Malignancies of the female genital tract in childhood and adolescence

2002 ◽  
Vol 10 (2) ◽  
pp. 133-147 ◽  
Author(s):  
E Brockbank ◽  
T Ind
Keyword(s):  
Teenage Pregnancy ◽  
Reproductive Tract ◽  
Female Genital Tract ◽  
Female Reproductive Tract ◽  
Childhood And Adolescence ◽  
Malignant Tumours ◽  
Ovarian Tumours ◽  
Adults And Children ◽  
The Relationship ◽  
Female Genital

Malignant tumours of the female reproductive tract in childhood and adolescence are rare. The comparative frequencies of tumours in adults and children may be related to the relative accumulation of exposure to environmental factors. An example might be the relationship between exposure to human papillomavirus and the development of vulval, vaginal and cervical cancers. Some cancers in childhood are associated with factors specific to the time of life. Examples include in-utero stilboestrol exposure related to clear cell carcinoma and teenage pregnancy associated with gestational trophoblastic tumours. In childhood and adolescence, 67% of all ovarian tumours are germ cell in origin. This differs significantly to the distribution of ovarian tumours in adults.

Migration and motility of spermatozoa in the female reproductive tract of the soft tick Ornithodoros moubata (Acari, Argasidae)

Parasitology ◽  
2009 ◽  
Vol 136 (5) ◽  
pp. 511-521 ◽  
Author(s):  
J. H. RESLER ◽  
J. L. FRAZIER ◽  
J. G. SHEPHERD ◽  
J. D. MODAFFERI
Keyword(s):  
Genital Tract ◽  
Reproductive Tract ◽  
Female Genital Tract ◽  
Female Reproductive Tract ◽  
Gliding Motility ◽  
Soft Tick ◽  
Ornithodoros Moubata ◽  
Different Types ◽  
The Many ◽  
Female Genital

SUMMARYThe spermatozoa of ticks are anomalous in many respects: they are very large, cytoplasm-rich cells which lack a flagellum but move with a peculiar gliding motility. Their metamorphosis after deposition in the female has been well documented, but many of the subsequent events in the career of the spermatozoa are controversial or poorly documented. Our observations of motility imply that the many types of motility that have been reported (up to 5 different types in several reports) can be reduced to 2 apparently independent types of active motility: (1) gliding motility generated along the whole spermatozoon and (2) contortions of the anterior tip of the head. These types of motility appear as a consequence of sperm maturation after transfer to the female, but only become pronounced if the female has taken a recent bloodmeal. A consequence of this enhanced gliding motility after feeding is the movement of the spermatozoa out of the naturally ruptured neck of the spermatophore and up the female genital tract. This occurs without any apparent assistance from the female's musculature and likely is the prime mechanism of movement of the spermatozoa to the site of fertilization.

Distribution of Trimethoprim and Sulfametopyrazine in the Female Reproductive Tract

1986 ◽  
Vol 14 (2) ◽  
pp. 101-104 ◽  
Author(s):  
Paulo Cesar Preza ◽  
Claudia Moura ◽  
Aguinaldo Leite Filho ◽  
Valeria Cavallari ◽  
Franklin Nüdemberg ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Reproductive Tract ◽  
Female Genital Tract ◽  
Reproductive Organs ◽  
Female Reproductive Tract ◽  
Bacterial Strains ◽  
Dose Ratio ◽  
Reproductive Tract Infections ◽  
Tract Infections ◽  
Female Genital

A combination of trimethoprim (TMP) 250 mg and sulfametopyrazine (SMP) 200 mg (dose ratio 5:4) in capsules was administered to ten patients undergoing hysterectomy for uterine leiomyoma. Each patient received a total of 3 of these Kelfiprim capsules: 2 capsules in a single administration 36 hours before surgery and 1 capsule 24 hours later. TMP and SMP concentrations were analyzed in plasma and also in the ovary, Fallopian tube and uterus, removed during surgery. The results indicated that in the reproductive organs of the female genital tract TMP reaches the same concentrations as in plasma. In contrast SMP is 3 to 3·5 times less concentrated in these tissues compared with plasma. At the TMP/SMP ratios obtained in these various organs synergism of the two compounds is reported to be particularly prominent for most bacterial strains. These findings indicate that this TMP-SMP combination may be useful in the treatment of female reproductive tract infections.

A comparison of sperm and embryo transport in the female reproductive tract of marsupial and eutherian mammals

1994 ◽  
Vol 6 (4) ◽  
pp. 451 ◽  
Author(s):  
DA Taggart
Keyword(s):  
Structure Function ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Current Knowledge ◽  
Female Genital Tract ◽  
Female Reproductive Tract ◽  
Embryo Transport ◽  
Female Genital

A review on current knowledge of sperm and embryo transport in the female reproductive tract of marsupials. Some of the unique features of gamete structure-function and female genital tract morphology will be described and compared with data available on eutherian mammals.

scholarly journals Atypical Cervical Stromal Cells Masquerading as Malignancy

2021 ◽  
Vol 8 (2) ◽  
pp. C30-31
Author(s):  
Shraddha Avinash Kurekar ◽  
Jayashri Popat Chaudhari ◽  
Asha Sharad Shenoy ◽  
Rachana Ajay Chaturvedi
Keyword(s):  
Stromal Cells ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Female Genital Tract ◽  
Female Reproductive Tract ◽  
Female Genital

Atypical stromal cells (ASCs) of the female genital tract are uncommon and found in various polypoid lesions of the vulva, vagina, cervix and endometrium. Although they are benign; they can be misinterpreted as a malignant. Hence it is important for a pathologist to identify the ASCs in the specimens or biopsies of lower Female genital tract and avoid over diagnosis as a malignancy. We present a case of atypical cervical stromal cells in a 45-year-old female. On microscopy, Atypical stromal cells were stellate, enlarged in size, with moderate to severely atypical hyperchromatic, multilobulated nuclei without any mitoses. Their chromatin was dense often with prominent nucleoli. This report highlights the significance of awareness about the occurrence of these cells in the female reproductive tract.

XX.—Studies on Reproduction in the Albino Mouse. III. The Duration of Life of Spermatozoa in the Female Reproductive Tract

1940 ◽  
Vol 59 ◽  
pp. 207-218 ◽  
Author(s):  
Hugo Merton
Keyword(s):  
Artificial Insemination ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Female Genital Tract ◽  
Maximum Activity ◽  
Female Reproductive Tract ◽  
Male Genital Tract ◽  
Exact Data ◽  
Female Genital ◽  
Male Genital

The method of artificial insemination in the mouse, which has been used successfully only once previously (Mark and Long, 1911), has made it possible to collect exact data on the duration of life and the fertilising capacity of spermatozoa in the female genital tract. Earlier results concerning the conditions under which spermatozoa from the male genital tract attain their maximum activity (Merton, II) and the exact knowledge of the time of parturition (Merton, I) were helpful in carrying out artificial insemination during the following œstrous period.

scholarly journals The Interaction Between Microorganisms, Metabolites, and Immune System in the Female Genital Tract Microenvironment

2020 ◽  
Vol 10 ◽  
Author(s):  
Huanrong Li ◽  
Yuqin Zang ◽  
Chen Wang ◽  
Huiyang Li ◽  
Aiping Fan ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Pregnancy Outcomes ◽  
Reproductive Tract ◽  
Female Genital Tract ◽  
Host Immunity ◽  
Female Reproductive Tract ◽  
Premature Delivery ◽  
Adverse Pregnancy ◽  
Symptoms And Signs ◽  
Female Genital

The female reproductive tract microenvironment includes microorganisms, metabolites, and immune components, and the balance of the interactions among them plays an important role in maintaining female reproductive tract homeostasis and health. When any one of the reproductive tract microorganisms, metabolites, or immunity is out of balance, it will affect the other two, leading to the occurrence and development of diseases and the appearance of corresponding symptoms and signs, such as infertility, miscarriage, premature delivery, and gynecological tumors caused by infectious diseases of the reproductive tract. Nutrients in the female reproductive tract provide symbiotic and pathogenic microorganisms with a source of nutrients for their own reproduction and utilization. At the same time, this interaction with the host forms a variety of metabolites. Changes in metabolites in the host reproductive tract are related not only to the interaction between the host and microbiota under dysbiosis but also to changes in host immunity or the environment, all of which will participate in the pathogenesis of diseases and lead to disease-related phenotypes. Microorganisms and their metabolites can also interact with host immunity, activate host immunity, and change the host immune status and are closely related to persistent genital pathogen infections, aggravation of infectious diseases, severe pregnancy outcomes, and even gynecological cancers. Therefore, studying the interaction between microorganisms, metabolites, and immunity in the reproductive tract cannot only reveal the pathogenic mechanisms that lead to inflammation of the reproductive tract, adverse pregnancy outcomes and tumorigenesis but also provide a basis for further research on the diagnosis and treatment of targets.

scholarly journals Does the Act of Copulation per se, without Considering Seminal Deposition, Change the Expression of Genes in the Porcine Female Genital Tract?

2020 ◽  
Vol 21 (15) ◽  
pp. 5477
Author(s):  
Manuel Alvarez-Rodriguez ◽  
Cristina A. Martinez ◽  
Dominic Wright ◽  
Heriberto Rodriguez-Martinez
Keyword(s):  
Gene Expression ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Female Genital Tract ◽  
Female Reproductive Tract ◽  
Smooth Muscle Contractility ◽  
Expression Of Genes ◽  
Per Se ◽  
Natural Mating ◽  
Transcriptomic Changes

Semen—through its specific sperm and seminal plasma (SP) constituents—induces changes of gene expression in the internal genital tract of pigs, particularly in the functional sperm reservoir at the utero-tubal junction (UTJ). Although seminal effects are similarly elicited by artificial insemination (AI), major changes in gene expression are registered after natural mating, a fact suggesting the act of copulation induces per se changes in genes that AI does not affect. The present study explored which pathways were solely influenced by copulation, affecting the differential expression of genes (DEGs) of the pre/peri-ovulatory genital tract (cervix, distal uterus, proximal uterus and UTJ) of estrus sows, 24 h after various procedures were performed to compare natural mating with AI of semen (control 1), sperm-free SP harvested from the sperm-peak fraction (control 2), sperm-free SP harvested from the whole ejaculate (control 3) or saline-extender BTS (control 4), using a microarray chip (GeneChip® porcine gene 1.0 st array). Genes related to neuroendocrine responses (ADRA1, ADRA2, GABRB2, CACNB2), smooth muscle contractility (WNT7A), angiogenesis and vascular remodeling (poFUT1, NTN4) were, among others, overrepresented with distal and proximal uterine segments exhibiting the highest number of DEGs. The findings provide novel evidence that relevant transcriptomic changes in the porcine female reproductive tract occur in direct response to the specific act of copulation, being semen-independent.

Female genital tract rhabdomyosarcoma in childhood and adolescence: A single center experience.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e22518-e22518
Author(s):  
Inci Yaman Bajin ◽  
Tezer Kutluk ◽  
Ferah Yildiz ◽  
İbrahim Karnak ◽  
Berna Oğuz ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Clinical Features ◽  
Genital Tract ◽  
Early Stage ◽  
Female Genital Tract ◽  
Alveolar Type ◽  
Childhood And Adolescence ◽  
High Survival ◽  
Treatment Results ◽  
Female Genital

e22518 Background: Rhabdomyosarcoma is a rare tumor in children and adolescents, presenting 3% to 4% of all pediatric cancers. The female genital tract is considered as a favorable site of childhood RMS. The outcome has improved significantly during the last two decades, attributed to risk stratification and multimodality management of these challenging tumors. Here we present the clinical features and treatment results of girls with genital tract rhabdomyosarcoma to discuss. Methods: Fourteen girls with vaginal and uterine servical rhabdomyosarcoma younger than 18 years of age diagnosed and followed up between the years of 1995 and 2019 were included in this analysis. The clinical features and treatment results of patients were recorded from patient files and hospital information system retrospectively. Results: There were seven cases with vaginal and seven with uterin cervical carcinoma. All patients presented with polypoid masses protruding from the vagina. Median age of patients at diagnosis was 71 months (range 8-200 months). The IRS modified TNM staging was stage I for all the patients. All cases had embryonic type of RMS except one with alveolar type. All patients were treated with surgery and adjuvant chemotherapy, three received radiotherapy additionally. All achieved complete remission. Four patients experienced tumor relapse, 1 patient died with progressive disease. The median follow-up time was 75 months (7-271 months) for 13 patients who were alive with remission. Conclusions: Rhabdomyosarcoma is a rare sarcoma with a higher incidence in children and adolescents. With current treatment strategies, female genital tract rhabdomyosarcomas have a good prognosis. Favorable prognostic factors such as early stage at diagnosis and a favorable histology may contribute to the excellent observed survival. All parties who had involved on the care of these girls must be aware of the high survival with proper treatment to avoid treatment related morbidities and mortalities. Because of the rareness of the disease we wanted to share our experience.

Hydrogen peroxide levels in mouse oocytes and early cleavage stage embryos developed in vitro or in vivo

Development ◽  
1990 ◽  
Vol 109 (2) ◽  
pp. 501-507 ◽  
Author(s):  
M.H. Nasr-Esfahani ◽  
J.R. Aitken ◽  
M.H. Johnson
Keyword(s):  
Reproductive Tract ◽  
Female Reproductive Tract ◽  
Cell Stage ◽  
Mouse Oocytes ◽  
Early Embryos ◽  
Individual Mouse ◽  
The Relationship ◽  
Developmental Block

We describe a fluorimetric method for measuring the level of H2O2 in individual mouse oocytes and early embryos. Levels of H2O2 are low but detectable in unfertilized oocytes recovered freshly from the female reproductive tract. The levels in early cleaving embryos (1-cell to 8-cell stages) immediately after recovery from the female tract seem to be slightly higher the later the stage examined. However, when embryos are cultured in vitro from the 1-cell or early 2-cell stage, H2O2 levels rise when the embryos reach the mid-2-cell stage and remain elevated until they enter the early 4-cell stage. No equivalent elevation of H2O2 is seen during the transition from 1-cell to 2-cell or from 4-cell to 8-cell stages. Embryos that are able to develop successfully in vitro, as well as those that show a developmental block at the 2-cell stage on culture in vitro, both show this rise in H2O2 levels after in vitro culture. The relationship between the rise in H2O2 and the ‘2-cell block’ to development is discussed.

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