scholarly journals Potential of food intake biomarkers in nutrition research

2020 ◽  
Vol 79 (4) ◽  
pp. 487-497
Author(s):  
Aoife E. McNamara ◽  
Lorraine Brennan
Keyword(s):  
Food Intake ◽  
Metabolic Pathways ◽  
Nutrient Intake ◽  
Biomarker Discovery ◽  
Dietary Habits ◽  
Dietary Assessment ◽  
Major Area ◽  
Area Of Interest ◽  
Nutrition Research ◽  
Specific Food

The influence of dietary habits on health/disease is well-established. Accurate dietary assessment is essential to understand metabolic pathways/processes involved in this relationship. In recent years, biomarker discovery has become a major area of interest for improving dietary assessment. Well-established nutrient intake biomarkers exist; however, there is growing interest in identifying and using biomarkers for more accurate and objective measurements of food intake. Metabolomics has emerged as a key tool used for biomarker discovery, employing techniques such as NMR spectroscopy, or MS. To date, a number of putatively identified biomarkers were discovered for foods including meat, cruciferous vegetables and legumes. However, many of the results are associations only and lack the desired validation including dose–response studies. Food intake biomarkers can be employed to classify individuals into consumers/non-consumers of specific foods, or into dietary patterns. Food intake biomarkers can also play a role in correcting self-reported measurement error, thus improving dietary intake estimates. Quantification of food intake was previously performed for citrus (proline betaine), chicken (guanidoacetate) and grape (tartaric acid) intake. However, this area still requires more investigation and expansion to a range of foods. The present review will assess the current literature of identified specific food intake biomarkers, their validation and the variety of biomarker uses. Addressing the utility of biomarkers and highlighting gaps in this area is important to advance the field in the context of nutrition research.

scholarly journals Development and Validation of an Objective, Passive Dietary Assessment Method for Estimating Food and Nutrient Intake in Households in Low- and Middle-Income Countries: A Study Protocol

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Modou L Jobarteh ◽  
Megan A McCrory ◽  
Benny Lo ◽  
Mingui Sun ◽  
Edward Sazonov ◽  
...  
Keyword(s):  
Food Intake ◽  
Nutrient Intake ◽  
Dietary Assessment ◽  
Objective Measure ◽  
Assessment Method ◽  
Nutritional Deficiencies ◽  
Middle Income ◽  
Middle Income Countries ◽  
Food And Nutrient Intake ◽  
Low And Middle Income

ABSTRACT Malnutrition is a major concern in low- and middle-income countries (LMIC), but the full extent of nutritional deficiencies remains unknown largely due to lack of accurate assessment methods. This study seeks to develop and validate an objective, passive method of estimating food and nutrient intake in households in Ghana and Uganda. Household members (including under-5s and adolescents) are assigned a wearable camera device to capture images of their food intake during waking hours. Using custom software, images captured are then used to estimate an individual's food and nutrient (i.e., protein, fat, carbohydrate, energy, and micronutrients) intake. Passive food image capture and assessment provides an objective measure of food and nutrient intake in real time, minimizing some of the limitations associated with self-reported dietary intake methods. Its use in LMIC could potentially increase the understanding of a population's nutritional status, and the contribution of household food intake to the malnutrition burden. This project is registered at clinicaltrials.gov (NCT03723460).

scholarly journals Twin studies advance the understanding of gene–environment interplay in human nutrigenomics

2014 ◽  
Vol 27 (2) ◽  
pp. 242-251 ◽  
Author(s):  
Tess Pallister ◽  
Tim D. Spector ◽  
Cristina Menni
Keyword(s):  
Dietary Assessment ◽  
Twin Studies ◽  
Food Group ◽  
Epidemiological Studies ◽  
Individual Variability ◽  
Global Epidemic ◽  
Relevant Today ◽  
Nutrition Research ◽  
Gene Environment ◽  
Specific Food

Investigations into the genetic architecture of diet–disease relationships are particularly relevant today with the global epidemic of obesity and chronic disease. Twin studies have demonstrated that genetic makeup plays a significant role in a multitude of dietary phenotypes such as energy and macronutrient intakes, dietary patterns, and specific food group intakes. Besides estimating heritability of dietary assessment, twins provide a naturally unique, case–control experiment. Due to their shared upbringing, matched genes and sex (in the case of monozygotic (MZ) twin pairs), and age, twins provide many advantages over classic epidemiological approaches. Future genetic epidemiological studies could benefit from the twin approach particularly where defining what is ‘normal’ is problematic due to the high inter-individual variability underlying metabolism. Here, we discuss the use of twins to generate heritability estimates of food intake phenotypes. We then highlight the value of discordant MZ pairs to further nutrition research through discovery and validation of biomarkers of intake and health status in collaboration with cutting-edge omics technologies.

scholarly journals Food and nutrient intake of children and adolescents living in Germany: results from EsKiMo II

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Clarissa Lage Barbosa ◽  
Anna-Kristin Brettschneider ◽  
Marjolein Haftenberger ◽  
Franziska Lehmann ◽  
Almut Richter ◽  
...  
Keyword(s):  
Vitamin D ◽  
Food Intake ◽  
Children And Adolescents ◽  
Nutrient Intake ◽  
Dietary Habits ◽  
Age Groups ◽  
Dietary Guidelines ◽  
Health Examination ◽  
Food And Nutrient Intake ◽  
And Gender

AbstractIntroductionAn appropriate diet is particularly important for development, growth and health of children and adolescents. The living and social environments, as well as the food market and dietary habits have changed in recent decades. The second “Eating Study as a KiGGS Module” EsKiMo II (2015–2017) provides a current overview of the food and nutrient intake of children and adolescents living in Germany.Material and MethodsAbout ten years after EsKiMo I (2006; N = 2,506), EsKiMo II (2015–2017) investigated the dietary behavior of 2,644 children and adolescents aged six to 17 years who previously participated in the second wave of the “German Health Interview and Examination Survey for Children and Adolescents” (KiGGS Wave 2) of the Robert Koch Institute. Food intake of the 6–11 year-olds was assessed by weighted food records on three consecutive days and one independent day. Adolescents (12–17 years) were interviewed about their food intake during the past four weeks using the Dietary Interview Software for Health Examination Studies (DISHES). Individual food group intake was compared with the food based dietary guidelines for children and adolescents in Germany. Energy and nutrient intake was calculated using the German Nutrient Database (BLS 3.02); intake from supplements was included. Individual intakes were compared with the Estimated Average Requirements (EAR) for Nordic countries.ResultsMost children and adolescents do not achieve the recommendation for fruits, vegetables, and milk/dairy products, whereas the maximal recommended intake of meat and “tolerated foods”, such as sweets and soft-drinks, is exceeded by almost all children and adolescents.The mean energy intake proportions (En%) for macronutrients correspond to the reference values. The majority of children and adolescents have intakes above the EAR for most micronutrients, except for iodine and vitamin D for all age groups and gender, and iron for the 12–17-year-old girls.DiscussionEsKiMo II observed that the majority of the 6–17-year-olds is adequately supplied with macronutrients and most vitamins and minerals. Vitamin D and iodine supply are critical for all age groups and gender. However, there is much potential to improve food consumption patterns. These results are relevant for decision-making, and evaluation of nutrition, consumer and health policies.

scholarly journals The Potential of Multi-Biomarker Panels in Nutrition Research: Total Fruit Intake as an Example

2021 ◽  
Vol 7 ◽  
Author(s):  
Aoife E. McNamara ◽  
Janette Walton ◽  
Albert Flynn ◽  
Anne P. Nugent ◽  
Breige A. McNulty ◽  
...  
Keyword(s):  
Food Intake ◽  
Intervention Study ◽  
Dietary Habits ◽  
Cross Sectional Study ◽  
Fruit Intake ◽  
Sectional Study ◽  
Cross Sectional ◽  
Biomarker Panel ◽  
Nutrition Research ◽  
The Cross

Dietary and food intake biomarkers offer the potential of improving the accuracy of dietary assessment. An extensive range of putative intake biomarkers of commonly consumed foods have been identified to date. As the field of food intake biomarkers progresses toward solving the complexities of dietary habits, combining biomarkers associated with single foods or food groups may be required. The objective of this work was to examine the ability of a multi-biomarker panel to classify individuals into categories of fruit intake. Biomarker data was measured using 1H NMR spectroscopy in two studies: (1) An intervention study where varying amounts of fruit was consumed and (2) the National Adult Nutrition Survey (NANS). Using data from an intervention study a biomarker panel (Proline betaine, Hippurate, and Xylose) was constructed from three urinary biomarker concentrations. Biomarker cut-off values for three categories of fruit intake were developed. The biomarker sum cut-offs were ≤ 4.766, 4.766–5.976, >5.976 μM/mOsm/kg for <100, 101–160, and >160 g fruit intake. The ability of the biomarker sum to classify individuals into categories of fruit intake was examined in the cross-sectional study (NANS) (N = 565). Examination of results in the cross-sectional study revealed excellent agreement with self-reported intake: a similar number of participants were ranked into each category of fruit intake. The work illustrates the potential of multi-biomarker panels and paves the way forward for further development in the field. The use of such panels may be key to distinguishing foods and adding specificity to the predictions of food intake.

scholarly journals Metabolomics as a tool in the identification of dietary biomarkers

2016 ◽  
Vol 76 (1) ◽  
pp. 42-53 ◽  
Author(s):  
Helena Gibbons ◽  
Lorraine Brennan
Keyword(s):  
Measurement Errors ◽  
Biomarker Discovery ◽  
Dietary Assessment ◽  
Present Review ◽  
Metabolic Profiles ◽  
Dietary Biomarkers ◽  
Dietary Assessment Methods ◽  
Nutrition Research ◽  
Complementary Approach ◽  
Food Diaries

Current dietary assessment methods including FFQ, 24-h recalls and weighed food diaries are associated with many measurement errors. In an attempt to overcome some of these errors, dietary biomarkers have emerged as a complementary approach to these traditional methods. Metabolomics has developed as a key technology for the identification of new dietary biomarkers and to date, metabolomic-based approaches have led to the identification of a number of putative biomarkers. The three approaches generally employed when using metabolomics in dietary biomarker discovery are: (i) acute interventions where participants consume specific amounts of a test food, (ii) cohort studies where metabolic profiles are compared between consumers and non-consumers of a specific food and (iii) the analysis of dietary patterns and metabolic profiles to identify nutritypes and biomarkers. The present review critiques the current literature in terms of the approaches used for dietary biomarker discovery and gives a detailed overview of the currently proposed biomarkers, highlighting steps needed for their full validation. Furthermore, the present review also evaluates areas such as current databases and software tools, which are needed to advance the interpretation of results and therefore enhance the utility of dietary biomarkers in nutrition research.

DIETARY ASSESSMENT AND NUTRIENT INTAKE OF PREGNANT DIABETIC WOMEN FROM NAGPUR CITY

2019 ◽  
Author(s):  
Sangita R. Meghal and Kalpana Jadhav Sangita R. Meghal and Kalpana Jadhav ◽  
Keyword(s):  
Nutrient Intake ◽  
Dietary Assessment ◽  
Pregnant Diabetic

Cultural Relevance of a Fruit and Vegetable Food Frequency Questionnaire

2005 ◽  
Vol 66 (4) ◽  
pp. 231-236 ◽  
Author(s):  
Judy Paisley ◽  
Marlene Greenberg ◽  
Jess Haines
Keyword(s):  
Food Frequency Questionnaire ◽  
Dietary Assessment ◽  
Cultural Relevance ◽  
Assessment Tools ◽  
Comparative Approach ◽  
Fruit And Vegetable ◽  
Food Frequency ◽  
Research And Practice ◽  
Vegetable Food ◽  
Nutrition Research

Purpose: Canada’s multicultural population poses challenges for culturally competent nutrition research and practice. In this qualitative study, the cultural relevance of a widely used semiquantitative fruit and vegetable food frequency questionnaire (FFQ) was examined among convenience samples of adults from Toronto’s Cantonese-, Mandarin-, Portuguese-, and Vietnamesespeaking communities. Methods: Eighty-nine participants were recruited through community-based organizations, programs, and advertisements to participate in semi-structured interviews moderated in their native language. Data from the interviews were translated into English and transcribed for analysis using the constant comparative approach. Results: Four main themes emerged from the analysis: the cultural relevance of the foods listed on the FFQ, words with multiple meanings, the need for culturally appropriate portionsize prompts, and the telephone survey as a Western concept. Conclusions: This research highlights the importance of investing resources to develop culturally relevant dietary assessment tools that ensure dietary assessment accuracy and, more important, reduce ethnocentric biases in food and nutrition research and practice. The transferability of findings must be established through further research.

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