One-stage procedure to establish osseointegration: a zero to five years follow-up report

1995 ◽  
Vol 109 (7) ◽  
pp. 593-598 ◽  
Author(s):  
Anders Tjellström ◽  
Gösta Granström
Keyword(s):  
Success Rate ◽  
Hearing Aids ◽  
Mastoid Process ◽  
Case Scenario ◽  
Two Stage ◽  
Worst Case ◽  
One Stage ◽  
The One ◽  
Lost To Follow Up

AbstractA cohort of 214 patients, who were operated on to insert implants in the mastoid process for the retention of bone-anchored hearing aids and auricular prostheses, was followed-up over a five-year period. About half the group were operated on using the conventional two-stage procedure allowing three to four months for osseointegration. In the second group (one-stage group) the skin penetrating coupling was connected at the time of the implant insertion. The success rate for stable implants was found to be the same in both groups. In the one-stage group four out of 161 implants inserted were lost and in the two stage group three out of 120. The cumulative success rate was also found to be the same. A ‘worst case’ table where patients lost to follow-up, patients who died during the study period, and patients who for some reason left the study is also included. The importance of this ‘worst case’ scenario when follow-up data are presented is discussed.

Pantalar Arthrodesis: A Long-term Follow-up

Foot & Ankle ◽  
1981 ◽  
Vol 1 (5) ◽  
pp. 279-283 ◽  
Author(s):  
Gene R. Barrett ◽  
Leslie C. Meyer ◽  
Edward W. Bray ◽  
Richard G. Taylor ◽  
Frank J. Kolb
Keyword(s):  
Spinal Cord ◽  
South Carolina ◽  
Spinal Cord Trauma ◽  
Two Stage ◽  
One Stage ◽  
Ankle Fusion ◽  
Long Term Follow Up ◽  
The One

Eighty-three pantalar arthrodeses in 69 patients performed at the Shriners Hospital for Crippled Children, Greenville, South Carolina, between 1941 and 1977 were evaluated. Follow-up was from 1 to 33 years. Diagnoses included poliomyelitis, myelodysplasia, arthrogryposis, clubfeet, and extremity or spinal cord trauma. Methods of fusion were one-stage pantalar arthrodesis, two-stage triple ankle fusion, one-stage completion of prior tarsal fusion, and one-stage denudation of the talus. Pantalar arthrodesis is successful in the paralytic sensitive foot with a stable knee and there is no greater incidence of nonunion in the one-stage (Hunt-Thompson) procedure than in the two-stage procedure. Complications and failure of fusion are common in the insensitive foot.

Exeter Universal cemented femoral component

2020 ◽  
Vol 102-B (10) ◽  
pp. 1319-1323
Author(s):  
Fouzia Khatun ◽  
Damien F. Gill ◽  
Amit Atrey ◽  
Matthew Porteous
Keyword(s):  
Femoral Component ◽  
Acetabular Component ◽  
District General Hospital ◽  
Long Term Results ◽  
Case Scenario ◽  
Worst Case ◽  
Joint Registry ◽  
Component Revision ◽  
Lost To Follow Up

Aims We present the results, in terms of survival, clinical outcome, and radiological appearance at 20 years, in a cohort of 225 cemented Exeter Universal femoral components (Stryker, Newbury, UK) implanted in 207 patients, at a district general hospital. Methods All patients in this study had a total hip arthroplasty (THA) using an Exeter Universal femoral component with a cemented (n = 215) or cementless (n = 10) acetabular component. Clinical and radiological data were collected prospectively at one year, five years, and every five years thereafter. Patients lost to radiological and clinical follow-up (five) were cross-referenced with National Joint Registry (NJR) data and general practitioner (GP) records to assess whether they had undergone revision for any reason. Results During this period of study 144 patients (157 hips) died (69.78%). Two patients were lost to follow-up, leaving 61 patients (66 hips) available for review (29.33%). Of the 225 hips, three underwent revision for femoral failure with osteolysis. One underwent femoral component revision for treatment of a periprosthetic fracture. Eight underwent revision of the acetabular component only for loosening. Two hips had both components revised, when components were found to be loose at time of revision for acetabular loosening, though no radiological femoral osteolysis. Two patients underwent revision for infection. Using femoral loosening as an endpoint, the survival of the Exeter Universal femoral component was 98.7% (n = 220, 95% confidence interval (CI) 96.1% to 100%) at 20 to 22 years. Survival with an endpoint of revision for any reason was 92.6% (n = 209, 95% CI 89.4 to 95.55), with a ‘worst-case scenario’ (considering two patients lost to follow-up to have failed), the overall survival rate was 91.7% (n = 207, 95% CI 87.8 to 95.9) at 20 to 22 years. Conclusion Our results confirm excellent long-term results for the cemented Exeter Universal femoral componentimplanted outside of the originating centre. Cite this article: Bone Joint J 2020;102-B(10):1319–1323.

Two-Stage Procedure for the Quantitative Determination of Autoprothrombin III Concentration and Some Applications

1967 ◽  
Vol 18 (01/02) ◽  
pp. 198-210 ◽  
Author(s):  
Ronald S Reno ◽  
Walter H Seegers
Keyword(s):  
Prothrombin Time ◽  
Factor Vii ◽  
Two Stage ◽  
Pronounced Increase ◽  
One Stage ◽  
Assay Procedure ◽  
Bovine Plasma ◽  
The One ◽  
Autoprothrombin C

SummaryA two-stage assay procedure was developed for the determination of the autoprothrombin C titre which can be developed from prothrombin or autoprothrombin III containing solutions. The proenzyme is activated by Russell’s viper venom and the autoprothrombin C activity that appears is measured by its ability to shorten the partial thromboplastin time of bovine plasma.Using the assay, the autoprothrombin C titre was determined in the plasma of several species, as well as the percentage of it remaining in the serum from blood clotted in glass test tubes. Much autoprothrombin III remains in human serum. With sufficient thromboplastin it was completely utilized. Plasma from selected patients with coagulation disorders was assayed and only Stuart plasma was abnormal. In so-called factor VII, IX, and P.T.A. deficiency the autoprothrombin C titre and thrombin titre that could be developed was normal. In one case (prethrombin irregularity) practically no thrombin titre developed but the amount of autoprothrombin C which generated was in the normal range.Dogs were treated with Dicumarol and the autoprothrombin C titre that could be developed from their plasmas decreased until only traces could be detected. This coincided with a lowering of the thrombin titre that could be developed and a prolongation of the one-stage prothrombin time. While the Dicumarol was acting, the dogs were given an infusion of purified bovine prothrombin and the levels of autoprothrombin C, thrombin and one-stage prothrombin time were followed for several hours. The tests became normal immediately after the infusion and then went back to preinfusion levels over a period of 24 hrs.In other dogs the effect of Dicumarol was reversed by giving vitamin K1 intravenously. The effect of the vitamin was noticed as early as 20 min after administration.In response to vitamin K the most pronounced increase was with that portion of the prothrombin molecule which yields thrombin. The proportion of that protein with respect to the precursor of autoprothrombin C increased during the first hour and then started to go down and after 3 hrs was equal to the proportion normally found in plasma.

Standardization of Factor VIII – IV. Establishment of the 3rd International Standard for Factor VIII: C Concentrate

1983 ◽  
Vol 50 (03) ◽  
pp. 697-702 ◽  
Author(s):  
T W Barrowcliffe ◽  
A D Curtis ◽  
D P Thomas
Keyword(s):  
Factor Viii ◽  
High Purity ◽  
Collaborative Study ◽  
World Health ◽  
Current Standard ◽  
Two Stage ◽  
International Standard ◽  
One Stage ◽  
The One ◽  
Health Organization

SummaryAn international collaborative study was carried out to establish a replacement for the current (2nd) international standard for Factor VIII: C, concentrate. Twenty-six laboratories took part, of which 17 performed one-stage assays, three performed two-stage assays and six used both methods. The proposed new standard, an intermediate purity concentrate, was assayed against the current standard, against a high-purity concentrate and against an International Reference Plasma, coded 80/511, previously calibrated against fresh normal plasma.Assays of the proposed new standard against the current standard gave a mean potency of 3.89 iu/ampoule, with good agreement between laboratories and between one-stage and two- stage assays. There was also no difference between assay methods in the comparison of high-purity and intermediate purity concentrates. In the comparison of the proposed standard with the plasma reference preparation, the overall mean potency was 4.03 iu/ampoule, but there were substantial differences between laboratories, and the two-stage method gave significantly higher results than the one stage method. Of the technical variables in the one-stage method, only the activation time with one reagent appeared to have any influence on the results of this comparison of concentrate against plasma.Accelerated degradation studies showed that the proposed standard is very stable. With the agreement of the participants, the material, in ampoules coded 80/556, has been established by the World Health Organization as the 3rd International Standard for Factor VIII :C, Concentrate, with an assigned potency of 3.9 iu/ampoule.

Status and Determinants of Treatment Outcomes Among New Tuberculosis Patients in South Korea: A Retrospective Cohort Study

2021 ◽  
pp. 101053952110005
Author(s):  
Hyunjin Son ◽  
Jeongha Mok ◽  
Miyoung Lee ◽  
Wonseo Park ◽  
Seungjin Kim ◽  
...  
Keyword(s):  
Cohort Study ◽  
South Korea ◽  
Success Rate ◽  
Treatment Outcomes ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Health Care Facilities ◽  
Tuberculosis Patients ◽  
Lost To Follow Up

This is a retrospective cohort study using notification data in South Korea. We evaluated the nationwide status, regional differences, and the determinants of treatment outcomes among tuberculosis patients. Treatment success rate improved from 77.0% in 2012 to 86.0% in 2015. The lost to follow-up rate was higher among older people, males, and foreign nationals. Health care facilities designated for the Public-Private Mix (PPM) project showed higher success rate and lower rate of lost to follow-up. Moreover, municipalities with low regional deprivation index had higher PPM project coverage. Since there is a large regional difference in the coverage of the PPM project, an additional community-based support program should be implemented, especially for tuberculosis patients residing in region with low PPM project coverage.

scholarly journals Study on the Leakage and Inter-Stage Pressure Drop Characteristics of Two-Stage Finger Seal

2021 ◽  
Vol 11 (5) ◽  
pp. 2239
Author(s):  
Hailin Zhao ◽  
Hua Su ◽  
Guoding Chen ◽  
Yanchao Zhang
Keyword(s):  
Pressure Drop ◽  
Pressure Difference ◽  
Radial Displacement ◽  
Mean Square ◽  
The Finite Element Method ◽  
Axial Pressure ◽  
Two Stage ◽  
One Stage ◽  
The One ◽  
Lower Contact

To solve the high leakage and high wear problems faced by sealing devices in aeroengines under the condition of high axial pressure difference, the two-stage finger seal is proposed in this paper. The finite element method and computational fluid dynamics (FEM/CFD) coupling iterative algorithm of the two-stage finger seal is developed and validated. Then the performance advantages of two-stage finger seal compared to the one-stage finger seal are studied, as well as the leakage and the inter-stage pressure drop characteristics of two-stage finger seal are investigated. Finally, the measure to improve the inter-stage imbalance of pressure drop of two-stage finger seal is proposed. The results show that the two-stage finger seal has lower leakage and lower contact pressure than the one-stage finger seal at high axial pressure difference, but there exists an inter-stage imbalance of pressure drop. Increasing the axial pressure difference and the root mean square (RMS) roughness of finger element can aggravate the imbalance of pressure drop, while the radial displacement excitation of rotor has little influence on it. The results also indicate that the inter-stage imbalance of pressure drop of the two-stage finger seal can be improved by increasing the number of finger elements of the 1st finger seal and decreasing the number of finger elements of the 2nd finger seal.

Prospective cohort study of Kaposi sarcoma treated under real-world conditions in Malawi.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 11569-11569
Author(s):  
Edwards Kasonkanji ◽  
Yolanda Gondwe ◽  
Morgan Dewey ◽  
Joe Gumulira ◽  
Matthew Painschab ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kaposi Sarcoma ◽  
Median Number ◽  
Sub Saharan Africa ◽  
Worst Case ◽  
Loss To Follow Up ◽  
Presenting Symptoms ◽  
Grade 3 ◽  
Lost To Follow Up

11569 Background: Kaposi sarcoma (KS) is the leading cancer in Malawi (34% of cancers). Outside of clinical trials, prospective KS studies from sub-Saharan Africa (SSA) are few and limited by loss to follow up. We conducted a prospective KS cohort study of standard of care bleomycin/vincristine (BV) at Lighthouse HIV clinic, in Lilongwe, Malawi. Methods: We enrolled pathologically confirmed, newly diagnosed, HIV+ KS patients from Feb 2017 to Jun 2019. We collected clinical and treatment characteristics, toxicity, and outcomes of KS with follow-up censored Jun 2020. Patients were treated with bleomycin (25 mg/m2) and vincristine (0.4 mg/m2) every 14 days for a planned maximum of 16 cycles. STATA v13.0 was used to calculate descriptive statistics and Kaplan Meier survival analysis. Toxicity was graded using NCI CTCAE v5.0. Results: We enrolled 138 participants, median age 36 (IQR 32-44) and 110 (80%) male. By ACTG staging, 107 (78%) were T1 (tumour severity), 46 (33%) were S1 (illness severity) and 46 (33%) had Karnofsky performance status ≤70. Presenting symptoms included edema in 69 (53%), visceral disease in 9 (7%), and oral involvement in 43 (33%). Prior to KS diagnosis, 70 (51%) participants were aware of being HIV+ for median 17 months (IQR 6-60) and had been on ART for median 16 months (IQR 6-60). Median CD4 count was 197 (IQR 99-339), median HIV-viral load was 2.6 log copies/mL (IQR 1.6 – 4.8) and 57% were HIV-suppressed ( < 1000 HIV copies/ml). The median number of cycles was 16 (IQR 7-16). 62 (45%) participants missed at least one dose due to stock out. Amongst patients with missed doses, the median number was 3 (IQR 2-4) for bleomycin and 2 (IQR 1-3) for vincristine. 14 (10%) participants experienced at least one reduced dose due to toxicity. 5 (4%) participants suffered grade ≥3 anaemia, 13 (9%) grade ≥3 neutropenia, and one participant had grade 4 bleomycin-induced dermatitis. There was no reported grade ≥3 bleomycin lung toxicity or vincristine-induced neuropathy. Of 115 evaluable participants, responses at the end of therapy were: complete response in 52 (45%), partial response in 27 (23%) stable disease in 5 (4%), and progressive disease in 31 (28%). Median duration of follow-up was 20 months. At censoring, 69 (50%) were alive, 36 (26%) dead, and 33 (24%) lost to follow-up. Overall survival is shown Table as crude and worst-case scenario; worst-case assumes all participants lost to follow up died. Conclusions: Here, we present one of the most complete characterizations of KS presentation and treatment from SSA. As in other studies from the region, the majority of patients presented with advanced disease, chemotherapy stock-outs and loss to follow up were common, and mortality was high. Studies are planned to understand the virologic characteristics, improve therapies, and better implement existing therapies.[Table: see text]

Topology Optimization of Dynamic Systems Under Uncertain Loads: An H∞-Norm-Based Approach

2019 ◽  
Vol 14 (2) ◽  
Author(s):  
Paolo Venini
Keyword(s):  
Topology Optimization ◽  
Structural Parameters ◽  
Goal Function ◽  
Dynamic Compliance ◽  
Case Scenario ◽  
Worst Case ◽  
Original Definition ◽  
Optimal Material ◽  
The One ◽  
Definition Of

An innovative approach to topology optimization of dynamic system is introduced that is based on the system transfer-function H∞-norm. As for the structure, the proposed strategy allows to determine the optimal material distribution that ensures the minimization of a suitable goal function, such as (an original definition of) the dynamic compliance. Load uncertainty is accounted for by means of a nonprobabilistic convex-set approach (Ben-Haim and Elishakoff, 1990, Convex Models of Uncertainty in Applied Mechanics, Elsevier Science, Amsterdam). At each iteration, the worst load is determined as the one that maximizes the current dynamic compliance so that the proposed strategy fits the so-called worst case scenario (WCS) approach. The overall approach consists of the repeated solution of the two steps (minimization of the dynamic compliance with respect to structural parameters and maximization of the dynamic compliance with respect to the acting load) until convergence is achieved. Results from representative numerical studies are eventually presented along with extensions to the proposed approach that are currently under development.

scholarly journals Intelligent design af fokusgrupper - om metodisk design af fokusgrupper og menneskets forskellige intelligenser

2008 ◽  
Vol 24 (45) ◽  
pp. 13
Author(s):  
Lene Heiselberg
Keyword(s):  
Focus Groups ◽  
Intelligent Design ◽  
Verbal Intelligence ◽  
Case Scenario ◽  
Worst Case ◽  
Apparent Lack ◽  
Self Confidence ◽  
Media Research ◽  
The One ◽  
Interviewing Techniques

Når man arbejder professionelt med at gennemføre kvalitative mini- og fokusgruppeanalyser, kan det ikke undgås, at man som moderator indimellem tænker: Hvorfor deltager hun ikke? Hvad kan jeg gøre for at inkludere hende i diskussionen? Ofte skyldes nogle deltageres manglende engagement, at mini- eller fokusgruppens metodiske design favoriserer de deltagere, som har en fremtrædende verbalsproglig intelligens, og samtidig ekskluderes de, der har andre fremtrædende intelligenser, fra at yde det maksimale. En sådan situation er meget uheldig og kan i værste fald give en undersøgelse bias. Derfor har vi i DR Medieforskning arbejdet med en pragmatisk tilgang til problemet, hvor vi har afprøvet et metodisk design, som inkluderer kvalitative interviewteknikker og procesværktøjer, som appellerer til samtlige intelligenser. Som et resultat af en målrettet indsats for at inkludere flere intelligenser i det metodiske design, oplever vi, at deltagerne har mere lyst til at engagere sig og gør det med større selvsikkerhed. Desuden oplever vi i mindre grad fænomenet “cognitive tuning” , og derfor kan vi arbejde med flere og bedre data i analyse- og fortolkningsfasen. Intelligent design of focus groups - article about methodological design of focus groups and the different intelligences When you work professionally with the conducting and moderating of qualitative mini- and focus groups, you can't avoid sometimes thinking: Why isn’t she participating? What can I do to include her in the discussion? A participant's apparent lack of enthusiasm is often caused by the methodological design of the focus group giving preference to participants who have an explicit verbal intelligence, and as a consequence excludes participants with other explicit intelligences from contributing. A situation like the one described above is very undesirable and in a worst-case scenario it can cause a study to be biased. In order to try to solve this problem DR Media Research applied a methodological design which includes qualitative interviewing techniques and processing tools, which appeal to all of the intelligences instead of just one. As a result of this work, we find that the participants are more eager to participate and that they do it with greater self-confidence. In addition we encounter less cognitive tuning, and are therefore able to work with richer data in the phases of analysis and interpretation.

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