scholarly journals Synthetic Biology – Towards an Engineering Science

2014 ◽  
Vol 22 (S1) ◽  
pp. S102-S112
Author(s):  
Marc-denis Weitze ◽  
Alfred Pühler
Keyword(s):  
Information Technology ◽  
Synthetic Biology ◽  
Molecular Biology ◽  
Structural Features ◽  
Research Field ◽  
Engineering Science ◽  
Engineering Sciences ◽  
New Research ◽  
Science Of The Artificial

The new research field of synthetic biology is emerging from molecular biology, chemistry, biotechnology, information technology and engineering. This paper describes synthetic biology as a ‘Science of the Artificial’ and identifies structural features of engineering sciences that can be applied to this new kind of biology as opposed to traditional biology. The search for laws already in traditional biology has been difficult. In Synthetic Biology, action and application stand in the foreground and laws increasingly lose ground as a meaningful concept.

scholarly journals Sapogenin based self-assembly structures activating a non-apoptotic cell death via multiple pathways

2021 ◽  
Author(s):  
Göklem Üner ◽  
Erdal Bedir ◽  
Onur Serçinoğlu ◽  
Petek Ballar Kırmızıbayrak
Keyword(s):  
Cell Death ◽  
Self Assembly ◽  
Apoptotic Cell ◽  
Biological Activities ◽  
Structural Features ◽  
Research Field ◽  
Supramolecular Structures ◽  
Cancer Drug ◽  
Cell Death Pathways ◽  
New Research

AbstractInduction of distinct cell death pathways is critical to deal with tumor heterogeneity and therapeutic resistance. In our previous study, we reported a promising saponin analog (AG-08) for cancer therapy inducing non-canonical necrotic cell death. Here, we describe that AG-08 forms unique supramolecular structures responsible for its biological activity. After internalization via non-canonical endocytosis pathway, these structures affect several cell signaling pathways including unfolded protein response, immune response, oxidative stress and heat stress. Moreover, we prepared 18 analogs to reveal the role of residues on the formation of supramolecular structures and biological activities. The results have demonstrated that unique structural features are required for particulate structures and unprecedented cell death mechanism. Although small molecule based supramolecular assemblies have widely been accepted as nuisance for drug discovery studies, our results indicate that they may provide a new research field for anti-cancer drug development studies.

Application of Nanotechnology in Global Issues

2020 ◽  
pp. 292-300 ◽  
Author(s):  
Ranjit Barua ◽  
Sudipto Datta ◽  
Jonali Das
Keyword(s):  
Information Technology ◽  
21St Century ◽  
Modern Society ◽  
Research Field ◽  
Food Technology ◽  
Early 21St Century ◽  
Global Issues ◽  
Research Areas ◽  
Modern Engineering ◽  
New Research

Nanotechnology basically means any kind of technology in a nanoscale, which can be applied in the existent world. It is a comparatively new research field, but it is not a completely new area and the research draws insights from many other research areas. It is generally considered that nanotechnology makes possible the coming of the new Industrial Renaissance since it has the potential for a reflective impact on modern society and economy in the early 21st century, similar to that of information technology (IT), electronics technology, especially in semiconductor technology or molecular and cellular biology. The purpose of this chapter is to look into the present aspects of nanotechnology. In this chapter, the authors discuss a variety of applications of nanotechnology in recent decades like modern engineering, robotics, food technology, medicine, etc., and also they indicate the current and potential uses of nanoscience and nanotechnologies. Social and ethical impacts as well as health and environmental impacts will be highlighted.

scholarly journals From mammoths to materials: synthetic biology moves into the biomaterial space

2018 ◽  
Vol 40 (1) ◽  
pp. 20-23
Author(s):  
Michael R. Behrens ◽  
Warren C. Ruder
Keyword(s):  
Synthetic Biology ◽  
Recombinant Dna ◽  
Biological Systems ◽  
Biological Properties ◽  
Research Field ◽  
Environmental Cues ◽  
Research Directions ◽  
The Future ◽  
New Research ◽  
Societal Problems

Synthetic biology is a relatively new research field that employs synthetic recombinant DNA technologies to engineer capabilities for addressing a wide variety of scientific and societal problems. We highlight a few noteworthy projects and achievements spanning the field of synthetic biology. In particular, some of the ways synthetic biological tools have been used to create novel biomaterials. Biological systems, like cells or larger organisms, can be made not only to synthesize new biomaterials but also to act as biomaterial constituents themselves, imbuing the materials with useful biological properties like the ability to respond dynamically to environmental cues. Looking into the future, there are many promising research directions synthetic biologists can take to develop tomorrow's biomaterials.

Wspólnota semantyczno-leksykalna języków europejskich. O monografii: А.А. Кретов, О.М. Воевудская, И.А. Меркулова, В.Т. Титов, Единство Европы по данным лексики (Воронеж: Издательский дом ВГУ, 2016, ss. 413 [1])

2018 ◽  
Vol 2 (XXIII) ◽  
pp. 121-133
Author(s):  
Katarzyna Wojan
Keyword(s):  
Comparative Research ◽  
Lexical Semantics ◽  
Research Field ◽  
Original Research ◽  
Linguistic Typology ◽  
Lexical Semantic ◽  
Theoretical Linguistics ◽  
Research Concept ◽  
New Research

This article outlines the original research concept developed and applied by the Voronezh researchers, which brought both quantitative and qualitative results to the field of linguistic comparative research. Their monograph is devoted to the macrotypological unity of the lexical semantics of the languages in Europe. In addition, semantic stratification of Russian and Polish lexis has been analyzed. Their research concept is now known as the “lexical-semantic macrotypological school of Voronezh.” Representatives of this school have created a new research field in theoretical linguistics – a lexical-semantic language macrotypology as a branch of linguistic typology. The monograph has been widely discussed and reviewed in Russia.

Judicial geography as a legal science and academic discipline

2019 ◽  
Vol 5 (4) ◽  
pp. 122-137
Author(s):  
Almaz F. Abdulvaliev
Keyword(s):  
Criminal Law ◽  
Climatic Factors ◽  
Academic Discipline ◽  
Preliminary Investigation ◽  
Criminal Procedure ◽  
Mapping Method ◽  
Research Field ◽  
Point Of View ◽  
Theoretical Development ◽  
New Research

This article presents the conceptual foundations for the formation of a new research field “Judicial Geography”, including the prerequisites for its creation, academic, and theoretical development, both in Russia and abroad. The purpose of the study is to study the possibility of applying geographical methods and means in criminal law, criminal procedure, and in judicial activity in general via the academic direction “Judicial Geography”. The author describes in detail the main elements of judicial geography and its role and significance for such legal sciences, as criminal law, criminal procedure, criminalistics, and criminology among others. The employed research methods allow showing the main vectors of the development of judicial geography, taking into account the previous achievements of Russian and worldwide academics. The author indicates the role and place of judicial geography in the system of legal sciences. This study suggests a concept of using scientific geographical methods in the study of various legal phenomena of a criminal and criminal-procedural nature when considering the idea of building judicial bodies and judicial instances, taking into account geographical and climatic factors. In this regard, the author advises to introduce the special course “Judicial Geography”, which would allow law students to study the specifics of the activities of the judiciary and preliminary investigation authorities from a geographical point of view, as well as to use various geographical methods, including the mapping method, in educational and practical activities. The author concludes that forensic geography may become a new milestone for subsequent scientific research in geography and jurisprudence.

scholarly journals The Flexible Burr X-G Family: Properties, Inference, and Applications in Engineering Science

Symmetry ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 474
Author(s):  
Abdulhakim A. Al-Babtain ◽  
Ibrahim Elbatal ◽  
Hazem Al-Mofleh ◽  
Ahmed M. Gemeay ◽  
Ahmed Z. Afify ◽  
...  
Keyword(s):  
Numerical Simulations ◽  
Exponential Distribution ◽  
Real Data ◽  
Exponential Model ◽  
Statistical Properties ◽  
Engineering Science ◽  
Data Sets ◽  
Engineering Sciences ◽  
General Statistical ◽  
Anderson Darling

In this paper, we introduce a new flexible generator of continuous distributions called the transmuted Burr X-G (TBX-G) family to extend and increase the flexibility of the Burr X generator. The general statistical properties of the TBX-G family are calculated. One special sub-model, TBX-exponential distribution, is studied in detail. We discuss eight estimation approaches to estimating the TBX-exponential parameters, and numerical simulations are conducted to compare the suggested approaches based on partial and overall ranks. Based on our study, the Anderson–Darling estimators are recommended to estimate the TBX-exponential parameters. Using two skewed real data sets from the engineering sciences, we illustrate the importance and flexibility of the TBX-exponential model compared with other existing competing distributions.

scholarly journals Molecular biology approaches in bioadhesion research

2014 ◽  
Vol 5 ◽  
pp. 983-993 ◽  
Author(s):  
Marcelo Rodrigues ◽  
Birgit Lengerer ◽  
Thomas Ostermann ◽  
Peter Ladurner
Keyword(s):  
Molecular Biology ◽  
Biological Function ◽  
Molecular Approach ◽  
Research Groups ◽  
Blast Search ◽  
Search Facility ◽  
New Research ◽  
And Function ◽  
Functional Analyses

The use of molecular biology tools in the field of bioadhesion is still in its infancy. For new research groups who are considering taking a molecular approach, the techniques presented here are essential to unravelling the sequence of a gene, its expression and its biological function. Here we provide an outline for addressing adhesion-related genes in diverse organisms. We show how to gradually narrow down the number of candidate transcripts that are involved in adhesion by (1) generating a transcriptome and a differentially expressed cDNA list enriched for adhesion-related transcripts, (2) setting up a BLAST search facility, (3) perform an in situ hybridization screen, and (4) functional analyses of selected genes by using RNA interference knock-down. Furthermore, latest developments in genome-editing are presented as new tools to study gene function. By using this iterative multi-technologies approach, the identification, isolation, expression and function of adhesion-related genes can be studied in most organisms. These tools will improve our understanding of the diversity of molecules used for adhesion in different organisms and these findings will help to develop innovative bio-inspired adhesives.

Music Neurotechnology for Sound Synthesis: Sound Synthesis with Spiking Neuronal Networks

Leonardo ◽  
2009 ◽  
Vol 42 (5) ◽  
pp. 439-442 ◽  
Author(s):  
Eduardo R. Miranda ◽  
John Matthias
Keyword(s):  
Cortical Neurons ◽  
Neuronal Networks ◽  
Research Area ◽  
Sound Synthesis ◽  
Ongoing Research ◽  
Computer Interfaces ◽  
Engineering Sciences ◽  
New Research ◽  
Sound Files

Music neurotechnology is a new research area emerging at the crossroads of neurobiology, engineering sciences and music. Examples of ongoing research into this new area include the development of brain-computer interfaces to control music systems and systems for automatic classification of sounds informed by the neurobiology of the human auditory apparatus. The authors introduce neurogranular sampling, a new sound synthesis technique based on spiking neuronal networks (SNN). They have implemented a neurogranular sampler using the SNN model developed by Izhikevich, which reproduces the spiking and bursting behavior of known types of cortical neurons. The neurogranular sampler works by taking short segments (or sound grains) from sound files and triggering them when any of the neurons fire.

Improvement of Superplasticity in Fine-Grained Oxide Ceramics Based on the Concept of Grain Boundary Plasticity

2016 ◽  
Vol 838-839 ◽  
pp. 34-40
Author(s):  
Hidehiro Yoshida ◽  
Koji Morita ◽  
Byung Nam Kim ◽  
Koji Matsui ◽  
Yuichi Ikuhara ◽  
...  
Keyword(s):  
Grain Boundary ◽  
Atomic Structure ◽  
Nucleation And Growth ◽  
Phenomenological Analysis ◽  
Research Field ◽  
Oxide Ceramics ◽  
Cavity Nucleation ◽  
Fine Grained ◽  
Experimental Strain ◽  
New Research

Superplasticity in fine-grained oxide ceramics has been generally elucidated on the basis of their experimental strain rate-flow stress relationship and phenomenological analysis of cavity nucleation and growth. It has been widely accepted that the high temperature superplastic flow and failure in ceramics is significantly influenced by the atomic structure and chemistry of grain boundaries. Such phenomenon cannot be explained based on the classical phenomenological analysis. Our research group has therefore proposed to establish a new research field, grain boundary plasticity, to describe the superplastic deformation related to the grain boundary atomic structure. This paper aims to point out the importance of the atomistic analysis of grain boundary to develop new superplastic ceramics.

Perceptions and pathways of resilience in Addis Ababa

2018 ◽  
Vol 36 (4) ◽  
pp. 337-352
Author(s):  
Nicole Baron ◽  
Zegeye Cherenet
Keyword(s):  
Addis Ababa ◽  
Research Field ◽  
Change Resistance ◽  
Theory Approach ◽  
Expert Interviews ◽  
Urban Resilience ◽  
Initial Attempt ◽  
Content Type ◽  
African Perspective ◽  
New Research

Purpose Resilience has recently attracted widespread interest in the field of urban planning and theory. However, the research that has been conducted on urban resilience in Africa has major theoretical and methodological gaps. This can lead to problems when designing and implementing resilience strategies there. Understanding African perspectives can be a way of tackling these. The paper aims to discuss these issues. Design/methodology/approach Using the example of Addis Ababa, Ethiopia, this paper analyses expert interviews based on a grounded theory approach. The goal is to explore locally specific perceptions of and pathways to urban resilience. By comparing these findings to those reported in the existing literature, differences and overlaps are identified. Findings This study provides evidence for the existence of locally specific perceptions of and pathways to urban resilience. Furthermore, it identifies urban development pathways such as complete urban makeover (tabula rasa) and complete negation of change (resistance). Research limitations/implications Because this study uses Addis Ababa as a singular case and expert interviews as method, it rather represents an initial attempt at exploring a new research field than claiming generalisability. Its quality and significance lie in its discursive approach and theory formation. Practical implications This exemplary study from Ethiopia demonstrates that a regionally specific understanding of urban resilience is valuable for the design and implementation of urban resilience strategies. Originality/value This study offers unique insights into urban resilience from an African perspective and into the manifestation of urban resilience in Addis Ababa.

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