Behaviour problems in adolescents with cardiac disease: an exploratory study in a paediatric cardiology outpatient clinic

2012 ◽  
Vol 23 (3) ◽  
pp. 368-376 ◽  
Author(s):  
Maria M. da Silva ◽  
Teresa H. Schoen-Ferreira ◽  
Maria S. B. Diógenes ◽  
Antonio C. Carvalho
Keyword(s):  
Heart Disease ◽  
Cardiac Disease ◽  
Female Gender ◽  
Behavioural Problems ◽  
Healthy Controls ◽  
Male Adolescents ◽  
The Social ◽  
Significant Difference ◽  
Acquired Heart Disease ◽  
Male Patients

AbstractAimsTo assess behavioural problems in adolescents with congenital and acquired heart disease in comparison with healthy controls. The perception of behavioural problems by the patients’ parents was also assessed and compared.MethodsA cross-sectional study was carried out in 130 adolescents with congenital and acquired heart disease and 246 healthy controls. The second part of the Youth Self-Report was applied to the patients and controls, and the Child Behavior Checklist to the patients’ parents.ResultsMale patients showed significantly fewer behavioural problems compared with male controls. No significant difference was found in the female gender. Healthy male adolescents scored significantly higher in the Internalising, Externalising, and in the Total Problems scales. Patients scored significantly higher only on the Social Problems subscale. Female patients in middle and late adolescence and male patients in early adolescence displayed more problems. No significant difference was found between the diagnostic groups. Operated patients did not differ from the non-operated ones. Patients scored significantly lower than did their parents.ConclusionsMale adolescents with cardiac disease reported fewer behavioural problems when compared with healthy controls, but no difference was observed in the female gender. Patients also reported fewer behavioural problems than did their parents. Adolescents with cardiac disease scored higher than did controls only on the Social Problems subscale. Analysing the patients’ behavioural profile, female patients in middle and late adolescence and male patients in early adolescence were the most problematic ones. No difference was observed between the diagnostic groups, nor between operated and non-operated patients.

Over-expression of IL-6 coding gene in the peripheral blood of migraine with aura patients

2021 ◽  
pp. 1-5
Author(s):  
Mahdi Ramezani ◽  
Alireza Komaki ◽  
Mohammad Mahdi Eftekharian ◽  
Mehrdokht Mazdeh ◽  
Soudeh Ghafouri-Fard
Keyword(s):  
Migraine With Aura ◽  
Peripheral Blood ◽  
Healthy Subjects ◽  
Migraine Without Aura ◽  
P Value ◽  
Healthy Controls ◽  
Over Expression ◽  
Significant Difference ◽  
Male Patients ◽  
Years Lived With Disability

Migraine is a common disorder which is placed among the top ten reasons of years lived with disability. Cytokines are among the molecules that contribute in the pathophysiology of migraine. In the current study, we evaluated expression levels of IL-6 coding gene in the peripheral blood of 120 migraine patients (54 migraine without aura and 66 migraine with aura patients) and 40 healthy subjects. No significant difference was detected in expression of IL-6 between total migraine patients and healthy controls (Posterior beta = 0.253, P value = 0.199). The interaction effect between gender and group was significant (Posterior beta =-1.274, P value = 0.011), therefore, we conducted subgroup analysis within gender group. Such analysis revealed that while expression of this gene is not different between male patients and male controls (Posterior beta =-0.371, P value > 0.999), it was significantly over-expressed in female patients compared with female controls (Posterior beta = 0.86, P= 0.002). Expression of IL-6 was significantly higher in patients with aura compared with controls (Posterior beta = 0.63, adjusted P value = 0.019). However, expression of this cytokine coding gene was not different between patients without aura and healthy subjects (Posterior beta = 0.193, adjusted P value = 0.281). Therefore, IL-6 might be involved in the pathophysiology of migraine among females and migraine with aura among both sexes.

Low Level of Serum Sclerostin in Adult Patients with Tumor-induced Osteomalacia Comparing with X-linked Hypophosphatemia

2021 ◽  
Author(s):  
Xiaolin Ni ◽  
Qi Zhang ◽  
Xiang Li ◽  
Qianqian Pang ◽  
Yiyi Gong ◽  
...  
Keyword(s):  
Bone Mass ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Significant Difference ◽  
Healthy Control ◽  
Premenopausal Patients ◽  
Male Patients ◽  
Sclerostin Level ◽  
Sclerostin Antibody

Abstract Context Sclerostin is an inhibitor of Wnt-β-catenin signaling to regulate bone formation. Circulating sclerostin levels were reported to be elevated in patients with X-linked hypophosphatemia (XLH), and sclerostin antibody (Scl-Ab) has been shown to increase bone mass and normalize circulating phosphate levels in Hyp mice. However, circulating sclerostin level in acquired hypophosphatemic patients with tumor-induced osteomalacia (TIO) remains rare reported. Objectives This study was designed to evaluate serum sclerostin levels in TIO patients comparing them with age-, sex- matched healthy controls and XLH patients, and analyze correlation of circulating sclerostin with BMD and laboratory parameters. Design, Setting and Participants 190 individuals including 83 adult TIO patients, 83 adult healthy controls and 24 adult XLH patients were enrolled in this cross-sectional study. Main outcome measures Serum sclerostin levels were determined in TIO patients, healthy controls and XLH patients. Results TIO patients (43 male and 40 female) aged 44.3 ± 8.7 (mean ± SD) years had lower levels of circulating sclerostin than healthy controls (94.2 ± 45.8 vs 108.4 ± 42.3 pg/mL, p = 0.01) with adjustment for age, gender, BMI and diabetes rate. Sclerostin levels were positively associated with age (r = 0.238, p = 0.030). Male patients had higher sclerostin level than female patients (104.7 ± 47.3 vs 83.0 ± 41.8 pg/mL, p = 0.014) and postmenopausal patients had higher tendency of sclerostin level than premenopausal patients (98.4 ± 48.8 vs 71.6 ± 32.3 ng/ml, p = 0.05). Sclerostin levels were positively associated with BMD of L1-4 (r = 0.255, p = 0.028), femoral neck (r = 0.242, p = 0.039) and serum calcium (r = 0.231, p = 0.043). TIO subgroup patients (n=24, 35.9 ± 7.3 years old) comparing with age-, sex-matched adult XLH patients and healthy controls revealed significant difference of sclerostin levels (XLH, TIO and healthy control were 132.0 ± 68.8, 68.4 ± 31.3 and 98.6 ± 41.1 pg/mL, respectively, p < 0.001). Conclusions Circulating sclerostin levels were decreased in TIO patients but increased in XLH patients, which might be result of histological abnormality and bone mass.

Social Skills and Family Climate of Behaviorally Disordered Adolescents

1988 ◽  
Vol 13 (4) ◽  
pp. 253-262 ◽  
Author(s):  
Malka Margalit ◽  
Amazia Weisel ◽  
Tali Heiman ◽  
Shmuel Shulman
Keyword(s):  
Social Skills ◽  
Family Environment ◽  
Classroom Behavior ◽  
Family Climate ◽  
Behaviorally Disordered ◽  
Teachers Perceptions ◽  
Male Adolescents ◽  
The Social ◽  
Significant Difference ◽  
The Family

The social skills structure of behaviorally disordered adolescents was investigated in relation to their family climate and school competence and adjustment. The sample consisted of 109 male adolescents — 53 behaviorally disordered and 56 nondisabled students. The instruments were the Hebrew adaptations of the Social Skills Checklist, the Family Environment Scale, and the Classroom Behavior Inventory. The comparison between the factorial structure of the behaviorally disordered and the nondisabled responses show that the behaviorally disordered adolescents reported a global social skills concept, whereas their controls revealed a more differential concept. A significant difference was found between the two groups' perceptions of family climate: The behaviorally disordered adolescents viewed their families as more cohesive and organized, more emphasizing of the achievements and independence of the family members, and less enabling the expression of emotions. Teachers' perceptions of their behaviorally disordered students' social skills were also compared with the behaviorally disordered adolescents' self-reports, and significant differences were found. The teachers perceived a differential structure of skills, whereas the adolescents reported a global profile of higher functioning. Aspects of classroom behavior style and family climate were the best predictors of the social skills. Intervention planning should attend to the multivariate nature of social skills.

scholarly journals Gender and Quality of Life After Cerebral Stroke

2010 ◽  
Vol 10 (2) ◽  
pp. 94-99 ◽  
Author(s):  
Amra Zalihić ◽  
Vedran Markotić ◽  
Dino Zalihić ◽  
Mirela Mabić
Keyword(s):  
Quality Of Life ◽  
Life Quality ◽  
Female Gender ◽  
Cerebral Stroke ◽  
Female Patients ◽  
Negative Prognostic Factor ◽  
Significant Difference ◽  
Medium Range ◽  
Male Patients

The aim of this work is to investigate the influence of gender on recovery after cerebral stroke.It is believed that functional outcome of cerebral stroke (CS) depends on gender. Female gender is mildly negative prognostic factor in after stroke results. Two hundred and two patients who had first ischemic cerebral stroke were questioned with help of, HADS and WHOQOL-Bref questionnaires, looking for differences in recovery depending on gender. Average patients' age was 72+/-13 (ME+/-IR) years. The youngest patient had 40 years, and the oldest 92 years, and medium range was 52 years. There were 112 males and 90 females. Quality of life was equally graded by both male and female after CS (p=0.208). Male patients had significantly better results in physical (p=0.035) and psychological (p=0.020) domain of life quality. After CS, male patients had better results only in memory dimension (p=0.003). Anxiety was statistically more frequent among female patients (p=0.009). Gender did not influence frequency of metabolic syndrome in patients with CS. Quality of life after CS was better in male patients, and statistically significant difference has been shown in physical, psychological domain and memory dimension. Female patients were more anxious then male after CS.

Comprehensive dental evaluation of children with congenital or acquired heart disease

2012 ◽  
Vol 23 (5) ◽  
pp. 705-710 ◽  
Author(s):  
Kenan Cantekin ◽  
Isin Cantekin ◽  
Yasemin Torun
Keyword(s):  
Heart Disease ◽  
Children And Adolescents ◽  
Oral Hygiene ◽  
Cardiac Disease ◽  
Heart Diseases ◽  
Treatment Plan ◽  
Caries Experience ◽  
Univentricular Heart ◽  
Healthy Children ◽  
Acquired Heart Disease

AbstractObjectiveThe aims of this case–control study were to (a) compare the caries experience and oral hygiene, and (b) quantify the persistence of a delay in the dental age in children with cardiac disease and a group of healthy children.Methods and MaterialsThe study population comprised a group of 268 3- to 16-year-old children and adolescents with a cardiac disease and a group of 268 age- and sex-matched healthy children and adolescents. Specifically, the decayed, missed, and filled teeth indices, simplified oral hygiene index, and the dental ages of the two groups of children were calculated and then compared.ResultsAlthough the oral health of the children with either a congenital or an acquired heart disease was the same as that of the healthy children, there were significant differences in the decayed, missed, and filled teeth indices. Dental ages of the children with a congenital heart disease were significantly lower than those of healthy children. The findings showed that complex univentricular heart diseases had the highest negative impact on dental development (−1.1), followed by complex biventricular (−0.9), simple surgical (−0.5), and mild (−0.4) heart disease patients.ConclusionOnce thorough knowledge of the child's cardiac status is gained, a definitive dental treatment plan for the child with a cardiac disease can be established.

scholarly journals A Comparison of Dynamic Postural Stability Between Asymptomatic Controls and Male Patients One Year After ACL Reconstruction (Pilot Study)

2014 ◽  
Vol 2 (11_suppl3) ◽  
pp. 2325967114S0028
Author(s):  
Muhammed Baybars Ataoglu ◽  
Zeynep Hazar ◽  
Nihan Kafa ◽  
Mustafa Özer ◽  
Seyit Citaker
Keyword(s):  
Acl Reconstruction ◽  
Postural Stability ◽  
Healthy Controls ◽  
Balance Test ◽  
Significant Difference ◽  
Male Patients ◽  
Star Excursion Balance Test ◽  
One Year ◽  
General Physical ◽  
Dynamic Postural Stability

Objectives: The purpose of this study was to determine if dynamic postural stability gained one year after ACL reconstruction in patients who received rehabilitation. Methods: Seven male patients (mean age=32,66 ±6,47) who had previously undergone ACL reconstruction (ACL-R) and 7 sex-and general physical activity matched uninjured controls included to study. Mean time since original injury was 13±3,31 months. Dynamic postural control was assessed with 20° knee flexion with Star Excursion Balance test. Each participant performed 3 trials of the anterior, posterior-medial, and posterior-lateral directional components of the SEBT. Reach distances for each directional component were compared with non-injured leg and healthy controls’. Results: There was no significant difference in all directions of Star Excursion Balance test between neither the operated and uninjured knees of patients nor between patients and healthy controls (p>0,05). Conclusion: No deficits in dynamic postural stability were present average one year after ACL reconstruction in patients who received rehabilitation. It can be said that rehabilitation is effective in the recovery of dynamic postural stability.

Cardiac disease in pregnancy. Part 2: acquired heart disease

2007 ◽  
Vol 9 (2) ◽  
pp. 83-87 ◽  
Author(s):  
Emily Gelson ◽  
Mark Johnson ◽  
Michael Gatzoulis ◽  
Uebing Abselm
Keyword(s):  
Heart Disease ◽  
Cardiac Disease ◽  
Acquired Heart Disease ◽  
In Pregnancy

scholarly journals Association of serum uric acid levels with COVID-19 severity

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fang Hu ◽  
Yifan Guo ◽  
Jianghong Lin ◽  
Yingjuan Zeng ◽  
Juan Wang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Linear Regression Analysis ◽  
Healthy Controls ◽  
Time Points ◽  
Female Patients ◽  
Significant Difference ◽  
Severe Group ◽  
Male Patients

Abstract Aims Hyperuricemia has attracted increasing attention. However, limited concern has been paid to the potential dangers of lowering serum uric acid (SUA). We observed lower levels of SUA in patients with COVID-19. Therefore, we aim to explore whether patients with COVID-19 had SUA lower than normal and the relationship of SUA and the severity of COVID-19. Methods This was a case–control study based on 91 cases with COVID-19 and 273 age- and sex-matched healthy control subjects. We first compared SUA levels and uric acid/creatinine (UA/Cr) ratio between patients with COVID-19 and the healthy controls. Then, we examined the association of SUA levels and UA/Cr ratios with COVID-19 severity in COVID-19 cases only, defined according to the fifth edition of China’s Diagnosis and Treatment Guidelines of COVID-19. Results SUA levels in patients with COVID-19 were 2.59% lower, UA/Cr ratios 6.06% lower at admission compared with healthy controls. In sex stratified analysis, levels of SUA and UA/Cr were lower in male patients with COVID-19 while only level of SUA was lower in female patients with COVID-19. Moreover, SUA and UA/Cr values were 4.27 and 8.23% lower in the severe group than that in the moderate group among male COVID-19 patients. Bivariate and partial correlations analysis showed negative correlations between SUA or UA/Cr ratio and COVID-19 after adjusting for age, sex, BMI and eGFR. A multiple linear regression analysis showed that SARS-CoV-2 infection and male sex were independent risk factors associated with lower SUA levels. Male patients with COVID-19 accompanied by low SUA levels had higher risk of developing severe symptoms than those with high SUA levels (incidence rate ratio: 4.05; 95% CI:1.11, 14.72) at admission. Comparing SUA and UA/Cr ratio at three time points (admission, discharge, and follow-up), we found that male patients experienced severe symptoms had lower SUA and UA/Cr ratio levels comparing to moderate patients, but no significant difference between three time points. On the contrary, female patients had lower SUA and UA/Cr ratio at discharge than those at admission, but no significant difference of SUA and UA/Cr ratio between moderate and severe group. Conclusion Patients with COVID-19 had SUA and UA/Cr values lower than normal at admission. Male COVID-19 patients with low SUA levels had a significantly higher crude risk of developing severe symptoms than those with high SUA levels. During disease aggravation, the level of SUA gradually decreased until discharge. At the follow-up exam, the level of SUA was similar to the levels at admission.

Cardiac disease in pregnancy

2020 ◽  
pp. 151-162
Author(s):  
Philip Steer
Keyword(s):  
Heart Disease ◽  
Cardiac Disease ◽  
Developed Countries ◽  
Care Needs ◽  
The United Kingdom ◽  
Risk Of Mortality ◽  
Acquired Heart Disease ◽  
Causes Of Mortality ◽  
Preconception Counselling ◽  
Impaired Cardiac Function

Cardiac disease has become the single most important cause of maternal death in the United Kingdom and other developed countries over the last 30 years, mostly due to acquired heart disease secondary to women having their pregnancies later in life. The main causes of mortality are myocardial infarction/ischaemic heart disease (one-third) and cardiomyopathy (a further third). The remaining deaths are mostly associated with rheumatic heart disease, congenital heart disease, and pulmonary hypertension (about 5–10% each). Pregnancy represents a challenge to women with impaired cardiac function because of the cardiovascular changes associated with the increase in blood supply to the uterus and placenta. Preconception counselling is vital and should cover the risk of mortality, morbidity, and the increased rate of preterm birth and fetal growth restriction in affected women. Antenatal and intrapartum care needs to be planned by a multidisciplinary team and delivered by staff with appropriate expertise.

Platelet Release Reaction in vivo in Patients with Ischaemic Heart Disease after Isometric Exercise and its Prevention with Dipyridamole

1979 ◽  
Vol 42 (05) ◽  
pp. 1589-1597 ◽  
Author(s):  
Tadahiro Sano ◽  
Takeshi Motomiya ◽  
Hiroh Yamazaki
Keyword(s):  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Isometric Exercise ◽  
Crossover Fashion ◽  
Healthy Controls ◽  
Simple Method ◽  
Release Reaction ◽  
Significant Difference ◽  
Platelet Release

SummaryIn 20 patients with ischaemic heart disease (IHD), platelet sensitivity to ADP- aggregation, plasma von Willebrand factor (vWF) and plasma β-thromboglobulin (β-TG) were measured before and after isometric exercise. Effect of dipyridamole on these determinants was studied in a crossover fashion. To assess plasma vWF level, a new simple method was employed which has the advantage of not requiring an optical aggregometer and was proved to be reproducible.No significant difference was seen in platelet sensitivity to ADP-aggregation, vWF and β-TG among healthy controls, IHD patients on placebo and on dipyridamole at rest. After exercise, platelet sensitivity to aggregation, plasma vWF and β-TG increased significantly in IHD patients on placebo. In healthy controls, no significant changes were seen. On dipyridamole, above changes seen in IHD patients were not seen.The results suggests that isometric exercise may induce platelet release reaction in vivo and may produce hypercoagulable state in IHD patients. These phenomena may be prevented by pretreatment with dipyridamole.

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