Immunity to polio, measles and rubella in women of child-bearing age and estimated congenital rubella syndrome incidence, Cambodia, 2012

2014 ◽  
Vol 143 (9) ◽  
pp. 1858-1867 ◽  
Author(s):  
B. MAO ◽  
K. CHHENG ◽  
K. WANNEMUEHLER ◽  
E. VYNNYCKY ◽  
S. BUTH ◽  
...  
Keyword(s):  
Potential Role ◽  
Congenital Rubella Syndrome ◽  
Childhood Vaccination ◽  
Age Group ◽  
Congenital Rubella ◽  
Child Bearing ◽  
Age Structured ◽  
Serological Data ◽  
And Control ◽  
Rubella Antibody

SUMMARYSignificant gaps in immunity to polio, measles, and rubella may exist in adults in Cambodia and threaten vaccine-preventable disease (VPD) elimination and control goals, despite high childhood vaccination coverage. We conducted a nationwide serological survey during November–December 2012 of 2154 women aged 15–39 years to assess immunity to polio, measles, and rubella and to estimate congenital rubella syndrome (CRS) incidence. Measles and rubella antibodies were detected by IgG ELISA and polio antibodies by microneutralization testing. Age-structured catalytic models were fitted to rubella serological data to predict CRS cases. Overall, 29·8% of women lacked immunity to at least one poliovirus (PV); seroprevalence to PV1, PV2 and PV3 was 85·9%, 93·4% and 83·3%, respectively. Rubella and measles antibody seroprevalence was 73·3% and 95·9%, respectively. In the 15–19 years age group, 48·2% [95% confidence interval (CI) 42·4–54·1] were susceptible to either PV1 or PV3, and 40·3% (95% CI 33·0–47·5) to rubella virus. Based on rubella antibody seroprevalence, we estimate that >600 infants are born with CRS in Cambodia annually. Significant numbers of Cambodian women are still susceptible to polio and rubella, especially those aged 15–19 years, emphasizing the need to include adults in VPD surveillance and a potential role for vaccination strategies targeted at adults.

scholarly journals Introduction of rubella-containing-vaccine to Madagascar: implications for roll-out and local elimination

2016 ◽  
Vol 13 (117) ◽  
pp. 20151101 ◽  
Author(s):  
Amy Wesolowski ◽  
Keitly Mensah ◽  
Cara E. Brook ◽  
Miora Andrianjafimasy ◽  
Amy Winter ◽  
...  
Keyword(s):  
Vaccine Coverage ◽  
Local Extinction ◽  
Surveillance Systems ◽  
Global Alliance ◽  
Congenital Rubella ◽  
Age Of Infection ◽  
Age Structured ◽  
Serological Data ◽  
The Impact ◽  
Roll Out

Few countries in Africa currently include rubella-containing vaccination (RCV) in their immunization schedule. The Global Alliance for Vaccines Initiative (GAVI) recently opened a funding window that has motivated more widespread roll-out of RCV. As countries plan RCV introductions, an understanding of the existing burden, spatial patterns of vaccine coverage, and the impact of patterns of local extinction and reintroduction for rubella will be critical to developing effective programmes. As one of the first countries proposing RCV introduction in part with GAVI funding, Madagascar provides a powerful and timely case study. We analyse serological data from measles surveillance systems to characterize the epidemiology of rubella in Madagascar. Combining these results with data on measles vaccination delivery, we develop an age-structured model to simulate rubella vaccination scenarios and evaluate the dynamics of rubella and the burden of congenital rubella syndrome (CRS) across Madagascar. We additionally evaluate the drivers of spatial heterogeneity in age of infection to identify focal locations where vaccine surveillance should be strengthened and where challenges to successful vaccination introduction are expected. Our analyses indicate that characteristics of rubella in Madagascar are in line with global observations, with an average age of infection near 7 years, and an impact of frequent local extinction with reintroductions causing localized epidemics. Modelling results indicate that introduction of RCV into the routine programme alone may initially decrease rubella incidence but then result in cumulative increases in the burden of CRS in some regions (and transient increases in this burden in many regions). Deployment of RCV with regular supplementary campaigns will mitigate these outcomes. Results suggest that introduction of RCV offers a potential for elimination of rubella in Madagascar, but also emphasize both that targeted vaccination is likely to be a lynchpin of this success, and the public health vigilance that this introduction will require.

scholarly journals EDUKASI PEMBERIAN IMUNISASI MR (MEASLES RUBELLA) PADA IBU YANG MEMILIKI ANAK USIA BALITA

2021 ◽  
Vol 3 (1) ◽  
pp. 45
Author(s):  
Melia Pebrina ◽  
Fenny Fernando ◽  
Annisa Novita Sary
Keyword(s):  
Community Service ◽  
Health Workers ◽  
Immunization Coverage ◽  
Congenital Rubella Syndrome ◽  
Rubella Vaccine ◽  
Under Five ◽  
Measles Elimination ◽  
Congenital Rubella ◽  
And Control ◽  
Immunization Campaign

Campak dan Rubella merupakan penyakit infeksi menular melalui saluran nafas yang disebabkan oleh virus Campak dan Rubella.Vaksin MR (Measles Rubella) memberikan manfaat seperti dapat melindungi anak dari kecacatan dan kematian akibat komplikasi pneumonia, diare, kerusakan otak, ketulian, kebutaan, dan penyakit jantung bawaan. Indonesia telah berkomitmen untuk mencapai eliminasi campak dan pengendalian rubella/Congenital Rubella Syndrome (CRS) pada tahun 2020. Berdasarkan hasil surveilans dan cakupan imunisasi, maka imunisasi campak rutin saja belum cukup untuk mencapai target eliminasi campak. Sedangkan untuk akselerasi pengendalian rubella/CRS maka perlu dilakukan kampanye imunisasi tambahan sebelum introduksi vaksin MR ke dalam imunisasi rutin. Program Pengabdian Masyarakat ini melalui penerapan Ipteks bagi masyarakat bertujuan mengenalkan dan tercapainya cakupan imunisasi measles rubella. Kegiatan pengabmas dilaksanakan hari Rabu  tanggal 18 Februari 2021 pukul 10.00 Wib, tempat pelaksanaan di Puskesmas Nanggalo Padang. Peserta yang hadir jumlah 15 orang ibu-ibu yang mempunyai anak usia balita. Berdasarkan hasil kegiatan tersebut terjadinya peningkatan pengetahuan ibu yang mempunyai anak usia balita tentang pemberian imunisasi MR. Diharapkan petugas kesehatan meningkatkan edukasi tentang pemberian imunisasi MR.  Kata Kunci: Imunisasi MR (Measles Rubella)  ABSTRACT Measles and Rubella are infectious diseases that are transmitted through the respiratory tract caused by the measles and rubella viruses. The MR (Measles Rubella) vaccine provides benefits such as protecting children from disability and death due to complications of pneumonia, diarrhea, brain damage, deafness, blindness and heart disease. built-in. Indonesia has committed to achieve elimination of measles and control of rubella / Congenital Rubella Syndrome (CRS) by 2020. Based on the results of surveillance and immunization coverage, routine measles immunization alone is not sufficient to achieve the target of measles elimination. Meanwhile, for the acceleration of rubella / CRS control, it is necessary to carry out an additional immunization campaign before the introduction of the MR vaccine into routine immunization. This Community Service Program through the application of science and technology for the community aims to introduce and achieve measles rubella immunization coverage. Community service activities will be carried out on Wednesday, February 18, 2021 at 10.00 WIB, the place of implementation is at the Nanggalo Padang Health Center. Participants who attended were 15 mothers who have children under five. Based on the results of these activities there is an increase in the knowledge of mothers who have children aged under five about giving MR immunization. It is hoped that health workers will increase education about MR immunization. Keywords: immunization MR (Measles Rubella)Campak dan Rubella merupakan penyakit infeksi menular melalui saluran nafas yang disebabkan oleh virus Campak dan Rubella.Vaksin MR (Measles Rubella) memberikan manfaat seperti dapat melindungi anak dari kecacatan dan kematian akibat komplikasi pneumonia, diare, kerusakan otak, ketulian, kebutaan, dan penyakit jantung bawaan. Indonesia telah berkomitmen untuk mencapai eliminasi campak dan pengendalian rubella/Congenital Rubella Syndrome (CRS) pada tahun 2020. Berdasarkan hasil surveilans dan cakupan imunisasi, maka imunisasi campak rutin saja belum cukup untuk mencapai target eliminasi campak. Sedangkan untuk akselerasi pengendalian rubella/CRS maka perlu dilakukan kampanye imunisasi tambahan sebelum introduksi vaksin MR ke dalam imunisasi rutin. Program Pengabdian Masyarakat ini melalui penerapan Ipteks bagi masyarakat bertujuan mengenalkan dan tercapainya cakupan imunisasi measles rubella. Kegiatan pengabmas dilaksanakan hari Rabu  tanggal 18 Februari 2021 pukul 10.00 Wib, tempat pelaksanaan di Puskesmas Nanggalo Padang. Peserta yang hadir jumlah 15 orang ibu-ibu yang mempunyai anak usia balita. Berdasarkan hasil kegiatan tersebut terjadinya peningkatan pengetahuan ibu yang mempunyai anak usia balita tentang pemberian imunisasi MR. Diharapkan petugas kesehatan meningkatkan edukasi tentang pemberian imunisasi MR.  Kata Kunci: Imunisasi MR (Measles Rubella)  ABSTRACT Measles and Rubella are infectious diseases that are transmitted through the respiratory tract caused by the measles and rubella viruses. The MR (Measles Rubella) vaccine provides benefits such as protecting children from disability and death due to complications of pneumonia, diarrhea, brain damage, deafness, blindness and heart disease. built-in. Indonesia has committed to achieve elimination of measles and control of rubella / Congenital Rubella Syndrome (CRS) by 2020. Based on the results of surveillance and immunization coverage, routine measles immunization alone is not sufficient to achieve the target of measles elimination. Meanwhile, for the acceleration of rubella / CRS control, it is necessary to carry out an additional immunization campaign before the introduction of the MR vaccine into routine immunization. This Community Service Program through the application of science and technology for the community aims to introduce and achieve measles rubella immunization coverage. Community service activities will be carried out on Wednesday, February 18, 2021 at 10.00 WIB, the place of implementation is at the Nanggalo Padang Health Center. Participants who attended were 15 mothers who have children under five. Based on the results of these activities there is an increase in the knowledge of mothers who have children aged under five about giving MR immunization. It is hoped that health workers will increase education about MR immunization. Keywords: immunization MR (Measles Rubella)

scholarly journals Immunity Gaps Across Age and Space to Tailor Immunization Activities in Zambia: Measles and Rubella Seroprevalence Using a National Biorepository

2021 ◽  
Author(s):  
Andrea C. Carcelen ◽  
Amy K. Winter ◽  
William J. Moss ◽  
Innocent Chilumba ◽  
Irene Mutale ◽  
...  
Keyword(s):  
Large Scale ◽  
Age Groups ◽  
Childhood Vaccination ◽  
Serum Samples ◽  
Vaccine Introduction ◽  
Congenital Rubella ◽  
Innovative Methods ◽  
Seroprevalence Data ◽  
The Cost ◽  
And Control

Abstract Background: High-quality, representative serological surveys allow direct estimates of immunity profiles to inform vaccination strategies but can be costly and logistically challenging. Leveraging residual serum samples is one way to increase their feasibility.Methods: We subsampled 9,854 residual sera from a 2016 national HIV survey in Zambia and tested these specimens for anti-measles and anti-rubella virus IgG antibodies using indirect enzyme immunoassays. We demonstrate innovative methods for sampling residual sera and analyzing seroprevalence data, as well as the value of seroprevalence estimates to understand and control measles and rubella. Results: National measles and rubella seroprevalence for individuals younger than 50 years was 82·8% (95% CI 81·6, 83·9%) and 74·9% (95% CI 73·7%, 76·0%), respectively. Despite a successful childhood vaccination program, measles immunity gaps persisted across age groups and districts, indicating the need for additional activities to complement routine immunization. Prior to vaccine introduction, we estimated a rubella burden of 96 congenital rubella syndrome cases per 100,000 live births.Conclusion: Residual samples from large-scale surveys can reduce the cost and challenges of conducting serosurveys, and multiple pathogens can be tested. Procedures to access specimen quality, ensure ethical approvals, and link sociodemographic data can improve the timeliness and value of results.

scholarly journals Epidemio-clinical aspects of congenital rubella syndrome in Madagascar

2020 ◽  
Vol 8 (2) ◽  
pp. 424
Author(s):  
Todisoa N. Andriatahina ◽  
Lantonirina Ravaoarisoa ◽  
Andrianina H. Ranivoson ◽  
Vonintsoa L. Rahajamanana ◽  
Zina A. Randriananahirana ◽  
...  
Keyword(s):  
Congenital Rubella Syndrome ◽  
World Health ◽  
Clinical Aspects ◽  
Age Group ◽  
Pediatric Practice ◽  
Rubella Vaccine ◽  
Clinical Criteria ◽  
Congenital Rubella ◽  
Expanded Program On Immunization ◽  
Health Organization

Background: Congenital rubella syndrome is the first congenital defect preventable by vaccination. The purpose of this study was to provide basic information on the extent and epidemiology of congenital rubella syndrome in Madagascar.Methods: A retrospective and descriptive study from January 2013 to May 2019 was conducted in 8 hospitals in 2 provinces of Madagascar, Antananarivo and Toliara. The study included children who attended the services selected during the study period and who had the following conditions: children aged of 0 to 59 months, regardless of vaccination status, meeting the World Health Organization clinical criteria for congenital rubella syndrome with or without biological confirmation.Results: Of the 152,304 cases of children of all ages who visited or were hospitalized during the study period, 112 clinically confirmed cases of congenital rubella syndrome were identified. The age group 0 to 11 months involved 60 children (53.6%). Congenital heart disease was found in 83.0% of cases, mental backwardness in 43.7% and microcephaly in 26.8%. Twenty-three among (20.5%) them died. The death was due to cardiac diseases in 16 children.Conclusions: Findings confirm that the diagnosis of congenital rubella syndrome is underestimated in current pediatric practice in Madagascar. The introduction of the rubella vaccine in the Expanded Program on Immunization and the implementation of an effective and sustainable surveillance system for congenital rubella syndrome in the country is a proved effective tool for the prevention of this disease.

Congenital Rubella Syndrome: A Case Report on Changes in Viral Load and Rubella Antibody Titers

PEDIATRICS ◽  
2016 ◽  
Vol 137 (5) ◽  
pp. e20153333-e20153333 ◽  
Author(s):  
K. Nagasawa ◽  
N. Ishiwada ◽  
A. Ogura ◽  
T. Ogawa ◽  
N. Takeuchi ◽  
...  
Keyword(s):  
Case Report ◽  
Viral Load ◽  
Congenital Rubella Syndrome ◽  
Congenital Rubella ◽  
Antibody Titers ◽  
Rubella Antibody

scholarly journals Rubella in the Russian Federation: epidemiological features and control measures to prevent the congenital rubella syndrome

2000 ◽  
Vol 125 (2) ◽  
pp. 359-366 ◽  
Author(s):  
V. V. SEMERIKOV ◽  
I. N. LAVRENTYEVA ◽  
V. F. POPOV ◽  
M. A. FLETCHER ◽  
M. E. KOLOTOV
Keyword(s):  
Pregnant Women ◽  
Russian Federation ◽  
Haemagglutination Inhibition ◽  
Congenital Rubella Syndrome ◽  
Control Measures ◽  
Epidemiological Surveillance ◽  
Childbearing Age ◽  
Congenital Rubella ◽  
The Russian Federation ◽  
And Control

A review of the epidemiology of clinical rubella in the Perm region of the Russian Federation from 1979–97 showed that the incidence was about 220 cases per 100000 population. Congenital rubella syndrome (CRS) accounted for 15% of birth defects and for about 3·5 cases of CRS per 1000 live births per year. Surveys of the seroepidemiology of rubella infection revealed that the susceptibility rate among pregnant women (i.e. rubella virus antibody haemagglutination-inhibition (HAI) assay titres < 10) was 16·5%. As serum rubella antibody HAI titres [ges ] 10 both prevented infection in pregnant women and protected their foetuses, serological testing has been introduced into the routine antenatal services. Pre-existing rubella antibodies were found not to interfere with the immune response to vaccination, so selective immunization was provided to girls approaching puberty and to women of childbearing age. A programme of epidemiological surveillance is being developed to define tactics for the widescale introduction of rubella vaccination.

scholarly journals Burden of congenital rubella syndrome (CRS) in India based on data from cross-sectional serosurveys, 2017 and 2019–20

2021 ◽  
Vol 15 (7) ◽  
pp. e0009608
Author(s):  
Devika Shanmugasundaram ◽  
Shally Awasthi ◽  
Bhagirathi Dwibedi ◽  
S. Geetha ◽  
Manish Jain ◽  
...  
Keyword(s):  
Congenital Rubella Syndrome ◽  
Age Group ◽  
Igg Antibodies ◽  
Live Births ◽  
Force Of Infection ◽  
Congenital Rubella ◽  
Infection Models ◽  
Age Dependent ◽  
Antenatal Clinics ◽  
Elimination Goal

Background India has set a goal to eliminate measles and rubella/Congenital Rubella Syndrome (CRS) by 2023. Towards this goal, India conducted nationwide supplementary immunization activity (SIA) with measles-rubella containing vaccine (MRCV) targeting children aged between 9 months to <15 years and established a hospital-based sentinel surveillance for CRS. Reliable data about incidence of CRS is necessary to monitor progress towards the elimination goal. Methods We conducted serosurveys in 2019–20 among pregnant women attending antenatal clinics of 6 hospitals, which were also sentinel sites for CRS surveillance, to estimate the prevalence of IgG antibodies against rubella. We systematically sampled 1800 women attending antenatal clinics and tested their sera for IgG antibodies against rubella. We used rubella seroprevalence data from the current survey and the survey conducted in 2017 among antenatal women from another 6 CRS surveillance sites to construct a catalytic models to estimate the incidence and burden of CRS. Result The seroprevalence of rubella antibodies was 82.3% (95% CI: 80.4–84.0). Rubella seropositivity did not differ by age group and educational status. Based on the constant and age-dependent force of infection models, we estimated that the annual incidence of CRS in India was 225.58 per 100,000 live births (95% CI: 217.49–232.41) and 65.47 per 100,000 live births (95% CI: 41.60–104.16) respectively. This translated to an estimated 14,520 (95% CI: 9,225–23,100) and 50,028 (95% CI: 48,234–51,543) infants with CRS every year based on age-dependent and constant force of infection models respectively. Conclusions Our findings indicated that about one fifth of women in the reproductive age group in India were susceptible for rubella. The estimates of CRS incidence will serve as a baseline to monitor the impact of MRCV SIAs, as well progress towards the elimination goal of rubella/CRS.

scholarly journals Rubella metapopulation dynamics and importance of spatial coupling to the risk of congenital rubella syndrome in Peru

2010 ◽  
Vol 8 (56) ◽  
pp. 369-376 ◽  
Author(s):  
C. J. E. Metcalf ◽  
C. V. Munayco ◽  
G. Chowell ◽  
B. T. Grenfell ◽  
O. N. Bjørnstad
Keyword(s):  
Spatial Dynamics ◽  
Congenital Rubella Syndrome ◽  
Metapopulation Dynamics ◽  
Childbearing Age ◽  
Age Classes ◽  
Health Value ◽  
Spatial Coupling ◽  
Congenital Rubella ◽  
Colonization Dynamics ◽  
Age Structured

Rubella is generally a mild childhood disease, but infection during early pregnancy may cause spontaneous abortion or congenital rubella syndrome (CRS), which may entail a variety of birth defects. Consequently, understanding the age-structured dynamics of this infection has considerable public health value. Vaccination short of the threshold for local elimination of transmission will increase the average age of infection. Accordingly, the classic concern for this infection is the potential for vaccination to increase incidence in individuals of childbearing age. A neglected aspect of rubella dynamics is how age incidence patterns may be moulded by the spatial dynamics inherent to epidemic metapopulations. Here, we use a uniquely detailed dataset from Peru to explore the implications of this for the burden of CRS. Our results show that the risk of CRS may be particularly severe in small remote regions, a prediction at odds with expectations in the endemic situation, and with implications for the outcome of vaccination. This outcome results directly from the metapopulation context: specifically, extinction–re-colonization dynamics are crucial because they allow for significant leakage of susceptible individuals into the older age classes during inter-epidemic periods with the potential to increase CRS risk by as much as fivefold.

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