The nature of the semantic/episodic memory distinction: A missing piece of the “working through” process

2015 ◽  
Vol 38 ◽  
Author(s):  
Stanley B. Klein ◽  
Hans J. Markowitsch
Keyword(s):  
Episodic Memory ◽  
Autobiographical Memory ◽  
Memory Systems ◽  
Therapeutic Approaches ◽  
Working Through ◽  
Target Article ◽  
Two Systems

AbstractThe relations between the semantic and episodic-autobiographical memory systems are more complex than described in the target article. We argue that understanding the noetic/autonoetic distinction provides critical insights into the foundation of the delineation between the two memory systems. Clarity with respect to the criteria for classification of these two systems, and the evolving conceptualization of episodic memory, can further neuroscientifically informed therapeutic approaches.

Sociocultural memory development research drives new directions in gadgetry science

2019 ◽  
Vol 42 ◽  
Author(s):  
Penny Van Bergen ◽  
John Sutton
Keyword(s):  
Episodic Memory ◽  
Autobiographical Memory ◽  
Developmental Psychology ◽  
Cross Cultural ◽  
Memory Development ◽  
Development Research ◽  
Cultural Research ◽  
New Directions ◽  
Cross Cultural Research

Abstract Sociocultural developmental psychology can drive new directions in gadgetry science. We use autobiographical memory, a compound capacity incorporating episodic memory, as a case study. Autobiographical memory emerges late in development, supported by interactions with parents. Intervention research highlights the causal influence of these interactions, whereas cross-cultural research demonstrates culturally determined diversity. Different patterns of inheritance are discussed.

scholarly journals Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Antonio Marra ◽  
Dario Trapani ◽  
Giulia Viale ◽  
Carmen Criscitiello ◽  
Giuseppe Curigliano
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Residual Disease ◽  
Therapeutic Approaches ◽  
Minimal Residual Disease Monitoring ◽  
Anticancer Treatment ◽  
Immune Contexture

Abstract Triple-negative breast cancer (TNBC) is not a unique disease, encompassing multiple entities with marked histopathological, transcriptomic and genomic heterogeneity. Despite several efforts, transcriptomic and genomic classifications have remained merely theoretic and most of the patients are being treated with chemotherapy. Driver alterations in potentially targetable genes, including PIK3CA and AKT, have been identified across TNBC subtypes, prompting the implementation of biomarker-driven therapeutic approaches. However, biomarker-based treatments as well as immune checkpoint inhibitor-based immunotherapy have provided contrasting and limited results so far. Accordingly, a better characterization of the genomic and immune contexture underpinning TNBC, as well as the translation of the lessons learnt in the metastatic disease to the early setting would improve patients’ outcomes. The application of multi-omics technologies, biocomputational algorithms, assays for minimal residual disease monitoring and novel clinical trial designs are strongly warranted to pave the way toward personalized anticancer treatment for patients with TNBC.

Advances in the Biology and Genetics of the Podocytopathies: Implications for Diagnosis and Therapy

2009 ◽  
Vol 133 (2) ◽  
pp. 201-216 ◽  
Author(s):  
Laura Barisoni ◽  
H. William Schnaper ◽  
Jeffrey B. Kopp
Keyword(s):  
Current Knowledge ◽  
Diffuse Mesangial Sclerosis ◽  
Therapeutic Approaches ◽  
Glomerular Diseases ◽  
Podocyte Injury ◽  
Collapsing Glomerulopathy ◽  
Novel Approach ◽  
Genes Encoding ◽  
Glomerular Morphology

AbstractContext.—Etiologic factors and pathways leading to altered podocyte phenotype are clearly numerous and involve the activity of different cellular function.Objective.—To focus on recent discoveries in podocyte biology and genetics and their relevance to these human glomerular diseases, named podocytopathies.Data Sources.—Genetic mutations in genes encoding for proteins in the nucleus, slit diaphragm, podocyte cytoplasm, and cell membrane are responsible for podocyte phenotype and functional abnormalities. Podocyte injury may also derive from secondary stimuli, such as mechanical stress, infections, or use of certain medications. Podocytes can respond to injury in a limited number of ways, which include (1) effacement, (2) apoptosis, (3) arrest of development, and (4) dedifferentiation. Each of these pathways results in a specific glomerular morphology: minimal change nephropathy, focal segmental glomerulosclerosis, diffuse mesangial sclerosis, and collapsing glomerulopathy.Conclusions.—Based on current knowledge of podocyte biology, we organized etiologic factors and morphologic features in a taxonomy of podocytopathies, which provides a novel approach to the classification of these diseases. Current and experimental therapeutic approaches are also discussed.

scholarly journals Validation of a new wearable device for type 3 sleep test without flowmeter

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249470
Author(s):  
Mauro Contini ◽  
Antonio Sarmento ◽  
Paola Gugliandolo ◽  
Alessandra Leonardi ◽  
Gianluigi Longinotti-Buitoni ◽  
...  
Keyword(s):  
Simultaneous Recording ◽  
Screening Tests ◽  
Respiratory Flow ◽  
Ventilation Monitoring ◽  
Two Systems ◽  
Test Instrumentation ◽  
Central Apneas ◽  
Type 3

Background Ventilation monitoring during sleep is performed by sleep test instrumentation that is uncomfortable for the patients due to the presence of the flowmeter. The objective of this study was to evaluate if an innovative type 3 wearable system, the X10X and X10Y, is able to correctly detect events of apnea and hypopnea and to classify the severity of sleep apnea without the use of a flowmeter. Methods 40 patients with sleep disordered breathing were analyzed by continuous and simultaneous recording of X10X and X10Y and another certified type 3 system, SOMNOtouch, used for comparison. Evaluation was performed in terms of quality of respiratory signals (scores from 1, lowest, to 5, highest), duration and classification of apneas, as well as identification and duration of hypopneas. Results 580 periods were evaluated. Mean quality assigned score was 3.37±1.42 and 3.25±1.35 for X10X and X10Y and SOMNOtouch, respectively. The agreement between the two systems was evaluated with grades 4 and 5 in 383 out of 580 cases. A high correlation (r2 = 0.921; p<0.001) was found between the AHI indexes obtained from the two systems. X10X and X10Y devices were able to correctly classify 72.3% of the obstructive apneas, 81% of the central apneas, 61.3% of the hypopneas, and 64.6% of the mixed apneas when compared to SOMNOtouch device. Conclusion The X10X and X10Y devices are able to provide a correct grading of sleep respiratory disorders without the need of a nasal cannula for respiratory flow measurement and can be considered as a type 3 sleep test device for screening tests.

scholarly journals An Integrated View on Neuronal Subsets in the Peripheral Nervous System and Their Role in Immunoregulation

2021 ◽  
Vol 12 ◽  
Author(s):  
Manuel O. Jakob ◽  
Michael Kofoed-Branzk ◽  
Divija Deshpande ◽  
Shaira Murugan ◽  
Christoph S. N. Klose
Keyword(s):  
Nervous System ◽  
Immune Responses ◽  
Peripheral Nervous System ◽  
Tissue Homeostasis ◽  
Therapeutic Approaches ◽  
Immune Reactions ◽  
Peripheral Neurons ◽  
Inflammatory Signals ◽  
Neuronal Regulation

The peripheral nervous system consists of sensory circuits that respond to external and internal stimuli and effector circuits that adapt physiologic functions to environmental challenges. Identifying neurotransmitters and neuropeptides and the corresponding receptors on immune cells implies an essential role for the nervous system in regulating immune reactions. Vice versa, neurons express functional cytokine receptors to respond to inflammatory signals directly. Recent advances in single-cell and single-nuclei sequencing have provided an unprecedented depth in neuronal analysis and allowed to refine the classification of distinct neuronal subsets of the peripheral nervous system. Delineating the sensory and immunoregulatory capacity of different neuronal subsets could inform a better understanding of the response happening in tissues that coordinate physiologic functions, tissue homeostasis and immunity. Here, we summarize current subsets of peripheral neurons and discuss neuronal regulation of immune responses, focusing on neuro-immune interactions in the gastrointestinal tract. The nervous system as a central coordinator of immune reactions and tissue homeostasis may predispose for novel promising therapeutic approaches for a large variety of diseases including but not limited to chronic inflammation.

A Scene-Based Episodic Memory System for a Simulated Autonomous Creature

2013 ◽  
Vol 4 (1) ◽  
pp. 32-64 ◽  
Author(s):  
Elisa C. Castro ◽  
Ricardo R. Gudwin
Keyword(s):  
Episodic Memory ◽  
Navigation System ◽  
Cognitive Architecture ◽  
Human Memory ◽  
Memory Systems ◽  
Memory Module ◽  
The Past ◽  
3D Environment ◽  
Main Ideas

In this paper the authors present the development of a scene-based episodic memory module for the cognitive architecture controlling an autonomous virtual creature, in a simulated 3D environment. The scene-based episodic memory has the role of improving the creature’s navigation system, by evoking the objects to be considered in planning, according to episodic remembrance of earlier scenes testified by the creature where these objects were present in the past. They introduce the main background on human memory systems and episodic memory study, and provide the main ideas behind the experiment.

scholarly journals Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2008 ◽  
Author(s):  
Nicole Wesch ◽  
Vladimir Kirkin ◽  
Vladimir V. Rogov
Keyword(s):  
Protein Interactions ◽  
Membrane Trafficking ◽  
Structural Features ◽  
Structural Level ◽  
Interacting Proteins ◽  
Therapeutic Approaches ◽  
Basic Principles ◽  
Interaction Partners ◽  
Shed Light

Autophagy is a common name for a number of catabolic processes, which keep the cellular homeostasis by removing damaged and dysfunctional intracellular components. Impairment or misbalance of autophagy can lead to various diseases, such as neurodegeneration, infection diseases, and cancer. A central axis of autophagy is formed along the interactions of autophagy modifiers (Atg8-family proteins) with a variety of their cellular counter partners. Besides autophagy, Atg8-proteins participate in many other pathways, among which membrane trafficking and neuronal signaling are the most known. Despite the fact that autophagy modifiers are well-studied, as the small globular proteins show similarity to ubiquitin on a structural level, the mechanism of their interactions are still not completely understood. A thorough analysis and classification of all known mechanisms of Atg8-protein interactions could shed light on their functioning and connect the pathways involving Atg8-proteins. In this review, we present our views of the key features of the Atg8-proteins and describe the basic principles of their recognition and binding by interaction partners. We discuss affinity and selectivity of their interactions as well as provide perspectives for discovery of new Atg8-interacting proteins and therapeutic approaches to tackle major human diseases.

Endometriotic lesions

2019 ◽  
Vol 11 (2) ◽  
pp. 62-76
Author(s):  
Sri PK Maharajaa ◽  
Razan Asally ◽  
Robert Markham ◽  
Frank Manconi
Keyword(s):  
Immune Cell ◽  
Histopathological Examination ◽  
Abdominal Cavity ◽  
Reproductive Age ◽  
Deep Infiltrating Endometriosis ◽  
Therapeutic Approaches ◽  
Nerve Fibres ◽  
Pain Mechanisms ◽  
Unmyelinated Nerve

Endometriosis is a complex gynaecological condition affecting women of reproductive age. It is characterised by the presence of lesions containing endometrial glands and stroma outside the uterus. The disease is typically associated with pelvic pain (including dysmenorrhoea and dyspareunia), infertility and bowel-related symptoms. Endometriotic lesions have a highly variable presentation and most commonly occur in the abdominal cavity. These lesions are broadly classified into peritoneal, ovarian and deep infiltrating endometriosis. There have been observations of increased density of nerve fibres and neurological molecules in the endometriotic lesions compared to the uninvolved peritoneum of women without endometriosis and the presence of unmyelinated nerve fibres were higher near the glands. The lesion sites are characterised by a range of immunological alterations, and specific immune cell populations have also been known to synthesise and secrete neurogenic factors. Endometriotic lesions are capable of producing prostaglandins which are direct generators of pain and are capable of inducing inflammation. Diagnosing the disease involves direct visualisation of the lesions through a laparoscopic or laparotomy, which is followed by histopathological examination of biopsied or excised lesions. The staging of endometriosis due to its complexity is highly variable as presentation and gaps in knowledge pose a great challenge in the classification of the disease. The medical management of endometriosis aims at providing adequate analgesia and suppression of the activity of the lesion. A better understanding of endometriotic lesion relationships between innervations and specific clinical characteristics may elucidate aspects of pain mechanisms and infertility in endometriosis and facilitate the development of novel therapeutic approaches.

B-Afferents: A fundamental division of the nervous system mediating homeostasis?

1990 ◽  
Vol 13 (2) ◽  
pp. 289-300 ◽  
Author(s):  
James C. Prechtl ◽  
Terry L. Powley
Keyword(s):  
Nervous System ◽  
Autonomic Function ◽  
Distinct Group ◽  
Cell Phenotype ◽  
Functional Relations ◽  
Target Article ◽  
Efferent Pathways ◽  
Reflex System ◽  
Practical Implications

AbstractThe peripheral nervous system (PNS) has classically been separated into a somatic division composed of both afferent and efferent pathways and an autonomic division containing only efferents. J. N. Langley, who codified this asymmetrical plan at the beginning of the twentieth century, considered different afferents, including visceral ones, as candidates for inclusion in his concept of the “autonomic nervous system” (ANS), but he finally excluded all candidates for lack of any distinguishing histological markers. Langley's classification has been enormously influential in shaping modern ideas about both the structure and the function of the PNS. We survey recent information about the PNS and argue that many of the sensory neurons designated as “visceral” and “somatic” are in fact part of a histologically distinct group of afferents concerned primarily autonomic function. These afferents have traditionally been known as “small dark” neurons or B-neurons. In this target article we outline an association between autonomic and B-neurons based on ontogeny, cell phenotype, and functional relations, grouping them together as part of a common reflex system involved in homeostasis. This more parsimonious classification of the PNS, made possible by the identification of a group of afferents associated primarily with the ANS, avoids a number of confusions produced by the classical orientation. It may also have practical implications for an understanding of nociception, homeostatic reflexes, and the evolution of the nervous system.

Remote memory in a patient with amnesia due to hypoxia

1987 ◽  
Vol 17 (3) ◽  
pp. 657-665 ◽  
Author(s):  
William W. Beatty ◽  
David P. Salmon ◽  
Nancy Bernstein ◽  
Nelson Butters
Keyword(s):  
Episodic Memory ◽  
Autobiographical Memory ◽  
Retrograde Amnesia ◽  
Semantic Memory ◽  
Remote Memory ◽  
Accurate Information ◽  
The Past ◽  
Excellent Preservation ◽  
Overall Performance ◽  
Test Of Knowledge

SynopsisIt has been suggested that amnesic patients suffer a selective loss of episodic memory while semantic memory remains well preserved. To assess the validity of this idea we studied remote memory in an amnesic patient, (M.R.L.), using several different measures that differ in the extent which they engage episodic or semantic memory. On two different versions of the Albert et al. (1979) remote memory battery M.R.L. displayed severe retrograde amnesia (RA) extending backwards in time for about 15 years with excellent preservation of older memories. With standard recall instructions his overall performance on the Crovitz test of autobiographical memory was impaired and all of M.R.L.'s specific, temporally dated memories were given from the first half of life. When asked to reconstruct his past residential history in detail, M.R.L. provided specific and generally accurate information for residences occupied from his boyhood until 1970, but thereafter his memory became quite unreliable. On a test of knowledge of terms commonly employed the surveying profession, in which he worked for the past 20 years, M.R.L.'s performance was also impaired. The consistent pattern of RA displayed by this patient on all of the tests of remote memory indicates that both episodic and semantic memory are impaired in amnesia.

Sign in / Sign up

Export Citation Format

Share Document