We-P11:149 Association of C-reactive protein with measures of obesity and insulin sensitivity in severe obese women with normal and impaired glucose tolerance

Background:We aimed to explore the association between self-reported leisure time physical activity (LTPA) and C-reactive protein (CRP) concentrations in men and women with and without impaired glucose tolerance (IGT).Methods:In a cross-sectional study, a random sample (n = 2,816) was examined with an oral glucose tolerance test, CRP and information about LTPA. Those with IGT or normal glucose tolerance (NGT) and CRP value ≤10 mg/L were selected (n = 2,367) for the study.Results:An inverse association between LTPA and CRP concentrations was observed in the population (P < .001), though, only in men with IGT (P = .023) and in women with NGT. Men with IGT, reporting slight physical activity up to 4 hours a week presented significantly higher CRP concentrations than normoglycemic men (∆0.6 mg/L, P = .004). However, this difference could not be found in men with IGT reporting more intense physical activity (∆0.01 mg/L, P = .944).Conclusions:Physical inactivity seems to have greater inflammatory consequences for men (vs. women) with IGT. More importantly, although 4 hours of physical activity per week is more than the usual minimum recommendation, an even greater intensity of LTPA appears to be required to limit subclinical inflammation in men with IGT.

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Effect of intensive lifestyle intervention on C-reactive protein in subjects with impaired glucose tolerance and obesity. Results from a randomized controlled trial with 5-year follow-up

Biomarkers ◽

10.1080/13547500802661266 ◽

2008 ◽

Vol 13 (7-8) ◽

pp. 671-679 ◽

Cited By ~ 7

Author(s):

Jonas Andersson ◽

Kurt Boman ◽

Jan-Håkan Jansson ◽

Torbjörn K. Nilsson ◽

Bernt Lindahl

Keyword(s):

Randomized Controlled Trial ◽

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Lifestyle Intervention ◽

Controlled Trial ◽

C Reactive Protein ◽

Reactive Protein ◽

Randomized Controlled ◽

Intensive Lifestyle Intervention

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First-Trimester Maternal Serum C-reactive Protein as a Predictor of Third-Trimester Impaired Glucose Tolerance

Reproductive Sciences ◽

10.1177/1933719114532843 ◽

2014 ◽

Vol 22 (1) ◽

pp. 90-93 ◽

Cited By ~ 7

Author(s):

Erica K. Berggren ◽

Hilary A. Roeder ◽

Kim A. Boggess ◽

Kevin Moss ◽

Steven Offenbacher ◽

...

Keyword(s):

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

First Trimester ◽

Maternal Serum ◽

C Reactive Protein ◽

Third Trimester ◽

Reactive Protein

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Effect of Massive Weight Loss on Inflammatory Adipocytokines and the Innate Immune System in Morbidly Obese Women

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2006-0960 ◽

2006 ◽

Vol 92 (2) ◽

pp. 483-490 ◽

Cited By ~ 112

Author(s):

Melania Manco ◽

J. Manuel Fernandez-Real ◽

Francesco Equitani ◽

Joan Vendrell ◽

Maria Elena Valera Mora ◽

...

Keyword(s):

Weight Loss ◽

Insulin Sensitivity ◽

Massive Weight Loss ◽

Innate Immune ◽

Low Grade ◽

Obese Women ◽

C Reactive Protein ◽

Reactive Protein ◽

Tnf Α ◽

Glucose Sensitivity

Abstract Context: Obesity may be regarded as a low-grade inflammatory state. Objective: The aim of this study was to evaluate changes in pro-inflammatory adipocytokines and the innate immune system, cardiovascular risk, and insulin sensitivity after massive weight loss. Design: This was a longitudinal study. Setting: The study was conducted at Catholic University, Rome. Subjects and Methods: There were 10 normoglucose-tolerant obese women evaluated before and 36 months after bilio-pancreatic diversion (BPD). Glucose sensitivity (M value) was estimated using the euglycemic-hyperinsulinemic clamp. Mannan-binding lectin (MBL), bactericidal/permeability increasing protein (BPI), α-defensins, soluble CD14 receptor (sCD14), C-reactive protein, adiponectin, leptin, visfatin, IL-6, and TNF-α were assayed. Results: After massive weight loss (53% of excess body weight), leptin (P ≤ 0.0001), IL-6 (P ≤ 0.0001), α-defensins (P ≤ 0.001), and C-reactive protein (P ≤ 0.0001) decreased significantly. Adiponectin increased significantly (P ≤ 0.001). Of the nine subjects who lost more than 20% of body mass index, sCD14 (2.87 ± 0.5 to 2.55 ± 0.5; P = 0.016) and visfatin levels (12.20 ± 0.93 to 10.63 ± 1.93 ng/ml; P = 0.045) decreased significantly. No significant changes were observed in TNF-α, BPI, or MBL. Insulin sensitivity more than doubled after BPD (P ≤ 0.0001). sCD14 changes were significantly associated with body mass index (r0 = 0.80; P = 0.003) and M changes (r0 = −0.59; P = 0.03). MBL correlated with insulin sensitivity in obese (r0 = 0.93; P = 0.0001) and post-BPD women (r0 = 0.66; P = 0.038). Adiponectin correlated negatively with cardiovascular risk (r0 = −0.709; P = 0.02) and IL-6 (r0 = −0.634; P = 0.05). Multiple linear regression analysis showed that changes in sCD14 were also significantly related to changes in insulin sensitivity. Conclusions: Surgically induced weight loss is capable of reversing low-grade inflammation, at least partially. The relationships between sCD14, MBL, BPI, and glucose sensitivity, and the role of TNF-α in obesity warrant further investigation.

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