Stimulated Virus Production in Vinblastine and Cytochalasin-Induced Multinucleate Cells
1970 ◽
Vol 28
◽
pp. 186-187
Keyword(s):
Exposure of cells to low sublethal but mitosis-arresting doses of vinblastine sulfate (Velban) results in the initial arrest of cells in mitosis followed by their subsequent return to an “interphase“-like stage. A large number of these cells reform their nuclear membranes and form large multimicronucleated cells, some containing as many as 25 or more micronuclei (1). Formation of large multinucleate cells is also caused by cytochalasin, by causing the fusion of daughter cells at the end of an otherwise .normal cell division (2). By the repetition of this process through subsequent cell divisions, large cells with 6 or more nuclei are formed.
2017 ◽
Vol 114
(29)
◽
pp. E5845-E5853
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Keyword(s):
1972 ◽
Vol 54
(3)
◽
pp. 657-664
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Keyword(s):
1990 ◽
Vol 190
(1)
◽
pp. 65-68
◽
Keyword(s):
Keyword(s):
1991 ◽
Vol 11
(6)
◽
pp. 2919-2928
Keyword(s):