

Vol 77 (2) ◽

pp. 401-407 ◽

Cited By ~ 18

Author(s):

J. A. Mahoudeau ◽

A. Delassalle ◽

H. Bricaire

Keyword(s):

Plasma Levels ◽

Benign Prostatic Hypertrophy ◽

Prostatic Hypertrophy ◽

Human Prostate ◽

Control Subjects ◽

Peripheral Plasma ◽

Significant Difference ◽

Before And After ◽

The Mean ◽

And Control

ABSTRACT Plasma levels of testosterone (T) and 5α-dihydrotestosterone (DHT) were determined by radioimmunoassay in 29 patients with benign prostatic hypertrophy (BPH) and in 56 control men of various ages. No significant difference was found in T, DHT nor DHT/T ratio between BPH and control subjects of similar age. Plasma DHT was higher in the prostatic than in the peripheral veins in 8/9 patients with BPH during laparotomy, indicating a prostatic secretion of DHT. No difference in the mean T nor the mean DHT was found in peripheral plasma before and after adenomectomy.

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Acute cold stress in rheumatoid arthritis inadequately activates stress responses and induces an increase of interleukin 6

Annals of the Rheumatic Diseases ◽

10.1136/ard.2008.089458 ◽

2008 ◽

Vol 68 (4) ◽

pp. 572-578 ◽

Cited By ~ 16

Author(s):

R H Straub ◽

G Pongratz ◽

H Hirvonen ◽

T Pohjolainen ◽

M Mikkelsson ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Stress Response ◽

Cold Stress ◽

Stress Responses ◽

Plasma Levels ◽

Acute Stress ◽

Whole Body ◽

Cold Therapy ◽

Before And After ◽

Sympathetic Stress

Objective:Acute stress in patients with rheumatoid arthritis (RA) should stimulate a strong stress response. After cryotherapy, we expected to observe an increase of hormones of the adrenal gland and the sympathetic nervous system.Methods:A total of 55 patients with RA were recruited for whole-body cryotherapy at −110°C and −60°C, and local cold therapy between −20°C and −30°C for 7 days. We measured plasma levels of steroid hormones, neuropeptide Y (sympathetic marker), and interleukin (IL)6 daily before and after cryotherapy.Results:In both therapy groups with/without glucocorticoids (GC), hormone and IL6 levels at baseline and 5 h after cold stress did not change over 7 days of cryotherapy. In patients without GC, plasma levels of cortisol and androstenedione were highest after −110°C cold stress followed by −60°C or local cold stress. The opposite was found in patients under GC therapy, in whom, unexpectedly, −110°C cold stress elicited the smallest responses. In patients without GC, adrenal cortisol production increased relative to other adrenal steroids, and again the opposite was seen under GC therapy with a loss of cortisol and an increase of dehydroepiandrosterone. Importantly, there was no sympathetic stress response in both groups. Patients without GC and −110°C cold stress demonstrated higher plasma IL6 compared to the other treatment groups (not observed under GC), but they showed the best clinical response.Conclusions:We detected an inadequate stress response in patients with GC. It is further shown that the sympathetic stress response was inadequate in patients with/without GC. Paradoxically, plasma levels of IL6 increased under strong cold stress in patients without GC. These findings confirm dysfunctional stress axes in RA.

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