Cognitive enhancement for the ageing world: opportunities and challenges

2018 ◽  
Vol 39 (10) ◽  
pp. 2308-2321 ◽  
Author(s):  
Marcello Ienca ◽  
David Martin Shaw ◽  
Bernice Elger

AbstractPopulation ageing and the global burden of dementia pose a major challenge for human societies and a priority for public health. Cognitive enhancement,i.e.the targeted amplification of core cognitive abilities, is raising increasing attention among researchers as an effective strategy to complement traditional therapeutic and assistive approaches, and reduce the impact of age-related cognitive disability. In this paper, we discuss the possible applicability of cognitive enhancement for public health purposes to mitigate the burden of population ageing and dementia. After discussing the promises and challenges associated with enhancing ageing citizens and people with cognitive disabilities, we argue that global societies have a moral obligation to consider the careful use of cognitive enhancement technologies as a possible strategy to improve individual and public health. In addition, we address a few primary normative issues and possible objections that could arise from the implementation of public health-oriented cognitive enhancement technologies.

2021 ◽  
Vol 8 ◽  
Author(s):  
Daisy Acosta ◽  
Jorge J. Llibre-Guerra ◽  
Ivonne Z. Jiménez-Velázquez ◽  
Juan J. Llibre-Rodríguez

During the last decade, the Caribbean Hispanic islands experienced accelerated demographic aging, representing the fastest aging region within Latin America. Age-related non-communicable diseases, including dementia, are now reported at high prevalence. The Caribbean islands share similar genetic ancestry, culture, migration patterns, and risk profiles, providing a unique setting to understand dementia in the Caribbean-Hispanics. This perspective article aimed to describe the impact of dementia in the Caribbean, at a local and regional level and reflect on research strategies to address dementia. We report on 10/66 project findings, described research projects and regional plans for the region. According to our results, the prevalence of dementia in the Caribbean is the highest in Latin America, with 11.7% in Dominican Republic, 11.6% in Puerto Rico, and 10.8% in Cuba. Preliminary data from new waves of the 10/66 study shows increasing numbers of dementia cases. Furthermore, dementia is expected to be one of the most serious medical and social issues confronted by Caribbean health systems. However, there is a scarcity of knowledge, awareness, and health services to deal with this public health crisis. In light of the new evidence, local and regional strategies are underway to better understand dementia trends for the region and develop policies aimed to decrease the impact of dementia. Implementation of our national plans is critical to deal with an aging population with high dementia rates. Current recommendations include emphasizing public health prevention campaigns to address modifiable risk factors and expand support to caregiver and family interventions.


2020 ◽  
Author(s):  
Ryan C Moore ◽  
Angela Y Lee ◽  
Jeffrey T Hancock ◽  
Meghan C Halley ◽  
Eleni Linos

BACKGROUND As COVID-19 poses different levels of threat to people of different ages, health communication regarding prevention measures such as social distancing and isolation may be strengthened by understanding the unique experiences of various age groups. OBJECTIVE The aim of this study was to examine how people of different ages (1) experienced the impact of the COVID-19 pandemic and (2) their respective rates and reasons for compliance or noncompliance with social distancing and isolation health guidance. METHODS We fielded a survey on social media early in the pandemic to examine the emotional impact of COVID-19 and individuals’ rates and reasons for noncompliance with public health guidance, using computational and content analytic methods of linguistic analysis. RESULTS A total of 17,287 participants were surveyed. The majority (n=13,183, 76.3%) were from the United States. Younger (18-31 years), middle-aged (32-44 years and 45-64 years), and older (≥65 years) individuals significantly varied in how they described the impact of COVID-19 on their lives, including their emotional experience, self-focused attention, and topical concerns. Younger individuals were more emotionally negative and self-focused, while middle-aged people were other-focused and concerned with family. The oldest and most at-risk group was most concerned with health-related terms but were lower in anxiety (use of fewer anxiety-related terms) and higher in the use of emotionally positive terms than the other less at-risk age groups. While all groups discussed topics such as acquiring essential supplies, they differentially experienced the impact of school closures and limited social interactions. We also found relatively high rates of noncompliance with COVID-19 prevention measures, such as social distancing and self-isolation, with younger people being more likely to be noncompliant than older people (<i>P</i>&lt;.001). Among the 43.1% (n=7456) of respondents who did not fully comply with health orders, people differed substantially in the reasons they gave for noncompliance. The most common reason for noncompliance was not being able to afford to miss work (n=4273, 57.3%). While work obligations proved challenging for participants across ages, younger people struggled more to find adequate space to self-isolate and manage their mental and physical health; middle-aged people had more concerns regarding childcare; and older people perceived themselves as being able to take sufficient precautions. CONCLUSIONS Analysis of natural language can provide insight into rapidly developing public health challenges like the COVID-19 pandemic, uncovering individual differences in emotional experiences and health-related behaviors. In this case, our analyses revealed significant differences between different age groups in feelings about and responses to public health orders aimed to mitigate the spread of COVID-19. To improve public compliance with health orders as the pandemic continues, health communication strategies could be made more effective by being tailored to these age-related differences.


Author(s):  
Gabriel K. Rousseau ◽  
Nina Lamson ◽  
Wendy A. Rogers

A variety of individual difference variables affect whether someone notices, encodes, comprehends, and complies with a product warning label. Failures at any of these stages reduce the effectiveness of warnings. Development of effective warnings must be based on understanding the characteristics of the product user. As the population grows older, consideration of age-related changes in perceptual and cognitive abilities becomes more relevant to the warning designer. Aging researchers have identified a variety of declines and changes in vision (e.g., acuity, contrast sensitivity, and color discrimination) and memory (e.g., working memory and prospective memory). By considering the abilities of the product user, the impact of age-related changes may be minimized. Based on cognitive aging research and theory, we will make recommendations about how designers can increase the effectiveness of warnings for older adults.


Author(s):  
Ana Borovecki ◽  
Pamela Tozzo ◽  
Nicoletta Cerri ◽  
Luciana Caenazzo

In recent years, a social trend toward delaying childbearing has been observed in women of reproductive age. A novel technomedical innovation was commercialized for non-medical reasons to healthy, ostensibly fertile women, who wished to postpone motherhood for various reasons such as educational or career demands, or because they had not yet found a partner. As a consequence, these women may be affected by age-related infertility when they decide to conceive, and fertility preservation techniques can be obtained through the so-called social egg freezing. This paper examines, from an ethical point of view, the impact of social egg freezing under some aspects that can involve policy making and resources allocation in public health. Due to the increasing demand for this procedure, some debated issues regard if it is reasonable to include social egg freezing in Public Healthcare System and consequently how to manage the storage of cryopreserved oocytes also from individual donors, how to support these egg banks and how to face, in the future, with the possibility that egg freezing will play a role in enabling childbearing for gays, lesbians, and unmarried persons. Social freezing may be advertised to harmonise gender differences, but we wonder if it is the proper solution to the problem or if it could also create further challenges. An ethical argumentation on these topics should address some questions that will be discussed.


2002 ◽  
Vol 14 (2) ◽  
pp. 139-159 ◽  
Author(s):  
Olivier Piguet ◽  
David A. Grayson ◽  
G. Anthony Broe ◽  
Robyn L. Tate ◽  
Hayley P. Bennett ◽  
...  

Background: Studies on normal aging and cognitive functioning commonly describe early and more pronounced age-related changes in executive functions (EFs) compared to other cognitive abilities. Two of the three most common neurodegenerative disorders associated with aging (vascular dementia [VaD] and extrapyramidal [EP]-related dementia) show executive dysfunctions in their clinical presentation; and these cognitive deficits are not uncommon in the third one: Alzheimer's disease (AD). Methods: Nine EF tests (yielding 12 measures) were administered to 123 randomly selected community dwellers, aged 81 years and over, with the view to determine the effect of age on performance. Markers of AD, VaD, and EP-related dementia, as well as sociodemographic and psychological variables, were selected and their contribution to EF performance was investigated. Results: Multiple linear regression analyses revealed the greatest contribution to EF scores from the markers of AD and estimated IQ but not from the markers of VaD and EP-related dementia or from age. Conclusions: These findings suggest that chronological age acts as a proxy variable mediating the impact of other factors such as subclinical signs of neurodegenerative disorders and that it has little independent contribution to make. They also indicate the importance of cognitive abilities supported by posterior cortical circuits in EF problem resolution. This study demonstrates that cognitive decline is not an ineluctable process that is associated with “normal” aging but rather represents, in many cases, a byproduct of neurodegenerative disorders, albeit themselves highly age-related.


2010 ◽  
Vol 16 (3) ◽  
pp. 412-423 ◽  
Author(s):  
MAHEEN M. ADAMSON ◽  
VIKTORIYA SAMARINA ◽  
XU XIANGYAN ◽  
VIRGINIA HUYNH ◽  
QUINN KENNEDY ◽  
...  

AbstractPrevious studies have consistently reported age-related changes in cognitive abilities and brain structure. Previous studies also suggest compensatory roles for specialized training, skill, and years of education in the age-related decline of cognitive function. The Stanford/VA Aviation Study examines the influence of specialized training and skill level (expertise) on age-related changes in cognition and brain structure. This preliminary report examines the effect of aviation expertise, years of education, age, and brain size on flight simulator performance in pilots aged 45–68 years. Fifty-one pilots were studied with structural magnetic resonance imaging, flight simulator, and processing speed tasks. There were significant main effects of age (p < .01) and expertise (p < .01), but not of whole brain size (p > .1) or education (p > .1), on flight simulator performance. However, even though age and brain size were correlated (r = −0.41), age differences in flight simulator performance were not explained by brain size. Both aviation expertise and education were involved in an interaction with brain size in predicting flight simulator performance (p < .05). These results point to the importance of examining measures of expertise and their interactions to assess age-related cognitive changes. (JINS, 2010, 16, 412–423.)


Author(s):  
Sara J. Czaja ◽  
Joseph Sharit ◽  
Sankaran Nair

The objective of the current research was to evaluate the impact of age on the performance of computer-based work in order to develop design interventions that enhance the ability of older adults to perform these tasks. Specifically, two computer tasks, data entry, and a complex problem solving were investigated. Participants ranged in age from 20–75 years. Overall, the results indicted age differences in performance of both tasks. The younger participants had higher levels of performance Further, the results indicated that age-related differences in component cognitive abilities were related to performance. These data were used to develop design interventions such as modifying the layout of screen information. This paper presents data from the intervention studies. Overall the findings indicate that the interventions improved performance for all participants. For example, there were fewer keystroke errors for the data entry task and problem solving time was reduced for the problem solving task. These data are discussed in terms of understanding the extent to which fundamental interface design interventions can benefit older adults.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
U Mons

Abstract Background Despite weak tobacco control, smoking in Germany has steadily declined over the last 25 years. As policymakers expect that this trend will reflect in a declining associated public health burden, I sought to quantify trends in smoking-attributable mortality (SAM) and smoking-attributable cancer incidence (SACI) and to explore the impact of population ageing. Methods Smoking and mortality statistics from 1992 to 2017 were obtained from the German Statistical Office, from which SAM was calculated separately for each cause of death causally associated with smoking. Cancer incidence data from 1999 to 2016 was obtained from the German Cancer Registry, and SACI was calculated separately for each cancer site causally associated with smoking. The impact of population ageing was explored by comparing crude and age-standardized SAM and SACI, respectively. To estimate the impact of population ageing on future SAM and SACI, a forward projection until 2035 was modelled. Results Preliminary results suggest that total SAM and SACI only slightly declined over time, while stronger decreases were seen in age-adjusted SAM and SACI. Differences between crude and age-standardized SAM and SACI seem to be particularly striking in men. The forward projection of SAM and SACI suggests that population ageing will lead to further steady increases within the next two decades in both sexes. Conclusions Results indicate that past decreases in SAM and SACI due to declines in smoking were largely compensated by population ageing. In the next two decades, population ageing will lead to a steady increase in SAM and SACI. Only by taking determined immediate action with a comprehensive set of evidence-based tobacco control polices could significant inroads into reducing the smoking-associated disease burden be achieved. Also, given still significant smoking rates in middle and old age, there is tremendous potential to curb the associated public health burden by intensifying cessation programs. Key messages Contrary to common expectations among policymakers, the smoking-attributable public health burden will strongly increase in the next decades. Determined immediate policy action is required to halt or attenuate these trends.


2021 ◽  
Vol 31 (Supplement_3) ◽  
Author(s):  
U Mons

Abstract Background Despite weak tobacco control, smoking in Germany has steadily declined over the last 25 years. As policymakers often expect that this trend will also reflect in a declining associated public health burden, I sought to quantify trends in smoking-attributable mortality (SAM) and to explore the impact of population ageing. Methods Smoking and mortality statistics from 1992 to 2018 were obtained from the German Statistical Office, from which SAM was calculated separately for each cause of death causally associated with smoking using Levin's formula for population-attributable fractions. The impact of population ageing was explored by comparing crude and age-standardized SAM, respectively. To estimate the impact of population ageing on future SAM, a forward projection until 2040 was modelled assuming continuation of smoking trends and constant mortality rates. Results About 126.900 deaths were attributable to smoking in Germany in 2018. Since 1992, total SAM declined only slightly, while stronger decreases were seen in age-adjusted SAM. Differences between crude and age-standardized SAM seem to be particularly striking in men. The forward projection of SAM suggests that recent increases in smoking in the middle aged as well as population ageing dynamics will lead to further steady increases within the next two decades in both sexes to about 138.250. Conclusions Results indicate that past decreases in SAM due to declines in smoking were largely compensated by population ageing. In the next two decades, current smoking trends and population ageing will lead to a steady increase in SAM. Only by taking determined immediate policy action could significant inroads into reducing the smoking-associated disease burden be achieved. Also, given still significant smoking rates in middle and old age, there is tremendous potential to curb the associated public health burden by intensifying cessation programs. Key messages Contrary to common expectations among policymakers, the smoking-attributable public health burden will strongly increase in the next decades in Germany. Determined immediate policy action is required to halt or attenuate these trends.


2017 ◽  
Vol 41 (S1) ◽  
pp. S34-S34
Author(s):  
A.K. Brem

Transcranial electrical stimulation (tES) is being widely investigated to understand and modulate human brain function. The interest in using tES to enhance cognitive abilities not only in patient populations but also in healthy individuals has grown in recent years. Specifically in combination with cognitive training tES has shown success in enhancing cognition. However, to date, we still know little about the impact of interindividual differences on intervention outcomes. A variety of tES techniques and their effects in combination with cognitive training, interactive effects of tES with baseline cognitive abilities and neurophysiological traits will be presented and following ramifications with regards to the development of individualised stimulation protocols will be discussed.Disclosure of interestThe author has not supplied his declaration of competing interest.


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