scholarly journals Robert Boyle's Memoirs for the Natural History of Human Blood (1684): Print, Manuscript and the Impact of Baconianism in Seventeenth-Century Medical Science

2007 ◽  
Vol 51 (2) ◽  
pp. 145-164 ◽  
Author(s):  
Harriet Knight ◽  
Michael Hunter
2021 ◽  
Vol 10 (6) ◽  
pp. 1161
Author(s):  
Raluca Pais ◽  
Thomas Maurel

The epidemiology and the current burden of chronic liver disease are changing globally, with non-alcoholic fatty liver disease (NAFLD) becoming the most frequent cause of liver disease in close relationship with the global epidemics of obesity, type 2 diabetes and metabolic syndrome. The clinical phenotypes of NAFLD are very heterogeneous in relationship with multiple pathways involved in the disease progression. In the absence of a specific treatment for non-alcoholic steatohepatitis (NASH), it is important to understand the natural history of the disease, to identify and to optimize the control of factors that are involved in disease progression. In this paper we propose a critical analysis of factors that are involved in the progression of the liver damage and the occurrence of extra-hepatic complications (cardiovascular diseases, extra hepatic cancer) in patients with NAFLD. We also briefly discuss the impact of the heterogeneity of the clinical phenotype of NAFLD on the clinical practice globally and at the individual level.


Thorax ◽  
2016 ◽  
Vol 71 (Suppl 3) ◽  
pp. A13.1-A13
Author(s):  
V Navaratnam ◽  
AW Fogarty ◽  
T McKeever ◽  
N Thompson ◽  
G Jenkins ◽  
...  

2021 ◽  
Vol 7 (2) ◽  
pp. 283-302
Author(s):  
Raf Van Rooy

Abstract In this paper, I explore the early history of the word standard as a linguistic term, arguing that it came to compete with the designation common language in the seventeenth century. The latter phrase was, in turn, formed by ideas on the Greek koine during the Renaissance and appears to have been the first widely used collocation referring to a standard language-like entity. In order to sketch this evolution, I first discuss premodern ideas on the koine. Then, I attempt to outline how the intuitive comparison of the koine with vernacular norms that were being increasingly regulated resulted in the development of the concept of common language, termed lingua communis in Latin (a calque of Greek hē koinḕ diálektos), in the sixteenth century. This phrase highlighted the communicative functionality of the vernaculars, which were being codified in grammars and dictionaries. Scholars contrasted these common languages with regional dialects, which had a limited reach in terms of communication. This distinction received a social and evaluative connotation during the seventeenth century, which created a need for terminological alternatives; an increasingly popular option competing with common language was standard, which was variously combined with language and tongue by English authors from about 1650 onwards, especially in Protestant circles, where the vernaculars tended to play a more prominent role than in Catholic areas. Of major importance for this evolution was the work and linguistic usage of the poet John Dryden (1631–1700). This essay uncovers the early history of standard as a key linguistic term, while also presenting a case study which shows the impact of the rediscovery of the Greek heritage on language studies in Western Europe, especially through the term common language.


2019 ◽  
pp. 25-55
Author(s):  
P. J. Dodd ◽  
C. Pretorius ◽  
B. G. Williams

Abstract In this chapter, we focus on mathematical models of tuberculosis epidemiology (TB) that include interactions with HIV and an explicit representation of transmission. We review the natural history of TB and illustrate how its features are simplified and incorporated in mathematical models. We then review the ways HIV influences the natural history of TB, the interventions that have been considered in models, and the way these individual-level effects are represented in models. We then go on to consider population-level effects, reviewing the TB/HIV modelling literature. We first review studies whose focus was on purely epidemiological modelling, and then studies whose focus was on modelling the impact of interventions. We conclude with a summary of the uses and achievements of TB/HIV modelling and some suggested future directions.


John Locke and Robert Boyle first met at some time before May 1660 but do not seem to have become closely acquainted until 1664 when they were both in Oxford. 1 Locke’s notebooks for 1664-67 contain many short entries ending ‘Mr.Boyle’, which appear to be details that Locke received from Boyle personally. 2 In his work, Boyle relied on various assistants, quite apart from craftsmen like glass-blowers and blacksmiths, who ranged from his amanuensis, needed because of his poor sight, and his servants who watched experiments through the night, to skilled collaborators like Robert Hooke. 3 In addition, Boyle was in touch with independent workers, notably Richard Lower whose name appears in Locke’s notebooks some time before Boyle’s; 4 and Dewhurst suggested that Locke was also a member of this group. 5 It is certainly true that Locke provided Boyle with barometric and meteorological readings about this time and that 21 of his headings for the ‘chymicall Analysis’ of blood are related to Boyle’s 46 headings in his Memoirs for the Natural History of Human Blood (1683/4). 6 But it is going too far to conclude from Locke’s practical notes on blood that he was then acting as Boyle’s assistant. Those notes come from Bodleian MS. Locke f.25. What they describe are not ‘experiments’ done by Locke, Boyle or anyone else. They are a record of the practical work Locke did when he attended a course of lectures in 1666 which were given by Peter Stahl, the German chemist brought by Boyle to Oxford in 1659.


Author(s):  
Jeremy Cohen

This chapter investigates the idea of the 'Jewish contribution' that was borne on Jews, non-Jews, and the interaction between them in modern times, from the seventeenth century to the present. It determines what role 'Jewish contribution' has played in 'Jewish self-definition' and how it has influenced the political, social, and cultural history of the Jews. It also discusses the biblical heritage that Jews, Christians, and Muslims share that highlights the people of the book and the impact of biblical monotheism on the history of religions. The chapter looks at the survival of the Jews as a distinct ethnic group and a multinational religious community that wrestles with the phenomenon to understand the reasons for their survival. It mentions the tragedy of the Nazi Holocaust and the re-establishment of the Jewish state in its wake that piqued the curiosity of the world.


2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S295-S296
Author(s):  
C Rodriguez Gutiérrez ◽  
A Elosua Gonzalez ◽  
C Prieto Martínez ◽  
S Rubio Iturria ◽  
M A Vicuña ◽  
...  

Abstract Background Knowing the natural history of ulcerative colitis (UC) is essential to understand the evolution of the disease, assess the impact of different therapeutic strategies, identify poor prognostic factors and provide patients with understandable information who help them in decision making. It has been suggested that biological drugs could modify natural history of UC and therefore decrease the rates of colectomy. In Spain, infliximab is approved for CU since 2005. Methods We performed a retrospective study that includes all patients with a definitive diagnosis (DD) of UC or Unclassifiable Colitis (UC) in the Navarra Incident Cohort (which includes all patients diagnosed between 2001 and 2003 in Navarra, Spain). Our objectives were to analyse the Colectomy Incidence Rate (CIR) from diagnosis to the end of follow-up (12-31-2017) and identify predictive factors of colectomy. Results We included 174 patients with DD of UC (42.5% E2 - 26.8% E3) and 5 of IC: 44.1 women, median age 39.2 years (7–88), median follow-up of 15.7 years. At the end of the follow-up, 8 patients underwent colectomy (CIR 3 surgeries per 100000patients-year). Timing of colectomy was: 3 at the initial diagnosis (<1 month), 2 in the first 2 years, 2 at 5 years and 1 at 12 years from diagnosis. All had previously received steroids, 5 immunomodulators and 2 biological agents. In 7 (87%) the surgery was urgent and the indication, megacolon in 3 (37.5%), severe outbreak in 3 (37.5%) and failure to medical treatment in 2 (25%). In 5 cases (62.5%), an ileoanal reservoir was made and in 3 definitive ileostomy. Conclusion In our cohort, global colectomy rates are lower than those reported in other series and occur mostly in the first 5 years of evolution.


1978 ◽  
Vol 40 (1-2) ◽  
pp. 61-109 ◽  
Author(s):  
Arthur Albert ◽  
Paul M. Gertman ◽  
Thomas A. Louis ◽  
Shu-ing Liu

1902 ◽  
Vol 70 (459-466) ◽  
pp. 74-79

I have found it necessary in labelling a series of models of the malaria parasite in the Central Hall of the Natural History Museum to use as simple and clear a terminology as possible. I think that this terminology will be found useful by others who are perplexed by such terms as “sporozoites,” “blasts,” “ookinetes,” “schizonts,” “amphionts,” and “sporonts”—terms which have their place in schemes dealing with the general morphology and life-history of the group Sporozoa, but are not, as experience shows, well suited for immediate use in describing and referring to the stages of the malaria parasite. It is necessary to treat the malaria parasite from the point of view of malaria; that is to say, to consider its significant phases to be those which it passes in the human blood. In reality its mature condition and most important motile, as well as its most prolific reproductive, phases are passed in the body of the mosquito.


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