scholarly journals Effects of between-person differences and within-person changes in symptoms of anxiety and depression on older age cognitive performance

2017 ◽  
Vol 48 (8) ◽  
pp. 1350-1358 ◽  
Author(s):  
E. J. Laukka ◽  
D. Dykiert ◽  
M. Allerhand ◽  
J. M. Starr ◽  
I. J. Deary
Keyword(s):  
Cognitive Function ◽  
Cognitive Performance ◽  
Negative Mood ◽  
Depression Scale ◽  
Population Based ◽  
Older Age ◽  
Anxiety And Depression ◽  
Sample Mean ◽  
Assessment And Treatment ◽  
Lothian Birth Cohort

AbstractBackgroundAnxiety and depression are both important correlates of cognitive function. However, longitudinal studies investigating how they covary with cognition within the same individual are scarce. We aimed to simultaneously estimate associations of between-person differences and within-person variability in anxiety and depression with cognitive performance in a sample of non-demented older people.MethodsParticipants in the Lothian Birth Cohort 1921 study, a population-based narrow-age sample (mean age at wave 1 = 79 years, n = 535), were examined on five occasions across 13 years. Anxiety and depression were measured with the Hospital Anxiety and Depression Scale (HADS) and cognitive performance was assessed with tests of reasoning, logical memory, and letter fluency. Data were analyzed using two-level linear mixed-effects models with within-person centering.ResultsDivergent patterns were observed for anxiety and depression. For anxiety, between-person differences were more influential; people who scored higher on HADS anxiety relative to other same-aged individuals demonstrated poorer cognitive performance on average. For depression, on the other hand, time-varying within-person differences were more important; scoring higher than usual on HADS depression was associated with poorer cognitive performance relative to the average level for that participant. Adjusting for gender, childhood mental ability, emotional stability, and disease burden attenuated these associations.ConclusionsThe results from this study highlight the importance of addressing both between- and within-person effects of negative mood and suggest that anxiety and depression affect cognitive function in different ways. The current findings have implications for assessment and treatment of older age cognitive deficits.

Pathways Between Acculturation and Health

2011 ◽  
Vol 33 (4) ◽  
pp. 524-539 ◽  
Author(s):  
Patricia Y. Miranda ◽  
Hector M. González ◽  
Wassim Tarraf
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Function ◽  
Structural Equation ◽  
Structural Equation Models ◽  
Depression Scale ◽  
The Elderly ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Functional Health ◽  
Cross Sectional

The purpose of this study was to assess the association between acculturation and functional health using multiple proxies of acculturation to examine explanatory pathways to clarify disparate health findings. A population-based cross-sectional, multistage probability sample from the Hispanic Established Populations for the Epidemiologic Studies of the Elderly ( N = 3,050) was used. The dependent variables of neuropsychiatric function were depressive symptoms (Center for Epidemiologic Studies Depression Scale [CES-D]) and cognitive function (mini-mental state examination [MMSE]) examined in separate multivariable regression and structural equation models to examine the pathways between acculturation proxies and neuropsychiatric function. Findings indicated that three acculturation proxies were associated with cognitive function but none were associated with depressive symptoms. English proficiency fully mediated the associations between other acculturation proxies and cognitive function. The findings suggest that language plays a central role in the pathway between acculturation and health among Mexican-origin populations.

Serum cholesterol and cognitive functions: the Lothian Birth Cohort 1936

2014 ◽  
Vol 27 (3) ◽  
pp. 439-453 ◽  
Author(s):  
Janie Corley ◽  
John M. Starr ◽  
Ian J. Deary
Keyword(s):  
Cognitive Function ◽  
Cognitive Ability ◽  
Birth Cohort ◽  
Old Age ◽  
Serum Cholesterol ◽  
Processing Speed ◽  
Verbal Ability ◽  
Older Age ◽  
Lothian Birth Cohort ◽  
Statin Use

ABSTRACTBackground:We examined the associations between serum cholesterol measures, statin use, and cognitive function measured in childhood and in old age. The possibility that lifelong (trait) cognitive ability accounts for any cross-sectional associations between cholesterol and cognitive performance in older age, seen in observational studies, has not been tested to date.Methods:Participants were 1,043 men and women from the Lothian Birth Cohort 1936 Study, most of whom had participated in a nationwide IQ-type test in childhood (Scottish Mental Survey of 1947), and were followed up at about age 70 years. Serum cholesterol measures included total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides, and cholesterol:HDL cholesterol ratio. Cognitive outcome measures were age 70 IQ (using the same test as at age 11 years), general cognitive ability (g), processing speed, memory, and verbal ability.Results:Higher TC, higher HDL-C, and lower triglycerides were associated with higher age 70 cognitive scores in most cognitive domains. These relationships were no longer significant after covarying for childhood IQ, with the exception a markedly attenuated association between TC and processing speed, and triglycerides and age 70 IQ. In the fully adjusted model, all conventionally significant (p < 0.05) effects were removed. Childhood IQ predicted statin use in old age. Statin users had lower g, processing speed, and verbal ability scores at age 70 years after covarying for childhood IQ, but significance was lost after adjusting for TC levels.Conclusions:These results suggest that serum cholesterol and cognitive function are associated in older age via the lifelong stable trait of intelligence. Potential mechanisms, including lifestyle factors, are discussed.

scholarly journals Cognitive Impairment after Severe Traumatic Brain Injury, Clinical Course and Impact on Outcome: A Swedish-Icelandic Study

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Maud Stenberg ◽  
Alison K. Godbolt ◽  
Catharina Nygren De Boussard ◽  
Richard Levi ◽  
Britt-Marie Stålnacke
Keyword(s):  
Cognitive Function ◽  
Clinical Course ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Hospital Anxiety ◽  
Early Screening ◽  
Multicenter Observational Study ◽  
Severe Tbi ◽  
Prospective Multicenter Observational Study ◽  
Over Time

Objective. To assess the clinical course of cognitive and emotional impairments in patients with severe TBI (sTBI) from 3 weeks to 1 year after trauma and to study associations with outcomes at 1 year.Methods. Prospective, multicenter, observational study of sTBI in Sweden and Iceland. Patients aged 18–65 years with acute Glasgow Coma Scale 3–8 were assessed with the Barrow Neurological Institute Screen for Higher Cerebral Functions (BNIS) and the Hospital Anxiety and Depression Scale (HADS). Outcome measures were Glasgow Outcome Scale Extended (GOSE) and Rancho Los Amigos Cognitive Scale-Revised (RLAS-R).Results. Cognition was assessed with the BNIS assessed for 42 patients out of 100 at 3 weeks, 75 patients at 3 months, and 78 patients at 1 year. Cognition improved over time, especially from 3 weeks to 3 months. The BNIS subscales “orientation” and “visuospatial and visual problem solving” were associated with the GOSE and RLAS-R at 1 year.Conclusion. Cognition seemed to improve over time after sTBI and appeared to be rather stable from 3 months to 1 year. Since cognitive function was associated with outcomes, these results indicate that early screening of cognitive function could be of importance for rehabilitation planning in a clinical setting.

scholarly journals PREVALENCE OF ANXIETY AND DEPRESSION SYNDROMES IN CORRELATION WITH MAJOR RISK FACTORS FOR CHRONIC NONINFECTIOUS DISEASES AMONG PATIENTS OF THE SAMARA REGION

2017 ◽  
Vol 2 (4) ◽  
pp. 18-22
Author(s):  
IA A Krylova ◽  
VI I Kupaev ◽  
AL L Slobodyanyuk ◽  
MS S Nurdina ◽  
OYu Yu Borisov
Keyword(s):  
Risk Factors ◽  
Social Activity ◽  
Severe Depression ◽  
Population Based ◽  
Older Age ◽  
Anxiety And Depression ◽  
Cross Sectional ◽  
Patient’S Satisfaction ◽  
Screening Programs ◽  
Clinical Level

Aim - to study the prevalence of syndromes of anxiety and depression in correlation with major risk factors (RF) of chronic noninfectious diseases among patients of the Samara region considering themselves healthy. Materials and methods. A comparative population-based cross-sectional study was based on a representative selection of patients (95 people) from the Samara region (rural and urban population) at the age of 19-68 years. Results. The study revealed a significant increase in the rates of fatigue, anxiety and depression in outpatients. The syndrome of anxiety of subclinical level was detected in 35.7% of patients, clinical level - in 23.2% of patients; the syndrome of subclinical depression was revealed in 21.0% of patients, and 4.2% had the clinical level. We discovered the correlation between the syndromes of anxiety and depression and the major RF of chronic noninfectious diseases and patient’s satisfaction with quality of medical care in the clinic. High levels of anxiety were more frequent in men, at older age, and were associated with physical inactivity. Severe depression more often occurred at older age and in the presence of hypercholesterolemia. The income level of the patient correlated with the level of stress exposure, physical activity and satisfaction with the work of the policlinics. We did not reveal the relationship between the syndromes of anxiety and/or depression and the level of income, degree of hypertension, social activity, smoking, alcohol consumption, and body mass index. Conclusion. The results indicate that the presence of the syndromes of anxiety and depression increases the risk of occurrence of other independent risk factors of chronic noninfectious diseases. The identified trends can serve as the basis for targeted screening programs for diagnostics and prevention of chronic noninfectious diseases.

The incidence of anxiety and depression in adult cancer outpatients in an area of social deprivation.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e20709-e20709
Author(s):  
Hannah Louise Chapman ◽  
Lucinda Melcher ◽  
Justin Shute
Keyword(s):  
Cancer Patients ◽  
Screening Tool ◽  
Social Deprivation ◽  
Clinical Sample ◽  
Demographic Data ◽  
Depression Scale ◽  
University Hospital ◽  
Clinical Population ◽  
Anxiety And Depression ◽  
Sample Mean

e20709 Background: Psychological distress is common in cancer patients and negatively impacts patient quality of life. Untreated depression predicts early death in patients with advanced cancer. Anxiety and depression may be unrecognised in cancer patients as symptoms can be mistakenly attributed to the underlying malignancy. We assessed the incidence of anxiety and depression in patients attending two hospitals located in areas of significant social deprivation and ethnic diversity. Methods: Patients attending the oncology department at North Middlesex University Hospital and Princess Alexandra Hospital during a one week period were invited to complete a questionnaire. We collected socio-demographic data. The rest of the questionnaire consisted of the Hospital Anxiety and Depression Scale (HADS). HADS is a 14 question, validated screening tool. Total scores range from 0-42, but can be divided into two subscales: HADS-D for depression and HADS-A for anxiety. Interpretation is based primarily on cut-off scores suggested by the test’s authors. In a previously reported non-clinical sample, mean total HADS was 9.82, HADS-D 3.68 and HADS-A 6.14. Results: 96 patients completed the questionnaire. 64 out of 96 patients (67%) were aged between 50 and 79 years. The majority were of white UK ethnicity. The most common types of cancer were breast and colorectal. Seventy five patients (78%) had a ‘normal’ total HADS (≤14). The mean scores for total HADS, HADS-D and HADS-A were 10.53, 4.61 and 5.93, respectively. On the HADS-A subscale, 14 patients had mild anxiety, 12 had moderate and 2 patients had severe anxiety. Depression scores were slightly lower: 12 patients had mild depression and 4 had moderate depression. No patient had severe depression. Only 6 (6%) patients reported taking anti-depressant medication. Conclusions: We demonstrate lower levels of anxiety and depression in a mixed group of cancer patients than previously reported. We explore the possible causes for this difference. Thresholds set to identify ‘cases’ in a non-clinical population may be too high for cancer patients. HADS is a useful screening tool in oncology patients but should be combined with clinical assessment to improve sensitivity and specificity.

scholarly journals Long-Term Follow-Up of Disability, Cognitive, and Emotional Impairments after Severe Traumatic Brain Injury

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Britt-Marie Stålnacke ◽  
Britt-Inger Saveman ◽  
Maud Stenberg
Keyword(s):  
Cognitive Function ◽  
Clinical Course ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Hospital Anxiety ◽  
Emotional Impairments ◽  
Long Term Follow Up ◽  
Severe Tbi

Aim. To assess the clinical course of disability, cognitive, and emotional impairments in patients with severe TBI (s-TBI) from 3 months to up to 7 years post trauma.Methods. A prospective cohort study of s-TBI in northern Sweden was conducted. Patients aged 18-65 years with acute Glasgow Coma Scale 3-8 were assessed with the Glasgow Outcome Scale Extended (GOSE), the Hospital Anxiety and Depression Scale (HADS), and the Barrow Neurological Institute Screen for Higher Cerebral Functions (BNIS) at 3 months, 1 year, and 7 years after the injury.Results. The scores on both GOSE and BNIS improved significantly from 3 months (GOSE mean:4.4±2.3, BNIS mean:31.5±7.0) to 1 year (GOSE mean:5.5±2.7,p=0.003, BNIS mean:33.2±6.3,p=0.04), but no significant improvement was found from 1 year to 7 years (GOSE mean:4.7±2.8,p=0.13, BNIS mean:33.5±3.9,p=0.424) after the injury. The BNIS subscale “speech/language” at 1 year was significantly associated with favourable outcomes on the GOSE at 7 years (OR=2.115, CI: 1.004-4.456,p=0.049).Conclusions. These findings indicate that disability and cognition seem to improve over time after s-TBI and appear to be relatively stable from 1 year to 7 years. Since cognitive function on some of the BNIS subscales was associated with outcome on the GOSE, these results indicate that both screening and follow-up of cognitive function could be of importance for the rehabilitation of persons with s-TBI.

Anxiety and depression in multiple sclerosis. A comparative population-based study in Nord-Trøndelag County, Norway

2009 ◽  
Vol 15 (12) ◽  
pp. 1495-1501 ◽  
Author(s):  
Ole-Petter Dahl ◽  
Eystein Stordal ◽  
Stian Lydersen ◽  
Rune Midgard
Keyword(s):  
Multiple Sclerosis ◽  
General Population ◽  
Depression Scale ◽  
Population Based ◽  
Anxiety And Depression ◽  
Multiple Sclerosis Population ◽  
Neuropsychiatric Manifestations ◽  
Duration Of Disease ◽  
Fatigue Severity ◽  
Multiple Sclerosis Patients

Anxiety and depression are widely distributed symptoms among multiple sclerosis patients and in the general population. We assessed the prevalence of anxiety and depression in the multiple sclerosis population in Nord-Trøndelag County, Norway compared with Norway’s general population. The Hospital Anxiety and Depression Scale questionnaire was completed by 172 MS patients and 56,000 controls. A cut-off of ≥8 was used to define significant symptoms of anxiety and depression. Fatigue was measured using Krupp’s Fatigue Severity Scale, with a mean cut-off of >4. Among men, 31.1% of the multiple sclerosis patients reported anxiety, while only 12.1% of the control population reported this symptom ( p = 0.002). For women, the prevalence of anxiety was 29.7% versus 17.4% ( p < 0.001). Depression was reported by 26.2% of the men with multiple sclerosis compared with 10.8% of the controls ( p < 0.001). The corresponding figures for women were 25.2% versus 10.4% ( p < 0.001). Anxiety and depression were not correlated with duration of disease or disability measured by the Expanded Disability Status Scale. Among women, fatigue was associated with anxiety ( p ≤ 0.010) and depression ( p = 0.007). No such association was found among men. Anxiety and depression occur more frequently in multiple sclerosis patients than in the general population. Fatigue was associated with these neuropsychiatric manifestations in only women.

scholarly journals The Christian Orthodox Church Fasting Diet Is Associated with Lower Levels of Depression and Anxiety and a Better Cognitive Performance in Middle Life

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 627
Author(s):  
Cleanthe Spanaki ◽  
Nikolaos E. Rodopaios ◽  
Alexandra Koulouri ◽  
Triantafyllos Pliakas ◽  
Sousana K. Papadopoulou ◽  
...  
Keyword(s):  
Mental Health ◽  
Cognitive Function ◽  
Cognitive Performance ◽  
Negative Binomial ◽  
Positive Impact ◽  
Depression Scale ◽  
Negative Binomial Regression ◽  
Later Life ◽  
Orthodox Church ◽  
Emotional Wellbeing

Lifestyle choices significantly influence mental health in later life. In this study we investigated the effects of the Christian Orthodox Church (COC) fasting diet, which includes long-term regular abstinence from animal-based products for half the calendar year, on cognitive function and emotional wellbeing of healthy adults. Two groups of fasting and non-fasting individuals were evaluated regarding their cognitive performance and the presence of anxiety and depression using the Mini Mental Examination Scale, the Hamilton Anxiety Scale, and the Geriatric Depression Scale (GDS), respectively. Data on physical activity, smoking, and vitamin levels were collected and correlated with mental health scoring. Negative binomial regression was performed to examine differences in the GDS scores between the two groups. Significantly lower levels of anxiety (7.48 ± 4.98 vs. 9.71 ± 5.25; p < 0.001) and depression (2.24 ± 1.77 vs. 3.5 ± 2.52; p < 0.001), along with better cognitive function (29.15 ± 0.79 vs. 28.64 ± 1.27; p < 0.001), were noticed in fasting compared to non-fasting individuals. GDS score was 31% lower (Incidence Rate Ratio: 0.69, 95% Confidence Interval: 0.56–0.85) in the fasting group compared to the control, while vitamin and ferrum levels did not differ. The COC fasting diet was found to have an independent positive impact on cognition and mood in middle-aged and elderly individuals.

scholarly journals Depresión, ansiedad, función cognitiva y dependencia funcional en adultos mayores hospitalizados

2021 ◽  
Vol 20 (1) ◽  
pp. 267-284
Author(s):  
Tirso Duran-Badillo ◽  
Víctor Alfonso Benítez - Rodríguez ◽  
Ma de la Luz Martínez - Aguilar ◽  
Gustavo Gutiérrez-Sánchez ◽  
Jorge Luis Herrera-Herrera ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Depression Scale ◽  
Cross Sectional Study ◽  
Anxiety And Depression ◽  
Cross Sectional ◽  
Cognitive Evaluation ◽  
Evaluation Test ◽  
Hospitalized Older Adults ◽  
The Relationship

Objetivo: Determinar la relación entre la depresión, ansiedad y función cognitiva con la dependencia en adultos mayores.Material y Método: Estudio descriptivo y correlacional de corte transversal en 98 adultos mayores hospitalizados. Se aplicó la Escala Hospitalaria de Ansiedad y Depresión, el test de evaluación cognitiva de Montreal e Índice de Barthel.Resultados: La edad, el género, la depresión, la ansiedad y la función cognitiva explican el 33% de la dependencia funcional. Las variables que influyen sobre la dependencia en las actividades básicas de la vida diaria fueron el género (p=.000), la depresión (p=.002) y la función cognitiva (p=.002).Conclusiones: En la valoración de la funcionalidad del adulto mayor hospitalizado es importante considerar el género, la depresión y la función cognitiva. Objective: Determine the relationship between depression, anxiety, and cognitive function with dependency in older adults.Materials and Method: Descriptive and correlational cross-sectional study conducted on 98 hospitalized older adults. The Hospital Anxiety and Depression Scale, the Montreal Cognitive Evaluation Test, and the Barthel Index were applied. Results: Age, gender, depression, anxiety, and cognitive function explain 33% of functional dependency. The variables that influence dependence to carry out basic activities in daily life were gender (p = .000), depression (p = .002), and cognitive function (p =.002).Conclusions: In assessing the functionality of hospitalized older adults, gender, depression, and cognitive function are important to consider. Resumo:Objetivo: determinar a relação entre depressão, ansiedade e função cognitiva com dependência em idosos.Material e Método: Estudo transversal descritivo e correlato em 98 idosos hospitalizados. Foi aplicada a Escala de Ansiedade e Depressão Hospitalar, o Teste de Avaliação Cognitiva de Montreal e o Índice de Barthel.Resultados: Idade, sexo, depressão, ansiedade e função cognitiva explicam 33% da dependência funcional. As variáveis que influenciam a dependência das atividades básicas da vida cotidiana foram sexo (p.000), depressão (p.002) e função cognitiva (p.002).Conclusões: Ao avaliar a funcionalidade do idoso hospitalizado é importante considerar gênero, depressão e função cognitiva.

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