277 RELATIONSHIP BETWEEN ACCELEROMETER-BASED MEASURES OF PHYSICAL ACTIVITY AND MEASURES OF FUNCTION AND SELF-REPORTED ACTIVITY IN ADULTS WITH KNEE OSTEOARTHRITIS: A PILOT STUDY FROM THE OSTEOARTHRITIS INITIATIVE

AbstractKnee osteoarthritis (OA) is a leading cause of chronic disability worldwide, but no diagnostic or prognostic biomarkers are available. Increasing evidence supports epigenetic dysregulation as a contributor to OA pathogenesis. In this pilot study, we investigated epigenetic patterns in peripheral blood mononuclear cells (PBMCs) as models to predict future radiographic progression in OA patients enrolled in the longitudinal Osteoarthritis Initiative (OAI) study. PBMC DNA was analyzed from baseline OAI visits in 58 future radiographic progressors (joint space narrowing at 24 months, sustained at 48 months) compared to 58 non-progressors. DNA methylation was quantified via Illumina microarrays and beta- and M-values were used to generate linear classification models. Data were randomly split into a 60% development and 40% validation subsets, models developed and tested, and cross-validated in a total of 40 cycles. M-value based models outperformed beta-value based models (ROC-AUC 0.81 ± 0.01 vs. 0.73 ± 0.02, mean ± SEM, comparison p = 0.002), with a mean classification accuracy of 73 ± 1% (mean ± SEM) for M- and 69 ± 1% for beta-based models. Adjusting for covariates did not significantly alter model performance. Our findings suggest that PBMC DNA methylation-based models may be useful as biomarkers of OA progression and warrant additional evaluation in larger patient cohorts.

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Linking physical activity with knee osteoarthritis outcomes: an evidence map using the osteoarthritis initiative

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2021.02.087 ◽

2021 ◽

Vol 29 ◽

pp. S60-S61

Author(s):

A.R. Budarick ◽

R.F. Moyer

Keyword(s):

Physical Activity ◽

Knee Osteoarthritis ◽

Evidence Map ◽

Osteoarthritis Initiative

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Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative

Frontiers in Medicine ◽

10.3389/fmed.2021.781219 ◽

2021 ◽

Vol 8 ◽

Author(s):

Mingyang Li ◽

Yong Nie ◽

Yi Zeng ◽

Yuangang Wu ◽

Yuan Liu ◽

...

Keyword(s):

Physical Activity ◽

Knee Osteoarthritis ◽

Subchondral Bone ◽

Volume Fraction ◽

Short Form ◽

Activity Level ◽

Mineral Density ◽

Trabecular Thickness ◽

Significant Difference ◽

Osteoarthritis Initiative

Bisphosphonate has great potential in KOA therapy, but whether the anti-resorption mechanism of bisphosphonate aggravates sclerosis of subchondral bone remains unclear. We found that bisphosphonate use did not increase sclerosis of subchondral bone in established KOA, perhaps resolving some concerns about bisphosphonate in patients with KOA.Introduction: Most studies have focused on the protective effect of bisphosphonate on early knee osteoarthritis (KOA) through its anti-resorption mechanism in osteoclasts. However, late KOA has a decreased rate of resorption, which is the opposite of early KOA. The risk of subchondral bone sclerosis in late KOA after using bisphosphonate has not been investigated using morphometry.Methods: Forty-five patients who had ever used bisphosphonate (or 33 patients with current use) were matched with controls through propensity matching methods, including age, body mass index (BMI), sex, health status (12-Item Short Form Survey physical health score), physical activity level (Physical Activity Scale for the Elderly score), vitamin D use, and calcium use. At the baseline and 12-month (or 18-month) follow-up, bone mineral density (BMD) of the tibia and hip was measured by dual-energy X-ray absorptiometry (DXA), and medial tibial subchondral bone morphometry: bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) were calculated based on 3-T trabecular MRI. Data were obtained from the Bone Ancillary Study in the Osteoarthritis Initiative (OAI) project.Results: The yearly percentage change in hip BMD of the current bisphosphonate-use group was significantly greater than that of the non-bisphosphonate-use group (0.7% vs. −1%, P = 0.02). The other outcomes (BV/TV, Tb.N, Tb.Sp, Tb.Th, tibia medial BMD, and tibia lateral BMD) between the two groups presented no significant difference. The non-bisphosphonate-use group experienced a significant increase in Tb.Th [2%, 95% CI = (1%, 4%), P = 0.01], while the bisphosphonate-use group presented no significant change [1%, 95% CI = (−2%, 4%), P = 0.54].Conclusions: Bisphosphonate use did not increase sclerosis of subchondral bone in established KOA. Bisphosphonate might have a stage-dependent effect on subchondral bone in KOA initiation and progression.

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Moderate Physical Activity and Prevention of Cartilage Loss in People With Knee Osteoarthritis: Data From the Osteoarthritis Initiative

Arthritis Care & Research ◽

10.1002/acr.23791 ◽

2019 ◽

Vol 71 (2) ◽

pp. 218-226 ◽

Cited By ~ 2

Author(s):

Alessio Bricca ◽

Wolfgang Wirth ◽

Carsten B. Juhl ◽

Jana Kemnitz ◽

David J. Hunter ◽

...

Keyword(s):

Physical Activity ◽

Knee Osteoarthritis ◽

Cartilage Loss ◽

Moderate Physical Activity ◽

Osteoarthritis Initiative

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Assessing physical activity in persons with knee osteoarthritis using accelerometers: Data from the osteoarthritis initiative

Arthritis Care & Research ◽

10.1002/acr.20305 ◽

2010 ◽

Vol 62 (12) ◽

pp. 1724-1732 ◽

Cited By ~ 70

Author(s):

Jing Song ◽

Pamela Semanik ◽

Leena Sharma ◽

Rowland W. Chang ◽

Marc C. Hochberg ◽

...

Keyword(s):

Physical Activity ◽

Knee Osteoarthritis ◽

Osteoarthritis Initiative

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Self-Referent Thoughts in Exercise: The Self-Perception in Exercise Questionnaire

European Journal of Psychological Assessment ◽

10.1027/1015-5759.13.3.195 ◽

1997 ◽

Vol 13 (3) ◽

pp. 195-205 ◽

Cited By ~ 2

Author(s):

Marit Sorensen

Keyword(s):

Physical Activity ◽

Pilot Study ◽

Physical Activity Level ◽

Convergent Validity ◽

English Language ◽

Lifestyle Changes ◽

Activity Level ◽

Language Version ◽

Social Comfort ◽

And Gender

Adherence to lifestyle changes - beginning to exercise, for example - is assumed to be mediated by self-referent thoughts. This paper describes a pilot study and three studies conducted to develop and validate a questionnaire for adults to determine their self-perceptions related to health-oriented exercise. The pilot study identified items pertinent to the domains considered important in this context, and began the process of selecting items. Study 2 examined the factor structure, reduced the number of items, determined the internal consistency of the factors, and explored the discriminative validity of the questionnaire as to physical activity level and gender. Four factors with a total of 24 items were accepted, measuring mastery of exercise, body perception, social comfort/discomfort in the exercise setting, and perception of fitness. All subscales had acceptable internal consistencies. Preliminary validity was demonstrated by confirming hypothesized differences in scores as to gender, age, and physical activity level. The third study examined and demonstrated convergent validity with similar existing subscales. The fourth study examined an English-language version of the questionnaire, confirming the existence of the factors and providing preliminary psychometric evidence of the viability of the questionnaire.

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