The impact of mild hypercholesterolemia on glycemic and hormonal profiles, menstrual characteristics and the ovarian morphology of women with polycystic ovarian syndrome

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Vasilios Pergialiotis ◽  
Eftihios Trakakis ◽  
Charalampos Chrelias ◽  
Nikolaos Papantoniou ◽  
Erifili Hatziagelaki
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Univariate Analysis ◽  
Density Lipoprotein ◽  
The Body ◽  
Human Reproduction ◽  
Model Assessment ◽  
Hormonal Profile ◽  
The Impact ◽  
Ovarian Syndrome

Abstract Background The severity of polycystic ovarian syndrome (PCOS) has been clearly associated with insulin resistance, obesity and metabolic syndrome. The purpose of the present cross-sectional study is to investigate whether mild hypercholesterolemia alters the biochemical and clinical profile of PCOS patients. Methods Our study is based on a prospectively collected population of women of reproductive age who were diagnosed with PCOS according to the definition of the Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ASRM/ESHRE) criteria. For the correlation analysis we used the non-parametric Spearman’s rank correlation coefficient. Partial correlation was also performed to control for potential confounders observed in the univariate analysis. Results Overall, 235 patients were included. Their mean age ranged between 14 and 45 years old and the body mass index (BMI) between 17 and 54. Women with mild hypercholesterolemia had a higher BMI and their fasting insulin was increased as well as indices of insulin resistance [Homeostatic model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI), Matsuda index] compared to women with PCOS with normal cholesterol levels. Correlation statistics suggested that the effect of serum lipids on the hormonal profile of patients was weak. Both low-density lipoprotein (LDL) and high-density lipoprotein (HDL) exerted a significant mild negative correlation to glucose and insulin. However, after controlling the results for BMI and age (the two variables that were found significantly different in the univariate analysis) we observed that this effect was non-significant. Conclusion Mild hypercholesterolemia does not affect the hormonal profile of patients with PCOS; hence, to date, there is no evidence to suggest its treatment for the correction of menstrual and hormonal abnormalities in PCOS women.

scholarly journals Insulin Resistance Increases the Risk of Spontaneous Abortion after Assisted Reproduction Technology Treatment

2007 ◽  
Vol 92 (4) ◽  
pp. 1430-1433 ◽  
Author(s):  
Li Tian ◽  
Huan Shen ◽  
Qun Lu ◽  
Robert J. Norman ◽  
Jim Wang
Keyword(s):  
Insulin Resistance ◽  
Spontaneous Abortion ◽  
Polycystic Ovarian Syndrome ◽  
Medical Center ◽  
Infertility Treatment ◽  
Medical Intervention ◽  
Model Assessment ◽  
High Prevalence ◽  
The Impact ◽  
Ovarian Syndrome

Abstract Objective: This study aims to examine the impact of insulin resistance (IR) on the risk of spontaneous abortion in patients who received infertility treatment. Patients and Methods: This is a cohort study of 107 patients who achieved their first pregnancy after infertility treatment in a tertiary medical center. A homeostasis model assessment of IR (HOMA-IR) was carried out. Patient demographic characteristics and pregnancy outcome were also recorded. Statistical comparison was made between patients with and without IR. Logistical regression analysis was used to assess the effect of IR and several other factors simultaneously on the risk of spontaneous abortion. Results: The incidence of spontaneous abortion was 17.8%. The association of IR with the risk of spontaneous abortion was significant after adjusting for other risk factors. The effect of overweight/obesity and polycystic ovarian syndrome was not statistically significant in the multivariate model. Discussion and Conclusion: This study suggested that IR was an independent risk factor for spontaneous abortion. Because of the high prevalence of IR in obese or polycystic ovarian syndrome patients, the risk of spontaneous abortion in these patients can be raised. Patients with IR should be advised to improve their insulin sensitivity through lifestyle change or medical intervention before infertility treatment to reduce their risk of spontaneous abortion.

scholarly journals Phenotypic Variation of Insulin Resistance among Polycystic Ovarian Syndrome Patients in Semiurban North Indian Population

2021 ◽  
Author(s):  
Chaitali Maitra ◽  
Ramesh Chandra Gupta ◽  
Rishika Raj
Keyword(s):  
Insulin Resistance ◽  
Regression Analysis ◽  
Polycystic Ovarian Syndrome ◽  
Specific Treatment ◽  
Reproductive Age ◽  
Model Assessment ◽  
Cross Sectional ◽  
Significant Difference ◽  
Ovarian Syndrome ◽  
Rotterdam Criteria

Introduction: Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder in the women of reproductive age. Studies show that there is an intensive relationship between insulin and gonadal function. As per Rotterdam Criteria, there are four major phenotypes of PCOS with different presentation. Early detection of Insulin Resistance (IR) and consequential prevention of Metabolic Syndrome (MS) associated with PCOS may lead to better prospect for the disease. Aim: To find the pattern of IR in all the phenotypes of PCOS in relation to Waist Hip Ratio (WHR), Body Mass Index (BMI) and Testosterone and thereby, providing data for designing phenotype specific treatment of the disease. Materials and Methods: In this cross-sectional observational study, fasting insulin and fasting glucose were analysed to calculate Homeostasis Model Assessment (HOMA-IR) and Testosterone for total 144 female subjects of reproductive age group (18-40 years). Subjects were classified in to four groups as per Rotterdam Criteria. Complete PCOS (PCO-COM), PCO with Oligo/Anovulation (PCO-O), Anovulation with Hyperandrogenism (O-HA), and PCO with Hyperandrogenism (PCO-HA). Regression analysis was done to find the relation among the study variables. Analysis of Variance (ANOVA) was used to analyse the significant variance among the groups. Results: IR was found to be maximum among O-HA phenotype (2.4±0.37) and lowest among PCO-HA phenotypes (1.3±0.22). Regression analysis shows that there exist significant associations between IR and BMI (t=4.96, p=0.001) as well as between IR and WHR (t=2.97, p=0.003). No independent association between testosterone and IR was observed. Conclusion: Significant difference of IR, WHR, and BMI was observed among the four phenotypes of PCOS. Due to increased IR, O-HA and PCO-COM phenotypes are more predisposed to Cardiometabolic consequences of PCOS.

The impact of insulin resistance and hyperandrogenemia on polysomnographic variables in obese adolescents with polycystic ovarian syndrome

2011 ◽  
Vol 16 (1) ◽  
pp. 169-175 ◽  
Author(s):  
Gideon de Sousa ◽  
Bernhard Schlüter ◽  
Dirk Buschatz ◽  
Thomas Menke ◽  
Eckardt Trowitzsch ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Obese Adolescents ◽  
The Impact ◽  
Ovarian Syndrome

scholarly journals Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats

2021 ◽  
Author(s):  
Muhammad Aliff Haslan ◽  
Nurdiana Samsulrizal ◽  
Nooraain Hashim ◽  
Noor Syaffinaz Noor Mohamad Zin ◽  
Farshad Hosseini Shirazi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Normal Control ◽  
Polycystic Ovarian Syndrome ◽  
Density Lipoprotein ◽  
Female Rats ◽  
Lipoprotein Cholesterol ◽  
Therapeutic Effects ◽  
Ficus Deltoidea ◽  
Ovarian Syndrome

Abstract Background: Insulin resistance and hormonal imbalances are key features in the pathophysiology of polycystic ovarian syndrome (PCOS). We have shown that Ficus deltoidea var. deltoidea Jack (Moraceae) can improve insulin sensitivity and hormonal profile in PCOS female rats. However, biological characteristics underpinning the therapeutic effects of F. deltoidea for treating PCOS remain to be clarified. This study aims to investigate the biochemical, hormonal, and histomorphometric changes in letrozole (LTZ)-induced PCOS female rats following treatment with F. deltoidea.Methods: PCOS was induced in rats except for normal control by administering LTZ at 1 mg/kg/day for 21 days. Methanolic extract of F. deltoidea leaf was then orally administered to the PCOS rats at the dose of 250, 500, or 1000 mg/kg/day, respectively for 15 consecutive days. Lipid profile was measured enzymatically in serum. The circulating concentrations of reproductive hormone and antioxidant enzymes were determined by ELISA assays. Ovarian and uterus histomorphometric changes were further observed by hematoxylin and eosin (H&E) staining.Results: The results showed that treatment with F. deltoidea at the dose of 500 and 1000 mg/kg/day reduced insulin resistance, obesity indices, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), malondialdehyde (MDA), testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) to near-normal levels in PCOS rats. The levels of high-density lipoprotein cholesterol (HDL), estrogen, and superoxide dismutase (SOD) also similar to those observed in normal control rats. Histomorphometric measurements confirmed that F. deltoidea increased the corpus luteum number and the endometrial thickness.Conclusions: F. deltoidea can reverse PCOS symptoms in female rats by improving insulin sensitivity, antioxidant activities, hormonal imbalance, and histological changes. These findings suggest the potential use of F. deltoidea as an adjuvant agent in the treatment program of PCOS.

scholarly journals Study of Serum Chemerin in Patients of Polycystic Ovarian Syndrome and its Relation to Insulin Resistance

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M R Halawa ◽  
R S Abdelbaky ◽  
Y M Eid ◽  
M S Nasr ◽  
L M Hendawy ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Polycystic Ovarian Syndrome ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Total Testosterone ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Obese Women ◽  
Ovarian Syndrome

Abstract Background study of chemerin level in polycystic ovarian syndrome (PCO) patients and its relation to insulin resistance (IR). Upon chemerin on adipose tissue and glucose metabolism, serum chemerin has been recently studied in (PCO) women Aim We aimed to study the level of serum chemerin in PCO patients and its relation to insulin resistance. Methods The current study included 45 subjects with PCO syndrome and 45 healthy subjects as a control group. PCO subjects were divided into 27 obese PCO and 18 lean PCO. Control women were divided into 25 obese women and 20 lean women. Measurement of serum chemerin levels, fasting blood glucose (FBG),fasting insulin (FIN), total testosterone and pelvic ultrasonography Results Serum chemerin was significantly higher in the obese PCOS group (99.65 ± 13.72 ng/mL) compared with lean PCOS (87.99 ± 5,64 ng/mL) and the obese (76.82 ± 2.39 ng/mL) and non-obese (69.19 ± 8.40 ng/mL) control groups. In PCOS women, serum chemerin levels were positively correlated with Body mass index (BMI) (r = 0.835, P < 0.001), Fasting blood glucose (FBG) (r = 0.493, P < 0.005), Fasting insulin (FIN) (r = 0.913, P < 0.001), Homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.9181, P < 0.001). Conclusion There is an increase in serum chemerin level in PCOS patients with even more significant increase in patients with obese PCOS.

scholarly journals Randomized double blind clinical trial evaluating the Ellagic acid effects on insulin resistance, oxidative stress and sex hormones levels in women with polycystic ovarian syndrome

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Mahnaz Kazemi ◽  
Fatemeh Lalooha ◽  
Mohammadreza Rashidi Nooshabadi ◽  
Fariba Dashti ◽  
Maria Kavianpour ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Clinical Trial ◽  
Sex Hormones ◽  
Polycystic Ovarian Syndrome ◽  
Density Lipoprotein ◽  
Double Blind ◽  
Tnf Α ◽  
The Mean ◽  
Ovarian Syndrome

Abstract Objective The design of this study was due to the report of the antioxidant properties of Ellagic acid (EA) for its evaluation on the Insulin resistance (IR), oxidative stress and sex hormones levels in women with polycystic ovarian syndrome (PCOS). Methods In this randomized, double-blind, placebo-controlled clinical trial, 60 patients were recruited. Patients were randomly allocated consumed a capsule containing 200 mg of EA per day (n = 30) or placebo (n = 30) for 8 weeks. The fasting blood sugar (FBS), insulin, IR, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), total antioxidant capacity (TAC), Malondialdehyde (MDA), C-reactive protein (CRP), Tumor necrosis factor-alpha (TNF-α), sex hormones and anti-mullerian hormone (AMH) were measured at the beginning and end of the study. Result At the end of the study, the mean of FBS, insulin, IR, TC, TG, LDL, MDA, CRP, TNF-α, total testosterone, prolactin and AMH were significantly decreased in the intervention group compared to the placebo group (P < 0.05). Also, there was a significant increase in the mean of TAC after supplementation with EA (P < 0.05). At the end of the study, no significant changes were observed in the mean of anthropometric factors, physical activity and food intake (P > 0.05). Conclusion EA supplementation can be helpful as a diet supplement in women with PCOS through improvement in insulin resistance. This supplement may be used to reduce metabolic disorders in women. Trial registration This study was retrospectively (07–07-2019) registered in the Iranian website (www.irct.ir) for registration of clinical trials (IRCT20141025019669N12).

scholarly journals An attempt to understand the concept of PCOS w. s. r. to artavavaha sroto dusti

2018 ◽  
Vol 6 (04) ◽  
Author(s):  
Dharmaraj Nagorao Lone ◽  
Chitra Gawande ◽  
Pratibha Kulkarni ◽  
Nagorao Dattarao Lone
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Modern Medicine ◽  
The Body ◽  
Reproductive Age ◽  
Fallopian Tubes ◽  
Women Of Reproductive Age ◽  
Androgen Excess ◽  
Hormonal Imbalance ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is the most common endocrine ovarian disorder affecting 5 to 10% women of reproductive age. It is also known as stein- laventhal syndrome or hyper androgenic Anovulation. The main primary character of PCOS is irregular menstrual cycle which leads to improper ovulation. Exact pathogenesis of PCOS is not understood clearly, it may be discussed under following headings: Abnormality of Hypothalamic-pituitary compartment (Hormonal imbalance), androgen excess, anovulation, obesity and insulin resistance etc. Srotas are the circulatory channels through which Dosha’s, Dhatu’s and Mala’s moves from one part to another part of the body. Each srotas has srotomoola, srotomarga and srotomukha. The moolasthana of artavavaha srotas are garbhashaya(uterus) and artavavahi dhamani’s(uterine & ovarian arteries). Artavavaha srotas may be categorized into Shonita artavavaha srotas which carries menstrual blood through blood vessels and capillaries of the uterus & Beejartavavaha srotas which carries ovum through fallopian tubes. Abnormality of Artavavaha srotas causes Vandhyatva, Maithuna Asahishnuta and Artavanasha. Vandhyatva caused due to abnormality in chaturvidha garbhottpadaka(rutu, kshetra, ambu and beeja) samagri. Maithuna Asahishnuta related to vatala, paripluta, vipluta and shandi yoniyapada, while Artavanasha related to Vandhya, Arajaska and shushka yonivyapada. All these symptoms like Vandhyatva, Maithuna Asahishnuta and Artavanasha are correlated with common symptoms of PCOS which include Infertility, Dyspareunia & Amenorrhoea respectively. As there is no curative treatment available in modern medicine, understanding of PCOS with reference to Artavavaha sroto dusti may be a ray of hope to treat PCOS with Ayurvedic remedies. KEY WORDS: Artava, Srotas, PCOS, Vandhyatva, Yonivyapada.

scholarly journals Early onset androgenic alopecia: not a cosmetic problem but a sign of life time risk factors. Male phenotypic equivalent of polycystic ovarian syndrome: Is There a Male Phenotype of PCOS

2021 ◽  
Vol 8 (4) ◽  
pp. 231-236
Author(s):  
Didem Dereli Akdeniz ◽  
Candeğer Yılmaz
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Free Testosterone ◽  
Control Group ◽  
Model Assessment ◽  
Androgenic Alopecia ◽  
Male Phenotype ◽  
Ovarian Syndrome

Objective: Polycystic ovarian syndrome (PCOS) was thought to be a gynecologic disorder and then accepted as a general endocrine and metabolic syndrome. The genetic component of PCOS seems to be very important in its etiology. Because of this reason there should be a male PCOS equivalent. Early androgenetic alopecia (EAGA) is a specific pattern of hair loss and it should start before age 30 years and it is claimed to be a male equivalent of PCOS in women. Materials and Methods: In this study we aimed to investigate the hormonal and metabolic parameters of men with EAGA and compare them with healthy age-matched controls. Thirty men with EAGA and 30 controls were screened for free testosterone, DHEAS, gonadotropins, 17OH progesterone, ACTH, fasting glucose, fasting insulin, homocysteine and metabolic profile. Homeostasis model assessment (HOMA) results were used for the marker of insulin sensitivity. Alopecia classification was made by using the scale of Hamilton with Norwood modification. Results: Patients with EAGA had higher free testosterone (25,12±3,05 vs 21,3±1,77), DHEAS (634,90±27,09 vs 578±17,82), LH (9,16±0,28 vs 5,13±0,40). The EAGA group had insulin resistance but the control group did not (HOMA results were 3,34±0,47 vs 1,43±0,3). The homocysteine levels of EAGA group were higher than controls (12,37±1,31 vs 9,33±2,12) which is another cardiovascular risk factor. The correlations that we found in our study among HOMA, serum androgen levels, homocysteine and alopecia scores were positive in EAGA patients. We didn’t find any correlations among those parameters in control group. Because of these findings men with EAGA can be considered as male synonym to PCOS syndrome. These young men should be followed for the same long time risk profile like PCOS women. Insulin resistance and its results like metabolic syndrome, diabetes and cardiovascular diseases are real risks but there may be even a risk for infertility. Conclusion: We aimed to investigate whether EAGA can be accepted as the male phenotype of PCOS and if they have elevated risk factors for chronic complications than their age and sex matched controls.

Effect of Metformin Treatment on Insulin Resistance Markers, and Circulating Irisin in Women with Polycystic Ovarian Syndrome (PCOS)

2019 ◽  
Vol 51 (09) ◽  
pp. 575-579 ◽  
Author(s):  
Asiyeh Masaeli ◽  
Hashem Nayeri ◽  
Mohammadreza Mirzaee
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Metabolic Diseases ◽  
Density Lipoprotein ◽  
Adult Women ◽  
Metformin Treatment ◽  
Polycystic Ovaries ◽  
Resistance Markers ◽  
17 Hydroxyprogesterone ◽  
Ovarian Syndrome

AbstractPolycystic ovarian syndrome (PCOS) is considered as a common endocrinal dysfunction among adult women characterized by polycystic ovaries, anovulation, and hyperandrogenism. Irisin is associated with metabolic parameters and insulin resistance. However, the association of irisin with PCOS remains poorly delineated. This study was aimed to examine circulating irisin levels and effects of metformin on this parameter in women with PCOS. Moreover, the association of irisin with insulin resistance markers was determined. Thirty-nine females with PCOS, aged 20–40 years, participated in this study and received 500 mg of metformin once daily for 3 months. Serum creatinine, blood urea nitrogen, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL), cholesterol, triglyceride, fasting blood sugar, testosterone, 17-hydroxyprogesterone, and irisin were assayed in the studied groups. Circulating irisin was significantly higher in PCOS women. Circulating irisin levels correlated with 17-hydroxyprogesterone, testosterone, and insulin. Three months metformin treatment decreased circulating irisin in PCOS women and improved IR. Circulating irisin is directly associated with insulin resistance in PCOS women and may be used as a biomarker for IR in these patients. Moreover, metformin as a confounding therapy in metabolic diseases can be used to regulate circulating irisin levels in PCOS women.

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