Anaemia is a predictor of early death or cardiac transplantation in children with idiopathic dilated cardiomyopathy

2011 ◽  
Vol 22 (3) ◽  
pp. 293-300 ◽  
Author(s):  
Issam Kammache ◽  
Giovanni Parrinello ◽  
Davide Marini ◽  
Damien Bonnet ◽  
Gabriella Agnoletti
Keyword(s):  
Confidence Interval ◽  
Dilated Cardiomyopathy ◽  
Cardiac Transplantation ◽  
Cox Model ◽  
Early Death ◽  
Hazard Ratio ◽  
Idiopathic Dilated Cardiomyopathy ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
First Diagnosis

AbstractIntroductionThe aim of our study was to establish the prevalence and the prognostic value of haematological abnormalities in children with cardiac failure.Patients and methodsA series of 218 consecutive children with a first diagnosis of idiopathic dilated cardiomyopathy were retrospectively examined. Haematological evaluation was performed at first diagnosis. Death or cardiac transplantation was the main outcome measure.ResultsThe median age was 0.6 years, ranging from 1 day to 15.8 years and median follow-up was 2.65 years, ranging from 0 to 17.2 years. After a median interval of 0.2 years, ranging from 0 to 8.7 years, 56 patients died and 25 were transplanted. Event-free survival at 1 and 5 years was 68% (95% confidence interval, 63–75%) and 62% (95% confidence interval, 56–69%). Blood levels of haemoglobin less than 10 grams per decilitre, urea over 8 millimoles per litre, and C-reactive protein over 10 milligrams per litre were found in 24%, 20%, and 24% of patients, respectively. The log-rank test showed that haemoglobin (p = 0.000) and C-reactive protein (p = 0.021) were predictors of death or transplantation. In the multivariate Cox model, haemoglobin (hazard ratio = 0.735; confidence interval = 0.636–0.849; p = 0.000) and urea (hazard ratio = 1.083; confidence interval = 1:002–1:171; p = 0.045) were predictive of poor outcome. Cubic spline functions showed that the positive role of haemoglobin on survival was linear for values less than 12 grams per decilitre and null for values more than 12 grams per decilitre. Adaptive index models for risk stratification and Classification and Regression Tree analysis allowed to identify the cut-off values for haemoglobin (less than 10.2 grams per decilitre) and urea (more than 8.8 millimoles per litre), as well as to derive a predictor model.ConclusionsIn children with idiopathic dilated cardiomyopathy, anaemia is the strongest independent prognostic factor of early death or transplantation.

C-Reactive Protein and Aortic Stiffness in Patients with Idiopathic Dilated Cardiomyopathy

2007 ◽  
Vol 24 (1) ◽  
Author(s):  
Feridun Kosar ◽  
Yüksel Aksoy ◽  
Gulacan Ozguntekin ◽  
Ertan Yetkin ◽  
Hakan Gunen
Keyword(s):  
Dilated Cardiomyopathy ◽  
Aortic Stiffness ◽  
Idiopathic Dilated Cardiomyopathy ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Association between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yasuharu Tabara ◽  
Kazuya Setoh ◽  
Takahisa Kawaguchi ◽  
Shinji Kosugi ◽  
Takeo Nakayama ◽  
...  
Keyword(s):  
Risk Factor ◽  
General Population ◽  
Confidence Interval ◽  
Cox Model ◽  
Prognostic Significance ◽  
High Sensitivity ◽  
Hazard Ratio ◽  
Reactive Protein ◽  
All Cause Mortality ◽  
Study Participants

AbstractCirculating levels of inflammatory proteins have to be prognostic markers of all-cause mortality. α1-Antitrypsin (AAT) is a major inflammatory plasma protein, but its association with all-cause mortality is unclear. We aimed to evaluate the prognostic significance of AAT levels for all-cause mortality. Study participants comprised 9682 community residents (53.5 ± 13.3 years old). During the 9.8-year follow-up period, 313 participants died from any cause. The mortality rate increased linearly with AAT quintiles (Q1, 18.2; Q2, 24.7; Q3, 23.8; Q4, 31.9; Q5, 64.6 per 10,000 person-years). There were significant correlations between AAT and high-sensitivity C-reactive protein (hsCRP) levels (correlation coefficient, 0.331; P < 0.001). However, the Cox model analysis, when adjusted for possible covariates including hsCRP, identified the fifth AAT quintile as a risk factor for all-cause death (hazard ratio, 2.12 [95% confidence interval, 1.41–3.18]; P < 0.001). An analysis of participants older than 50 years (hazard ratio, 1.98, P < 0.001) yielded similar results. The hazard ratio increased proportionately in combination with high AAT and high hsCRP levels, and the highest hazard ratio reached 4.51 (95% confidence interval, 3.14–6.54, P < 0.001). High AAT levels were determined to be an independent risk factor for mortality in the general population.

scholarly journals C-Reactive Protein and Atrial Fibrillation in Idiopathic Dilated Cardiomyopathy

2009 ◽  
Vol 32 (9) ◽  
pp. E45-E50 ◽  
Author(s):  
Dai, Shimo ◽  
Zhang Shu ◽  
Guo Ying hua ◽  
Jianmin Chu ◽  
Wei Hua ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Dilated Cardiomyopathy ◽  
Idiopathic Dilated Cardiomyopathy ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Pretreatment C-reactive protein and neutrophil counts as a predictor of metastasis in patients with osteosarcoma

2020 ◽  
Author(s):  
Yoshihiro Araki ◽  
Norio Yamamoto ◽  
Katsuhiro Hayashi ◽  
Akihiko Takeuchi ◽  
Shinji Miwa ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Prognostic Score ◽  
Univariate Analysis ◽  
Laboratory Data ◽  
Glasgow Prognostic Score ◽  
Hazard Ratio ◽  
C Reactive Protein ◽  
Cox Regression Analysis ◽  
Lymphocyte Ratio ◽  
Reactive Protein

Abstract Background: Systemic inflammation responses have been associated with cancer development, progression and metastasis. However, little is known about the risk of metastasis based on inflammatory-based scores in patients with osteosarcoma before treatment. We therefore estimated the predictive value of these parameters for metastasis in osteosarcoma.Methods: A total of 54 osteosarcoma patients were enrolled in this retrospective study. All had been diagnosed histologically, and their laboratory data at the first visit were collected from medical records. The lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte ratio (NLR), monocyte-neutrophil ratio (MNR), platelet-lymphocyte ratio (PLR), Glasgow prognostic score (GPS), neutrophil-platelet score (NPS), neutrophil counts (NC), lymphocyte counts (LC), monocyte counts (MC), and C-reactive protein (CRP) were evaluated.Results: High values of CRP, PLR, MNR, and NPS and a low NC were significantly associated with metastasis of osteosarcoma patients in the univariate analysis. A multivariate Cox regression analysis revealed that a high CRP level (>0.6mg/dL) (hazard ratio=9.7, 95% confidence interval=3.0-31 ; p=0.00010) and low NC (<4087/µL) (hazard ratio=0.13, 95% confidence interval =0.040-0.42 ; p=0.00080) were risk factors significantly associated with metastasis of osteosarcoma patients.Conclusions: Our study demonstrated that the combination of a high CRP level and low NC before treatment was a useful inflammatory-based prognostic indicator for metastasis in patients with osteosarcoma.

Coenzyme Q10 and high-sensitivity C-reactive protein in ischemic and idiopathic dilated cardiomyopathy

2008 ◽  
Vol 46 (3) ◽  
Author(s):  
Mehmet Şeneş ◽  
Ali Rıza Erbay ◽  
F. Meriç Yılmaz ◽  
B. Çiğdem Topkaya ◽  
Oğuzhan Zengi ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Coenzyme Q10 ◽  
High Sensitivity ◽  
Idiopathic Dilated Cardiomyopathy ◽  
C Reactive Protein ◽  
Reactive Protein

C-reactive protein predicts response to pentoxifylline in patients with idiopathic dilated cardiomyopathy

2004 ◽  
Vol 6 (6) ◽  
pp. 731-734 ◽  
Author(s):  
Karen Sliwa ◽  
Angela Woodiwiss ◽  
Elena Libhaber ◽  
Fitzgerald Zhanje ◽  
Carlos Libhaber ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Idiopathic Dilated Cardiomyopathy ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Prognostic impact of right bundle branch block in hospitalized patients with idiopathic dilated cardiomyopathy: a single-center cohort study

2018 ◽  
Vol 48 (1) ◽  
pp. 030006051880147 ◽  
Author(s):  
Li Lai ◽  
Rong Jiang ◽  
Wei Fang ◽  
Chao Yan ◽  
Yibin Tang ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Dilated Cardiomyopathy ◽  
Right Bundle Branch Block ◽  
Left Ventricular ◽  
Hazard Ratio ◽  
Hospitalized Patients ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Prognostic Impact ◽  
Bundle Branch Block ◽  
All Cause Mortality

Objective Idiopathic dilated cardiomyopathy (IDCM) is a primary myocardial disease resulting in symptoms of heart failure. Right bundle branch block (RBBB) is associated with increased cardiovascular risk and all-cause mortality. Therefore, the present study was performed to identify the prognostic impact of RBBB in patients with IDCM. Methods In total, 165 hospitalized patients with IDCM were evaluated. Receiver operating characteristic curve analysis was used to determine the cutoff point, and Cox regression was used to assess risk factors. Results After a median follow-up of 73.1 months (interquartile range, 36.1–88.7 months), 59 (35.8%) patients had died. All-cause mortality was significantly higher in patients with than without RBBB (log-rank χ2 = 9.400), P<0.05. Significant independent predictors of all-cause mortality in patients with IDCM were RBBB (hazard ratio, 2.898; 95% confidence interval, 1.201–6.995) and the left ventricular end-diastolic dimension (LVEDD) (hazard ratio, 1.034; 95% confidence interval, 1.004–1.066) at admission. Patients with RBBB and an LVEDD of ≥63 mm had the highest mortality (log-rank χ2 = 14.854), P<0.05. Conclusion RBBB was an independent predictor of all-cause mortality, and the combination of RBBB and LVEDD provided more clinically relevant information than RBBB alone for assessing the risk of all-cause mortality in patients with IDCM.

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