scholarly journals Queros as Inalienable Objects: Ritual Drinking Vessels and the End of the Inka Empire at Moqi (Locumba Valley, Southern Peru)

2021 ◽  
pp. 1-19
Author(s):  
Colleen Zori
Keyword(s):  
De Novo ◽  
Local Communities ◽  
Southern Peru ◽  
Political Ties ◽  
History Of ◽  
Community Expression ◽  
Inka Empire

Mutual toasting using pairs of intricately carved wooden cups, called queros, was the fundamental act incorporating local communities into the Inka Empire (AD 1400–1532). These cups then remained in the possession of provincial communities and were used to reaffirm political ties in subsequent state-sponsored events. I argue that the value of these cups derives from their inalienability: they were indelibly imbued with the power of the Inka state and were objects of memory embodying the history of local–imperial relationships. Archaeologically, queros are often found in mortuary contexts, usually as pairs. This suggests that these vessels functioned to authenticate claims to authority vis-à-vis the empire for an individual or kin group. Less frequently, queros are deposited singly and in ritualized non-mortuary contexts. I review archaeological examples and present two new queros from the site of Moqi (Upper Locumba Valley, southern Peru). At Moqi, these queros were used not only to promote a shared affinity with the empire but also to commemorate the sundering of the community's ties to the Inka state on abandonment of the site. Such community expression, at the expense of personal aggrandizement, may have been particularly important at Moqi and other sites constructed and populated de novo by the Inka.

scholarly journals R1352Q CACNA1A Variant in a Patient with Sporadic Hemiplegic Migraine, Ataxia, Seizures and Cerebral Oedema: A Case Report

2021 ◽  
pp. 123-130
Author(s):  
Anker Stubberud ◽  
Emer O’Connor ◽  
Erling Tronvik ◽  
Henry Houlden ◽  
Manjit Matharu
Keyword(s):  
Mental Retardation ◽  
Case Report ◽  
Genetic Testing ◽  
Head Trauma ◽  
Cerebral Oedema ◽  
De Novo ◽  
Minor Head Trauma ◽  
Hemiplegic Migraine ◽  
Wide Range ◽  
History Of

Mutations in the <i>CACNA1A</i> gene show a wide range of neurological phenotypes including hemiplegic migraine, ataxia, mental retardation and epilepsy. In some cases, hemiplegic migraine attacks can be triggered by minor head trauma and culminate in encephalopathy and cerebral oedema. A 37-year-old male without a family history of complex migraine experienced hemiplegic migraine attacks from childhood. The attacks were usually triggered by minor head trauma, and on several occasions complicated with encephalopathy and cerebral oedema. Genetic testing of the proband and unaffected parents revealed a de novo heterozygous nucleotide missense mutation in exon 25 of the <i>CACNA1A</i> gene (c.4055G&#x3e;A, p.R1352Q). The R1352Q <i>CACNA1A</i> variant shares the phenotype with other described <i>CACNA1A</i> mutations and highlights the interesting association of trauma as a precipitant for hemiplegic migraine. Subjects with early-onset sporadic hemiplegic migraine triggered by minor head injury or associated with seizures, ataxia or episodes of encephalopathy should be screened for mutations. These patients should also be advised to avoid activities that may result in head trauma, and anticonvulsants should be considered as prophylactic migraine therapy.

Craniopharyngioma arising de novo in middle age

1997 ◽  
Vol 86 (6) ◽  
pp. 1046-1048 ◽  
Author(s):  
Marc S. Arginteanu ◽  
Karin Hague ◽  
Robert Zimmerman ◽  
Mark J. Kupersmith ◽  
John H. Shaiu ◽  
...  
Keyword(s):  
Magnetic Resonance Image ◽  
De Novo ◽  
Middle Age ◽  
Benign Tumors ◽  
Fetal Life ◽  
Content Type ◽  
Steady Growth ◽  
History Of ◽  
Sixth Decade ◽  
Fine Print

✓ The authors report the case of a 55-year-old woman who developed a symptomatic craniopharyngioma within 2 years of obtaining a normal magnetic resonance image of her brain. Craniopharyngiomas are histologically benign tumors. They are thought to arise from embryonic remnants of Rathke's pouch and sac and to manifest themselves clinically after a steady growth that commences in fetal life. To the authors' knowlege, this is the first report that documents a tumor arising de novo in the sixth decade of life. This report appears to challenge the concept of the origin and natural history of craniopharyngiomas.

An Environmental Justice Analysis of British Air Quality

2003 ◽  
Vol 35 (5) ◽  
pp. 909-929 ◽  
Author(s):  
Gordon Mitchell ◽  
Danny Dorling
Keyword(s):  
Air Pollution ◽  
Air Quality ◽  
Environmental Justice ◽  
The Elderly ◽  
Local Communities ◽  
Car Ownership ◽  
National Study ◽  
Environmental Injustice ◽  
The Usa ◽  
History Of

This paper presents the results of the first national study of air quality in Britain to consider the implications of its distribution across over ten thousand local communities in terms of potential environmental injustice. We consider the recent history of the environmental justice debate in Britain, Europe, and the USA and, in the light of this, estimate how one aspect of air pollution, nitrogen dioxide (NO2) levels, affects different population groups differentially across Britain. We also estimate the extent to which people living in each community in Britain contribute towards this pollution, with the aid of information on the characteristics of the vehicles they own. We find that, although community NO x emission and ambient NO2 concentration are strongly related, the communities that have access to fewest cars tend to suffer from the highest levels of air pollution, whereas those in which car ownership is greatest enjoy the cleanest air. Pollution is most concentrated in areas where young children and their parents are more likely to live and least concentrated in areas to which the elderly tend to migrate. Those communities that are most polluted and which also emit the least pollution tend to be amongst the poorest in Britain. There is therefore evidence of environmental injustice in the distribution and production of poor air quality in Britain. However, the spatial distribution of those who produce and receive most of that pollution have to be considered simultaneously to see this injustice clearly.

Predictors Factors of Onset de Novo Heart failure after STEMI

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
S Abouradi ◽  
H Choukrani ◽  
A Maaroufi ◽  
A Drighil ◽  
R Habbal
Keyword(s):  
Heart Failure ◽  
De Novo ◽  
Microvascular Disease ◽  
Prior History ◽  
Killip Class ◽  
Funding Sources ◽  
Significant Difference ◽  
Primary Coronary Angioplasty ◽  
History Of ◽  
Predictor Factors

Abstract Funding Acknowledgements Type of funding sources: None. INTRODUCTION STEMI gets complicated very often by a heart failure (HF), which it is important to know associated factors. The aim of this study  was to determinate the predictor factors of onset of de novo HF after STEMI in patients with no prior history of heart failure recorded at baseline. METHODS A retrospective, descriptive study from 1 center in Morocco, including 210 patients hospitalized in a cardiology intensive care unit for STEMI from September 2019 to November 2020. The main outcomes were HF Killip class at hospital presentation and intra-hospital mortality. RESULTS The main age was 59.3 ± 7.02 and Sex ratio: 2, 86. The incidence of de novo HF at admission was higher in women (40, 4% vs. 29.5%, [OR 1, 61; 95%, [CI] 0, 83-3, 11). Forty-nine point eight percent were in Killip≥ 2. The method of early revascularization was Thrombolysis in 82, 3% compared to primary coronary angioplasty without significant difference in onset of the novo HF. There was no association of age, comorbidities, delay to hospital presentation and coronary involvement with incidence of onset of de novo HF.  Women had higher mortality than men with the novo HF (28, 6% vs. 20.5%; OR: 1, 55; 95%). CONCLUSION  Gender has appeared associated to onset of de novo HF after STEMI with a superiority of the female sex after controlling for others factors described in the literature. Anterior studies have related this to the increased prevalence of microvascular disease in women predisposing them to heart failure after STEMI.

scholarly journals The rare hemoglobin variant Hb Mizuho: report of a Swiss family and literature review

2021 ◽  
Author(s):  
Linet Njue ◽  
Cesare Medri ◽  
Peter Keller ◽  
Miriam Diepold ◽  
Behrouz Mansouri Taleghani ◽  
...  
Keyword(s):  
Literature Review ◽  
Hemolytic Anemia ◽  
De Novo ◽  
Clinical History ◽  
Molecular Techniques ◽  
De Novo Mutation ◽  
First Case ◽  
History Of ◽  
Transfusion Dependency ◽  
Unstable Hemoglobin

AbstractHb Mizuho is a very rare unstable hemoglobin; here, we describe the clinical history of three Swiss family members with Hb Mizuho together with a systematic review of the previously six published cases. The clinical history of the adult woman we report here is unique since this is the first Hb Mizuho presenting with Moyamoya complications and the first case reported with long-term erythrocyte exchange. The literature review showed that Hb Mizuho was mainly reported as a de novo mutation, with the exception of children descended from known cases. All published patients with this unstable hemoglobin showed severe hemolytic anemia with the exception of one; all were regularly transfused. Patients with higher HbF levels might require fewer transfusions. All patients underwent splenectomy at a median age of 4 years and had variable clinical improvement; some achieved complete resolution of transfusion dependency after splenectomy. Iron overload in Hb Mizuho patients seems to be mainly attributed to transfusions and has less to do with ineffective erythropoiesis. Diagnosis might be challenging; a normal hemoglobin electrophoresis should not rule out the diagnosis of unstable hemoglobin in patients with otherwise unexplained hemolytic anemia. This series shows the enormous utility of using molecular techniques for diagnosis.

De novo convulsive status epilepticus in patients with multiple sclerosis treated with dalfampridine

2018 ◽  
Vol 25 (4) ◽  
pp. 618-621 ◽  
Author(s):  
Emilie Panicucci ◽  
Mikael Cohen ◽  
Veronique Bourg ◽  
Fanny Rocher ◽  
Pierre Thomas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Status Epilepticus ◽  
De Novo ◽  
Case Reports ◽  
Brain Magnetic Resonance Imaging ◽  
Convulsive Status Epilepticus ◽  
Biological Tests ◽  
History Of ◽  
Magnetic Resonance Imaging Mri ◽  
History Of Epilepsy

Background: Dalfampridine extended release (DAL) is a broad-spectrum voltage-gated potassium channel blocker that is indicated in multiple sclerosis to improve the nerve conduction of demyelinated axons. Seizures are a known side effect of DAL, which is contraindicated in patients with a history of epilepsy. Objective: Three cases of multiple sclerosis (MS) with de novo convulsive status epilepticus (CSE) probably related to dalfampridine administration are described. Methods: No patients had a history of seizures or renal impairment. Biological tests were normal. A brain magnetic resonance imaging (MRI) showed diffuse cortical and subcortical atrophy without active inflammatory lesions. Results: All three patients presented with CSE that was attributed to DAL and so was discontinued. Conclusion: These case reports illustrate that, aside from seizures, de novo CSE is a potential complication of MS patients treated with DAL.

Alasdair MacIntyre, After Virtue

2016 ◽  
Author(s):  
John R. Wallach
Keyword(s):  
Moral Theory ◽  
Local Communities ◽  
Alasdair Macintyre ◽  
The Political ◽  
History Of ◽  
Liberal Individualism

This essay discusses the contribution of Alasdair MacIntyre’s After Virtue (1981) to a generation of moral theory. Pitched as a critique of liberal individualism (e.g., Rawls), modernity (e.g., amoral bureaucracies), and the antagonism toward the history of moral theory evinced by analytical philosophers, MacIntyre’s book urges a return toward moral traditions embedded in local communities as the best route to avoid what he regards as the soullessness of modernity and the abyss of Nietzschean philosophy. But his failure to reflect on the political valence of traditions in general or the Aristotelian and Thomist ones he values, seriously compromises his complaints about modernity and his suggestions for ways out.

scholarly journals Aboriginal entrepreneurship in the Northern Ob region

2019 ◽  
Vol 46 (2) ◽  
pp. 72-85
Author(s):  
Elena P. Martynova
Keyword(s):  
Indigenous People ◽  
Field Research ◽  
Local Communities ◽  
Community Members ◽  
Family Ties ◽  
The North ◽  
Structure Of Communities ◽  
Informal Economies ◽  
Economic Interaction ◽  
History Of

he article deals with the history of the development of entrepreneurship in the Northern Ob region among the Nenets, Khanty and Mansi. The author calls it «aboriginal” meaning that it as an economic activity that makes profit from the works directly related to the traditional sectors of the economy of the indigenous North peoples or from sale of products of economy. The article is based on the author’s field materials obtained during many years of field research (2000, 2002, 2003, 2008, 2011, 2013, 2017 years) in different areas of Khanty–Mansi Autonomous Okrug and Yamalo-Nenets Autonomous Okrug. It was found that two types of aboriginal entrepreneurship are developed in the Northern Ob region: institutional and informal. The first is represented by communities (either tribal or national) of indigenous people and farms. Their organization is socially oriented: communities are primarily a place of work for fishermen and reindeer herders. Community entrepreneurship is supported by the authorities of the district and the Okrug through a system of grants. The income of most community members is low, forcing them to seek additional income opportunities. The structure of communities of indigenous people is based on family ties. Informal aboriginal entrepreneurship spontaneously emerged in the crisis of the 1990-s and still does not give up its position. It provides the main income to families of private reindeer herders and fishermen. As a result of this aboriginal business quite stable client networks are formed that contribute to the social integration of local communities. Such entrepreneurship brings higher incomes, compared with the legalized formal ones, despite the lack of support from the “top” of the authorities. This largely contributes to its stability in the harsh northern conditions, where the market is small. The risk of being deceived is not an obstacle to the development of such business. The boundaries between institutional and informal economies in the North are penetrable and fluid. A private reindeer herder can be a member of the family community, and after delivering the minimum rate of products traditional industries can act as an independent businessman, selling products through his customers or visiting merchants. The same can be true for members of fishing communities. The interweaving of institutional and informal entrepreneurship forms a complex network of social and economic interaction in local communities.

scholarly journals A practical guide to buildde-novoassemblies for single tissues of non-model organisms: the example of a Neotropical frog

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3702 ◽  
Author(s):  
Santiago Montero-Mendieta ◽  
Manfred Grabherr ◽  
Henrik Lantz ◽  
Ignacio De la Riva ◽  
Jennifer A. Leonard ◽  
...  
Keyword(s):  
Defense Mechanisms ◽  
De Novo ◽  
Transcriptome Assembly ◽  
Cost Effective ◽  
Model Organisms ◽  
Rna Seq ◽  
Assembly Pipeline ◽  
Wide Variability ◽  
History Of ◽  
Inexperienced User

Whole genome sequencing (WGS) is a very valuable resource to understand the evolutionary history of poorly known species. However, in organisms with large genomes, as most amphibians, WGS is still excessively challenging and transcriptome sequencing (RNA-seq) represents a cost-effective tool to explore genome-wide variability. Non-model organisms do not usually have a reference genome and the transcriptome must be assembledde-novo. We used RNA-seq to obtain the transcriptomic profile forOreobates cruralis, a poorly known South American direct-developing frog. In total, 550,871 transcripts were assembled, corresponding to 422,999 putative genes. Of those, we identified 23,500, 37,349, 38,120 and 45,885 genes present in the Pfam, EggNOG, KEGG and GO databases, respectively. Interestingly, our results suggested that genes related to immune system and defense mechanisms are abundant in the transcriptome ofO. cruralis. We also present a pipeline to assist with pre-processing, assembling, evaluating and functionally annotating ade-novotranscriptome from RNA-seq data of non-model organisms. Our pipeline guides the inexperienced user in an intuitive way through all the necessary steps to buildde-novotranscriptome assemblies using readily available software and is freely available at:https://github.com/biomendi/TRANSCRIPTOME-ASSEMBLY-PIPELINE/wiki.

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