scholarly journals Scavenger receptor class-A plays diverse role in innate immunity, cell signaling and different pathologies

2016 ◽  
Vol 6 (7) ◽  
pp. 567-572
Author(s):  
Aamir Rana ◽  
Syed Sajjad Sattar ◽  
Afshann Shahzad ◽  
Ghulam Muhammad Ali ◽  
Yasir Waheed
Keyword(s):  
Innate Immunity ◽  
Cell Signaling ◽  
Scavenger Receptor ◽  
Class A ◽  
Scavenger Receptor Class

scholarly journals Tumor suppressive effect of scavenger receptor class A member 5 overexpression in colorectal cancer by regulating PI3K/AKT/mTOR pathway

2021 ◽  
Author(s):  
Yi Li ◽  
Feng Peng ◽  
Xiangyun Tan ◽  
Jin Wang ◽  
Yeqing Xu
Keyword(s):  
Colorectal Cancer ◽  
Tumor Volume ◽  
Scavenger Receptor ◽  
Mtor Pathway ◽  
Ki67 Expression ◽  
Class A ◽  
Scavenger Receptor Class ◽  
Sw480 Cells ◽  
And Migration

Abstract Background Colorectal cancer (CRC) exhibits high risks of morbidity and mortality. Objective To investigate the effect of scavenger receptor class A member 5 (SCRAR5) on CRC and its mechanism on modulation of cancer development. Methods The SCRAR5 expression in four kinds of CRC cell lines (SW620, SW480, HT29, and HCT116) was measured by quantitative PCR and western blotting, respectively. The effects of SCRAR5 abnormal expression on cell proliferation, apoptosis, and migration were analyzed by CCK-8 assay, EdU assay, colony-forming assay, flow cytometry assay, Transwell assay and wound healing assay, respectively. Meanwhile, the involvements of PI3K/AKT/mTOR pathway with the role of SCRAR5 were investigated by western blotting. Afterwards, the in vivo effects of SCRAR5 abnormal expression on CRC xenograft mice were finally investigated by evaluating tumor volume, apoptosis and Ki67 expression. Results SCRAR5 was lowly expressed in CRC cell lines, especially SW480 cells. Up-regulation of SCRAR5 significantly promoted cell apoptosis, reduced cell proliferation and migration in SW480 cells. Notably, SCRAR5 overexpression obviously inhibited the phosphorylation levels of PI3K, AKT, and mTOR. Reversely, SCRAR5 silence exhibited promoting effects on HT29 cells. Consistently, in vivo experiments also revealed that SCRAR5 overexpression remarkably suppressed tumor volume and Ki67 expression, as well as promoted cell apoptosis. Conclusions Overall, up-regulating of SCRAR5 obviously inhibited CRC tumor growth in vitro and in vivo, which might be related to PI3K/AKT/mTOR pathway.

scholarly journals Apoptotic Thymocyte Clearance in Scavenger Receptor Class A-Deficient Mice Is Apparently Normal

2000 ◽  
Vol 164 (9) ◽  
pp. 4861-4867 ◽  
Author(s):  
Nick Platt ◽  
Hiroshi Suzuki ◽  
Tatsuhiko Kodama ◽  
Siamon Gordon
Keyword(s):  
Scavenger Receptor ◽  
Class A ◽  
Scavenger Receptor Class ◽  
Deficient Mice

scholarly journals Scavenger receptor class a, member 3 is associated with severity of hand, foot, and mouth disease in a case-control study

Medicine ◽  
2019 ◽  
Vol 98 (40) ◽  
pp. e17471
Author(s):  
Ye Tian ◽  
Kai Zhou ◽  
Jing Hu ◽  
Ming-Feng Shan ◽  
Hong-Jian Chen ◽  
...  
Keyword(s):  
Case Control Study ◽  
Scavenger Receptor ◽  
Foot And Mouth Disease ◽  
Case Control ◽  
Mouth Disease ◽  
Class A ◽  
Scavenger Receptor Class ◽  
Foot And Mouth ◽  
Control Study

The structure and function of the scavenger receptor class A

2000 ◽  
pp. 108-114
Author(s):  
Takeshi Murakami ◽  
Yoshihiko Yamada ◽  
Takefumi Doi ◽  
Takao Hamakubo ◽  
Tatsuhiko Kodama
Keyword(s):  
Scavenger Receptor ◽  
Structure And Function ◽  
Class A ◽  
Scavenger Receptor Class ◽  
And Function

Exogenous surfactant changes the phenotype of alveolar macrophages in mice

2001 ◽  
Vol 280 (4) ◽  
pp. L689-L694 ◽  
Author(s):  
Boris W. Kramer ◽  
Alan H. Jobe ◽  
Machiko Ikegami
Keyword(s):  
Alveolar Macrophage ◽  
Alveolar Macrophages ◽  
Scavenger Receptor ◽  
Exogenous Surfactant ◽  
Surface Markers ◽  
Macrophage Phenotype ◽  
Surfactant Treatment ◽  
Class A ◽  
Scavenger Receptor Class

Alveolar macrophages are essential for the maintenance of surfactant homeostasis. We asked whether surfactant treatment would change alveolar macrophage number and whether the alveolar macrophage phenotype would become activated or apoptotic when challenged in vivo with exogenous surfactant. Surfactant pool size in mice was increased by repetitive surfactant treatments containing 120 mg/kg (110 μmol/kg) saturated phosphatidylcholine. The number of alveolar macrophages recovered by alveolar lavage decreased after the first dose by 49% and slightly increased after the second and third doses. Up to 28.5% of the macrophages became large and foamy, and their appearance normalized within 12 h. Surfactant treatment did not increase the percent of apoptotic or necrotic cells. The alveolar macrophages were not activated as indicated by no change in expression of CD14, CD16, CD54, CD95, and scavenger receptor class A types I and II after surfactant treatment. Surfactant treatment in healthy mice transiently changed the phenotype of alveolar macrophages to large and foamy without indications of changes in the surface markers characteristic of activation.

scholarly journals Bovine scavenger receptor class A (SR-A) exhibit specific patterns of regulation in the endometrium during the oestrous cycle and early pregnancy

2019 ◽  
Vol 31 (6) ◽  
pp. 1078 ◽  
Author(s):  
A. Vitorino Carvalho ◽  
C. Eozenou ◽  
C. Richard ◽  
N. Forde ◽  
G. D. Healey ◽  
...  
Keyword(s):  
Gene Expression ◽  
High Throughput ◽  
Early Pregnancy ◽  
Scavenger Receptor ◽  
Oestrous Cycle ◽  
Endometrial Gland ◽  
Class A ◽  
Scavenger Receptor Class ◽  
Immune Factors ◽  
Bovine Species

In mammals, tight regulation of maternal endometrial function is critical for pregnancy success. In bovine species, endometrial expression of members of the scavenger receptor class A (SR-A) has been listed in high-throughput analyses, but very little is known about the involvement of these immune factors during implantation in mammals. To provide first insights into the contribution of SR-A to endometrial physiology, we analysed the expression and regulation of all members of SR-A (SR-A1, SR-A3–SR-A6) during the oestrous cycle and early pregnancy in cattle. Levels of SR-A1 were increased on Day 20 of pregnancy, whereas SR-A3 levels were increased on Day 13 of the oestrous cycle and of the pregnancy. Although SR-A4 levels were reduced on Day 20 of the oestrous cycle, they remained high in pregnant animals. SR-A5 levels increased by Day 13 of the oestrous cycle and decreased on Day 20, but remained high in pregnant animals. Interferon-τ does not affect SR-A gene expression, whereas progesterone regulates the expression of the SR-A3 and SR-A5 transcripts. Endometrial SR-A3 appeared significantly higher in cows carrying invitro-produced embryos than in AI cows. Our data suggest that members of the SR-A family are involved in endometrial remodelling and regulation of endometrial gland physiology, both processes being critical for implantation in mammals.

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