A comment on the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine consensus of the polycystic ovarian syndrome

Magnetic resonance imaging (MRI), due to its optimal delineation of anatomy, has become the mainstay in imaging for diagnosing Müllerian duct anomalies (MDA). Pelvic MRI is requested for various conditions such as primary amenorrhoea, infertility or poor obstetric history with regard to MDA, as identifying the exact aetiology for these conditions is vital. Knowledge regarding the classification of MDA is important, as the treatment varies with respect to the different classes. As all the lesions do not fit within the classification of the American Society for Reproductive Medicine, a new anatomy-based classification was established by the European Society of Human Reproduction and Embryology and the European Society for Gynecological Endoscopy, to fulfil the needs of experts. We aim to discuss various classes of classified and unclassified MDA with regard to both the above-mentioned classifications and illustrate some of them using various cases based on pelvic MRI studies.

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Influence of body mass index in anti-Müllerian hormone levels in 951 non-polycystic ovarian syndrome women followed at a reproductive medicine unit

Endocrine ◽

10.1007/s12020-018-1555-y ◽

2018 ◽

Vol 61 (1) ◽

pp. 144-148 ◽

Cited By ~ 10

Author(s):

Joana Simões-Pereira ◽

Joaquim Nunes ◽

Ana Aguiar ◽

Sandra Sousa ◽

Cátia Rodrigues ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Reproductive Medicine ◽

Polycystic Ovarian Syndrome ◽

Hormone Levels ◽

Ovarian Syndrome

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SUN-LB1 Atypical Presentation Of Myocardial Infarction In A Young Patient With Polycystic Ovarian Syndrome

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.2004 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Shobha Mandal ◽

Ravi Ranjan Pradhan ◽

Mariam Avetisova ◽

Barbara Lidia Mols Kowalczewski

Keyword(s):

Myocardial Infarction ◽

Back Pain ◽

Polycystic Ovarian Syndrome ◽

Disease Risk ◽

Meta Analysis ◽

Cardiovascular Disease Risk ◽

Left Ventricular ◽

Human Reproduction ◽

Childbearing Age ◽

Ovarian Syndrome

Abstract Background: Polycystic ovarian syndrome (PCOS) is a very common and complex endocrine problem in women of childbearing age, with a prevalence of 4 to 12% globally. Myocardial infarction (MI) is the leading cause of death in women worldwide. PCOS increases the risk of MI because of chronic inflammation, endothelial dysfunction, impaired pulse wave velocity and its association with metabolic syndrome, and hormonal imbalance. Clinical Case: A 36-year-old female with a history of PCOS, hirsutism, severe acne on spironolactone, presented to ER with a chief complaint of lower back pain for 10 days that started after lifting a 60-pounds printer. The pain was attributed to musculoskeletal type, one dose of ketorolac intramuscularly was given and she was discharged on cyclobenzaprine. The next morning, she presented with worsening back pain and new-onset vomiting. Physical exam was normal except for BMI 34.6kg/m2; vitals were stable. Lab work showed elevated troponin of 1.43 which rose to 10.6 ng/ml (normal 0.00-0.034), cholesterol 125 mg/dL (less than 200), HDL 33 mg/dL (normal 40-59), LDL 164 mg/dL (normal 100-129). Electrocardiogram showed sinus tachycardia with Q wave changes in leads III and V1 to V3. Echocardiogram showed hypokinesia of left ventricular wall in the mid to apical anterior septum. Computed tomography (CT) scan of the thoracic spine was negative for abscess or fracture. CT of abdomen and pelvis as well as CT angiography chest were negative. Urine drug screening was also negative. As her presentation was attributed to MI, patient was started on heparin drip, aspirin, atorvastatin, and metoprolol. She underwent cardiac catheterization that showed 99% ostial left anterior descending artery stenosis; a drug-eluting stent was successfully placed. After intervention her back pain resolved. She was discharged on dual antiplatelet therapy (aspirin and Prasugrel) along with atorvastatin, metoprolol and nitroglycerin. Conclusion: This case suggests an association of PCOS with MI. A meta-analysis has shown a two-fold increase in risk of coronary artery disease in patients with PCOS (1). Future studies are need to examine opportunities for cardiovascular disease risk reduction in PCOS patients. Reference:1. de Groot PCM, Dekkers OM, Romijn JA, Dieben SWM, Helmerhorst FM. PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis. Human Reproduction Update 2011. 17 495-500.

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Polycystic Ovary Syndrome in Teenage and Young Women

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v37i2.40564 ◽

2019 ◽

Vol 37 (2) ◽

pp. 78-82

Author(s):

Kamrun Nahar

Keyword(s):

Polycystic Ovary Syndrome ◽

Young Women ◽

Reproductive Medicine ◽

Polycystic Ovary ◽

Human Reproduction ◽

Ovulatory Cycle ◽

Ovarian Dysfunction ◽

Ovary Syndrome ◽

Metabolic Derangement ◽

American Society

Polycystic ovary syndrome (PCOS) is an inherent ovarian dysfunction. It is a common health problem that can affect teen girls and young women. PCOS is characterized by hyperandrogenism, irregular ovulatory cycle and metabolic derangement , including glucose intolerance and hyperinsulinaemia. Hyperandrogenism is a clinical hallmark of PCOS. Hypersecretion of androgen by the stromal theca cell of polycystic ovary is cardinal clinical manifestation. Though the exact cause of PCOS is not known , the syndrome can result from disturbance in the hypothalamo pituitary ovarian axis and hyperinsulinaemia. Several definitions have been produced to describe the disease. European society of human reproduction and embryology and the American society for reproductive medicine in 2004 define PCOS as manifestation of two of the following three J Bangladesh Coll Phys Surg 2019; 37(2): 78-82

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Publication bias in reproductive medicine: from the European Society of Human Reproduction and Embryology annual meeting to publication

Human Reproduction ◽

10.1093/humrep/der044 ◽

2011 ◽

Vol 26 (6) ◽

pp. 1371-1376 ◽

Cited By ~ 10

Author(s):

Nikolaos P. Polyzos ◽

Antonis Valachis ◽

Evangelos Patavoukas ◽

Evangelos G. Papanikolaou ◽

Ioannis E. Messinis ◽

...

Keyword(s):

Annual Meeting ◽

Publication Bias ◽

European Society ◽

Reproductive Medicine ◽

Human Reproduction

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Treatment of endometriosis: a review with comparison of 8 guidelines

BMC Women s Health ◽

10.1186/s12905-021-01545-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Dimitrios Rafail Kalaitzopoulos ◽

Nicolas Samartzis ◽

Georgios N. Kolovos ◽

Evangelia Mareti ◽

Eleftherios Pierre Samartzis ◽

...

Keyword(s):

Oral Contraceptive ◽

Reproductive Medicine ◽

Oral Contraceptive Pill ◽

Reproductive Age ◽

Human Reproduction ◽

Women Of Reproductive Age ◽

Combined Oral Contraceptive ◽

Associated Symptoms ◽

Third Line ◽

American Society

Abstract Background Endometriosis, the presence of endometrial-like tissue outside the uterus, is a common clinical entity between women of reproductive age, with a prevalence of about 10%. Due to the variety of endometriosis-associated symptoms, a great variety of treatments have been implemented. The aim of this review is to give an overview on therapeutical approaches of eight national and international widely used guidelines. Methods Six national (College National des Gynecologues et Obstetriciens Francais, National German Guideline (S2k), Society of Obstetricians and Gynaecologists of Canada, American College of Obstetricians (ACOG) and Gynecologists, American Society for Reproductive Medicine (ASRM) and National Institute for Health and Care (NICE) and two international (World Endometriosis Society, European Society of Human Reproduction and Embryology) guidelines are included in this review. Conclusion All the above-mentioned guidelines agree that the combined oral contraceptive pill, progestogens are therapies recommended for endometriosis associated pain. Concerning infertility, there is no clear consensus about surgical treatment. Discrepancies are also found on recommendation of the second- and third-line treatments.

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Diagnostic and treatment of endometriosis - recommendations for clinical practice

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh160404019s ◽

2017 ◽

Vol 145 (1-2) ◽

pp. 89-94 ◽

Cited By ~ 1

Author(s):

Svetlana Spremovic-Radjenovic ◽

Jovan Bila ◽

Snezana Vidakovic ◽

Nebojsa Radunovic

Keyword(s):

Social Life ◽

Reproductive Medicine ◽

Imaging Techniques ◽

Human Reproduction ◽

Pelvic Cavity ◽

Therapeutic Modalities ◽

Chronic Inflammatory Reaction ◽

American Society ◽

The Impact ◽

Life Work

Endometriosis is characterized by endometrial tissue found outside of the uterus (primarily in the pelvic cavity), causing chronic inflammatory reaction, infertility, and pain. The impact of endometriosis on different aspects of women?s life is important, including family and social life, work, and reproduction. The usual way of examining endometriosis is history taking, recognition of typical symptoms, clinical examination, and the use of imaging techniques, but the diagnosis is made by histopathology findings, usually after laparoscopy. The aim is to represent current recommendations and guidelines referring to endometriosis diagnostics and therapy, proposed by two major societies dealing with reproductive medicine: European Society for Human Reproduction and Embryology (ESHRE) and American Society of Reproductive Medicine (ASRM). The recommendations refer primarily to the therapeutic modalities in infertility and pain problems caused by endometriosis, and represent the basis of appropriate strategy for overcoming numerous problems linked with this chronic illness.

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The impact of mild hypercholesterolemia on glycemic and hormonal profiles, menstrual characteristics and the ovarian morphology of women with polycystic ovarian syndrome

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2018-0002 ◽

2018 ◽

Vol 0 (0) ◽

Cited By ~ 1

Author(s):

Vasilios Pergialiotis ◽

Eftihios Trakakis ◽

Charalampos Chrelias ◽

Nikolaos Papantoniou ◽

Erifili Hatziagelaki

Keyword(s):

Insulin Resistance ◽

Polycystic Ovarian Syndrome ◽

Univariate Analysis ◽

Density Lipoprotein ◽

The Body ◽

Human Reproduction ◽

Model Assessment ◽

Hormonal Profile ◽

The Impact ◽

Ovarian Syndrome

Abstract Background The severity of polycystic ovarian syndrome (PCOS) has been clearly associated with insulin resistance, obesity and metabolic syndrome. The purpose of the present cross-sectional study is to investigate whether mild hypercholesterolemia alters the biochemical and clinical profile of PCOS patients. Methods Our study is based on a prospectively collected population of women of reproductive age who were diagnosed with PCOS according to the definition of the Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ASRM/ESHRE) criteria. For the correlation analysis we used the non-parametric Spearman’s rank correlation coefficient. Partial correlation was also performed to control for potential confounders observed in the univariate analysis. Results Overall, 235 patients were included. Their mean age ranged between 14 and 45 years old and the body mass index (BMI) between 17 and 54. Women with mild hypercholesterolemia had a higher BMI and their fasting insulin was increased as well as indices of insulin resistance [Homeostatic model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI), Matsuda index] compared to women with PCOS with normal cholesterol levels. Correlation statistics suggested that the effect of serum lipids on the hormonal profile of patients was weak. Both low-density lipoprotein (LDL) and high-density lipoprotein (HDL) exerted a significant mild negative correlation to glucose and insulin. However, after controlling the results for BMI and age (the two variables that were found significantly different in the univariate analysis) we observed that this effect was non-significant. Conclusion Mild hypercholesterolemia does not affect the hormonal profile of patients with PCOS; hence, to date, there is no evidence to suggest its treatment for the correction of menstrual and hormonal abnormalities in PCOS women.

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